A Model of Spatial Map Formation in the Hippocampus of the Rat

Blum, Kenneth I.; Abbott, L. F.

doi:10.1162/neco.1996.8.1.85

Cited by 352Memory and Neural MechanismsSpatial Cognition and NavigationNeural dynamics and brain function

A Model of Spatial Map Formation in the Hippocampus of the Rat

Blum, Kenneth I., Abbott, L. F.·1996·Neural Computation

DOI 10.1162/neco.1996.8.1.85

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Abstract

Using experimental facts about long-term potentiation (LTP) and hippocampal place cells, we model how a spatial map of the environment can be created in the rat hippocampus. Sequential firing of place cells during exploration induces, in the model, a pattern of LTP between place cells that shifts the location coded by their ensemble activity away from the actual location of the animal. These shifts provide a navigational map that, in a simulation of the Morris maze, can guide the animal toward its goal. The model demonstrates how behaviorally generated modifications of synaptic strengths can be read out to affect subsequent behavior. Our results also suggest a way that navigational maps can be constructed from experimental recordings of hippocampal place cells.

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A number of neurobiologically inspired, fully mechanistic computational models of navigational behavior have been developed to account for the ability of animals relying on allocentric frameworks to perform path planning without resorting to mentalistic explanations.
“A number of neurobiologically inspired, fully mechanistic computational models of navigational behavior have been developed to account for the ability of animals relying on allocentric frameworks to perform path planning, without the need to resort to “mentalistic” explanations”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [89]

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Authors: Blum, K. I., & Abbott, L. F.
Affiliations: Brandeis University (US)
ORCID: Abbott, L. F.
Venue: Neural Computation
Publisher: MIT Press
Published: 1996-01
Volume: 8
Issue: 1
Pages: 85-93
ISSN: 0899-7667 (ISSN-L)
1530-888X
DOI: 10.1162/neco.1996.8.1.85
OpenAlex: W2113273079
Cited by: 352
References: 33
Citations by year: 2026: 8 · 2025: 10 · 2024: 8 · 2023: 29 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 8 · 2012: 9
FWCI: 7.82
Type: journal article
Language: en
Open access: closed
Locations: Neural Computation (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
W. M. Keck Foundation
National Institute of Neurological Disorders and Stroke (NS07292., T32NS007292)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: hippocampus, place cells, long-term potentiation, rat navigation, Morris water maze, synaptic plasticity, spatial navigation
MeSH terms: Action Potentials, Animals, Brain Mapping, Cognition, Hippocampus, Models, Neurological, Long-Term Potentiation, Maze Learning, Rats

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A Model of Spatial Map Formation in the Hippocampus of the Rat

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