A polyphenol rescues lipid induced insulin resistance in skeletal muscle cells and adipocytes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works

Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714 · see citing works

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248 · see citing works

Antioxidant potential of ferulic acid

Graf, E. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90184-i · Cited by 1,115 · see citing works

Antioxidant Properties of Ferulic Acid and Its Related Compounds

Kikuzaki, H., Hisamoto, M., Hirose, K., Akiyama, K., & Taniguchi, H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf011348w · Cited by 1,016 · see citing works

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works

Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure

Nesto, R. W., Bell, D. S. H., Bonow, R. O., Fonseca, V. A., Grundy, S. M., Horton, E. S., Winter, M. L., Porte, D., Semenkovich, C. F., Smith, S. E., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103683.99399.7e · Cited by 831 · see citing works

Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

Samuel, V. T., Liu, Z.-X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X.-M., Monia, B. P., Bhanot, S., & Shulman, G. I. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30400 · Cited by 497 · see citing works

Synergistic interaction between exercise and insulin on peripheral glucose uptake.

DeFronzo, R. A., Ferrannini, E., Sato, Y., Felig, P., & Wahren, J. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110399 · Cited by 415 · see citing works

Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene

Mathews, S. T., Singh, G. P., Ranalletta, M., Cintrón, V. J., Qiang, X., Goustin, A. S., Jen, K. C., Charron, M. J., Jahnen‐Dechent, W., & Grunberger, G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2450 · Cited by 343 · see citing works

Once- and Twice-Daily Dosing With Rosiglitazone Improves Glycemic Control in Patients With Type 2 Diabetes

Phillips, L. S., Grunberger, G., Miller, E., Patwardhan, R., Rappaport, E. B., & Salzman, A. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.308 · Cited by 301 · see citing works

Bioavailability of Ferulic Acid

Bourne, L., & Rice-Evans, C. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9681 · Cited by 275 · see citing works

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

Sugii, S., Olson, P., Sears, D. D., Saberi, M., Atkins, A. R., Barish, G. D., Hong, S.-H., Castro, G. L., Yin, Y.-Q., Nelson, M. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912487106 · Cited by 255 · see citing works

Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice

FOTI, D. P., CHIEFARI, E. D., Fedele, M., Iuliano, R., Brunetti, L., Paonessa, F., Manfioletti, G., Barbetti, F., Brunetti, A., Croce, C. M., et al. (2005) · Nature Medicine · doi:10.1038/nm1254 · Cited by 221 · see citing works

Unraveling the mechanism of action of thiazolidinediones

Kahn, C. R., Chen, L., & Cohen, S. E. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11705 · Cited by 191 · see citing works

Antioxidant activity and hypoglycemic effect of ferulic acid in STZ‐induced diabetic mice and KK‐A y mice

Ohnishi, M., Matuo, T., Tsuno, T., Hosoda, A., Nomura, E., Taniguchi, H., Sasaki, H., & Morishita, H. (2004) · BioFactors · doi:10.1002/biof.552210161 · Cited by 183 · see citing works

NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

Dasgupta, S., Bhattacharya, S., Biswas, A., Majumdar, S. S., Mukhopadhyay, S., Ray, S., & Bhattacharya, S. (2010) · Biochemical Journal · doi:10.1042/bj20100330 · Cited by 168 · see citing works

Universally occurring phenylpropanoid and species-specific indolic metabolites in infected and uninfected Arabidopsis thaliana roots and leaves

Tan, J., Bednarek, P., Liu, J., Schneider, B., Svatoš, A., & Hahlbrock, K. (2004) · Phytochemistry · doi:10.1016/j.phytochem.2003.12.009 · Cited by 162 · see citing works

A Nucleoprotein Complex Containing Sp1, C/EBPβ, and HMGI-Y Controls Human Insulin Receptor Gene Transcription

FOTI, D. P., Iuliano, R., CHIEFARI, E. D., & Brunetti, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2720-2732.2003 · Cited by 135 · see citing works

Adipocyte Fetuin-A Contributes to Macrophage Migration into Adipose Tissue and Polarization of Macrophages

Chatterjee, P., Seal, S., Mukherjee, S., Kundu, R., Mukherjee, S., Ray, S., Mukhopadhyay, S., Majumdar, S. S., & Bhattacharya, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.495473 · Cited by 132 · see citing works

Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.

Boden, G., Homko, C., Mozzoli, M., Showe, L. C., Nichols, C., & Cheung, P. (2005) · Diabetes · doi:10.2337/diabetes.54.3.880 · Cited by 129 · see citing works

Molecular mechanism of insulin resistance

Bhattacharya, S., Dey, D., & Roy, S. S. (2007) · Journal of Biosciences · doi:10.1007/s12038-007-0038-8 · Cited by 116 · see citing works

Thiazolidinedione-Associated Congestive Heart Failure and Pulmonary Edema

Kermani, A., & Garg, A. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.9.1088 · Cited by 115 · see citing works

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

Galbo, T., Perry, R. J., Jurczak, M. J., Camporez, J. P., Alves, T. C., Kahn, M., Guigni, B. A., Serr, J., Zhang, D., Bhanot, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311176110 · Cited by 103 · see citing works

Dynamic interaction of HMGA1a proteins with chromatin

Harrer, M., Lührs, H., Bustin, M., Scheer, U., & Hock, R. (2004) · Journal of Cell Science · doi:10.1242/jcs.01160 · Cited by 95 · see citing works

Cellular Mechanism of Nutritionally Induced Insulin Resistance in Psammomys Obesus

Ikeda, Y., Olsen, G. S., Ziv, E., Hansen, L. L., Busch, A. K., Hansen, B. F., Shafrir, E., & Mosthaf, L. (2001) · Diabetes · doi:10.2337/diabetes.50.3.584 · Cited by 93 · see citing works

Relationship between in Vivo Insulin Resistance and Decreased Insulin Receptors in Obese Man*

KOLTERMAN, O. G., REAVEN, G. M., & OLEFSKY, J. M. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-3-487 · Cited by 85 · see citing works

Involvement of novel PKC isoforms in FFA induced defects in insulin signaling

Dey, D., Basu, D., Roy, S. S., Bandyopadhyay, A., & Bhattacharya, S. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.12.014 · Cited by 75 · see citing works

Palmitate-Activated Macrophages Confer Insulin Resistance to Muscle Cells by a Mechanism Involving Protein Kinase C θ and ε

Kewalramani, G., Fink, L. N., Asadi, F., & Klip, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026947 · Cited by 57 · see citing works

Bio‐assay Guided Isolation of α‐Glucosidase Inhibitory Constituents from Hibiscus Mutabilis Leaves

Kumar, D., Kumar, H., Vedasiromoni, J. R., & Pal, B. C. (2011) · Phytochemical Analysis · doi:10.1002/pca.1375 · Cited by 50 · see citing works

Prevention of insulin resistance and beta‐cell loss by abrogating PKCε‐induced serine phosphorylation of muscle IRS‐1 in Psammomys obesus

Mack, E., Ziv, E., Reuveni, H., Kalman, R., Niv, M. Y., Jörns, A., Lenzen, S., & Shafrir, E. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.881 · Cited by 36 · see citing works

Selective Growth Inhibitor toward Human Intestinal Bacteria Derived from Pulsatilla cernua Root

Lee, H., Beon, M., & Kim, M.-K. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010609z · Cited by 36 · see citing works

Mechanism of lipid induced insulin resistance: Activated PKCε is a key regulator

Dasgupta, S., Bhattacharya, S., Maitra, S., Pal, D., Majumdar, S. S., Datta, A., & Bhattacharya, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.01.001 · Cited by 32 · see citing works

Fatty acid represses insulin receptor gene expression by impairing HMGA1 through protein kinase Cε

Dey, D., Bhattacharya, A., Roy, S., & Bhattacharya, S. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.183 · Cited by 32 · see citing works

Cinnamic Acid and Its Derivatives: Mechanisms for Prevention and Management of Diabetes and Its Complications

Adisakwattana, S. (2017) · Nutrients · doi:10.3390/nu9020163 · Cited by 314 · see citing works

Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases

Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works

Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms—A Narrative Review

Wali, J. A., Jarzebska, N., Raubenheimer, D., Simpson, S. J., Rodionov, R. N., & O’Sullivan, J. (2020) · Nutrients · doi:10.3390/nu12051505 · Cited by 245 · see citing works

Ferulic acid improves lipid and glucose homeostasis in high‐fat diet‐induced obese mice

Naowaboot, J., Piyabhan, P., Munkong, N., Parklak, W., & Pannangpetch, P. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12514 · Cited by 131 · see citing works

Hybrid drug combination: Combination of ferulic acid and metformin as anti-diabetic therapy

Nankar, R. P., Prabhakar, P. K., & Doble, M. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.10.015 · Cited by 105 · see citing works

Influences of dietary oils and fats, and the accompanied minor content of components on the gut microbiota and gut inflammation: A review

Ye, Z., Xu, Y., & Liu, Y. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.05.001 · Cited by 85 · see citing works

Transcriptional Regulation of Glucose Metabolism: The Emerging Role of the HMGA1 Chromatin Factor

CHIEFARI, E. D., FOTI, D. P., Sgarra, R., Pegoraro, S., Arcidiacono, B., Brunetti, F. S., Greco, M., Manfioletti, G., & Brunetti, A. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00357 · Cited by 65 · see citing works

Protective Effects of Ferulic Acid on Metabolic Syndrome: A Comprehensive Review

Ye, L., Hu, P., Feng, L., Huang, L.-L., Wang, Y., Yan, X., Xiong, J., & Xia, H. (2022) · Molecules · doi:10.3390/molecules28010281 · Cited by 60 · see citing works

Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells

Yuan, H., Hu, Y., Zhu, Y., Zhang, Y., Luo, C., Li, Z., Wen, T., Zhuang, W., Zou, J., Hong, L., et al. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.025 · Cited by 57 · see citing works

miR-625 suppresses cell proliferation and migration by targeting HMGA1 in breast cancer

Zhou, W.-B., Zhong, C., Luo, X., Zhang, Y., Zhang, G., Zhou, D., & Liu, L. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.01.122 · Cited by 39 · see citing works

3-(4-Hydroxy-3-methoxyphenyl)propionic Acid Produced from 4-Hydroxy-3-methoxycinnamic Acid by Gut Microbiota Improves Host Metabolic Condition in Diet-Induced Obese Mice

Ohue‐Kitano, R., Taira, S., Watanabe, K., Masujima, Y., Kuboshima, T., Miyamoto, J., Nishitani, Y., Kawakami, H., Kuwahara, H., & Kimura, I. (2019) · Nutrients · doi:10.3390/nu11051036 · Cited by 38 · see citing works

Beneficial effects of metformin on muscle atrophy induced by obesity in rats

Hasan, M. M., Shalaby, S. M., El‐Gendy, J., & Abdelghany, E. M. A. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27852 · Cited by 37 · see citing works

Bioactive Components in Whole Grains for the Regulation of Skeletal Muscle Function

Li, Q., Yang, H., Song, S., Liu, J., Wang, Z., & Wang, J. (2022) · Foods · doi:10.3390/foods11182752 · Cited by 37 · see citing works

MiR-21 antagomir improves insulin resistance and lipid metabolism disorder in streptozotocin-induced type 2 diabetes mellitus rats

Wang, Y., Yang, L.-Z., Yang, D.-G., Zhang, Q., Deng, Z.-N., Wang, K., & Mao, X.-J. (2020) · Annals of Palliative Medicine · doi:10.21037/apm.2020.02.28 · Cited by 32 · see citing works

Hydrolyzed Bound Phenolics from Rice Bran Alleviate Hyperlipidemia and Improve Gut Microbiota Dysbiosis in High-Fat-Diet Fed Mice

Zhao, G., Zhang, R., Huang, F., Dong, L., Liu, L., Jia, X., Chi, J., Ma, Y., Deng, M., Chen, Y., et al. (2022) · Nutrients · doi:10.3390/nu14061277 · Cited by 25 · see citing works

Anti-insulin resistant effect of ferulic acid on high fat diet-induced obese mice

Naowaboot, J., Piyabhan, P., Tingpej, P., Munkong, N., Parklak, W., & Pannangpetch, P. (2018) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.248098 · Cited by 25 · see citing works

Beneficial effect of the methanolic leaf extract of Allium hookeri on stimulating glutathione biosynthesis and preventing impaired glucose metabolism in type 2 diabetes

Deka, B., Barge, S., Bharadwaj, S., Kashyap, B., Manna, P., Borah, J. C., & Talukdar, N. C. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108961 · Cited by 20 · see citing works

PKCε as a novel promoter of skeletal muscle differentiation and regeneration

Marcantonio, D. D., Galli, D., Carubbi, C., Gobbi, G., Queirolo, V., Martini, S., Merighi, S., Vaccarezza, M., Maffulli, N., Sykes, S. M., et al. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.09.017 · Cited by 19 · see citing works

Chronic Elevation of Skeletal Muscle [Ca2+]i Impairs Glucose Uptake. An in Vivo and in Vitro Study

Uryash, A., Mijares, A., Lopez, C. E., Adams, J. A., & Lopez, J. R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.872624 · Cited by 17 · see citing works

4-hydroxy-3-methoxycinnamic acid regulates orexigenic peptides and hepatic glucose homeostasis through phosphorylation of FoxO1

Kinyua, A. W., Ko, C. M., Doan, K. V., Yang, D. J., Huynh, M. K. Q., Moh, S. H., Choi, Y., & Kim, K. W. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.253 · Cited by 17 · see citing works

A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes

Oh, M., Lee, H. H. L., Lee, H., Do, M. H., Park, M., Lee, C. H., & Park, H. (2022) · Food & Function · doi:10.1039/d1fo04152e · Cited by 13 · see citing works

Coffee and Its Major Polyphenols in the Prevention and Management of Type 2 Diabetes: A Comprehensive Review

Kim, H., Kim, S. R., & Jung, U. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125544 · Cited by 12 · see citing works

Potential of Laurel (Laurus nobilis L.) Leaf Polyphenols for Modulation of Body Composition

Dobroslavić, E., Garofulić, I. E., & Ilich, J. Z. (2023) · Applied Sciences · doi:10.3390/app13042275 · Cited by 9 · see citing works

The Gut Microflora and its Metabolites Regulate the Molecular Crosstalk between Diabetes and Neurodegeneration

Lomis, S. W. N. (2015) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000577 · Cited by 9 · see citing works

Remodeling of white adipose tissue microenvironment against obesity by phytochemicals

Ke, S., Hu, Q., Zhu, G., Li, L., Sun, X., Cheng, H., Li, L., Yao, Y., & Li, H. (2023) · Phytotherapy Research · doi:10.1002/ptr.7758 · Cited by 5 · see citing works

Association of mitochondrial dysfunction and lipid metabolism with type 2 diabetes mellitus: A review of literature

Haghani, K., Asadi, P., Taheripak, G., Noori-Zadeh, A., Darabi, S., & Bakhtiyari, S. (2018) · Frontiers in Biology · doi:10.1007/s11515-018-1521-3 · Cited by 4 · see citing works

Pharmacological potential of ferulic acid for the treatment of metabolic diseases and its mechanism of action: A review

Reyad‐ul‐Ferdous, M., & Song, Y. (2021) · Physiology and Pharmacology · doi:10.52547/phypha.26.4.8 · Cited by 2 · see citing works

Dietary Long Chain Omega-3 Polyunsaturated Fatty Acids and Inflammatory Gene Expression in Type 2 Diabetes

Thomas, J., & Garg, M. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801585-8.00023-3

Ferulic acid improves palmitate-induced insulin resistance by regulating IRS-1/Akt and AMPK pathways in L6 skeletal muscle cells.

Park, J., & Han, J. S. (2024) · Toxicological Research · doi:10.1093/toxres/tfae197 · Cited by 9 · see citing works

Anti-insulin resistant effect of ferulic acid on high fat diet-induced obese mice

Naowaboot, J., Piyabhan, P., Tingpej, P., Munkong, N., Parklak, W., & Pannangpetch, P. (2018) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.248098 · Cited by 25 · see citing works

Free fatty acid induced impairment of insulin signaling is prevented by the diastereomeric mixture of calophyllic acid and isocalophyllic acid in skeletal muscle cells

Jaiswal, N., Naresh, G., Maurya, C. K., Narender, T., & Tamrakar, A. K. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.049 · Cited by 13 · see citing works

Attenuation of Free Fatty Acid (FFA)-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol is Linked to Activation of AMPK and Inhibition of mTOR and p70 S6K

Hartogh, D. J. D., Vlavcheski, F., Giacca, A., & Tsiani, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144900 · Cited by 57 · see citing works

Attenuation of skeletal muscle FFA-induced insulin resistance by the polyphenol resveratrol. Elucidation of the mechanisms involved

Sanli, T. (2008) · Brock University Digital Repository (Brock University)