Mechanisms for Decreased Function of B Cells in Aged Mice and Humans

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Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

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Post‐transcriptional regulation of gene expression by degradation of messenger RNAs

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B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching

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The cellular response to general and programmed DNA double strand breaks

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Age-related Defects in CD4 T Cell Cognate Helper Function Lead to Reductions in Humoral Responses

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EBF and E47 Collaborate to Induce Expression of the Endogenous Immunoglobulin Surrogate Light Chain Genes

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MAPKAP Kinase 2 Phosphorylates Tristetraprolin on in Vivo Sites Including Ser178, a Site Required for 14-3-3 Binding

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CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

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Induction of Early B Cell Factor (EBF) and Multiple B Lineage Genes by the Basic Helix-Loop-Helix Transcription Factor E12

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E-proteins directly regulate expression of activation-induced deaminase in mature B cells

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Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line.Preprint

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Regulation of Aged Humoral Immune Defense against Pneumococcal Bacteria by IgM Memory B Cell

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Immunosenescence and germinal center reaction

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Changes in the B-cell repertoire with age

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Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NF B

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Immunological studies of aging. IV. The contribution of thymic involution to the immune deficiencies of aging mice and reversal with thymopoietin32-36.

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Aid

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Effect of age on humoral immunity, selection of the B‐cell repertoire and B‐cell development

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Decreased Sensitivity of Tristetraprolin-deficient Cells to p38 Inhibitors Suggests the Involvement of Tristetraprolin in the p38 Signaling Pathway

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Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice.

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AID in somatic hypermutation and class switch recombination

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B Cell Maintenance in Aged Mice Reflects Both Increased B Cell Longevity and Decreased B Cell Generation

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Immunosenescence

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Changes in circuIating B cells and immunoglobulin cIasses and subcIasses in a healthy aged popuIation

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Age-related decline in the in vitro and in vivo syntheses of anti-tetanus toxoid antibody in humans.

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Reduced Ig class switch in aged mice correlates with decreased E47 and activation-induced cytidine deaminase

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Age-related changes in immune parameters in a very old population of Swedish people: A longitudinal study

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Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae

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Essential role of Id2 in negative regulation of IgE class switching

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B cells in the aged: CD27, CD5, and CD40 expression

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E2A activity is induced during B‐cell activation to promote immunoglobulin class switch recombination

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Aging-Dependent Exclusion of Antigen-Inexperienced Cells from the Peripheral B Cell Repertoire

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B lymphopoiesis is active throughout human life, but there are developmental age-related changes

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Aged T cells are hyporesponsive to costimulation mediated by CD28.

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Enhanced Differentiation of Splenic Plasma Cells but Diminished Long-Lived High-Affinity Bone Marrow Plasma Cells in Aged Mice

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Age‐related changes in antibody repertoire: contribution from T cells

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Tristetraprolin, a Negative Regulator of mRNA Stability, Is Increased in Old B Cells and Is Involved in the Degradation of E47 mRNA

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Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity

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B cell precursors are decreased in senescent mice, but retain normal mitotic activity in vivo and in vitro

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Decreased E12 and/or E47 Transcription Factor Activity in the Bone Marrow As Well As in the Spleen of Aged Mice

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Inhibition of IgG1 and IgE Production by Stimulation of the B Cell CTLA-4 Receptor

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The regulation and function of the Id proteins in lymphocyte development

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Decreased E47 in Senescent B Cell Precursors Is Stage Specific and Regulated Posttranslationally by Protein Turnover

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Altered VH gene segment utilization in the response to phosphorylcholine by aged mice.

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The Effects of Age on the Immune Response to Type III Pneumococcal Polysaccharide (SIII) and Bacterial Lipopolysaccharide (LPS) in BALB/c, SJL/J, and C3H Mice

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Age-dependent altered proportions in subpopulations of tonsillar lymphocytes

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Diversity of the Ig Repertoire is Maintained With Age In Spite of Reduced Germinal Centre Cells in Human Tonsil Lymphoid Tissue

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Accelerated Notch-Dependent Degradation of E47 Proteins in Aged B Cell Precursors Is Associated with Increased ERK MAPK Activation

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Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF

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CD40:CD40L Interactions in X-linked and Non-X-linked Hyper-IgM Syndromes

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Antibody diversity: one enzyme to rule them all

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Aged mice exhibit distinct B cell precursor phenotypes differing in activation, proliferation and apoptosis

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NF-kappaB is required for CD38-mediated induction of Cgamma1 germline transcripts in murine B lymphocytes

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Requirement for dual signals by anti-CD40 and IL-4 for the induction of nuclear factor-kappa B, IL-6, and IgE in human B lymphocytes.

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Characterization of the mUBC9-binding Sites Required for E2A Protein Degradation

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Human B cel proliferative responses during aging. Reduced RNA synthesis and DNA replication after signal transduction by surface immunoglobulins compared to B cell antigenic determinants CD20 and CD40

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Hyper-IgM syndromes: a model for studying the regulation of class switch recombination and somatic hypermutation generation

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Effect of Age on the Immunoglobulin Class Switch

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Cell death and longevity: implications of Fas‐mediated apoptosis in T‐cell senescence

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RNA Stability of the E2A -Encoded Transcription Factor E47 Is Lower in Splenic Activated B Cells from Aged Mice

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B cells and aging: gauging the interplay of generative, selective, and homeostatic events

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Immunophenotyping and T-cell proliferative capacity in a healthy aged population

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Aging, Immunity, and Infection

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Age-related changes in cell surface and senescence markers in the spleen of DBA/2 mice: A flow cytometric analysis

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Dysfunction of B Cell Leading to Failure of Immunoglobulin Response Is Ameliorated by Dietary Silk Peptide in 14-Month-Old C57BL/6 Mice

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Recommended Vaccines for Immunocompetent Older Adults: A Work Group Report of the AAAAI Asthma, Allergic & Immunologic Diseases in Older Adults Committee

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The Role of the E47-p21 Pathway in Long-Term Hematopoietic Stem Cells During Homeostasis and Under Repopulation Stress

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The Role of MicroRNAs in Immunosenescence Process

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Aging: An Etiological Factor in The Development of Intestinal Tumorigenesis

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Aging Differentially Effects Diet-Induced Obesity and Central Leptin Sensitivity in Rats

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AID in Aging and in Autoimmune Disease

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B cells as multifactorial players in multiple sclerosis pathogenesis

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Evaluierung immunmodulatorischer microRNAs im Rahmen von Immunoseneszenz und chronischer Herzinsuffizienz

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Additional file 2 of Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor

Xiao, T., Wei, M., Guo, X., Zhang, Y., Wang, Z., Xia, X., Qi, X., Wang, L., Li, X., & Leng, S. X. (2023) · Figshare · doi:10.6084/m9.figshare.23797379

Additional file 1 of Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor

Xiao, T., Wei, M., Guo, X., Zhang, Y., Wang, Z., Xia, X., Qi, X., Wang, L., Li, X., & Leng, S. X. (2023) · Figshare · doi:10.6084/m9.figshare.23797376

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RNA-binding proteins in aging and age-related diseases: roles, mechanisms, and a large language model analysis

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Age effects on mouse and human B cells

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Mechanisms for TNF-α-mediated down-regulation of murine B cell responses with age (113.13)

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Transcription Factors in Mature B-Cells During Aging

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Effects of aging on B cell function

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