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Cited by 392Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyAmino Acid Enzymes and Metabolism

Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices

Hestrin, Shaul, Sah, Pankaj, Nicoll, Roger A.·1990·Neuron
DOI 10.1016/0896-6273(90)90162-9
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Abstract

We studied with the whole-cell recording techniques, the mechanisms underlying the time course of the slow N-methyl-D-aspartate (NMDA), and fast non-NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in hippocampal slices. The rising phase of the NMDA receptor-mediated component of the EPSC as well as the decaying phase of the NMDA and non-NMDA component were highly temperature-sensitive, suggesting that neither of these processes is determined by free diffusion of transmitter. Moreover, glutamate uptake blockers enhanced the responses to exogenously applied glutamate, but had no effect on the decay of either the NMDA or non-NMDA components of the EPSCs. On the other hand, open channel blockers known to modify NMDA channel kinetics reduced the EPSC decay time. Thus, the present results support a model in which the rise time and decay of the NMDA component are determined primarily by slow channel kinetics and the decay of the non-NMDA component is due either to channel kinetics or to desensitization.

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Crossref · 10.1016/0896-6273(90)90162-9

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  • If τsyn = 100 ms for NMDA receptor-mediated synapses and wrec = 0.9, then τnetwork = 1 s.

    “For instance, if τsyn = 100 ms for the NMDA receptor-mediated synapses (Hestrin et al., 1990), and wrec = 0.9, then τnetwork = 1 s.”

    From Decision Making in Recurrent Neuronal Circuits (2008) · cites this paper as Hestrin et al., 1990

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Authors
Hestrin, S., Sah, P., & Nicoll, R. A.
Affiliations
University of California, San Francisco (US)
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
1990-09
Volume
5
Issue
3
Pages
247-253
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/0896-6273(90)90162-9
OpenAlex
W2036495604
Cited by
392
References
48
Citations by year
2026: 5 · 2025: 4 · 2024: 4 · 2023: 23 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 14 · 2014: 8 · 2013: 4 · 2012: 5
FWCI
6.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns024205-07)
  • National Institute of Mental Health (MH0037, MH-38256)
  • National Institute of Neurological Disorders and Stroke (NS 24205)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
excitatory postsynaptic currents, NMDA receptor, non-NMDA receptors, temperature sensitivity, glutamate uptake, open-channel blockers, receptor desensitization, channel kinetics, hippocampus
MeSH terms
Animals, Aspartic Acid, Dibenzocycloheptenes, Electrophysiology, Glutamates, Hippocampus, Kainic Acid, Ketamine, Synapses, Temperature, Time Factors, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Dizocilpine Maleate, Receptors, Neurotransmitter, Glutamic Acid, Rats, In Vitro Techniques

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