Synaptic basis for whisker deprivation-induced synaptic depression in rat somatosensory cortex
Open accessAbstract
Whisker deprivation weakens excitatory layer 4 (L4) inputs to L2/3 pyramidal cells in rat primary somatosensory (S1) cortex, which is likely to contribute to whisker map plasticity. This weakening has been proposed to represent long-term depression (LTD) induced by sensory deprivation in vivo. Here, we studied the synaptic expression mechanisms for deprivation-induced weakening of L4-L2/3 inputs and assessed its similarity to LTD, which is known to be expressed presynaptically at L4-L2/3 synapses. Whisker deprivation increased the paired pulse ratio at L4-L2/3 synapses and slowed the use-dependent block of NMDA receptor currents by MK-801 [(5S,10R)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate], indicating that deprivation reduced transmitter release probability at these synapses. In contrast, deprivation did not alter either miniature EPSC amplitude in L2/3 neurons or the amplitude of quantal L4-L2/3 synaptic responses measured in strontium, indicating that postsynaptic responsiveness was unchanged. In young postnatal day 12 (P12) rats, at least 4 d of deprivation were required to significantly weaken L4-L2/3 synapses. Similar weakening occurred when deprivation began at older ages (P20), when synapses are mostly mature, indicating that weakening is unlikely to represent a failure of synaptic maturation but instead represents a reduction in the strength of existing synapses. Thus, whisker deprivation weakens L4-L2/3 synapses by decreasing presynaptic function, similar to known LTD mechanisms at this synapse.
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Experience-dependent plasticity at excitatory synapses contributes to maturation of neuronal circuits in superficial cortical layers.
“While experience-dependent plasticity at excitatory synapses is known to contribute to the maturation of neuronal circuits in superficial layers of the cortex (Bender et al., 2006), recent work suggests that a specific population of interneurons is also involved in this process.”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Bender et al., 2006
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- Authors
- Bender, K. J., Allen, C. B., Bender, V. A., & Feldman, D. E.
- Affiliations
- University of California San Diego (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-04-19
- Volume
- 26
- Issue
- 16
- Pages
- 4155-4165
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3070309
- OpenAlex
- W2023937772
- Cited by
- 126
- References
- 68
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 5
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McKnight Endowment Fund for Neuroscience
- McKnight Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS046652)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- whisker deprivation, long-term depression, presynaptic depression, somatosensory cortex, layer 4, synaptic depression, NMDA receptor, paired-pulse ratio, sensory deprivation, synapse maturation
- MeSH terms
- Animals, Sensory Deprivation, Somatosensory Cortex, Synapses, Time Factors, Vibrissae, N-Methylaspartate, Dizocilpine Maleate, Excitatory Postsynaptic Potentials, Rats, Long-Evans, Long-Term Synaptic Depression, Rats
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