Age-related changes in immune parameters in a very old population of Swedish people: A longitudinal study
Abstract
This study used a longitudinal design to examine age-related changes in a well-defined sample of Swedish people ranging from 86 to 92 years of age at baseline. The longitudinal design encompassed three measurement occasions with 1 year intermeasurement intervals. The results were analyzed by multivariate analyses of variance (MANOVA), which is useful for comparing individuals over time. Healthy middle-aged subjects (39 years SD +/- 5.8) served as controls. The proliferative responses to Concanavalin A (Con A), a T-cell mitogen, indicated significant lower levels in responses of the old when the two groups were compared. The MANOVA revealed no significant change in mitogen responses over measurement occasions in the old sample as compared with the young. However, when cell types and lymphocyte subpopulations were examined, significant differences were found between the two age groups in many of these parameters and for some (lymphocyte percentages and numbers, CD3 numbers) the MANOVA indicated significant decreases over the measurement occasions in the very old. The results also consistently indicated significant intraindividual correlations in cell types, lymphocyte subpopulations, and mitogen responses over time.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Miller, R. A. (1991) · International review of cytology · doi:10.1016/s0074-7696(08)61527-2 · Cited by 353 · see citing works
Decline in mitogen induced proliferation of lymphocytes with increasing age.
Murasko, D. M., Weiner, P., & Kaye, D. (1987) · PubMed · Cited by 192 · see citing works
Absolute Peripheral Blood Lymphocyte Count and Subsequent Mortality of Elderly Men
Bender, B. S., Nagel, J. E., Adler, W. H., & Andres, R. (1986) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1986.tb04906.x · Cited by 110 · see citing works
Changes in Cognitive Functioning of the Oldest Old
Johansson, B. E. A., Zarit, S. H., & Berg, S. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.2.p75 · Cited by 88 · see citing works
Self-citationNext Steps in Describing Aging and Disease in Longitudinal Studies
Fozard, J. L., Metter, E. J., & Brant, L. J. (1990) · Journal of Gerontology · doi:10.1093/geronj/45.4.p116 · Cited by 86 · see citing works
Hallgren, H. M., Bergh, N., Rodysil, K. J., et al. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90045-0 · Cited by 66 · see citing works
Longitudinal Design and Longitudinal Analysis
Campbell, R. T., Mutran, E. J., & Parker, R. N. (1986) · Research on Aging · doi:10.1177/0164027586008004003 · Cited by 32 · see citing works
CYCLIC VARIATION IN THE RESPONSE OF LYMPHOCYTES TO PHYTOHEMAGGLUTININ IN HEALTHY INDIVIDUALS
Dionigi, R., Zonta, A., ALBEETARIO, F., et al. (1973) · Transplantation · doi:10.1097/00007890-197312000-00003 · Cited by 32 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Psychological stress and the human immune system: a meta-analytic study of 30 Years of inquiry
Segerstrom, S. C., & Miller, G. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.4.601 · Cited by 3,334 · see citing works
Olsson, J., Wikby, A., Johansson, B., Löfgren, S., Nilsson, B.-O., & Ferguson, F. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00210-4 · Cited by 474 · see citing works
Self-citationHuman immunosenescence: is it infectious?
Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00271.x · Cited by 405 · see citing works
Self-citationWikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407 · see citing works
Self-citationFrasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5283 · Cited by 333 · see citing works
Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P., Baylis, D., Syddall, H., Sayer, A. A., Cooper, C., & Lord, J. M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00849.x · Cited by 278 · see citing works
Role of CMV in immune senescence.
Pawelec, G., & Derhovanessian, E. (2011) · Virus Research · doi:10.1016/j.virusres.2010.09.010 · Cited by 201 · see citing works
Derhovanessian, E., Solana, R., Larbi, A., & Pawelec, G. (2008) · Immunity & Ageing · doi:10.1186/1742-4933-5-11 · Cited by 169 · see citing works
Immunosenenescence: role of cytomegalovirus
Pawelec, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.010 · Cited by 163 · see citing works
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112 · see citing works
Mechanisms for Decreased Function of B Cells in Aged Mice and Humans
Frasca, D., Landin, A. M., Riley, R. L., & Blomberg, B. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.2741 · Cited by 97 · see citing works
The SENIEUR protocol after 16 years
Pawelec, G., Ferguson, F. G., & Wikby, A. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00240-2 · Cited by 83 · see citing works
Self-citation
- Authors
- Wikby, A., Johansson, B., Ferguson, F., & Olsson, J.
- Affiliations
- Jönköping University (SE)
- Pennsylvania State University (US)
- Ryhov Hospital Jönköping (SE)
- Corresponding author
- Ferguson, Frederick
- ORCID
- Johansson, Boo
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 29
- Issue
- 5
- Pages
- 531-541
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2040745128
- Cited by
- 144
- References
- 8
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- aging, immune function, oldest old, lymphocyte subsets, mitogen response, concanavalin A, T cell proliferation, CD3+ T cells, within-person change, age-related immune decline
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Humans, Leukocyte Count, Longitudinal Studies, Lymphocyte Activation, Middle Aged, Sweden, Lymphocyte Subsets
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
