The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
Open accessAbstract
Non-A beta component of Alzheimer's disease amyloid (NAC) is the second component in the amyloid from brain tissue of patients affected with Alzheimer's disease. Its precursor protein (NACP) was shown to be a brain-specific protein. In rat brain, NACP was more abundant in the neocortex, hippocampus, olfactory bulb, striatum, thalamus, and cerebellum and less abundant in the brain stem. Confocal laser microscopy analysis revealed that anti-NACP immunostaining was colocalized with synaptophysin-immunoreactive presynaptic terminals. Ultrastructural analysis showed that NACP immunoreactivity was associated with synaptic vesicles. NACP sequence showed 95% identity with that of rat synuclein 1, a synaptic/nuclear protein previously identified in rat brain, and good homology with Torpedo synuclein from the electric organ synapse and bovine phosphoneuroprotein 14 (PNP-14), a brain-specific protein present in synapses. Therefore, NACP is a synaptic protein, suggesting that synaptic aberration observed in senile plaques might be involved in amyloidogenesis in Alzheimer's disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“αSyn is predominantly expressed within the presynaptic terminals of neurons [141–143]”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [141]
Citations
Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Self-citationStrittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
Maroteaux, L., Campanelli, J., & Scheller, R. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02804.1988 · Cited by 1,646
Wiedenmann, B. J., & Franke, W. W. (1985) · Cell · doi:10.1016/s0092-8674(85)80082-9 · Cited by 1,432
Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation
Kagawa, Y., & Racker, E. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61930-1 · Cited by 1,361
Kennelly, P. J., & Krebs, E. G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98436-x · Cited by 1,331
Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157
Identification of two distinct synucleins from human brain
Jakes, R., Spillantini, M. G., & Goedert, M. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00395-5 · Cited by 1,080
Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 900
Immunogenic structure of the influenza virus hemagglutinin
Green, N. H., Alexander, H., Olson, A. J., Alexander, S. P. H., Shinnick, T. M., Sutcliffe, J. G., & Lerner, R. A. (1982) · Cell · doi:10.1016/0092-8674(82)90202-1 · Cited by 756
Sequence identification of 2,375 human brain genes
Adams, M. D., Dubnick, M., Kerlavage, A. R., Moreno, R., Kelley, J. M., Utterback, T. R., Nagle, J. W., Fields, C., & Venter, J. C. (1992) · Nature · doi:10.1038/355632a0 · Cited by 754
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
Koo, E. H., Sisodia, S. S., Archer, D. R., Martin, L. J., Weidemann, A., Beyreuther, K., Fischer, P., Masters, C. L., & Price, D. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1561 · Cited by 733
Mass spectrometry of purified amyloid beta protein in Alzheimer's disease.
Mori, H., Takio, K., OGAWARA, M., & Selkoe, D. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41896-0 · Cited by 486
Shivers, B. D., Hilbich, C., Multhaup, G., Salbaum, M., Beyreuther, K. T., & SEEBURG, P. H. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02952.x · Cited by 442
Snow, A. D., Mar, H., Nochlin, D., Kimata, K., Kato, M., Suzuki, S., Hassell, J., & Wight, T. N. (1988) · PubMed Central · Cited by 418
Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation
Horstman, L. L., & Racker, E. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63241-7 · Cited by 396
The rat brain synucleins; family of proteins transiently associated with neuronal membrane
Maroteaux, L., & Scheller, R. H. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90043-w · Cited by 334
Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites
SCHUBERT, W. J., Prior, R., Weidemann, A., Dircksen, H., Multhaup, G., Masters, C. L., & Beyreuther, K. T. (1991) · Brain Research · doi:10.1016/0006-8993(91)91532-6 · Cited by 272
Patterns of aberrant sprouting in alzheimer's disease
Masliah, E., Mallory, M. E., Hansen, L. A., Alford, M. F., Albright, T., DeTeresa, R. M., Terry, R. D., Baudier, J., & Saitoh, T. (1991) · Neuron · doi:10.1016/0896-6273(91)90170-5 · Cited by 243
Self-citationCaporaso, G., Takei, K., Gandy, S., Matteoli, M., Mundigl, O., Greengard, P., & Camilli, P. V. D. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03122.1994 · Cited by 196
Cataldo, A. M., Hamilton, D. J., & Nixon, R. A. (1994) · Brain Research · doi:10.1016/0006-8993(94)91858-9 · Cited by 185
Masliah, E., Ellisman, M., Carragher, B., Mallory, M., Young, S., Hansen, L., Deteresa, R., & Terry, R. D. (1992) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199207000-00003 · Cited by 183
Self-citationThe Seminal Role of β-Amyloid in the Pathogenesis of Alzheimer Disease
Joachim, C. L., & Selkoe, D. J. (1992) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199205000-00003 · Cited by 181
Cataldo, A. M., Thayer, C. Y., Bird, E. D., Wheelock, T. R., & Nixon, R. A. (1990) · Brain Research · doi:10.1016/0006-8993(90)90456-l · Cited by 176
A new brain‐specific 14‐kDa protein is a phosphoprotein
Nakajo, S., TSUKADA, K., Omata, K., Nakamura, Y., & Nakaya, K. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18337.x · Cited by 170
Lassmann, H., Weiler, R., Fischer, P. A., Bancher, C., Jellinger, K. A., Floor, E., Danielczyk, W., SEITELBERGER, F., & Winkler, H. J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90003-k · Cited by 161
SP-40,40 is a constituent of Alzheimer's amyloid
Choi-Miura, N. H., Ihara, Y., Fukuchi, K., Takeda, M., Nakano, Y., Tobe, T., & Tomita, M. (1992) · Acta Neuropathologica · doi:10.1007/bf00296787 · Cited by 158
Card, J. P., Meade, R. P., & Davis, L. G. (1988) · Neuron · doi:10.1016/0896-6273(88)90131-6 · Cited by 155
Protein kinase C alteration is an early biochemical marker in Alzheimer's disease
Masliah, E., Cole, G. M., Hansen, L. A., Mallory, M. E., Albright, T., Terry, R. D., & Saitoh, T. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-09-02759.1991 · Cited by 125
Self-citationShibayama‐Imazu, T., Okahashi, I., Omata, K., Nakajo, S., Ochiai, H., Nakai, Y., Hama, T., Nakamura, Y., & Nakaya, K. (1993) · Brain Research · doi:10.1016/0006-8993(93)90796-p · Cited by 117
Immunodetection of the amyloid P component in Alzheimer's disease
Duong, T., Pommier, E. C., & Scheibel, A. B. (1989) · Acta Neuropathologica · doi:10.1007/bf00688180 · Cited by 111
Ishii, T., Haga, S., & Shimizu, F. (1975) · Acta Neuropathologica · doi:10.1007/bf00689569 · Cited by 110
Vinters, H. V., Nishimura, G. S., Secor, D. L., & Pardridge, W. M. (1990) · Europe PMC (PubMed Central) · Cited by 110
Shoji, M., Hirai, S., Yamaguchi, H., Harigaya, Y., & Kawarabayashi, T. (1990) · Brain Research · doi:10.1016/0006-8993(90)91187-l · Cited by 99
Masliah, E., Mallory, M. E., Hansen, L. A., Alford, M. F., DeTeresa, R. M., Terry, R. D., Baudier, J., & Saitoh, T. (1992) · Brain Research · doi:10.1016/0006-8993(92)90831-s · Cited by 91
Self-citationBellmann‐Weiler, R., Lassmann, H., Fischer, P. A., Jellinger, K. A., & Winkler, H. J. S. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81408-g · Cited by 89
Joachim, C. L., Games, D., Morris, J. R., Ward, P. J., Frenkel, D., & Selkoe, D. J. (1991) · PubMed Central · Cited by 88
Chromogranin A-like immunoreactive neurites are major constituents of senile plaques.
Muñoz, D. G. (1991) · PubMed · Cited by 82
Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease
Brion, J., Couck, A., Bruce, M. T., Anderton, B. H., & Flament-Durand, J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90697-t · Cited by 71
Accumulation of amyloid precursor fragment in Alzheimer plaques
Cole, G. M., Masliah, E., Shelton, E. R., Chan, H. W., Terry, R. D., & Saitoh, T. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90046-m · Cited by 64
Self-citationKawarabayashi, T., Shoji, M., Harigaya, Y., Yamaguchi, H., & Hirai, S. (1991) · Brain Research · doi:10.1016/0006-8993(91)90651-b · Cited by 58
Amyloidosis in aging and Alzheimer's disease.
Price, D. L., Walker, L. C., Martin, L. J., & Sisodia, S. S. (1992) · PubMed · Cited by 32
Complements, microglial cells and amyloid fibril formation
Ishii, T., & Haga, S. (1992) · Research in Immunology · doi:10.1016/0923-2494(92)80043-k · Cited by 25
Cited by
Sorted by citations
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836
Neuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345
Self-citationMasliah, E., Rockenstein, E. M., Veinbergs, I., Mallory, M. E., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., & Mucke, L. (2000) · Science · doi:10.1126/science.287.5456.1265 · Cited by 1,779
Self-citationMice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)80886-7 · Cited by 1,722
The many faces of α-synuclein: from structure and toxicity to therapeutic target
Lashuel, H. A., Overk, C., Oueslati, A., & Masliah, E. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3406 · Cited by 1,684
Self-citation
Metadata
- Authors
- Iwai, A., Masliah, E., Yoshimoto, M., Ge, N., Flanagan, L., Rohan de Silva, H. A., Kittel, A., & Saitoh, T.
- Affiliations
- University of California San Diego (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 14
- Issue
- 2
- Pages
- 467-475
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2059261643
- Cited by
- 1,316
- References
- 48
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 34 · 2023: 36 · 2022: 60 · 2021: 56 · 2020: 69 · 2019: 59 · 2018: 62 · 2017: 49 · 2016: 53 · 2015: 61 · 2014: 52 · 2013: 41 · 2012: 47
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Health Assistance Foundation
- National Institutes of Health
- National Institute on Aging (AG10689, AG05131, R01AG010689, P50AG005131)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- presynaptic proteins, synaptic vesicles, synaptophysin, amyloidogenesis, amyloid plaques, brain distribution, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Amino Acid Sequence, Animals, Antibodies, Antibody Specificity, Brain, Cattle, Humans, Molecular Sequence Data, Oligopeptides, Organ Specificity, Recombinant Proteins, Torpedo, Blotting, Western, Microscopy, Immunoelectron, Amyloid beta-Protein Precursor, Synaptophysin, Rats, Sprague-Dawley, Sequence Homology, Amino Acid, Microscopy, Confocal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review