Acoustic trauma increases ribbon number and size in outer hair cells of the mouse cochlea
Open accessAbstract
Outer hair cells (OHCs) in the mouse cochlea are contacted by up to three type II afferent boutons. On average, only half of these are postsynaptic to presynaptic ribbons. Mice of both sexes were subjected to acoustic trauma that produced a threshold shift of 44.2 ± 9.1 dB 7 days after exposure. Ribbon synapses of OHCs were quantified in post-trauma and littermate controls using immunolabeling of CtBP2. Visualization with virtual reality was used to determine 3-D cytoplasmic localization of CtBP2 puncta to the synaptic pole of OHCs. Acoustic trauma was associated with a statistically significant increase in the number of synaptic ribbons per OHC. Serial section TEM was carried out on similarly treated mice. This also showed a significant increase in the number of ribbons in post-trauma OHCs, as well as a significant increase in ribbon volume compared to ribbons in control OHCs. An increase in OHC ribbon synapses after acoustic trauma is a novel observation that has implications for OHC:type II afferent signaling. A mathematical model showed that the observed increase in OHC ribbons considered alone could produce a significant increase in action potentials among type II afferent neurons during strong acoustic stimulation.
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Ribbons of the OHCs increase in number and size after acoustic trauma, potentially providing stronger synaptic excitation to rouse previously silent type II contacts.
“Presynaptically, ribbons of the OHCs increase in number and size after acoustic trauma (53), potentially providing stronger synaptic excitation to rouse previously silent type II contacts (27).”
From Damage-evoked signals in cochlear neurons and supporting cells (2024) · cites this paper as [53]
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- Authors
- Wood, M. B., Nowak, N., Mull, K., Goldring, A., Lehar, M., & Fuchs, P. A.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Wood, Megan B
- Venue
- Journal of the Association for Research in Otolaryngology
- Published
- 2020-11-05
- Volume
- 22
- Issue
- 1
- Pages
- 19-31
- ISSN
- 1438-7573 (ISSN-L)
- 1525-3961
- PMC
- PMC7822997
- OpenAlex
- W3096326250
- Cited by
- 21
- References
- 62
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 7
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of the Association for Research in Otolaryngology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01 DC016559, T32 DC000023)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Keywords
- acoustic trauma, outer hair cells, ribbon synapses, CtBP2, threshold shift, mouse cochlea
- MeSH terms
- Acoustic Stimulation, Animals, Auditory Threshold, Hearing Loss, Noise-Induced, Synapses, Presynaptic Terminals, Hair Cells, Vestibular, Hair Cells, Auditory, Outer, Mice
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