The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The reeler gene-associated antigen on cajal-retzius neurons is a crucial molecule for laminar organization of cortical neurons
Open accessAbstract
In the neurological mutant mouse reeler, the histological organization of the neocortex develops abnormally and essentially results in an inversion of the relative positions of the cortical layers. The reeler mutation, therefore, provides an insight into the molecular mechanisms underlying the formation of the cortical layers. We have generated a monoclonal antibody (CR-50) that probes a distinct allelic antigen present in wild-type but not in reeler mutant mice. CR-50 reacted specifically with Cajal-Retzius neurons, one of the first cortical neurons to differentiate in the neocortex, but whose functional role is not known. When dissociated cerebral cortical cells were incubated with CR-50 in reaggregation culture, the genotype-dependent histogenetic assembly of wild-type cortical cells resembled that of reeler mutants. These findings revealed that the selective expression of a distinct molecule on Cajal-Retzius neurons is critical for the normal lamination of cortical neurons in the mammalian neocortex.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These data suggest that Reelin proteins are assembled and anchored to the surface of a cell membrane of the Reelin-secreting cells.”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“The CR-50 antibody has neutralizing activity of Reelin both in vitro and in vivo (13, 19–21).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“CR-50 antibody shows a function-blocking effect on Reelin from around this concentration (13)”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“some of the secreted Reelin is anchored to the surface of the Reelin-producing cells by an unknown mechanism.”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“This epitope region is essential for the Reelin functions, because CR-50 antibody inhibits laminar pattern formation in cortical reaggregation cultures (13), Purkinje cell alignment in cerebellar explant cultures (20), and an axonal branching pattern in the entorhinohippocampal pathway in vitro (19) and disrupts hippocampal development in vivo (21).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
Citations
Cites
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic, P. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450105 · Cited by 2,170
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Altman, J. (1972) · The Journal of Comparative Neurology · doi:10.1002/cne.901450305 · Cited by 912
Kostović, I., & RAKIC, P. T. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902970309 · Cited by 912
The migration of neuroblasts in the developing cerebral cortex.
Berry, M., & Rogers, A. W. (1965) · PubMed · Cited by 674
Allendoerfer, K. L., & Shatz, C. J. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.001153 · Cited by 653
Mechanisms of Cortical Development: A View From Mutations in Mice
Caviness, V. S., & RAKIC, P. T. (1978) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.01.030178.001501 · Cited by 653
Caviness, V. S. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90141-9 · Cited by 639
Falconer, D. S. (1951) · Journal of Genetics · doi:10.1007/bf02996215 · Cited by 539
Research works printed but not linked: 1
- Berry, 1965, The migration of neuroblastin the developing cerebral cortex, J. Anat., 99, 691
Cited by
Sorted by citations
Items 401–500 of 890
Nomura, T., Holmberg, J., Frisén, J., & Osumi, N. (2006) · Development · doi:10.1242/dev.02290 · Cited by 45
“(Chemicon), anti-reelin (Ogawa et al., 1995) or anti-EphA4 (Takemoto et”
Abnormal dispersion of a purkinje cell subset in the mouse mutant cerebellar deficient folia (cdf)
Beierbach, E., Park, C., Ackerman, S. L., Goldowitz, D., & Hawkes, R. B. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1052.abs · Cited by 45
Gilmore, E. C., & Herrup, K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09690.2001 · Cited by 46
“…resulting in the differential phosphorylation of the mouse disabled protein mDab1 (D’Arcangelo et al., 1995, 1997, 1999; Hirotsune et al., 1995; Ogawa et al., 1995; Howell et al., 1997, 1999; Sheldon et al., 1997; Ware et al., 1997; Rice et al., 1998; Hiesberger et al., 1999; Senzaki et al.,…”
BackgroundLamina-specific cell adhesion on living slices of hippocampus
Förster, E., Kaltschmidt, C., Deng, J., Cremer, H., Deller, T., & Frotscher, M. (1998) · Development · doi:10.1242/dev.125.17.3399 · Cited by 45
Region-specific alteration of GABAergic markers in the brain of heterozygous reeler mice
Nullmeier, S., Panther, P., Dobrowolny, H., Frotscher, M., Zhao, S., Schwegler, H., & Wolf, R. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07563.x · Cited by 43
“Besides its role in migration and positioning of neurons during embryogenesis (D’Arcangelo et al., 1995; Ogawa et al., 1995; Frotscher, 1998; Frotscher et al., 2003), reelin plays an important role in synaptogenesis and neuronal plasticity (for review, see Costa et al., 2001; Knuesel, 2010).”
BackgroundNeuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits
Ishii, K., Kubo, K., Endo, T., Yoshida, K., Benner, S., Ito, Y., Aizawa, H., Aramaki, M., Yamanaka, A., Tanaka, K. F., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3648-14.2015 · Cited by 46
“…(1) Reelin, a protein involved in laminar formation and neuronal migration in the developing cortex (Bar et al., 1995; D’Arcangelo et al., 1995; Ogawa et al., 1995; Nakajima et al., 1997; Honda et al., 2011; Sekine et al., 2014); (2) a constitutive-active form of Fyn (CA-Fyn), a member of the…”
BackgroundMeyer, G., & González‐Gómez, M. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx110 · Cited by 46
“2002), negativity for GABA, positivity for Reelin (Ogawa et al. 1995; Meyer and Goffinet 1998), and calretinin (Verney and Derer 1995), Perhaps more variable is the co-expression with NADPH-diaphorase/NOS (Duckett and Pearse 1968; Meyer and González-Hernández 1993; Santacana et al.”
BackgroundInfluentialHatanaka, Y., Kawasaki, T., Abe, T., Shioi, G., Kohno, T., Hattori, M., Sakakibara, A., Kawaguchi, Y., & Hirata, T. (2019) · iScience · doi:10.1016/j.isci.2019.10.034 · Cited by 42
Seike, M., Ikeda, M., Morimoto, A., Matsumoto, M., & Kodama, H. (2002) · Journal of Dermatological Science · doi:10.1016/s0923-1811(01)00155-4 · Cited by 44
Self-citationReelin Signaling and Cdk5 in the Control of Neuronal Positioning
Ohshima, T., & Mikoshiba, K. (2002) · Molecular Neurobiology · doi:10.1385/mn:26:2-3:153 · Cited by 46
“In reeler and scrambler/yotari mutants, the migrating cortical neurons appear incapable of splitting the preplate, with cortical plate neurons stacking up in an inverted order beneath the preplate (8,16).”
BackgroundInfluentialHeterotopic Neurogenesis in a Rat with Cortical Heterotopia
Lee, K. S., Collins, J. L., Anzivino, M. J., Frankel, E. A., & Schottler, F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09365.1998 · Cited by 44
“…(Marin-Padilla, 1978) and are believed to influence cortical organization through effects on cellular lamination (D’Arcangelo et al., 1995; Ogawa et al., 1995) and afferent/efferent connectivity (McConnell et al., 1989; Ghosh et al., 1990; DeCarlos and O’Leary, 1992; Ghosh and Shatz,…”
BackgroundMethodResultInfluentialHarrison, S. J., Nishinakamura, R., Jones, K. R., & Monaghan, A. P. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.002873 · Cited by 42
“Reelin is a secreted molecule expressed by Cajal-Retzius cells in the marginal zone (Ogawa et al., 1995; Schiffmann et al., 1997).”
BackgroundZhang, Z., & Galileo, D. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-17-06928.1998 · Cited by 51
Beta-Amyloid Impairs Reelin Signaling
Cuchillo‐Ibáñez, I., Balmaceda, V., Botella-López, A., Rábano, A., Ávila, J., & Sáez‐Valero, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072297 · Cited by 42
“When neurons were treated with Reelin in the presence of the CR50, an antiReelin antibody which neutralizes Reelin [18,19], the phosphorylation levels of tau increases, confirming that the observed effects are Reelin dependent (Figure 1).”
BackgroundChiara, F., Badaloni, A., Croci, L., Yeh, M. L., Cariboni, A. M., Hoerder‐Suabedissen, A., Consalez, G. G., Eickholt, B. J., Shimogori, T., Parnavelas, J. G., et al. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.02.034 · Cited by 45
“1 Current address: Charité-Universitätsmedizin Berlin 0012-1606 © 2012 Elsevier Inc. doi:10.1016/j.ydbio.2012.02.034 Open access under CC BY a b s t r a c t a r t i c l e i n f o”
BackgroundInfluentialHoareau, C., Borrell, V., Soriano, E., Krebs, M., Prochiantz, A., & Allinquant, B. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.012 · Cited by 42
Mouse Disabled1 (DAB1) Is a Nucleocytoplasmic Shuttling Protein
Honda, T., & Nakajima, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609061200 · Cited by 42
The Role of Robo3 in the Development of Cortical Interneurons
Barber, M., Meglio, T. D., Andrews, W. D., Hernandez-Miranda, L. R., Murakami, F., Chédotal, A., & Parnavelas, J. G. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp041 · Cited by 47
“…members of the Cajal--Retzius family make up a large portion of this group (Alcantara et al. 1998; Meyer et al. 1999), and the secreted protein is thought to be crucial for the establishment of normal lamination of the cortical plate (D’Arcangelo et al. 1995; Ogawa et al. 1995; Super et al. 2000).”
BackgroundResultInfluentialSato, Y., Kobayashi, D., Kohno, T., Kidani, Y., Prox, J., Becker‐Pauly, C., & Hattori, M. (2015) · The Journal of Biochemistry · doi:10.1093/jb/mvv102 · Cited by 42
Lossi, L., Castagna, C., Granato, A., & Merighi, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122088 · Cited by 43
“In the neocortex, after being synthesized by the Cajal–Retzius cells [20], the protein is secreted into 100”
MethodFunctional Importance of Covalent Homodimer of Reelin Protein Linked via Its Central Region
Yasui, N., Kitago, Y., Beppu, A., Kohno, T., Morishita, S., Gomi, H., Nagae, M., Hattori, M., & Takagi, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.242719 · Cited by 43
Reiner, O., Sapoznik, S., & Sapir, T. (2006) · NeuroMolecular Medicine · doi:10.1385/nmm:8:4:547 · Cited by 43
Stolt-Bergner, P. C., Chen, Y., Liu, P., Bock, H. H., Blacklow, S. C., & Herz, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413356200 · Cited by 41
Nishikawa, S. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.10.1024 · Cited by 42
Gonda, Y., Andrews, W. D., Tabata, H., Namba, T., Parnavelas, J. G., Nakajima, K., Kohsaka, S., Hanashima, C., & Uchino, S. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs141 · Cited by 47
Gao, F., Zhang, Q., Zheng, M., Liu, H., Hu, Y., Zhang, P., Zhang, Z., Qin, H., Feng, L., Wang, L., et al. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.12.008 · Cited by 42
“These cells, probably together with other interneurons, are finally located in the marginal zone and the subplate of the cerebral cortex, playing important roles in neuronal migration and cortical lamination (D'Arcangelo et al., 1995; Ogawa et al., 1995; Frotscher, 1997; Frotscher, 1998; Soriano and Del Rio, 2005; Tiv…”
BackgroundO’Dell, R. S., Ustine, C. J. M., Cameron, D. A., Lawless, S. M., Williams, R. M., Zipfel, W. R., & Olson, E. C. (2012) · Neural Development · doi:10.1186/1749-8104-7-25 · Cited by 39
Vílchez-Acosta, A., Manso, Y., Cárdenas, A., Elias-Tersa, A., Martínez‐Losa, M., Pascual, M., Álvarez‐Dolado, M., Nairn, A. C., Borrell, V., & Soriano, E. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2120079119 · Cited by 44
“However, migration deficits in CR-Reelin mice are considerably less dramatic than in reeler mutants, which exhibit an almost complete inversion of cortical layers (2, 7, 47).”
BackgroundCell Polarity in Cerebral Cortex Development—Cellular Architecture Shaped by Biochemical Networks
Hansen, A. H., Duellberg, C., Mieck, C., Loose, M., & Hippenmeyer, S. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00176 · Cited by 39
Directional Neuronal Migration Is Impaired in Mice Lacking Adenomatous Polyposis Coli 2
Shintani, T., Takeuchi, Y., Fujikawa, A., & Noda, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0590-12.2012 · Cited by 39
“…from that of other mutants, such as mice deficient in the Reelin/VLDLR/ApoER2 (Falconer, 1951; D’Arcangelo et al., 1995; Hirotsune et al., 1995; Ogawa et al., 1995; Trommsdorff et al., 1999), Cdk5/p35/p39 (Ohshima et al., 1996; Chae et al., 1997; Gilmore et al., 1998; Ko et al., 2001), Lis1…”
BackgroundTakeuchi, A., Hamasaki, T., Litwack, E. D., & O’Leary, D. D. M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl064 · Cited by 41
Arimatsu, Y., Ishida, M., Takiguchi‐Hayashi, K., & Uratani, Y. (1999) · Development · doi:10.1242/dev.126.4.629 · Cited by 40
Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation
O’Dell, R. S., Cameron, D. A., Zipfel, W. R., & Olson, E. C. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1629-15.2015 · Cited by 40
A genetic interaction between the APP and Dab1 genes influences brain development
Pramatarova, A., Chen, K., & Howell, B. W. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.09.008 · Cited by 39
“Mutations in other genes that encode components of the Reelin signaling pathway have very similar phenotypes (D'Arcangelo et al., 1995; Goffinet, 1997; Ogawa et al., 1995; Trommsdorff et al., 1999).”
BackgroundPerisomatic‐targeting granule cells in the mouse olfactory bulb
Naritsuka, H., Sakai, K., Hashikawa, T., Mori, K., & Yamaguchi, M. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22063 · Cited by 39
“Distribution of somata of type S cells in the substrata of the GCL Previous studies report that different subsets of “dendritictargeting” GCs have a preferred distribution of somata in distinct substrata of the GCL (Mori et al., 1983; Orona et al., 1983; Greer, 1987).”
BackgroundDevelopmental reelin expression and time point-specific alterations from lead exposure in zebrafish
Peterson, S. M., Zhang, J., & Freeman, J. L. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2013.04.007 · Cited by 40
Cellular physiology of the neonatal rat cerebral cortex
Luhmann, H. J., Hanganu, I. L., & Kilb, W. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00059-5 · Cited by 39
“Lack of reelin, as in the reeler mouse mutant (for review [59]), disturbance of the reelin signaling pathway [10,54] or ablation of Cajal-Retzius cells [63] causes disorders in cortical lamination.”
Cortical Dysplasia and Epilepsy: Animal Models
Schwartzkroin, P. A., Roper, S. N., & Wenzel, H. J. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-6376-8_12 · Cited by 39
Narayan, S., Nakajima, K., & Sawa, A. (2013) · The Neuroscientist · doi:10.1177/1073858412470168 · Cited by 37
Hirota, Y., Kubo, K., Fujino, T., Yamamoto, T. T., & Nakajima, K. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw369 · Cited by 40
“cells in the MZ of the Apoer2 KO mice, we performed double staining for Reelin (expressed in the C–R cells) (D’Arcangelo et al. 1995; Ogawa et al. 1995) and Tbr1 (strongly expressed in the C–R cells and deep-layer neurons and weakly expressed in the other cortical layers and in the IZ at P0) (Hevner et al.”
BackgroundMethodInfluentialThe heterogeneity of human Cajal-Retzius neurons
Meyer, G., & González‐Gómez, M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.059 · Cited by 39
Stick around: Cell–Cell Adhesion Molecules during Neocortical Development
de Agustín-Durán, D., Mateos-White, I., Fabra-Beser, J., & Gil-Sanz, C. (2021) · Cells · doi:10.3390/cells10010118 · Cited by 39
Soman-induced seizures rapidly activate astrocytes and microglia in discrete brain regions
Zimmer, L. A., Ennis, M. J., & Shipley, M. T. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970224)378:4 · Cited by 124
Dispersion of the neurons expressing layer specific markers in the reeler brain
Dekimoto, H., Terashima, T., & Katsuyama, Y. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01153.x · Cited by 38
“During development of the mammalian cerebral cortex Reelin is expressed in Cajal–Retzius cells (D’Arcangelo et al. 1995; Ogawa et al. 1995).”
BackgroundStructural Insights into Reelin Function: Present and Future
Ranaivoson, F. M., von Daake, S., & Comoletti, D. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00137 · Cited by 35
“…specific sub-types of cells, namely by Cajal-Retzius cells in marginal regions of the cerebral cortex and the hippocampus (D’Arcangelo et al., 1995; Ogawa et al., 1995; Del Río et al., 1997; Nakajima et al., 1997; Schiffmann et al., 1997; Alcantara et al., 1998), or by granule cell precursors…”
BackgroundAboitiz, F. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.7.655 · Cited by 37
“…extracellular matrix glycoprotein — reelin — has been identified that maps onto chromosome 5 and whose homozygotic mutant is responsible for the reeler phenotype (D’Arcangelo et al., 1995, 1997; Ogawa et al., 1995; Frotscher, 1997, 1998; D’Arcangelo and Curran, 1998; Curran and D’Arcangelo, 1998).”
BackgroundFuruta, A., Takashima, S., Yokoo, H., Rothstein, J. D., Wada, K., & Iwaki, T. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.01.005 · Cited by 37
Regulatory genes controlling cell fate choice in embryonic and adult neural stem cells
Gangemi, R. M. R., Perera, M., & Corte, G. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2004.02310.x · Cited by 37
“Two Hes genes are known to be expressed in the ventricular zone and in cultured neurospheres, Hes1 and Hes5, whose products have indeed been shown to be required for Notch signalling and hence essential in regulating the size of the NSC pool (Nakamura et al. 2000; Ohtsuka et al. 2001).”
BackgroundEvolutionarily Conserved, Alternative Splicing of Reelin during Brain Development
de Rouvroit, C. L., Bernier, B., Royaux, I. E., de Bergeyck, V., & Goffinet, A. M. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7019 · Cited by 35
García‐Femández, L. F., Rausell, E., Urade, Y., Hayaishi, O., Bernal, J., & Múñoz, A. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01514.x · Cited by 36
The development of hippocampal cellular assemblies
Li, G., & Pleasure, S. J. (2013) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.127 · Cited by 36
Cortical Interneurons Require p35/Cdk5 for their Migration and Laminar Organization
Rakić, S., Yanagawa, Y., Obata, K., Faux, C. H., Parnavelas, J. G., & Nikolić, M. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn213 · Cited by 36
Varga, C., Tamás, G., Barzó, P., Oláh, S., & Somogyi, P. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv045 · Cited by 34
“Reelin is a key signaling protein secreted during development by Cajal–Retzius cells (Ogawa et al. 1995; Hammond et al. 2006) and its expression is also retained in distinct GABAergic neurons in the adult cortex (Alcantara et al.”
BackgroundAbsence of Layer-Specific Cadherin Expression Profiles in the Neocortex of the Reeler Mutant Mouse
Hertel, N., & Redies, C. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq183 · Cited by 36
“Reelin (D’Arcangelo et al. 1995, 1997; Ogawa et al. 1995).”
BackgroundThe neurobiology of APOE in schizophrenia and mood disorders
Gibbons, A. S. (2010) · Frontiers in bioscience · doi:10.2741/3729 · Cited by 35
“Embryologically, it is secreted from Cajal Retzius cells to guide neurons and radial glial cells to their correct positions (152-154), while in the adult brain it is secreted by GABAergic interneurons and is involved in neurotransmission, memory formation and modulating synaptic plasticity (155-157), making it a likel…”
BackgroundTiming of Cortical Interneuron Migration Is Influenced by the Cortical Hem
Caronia, G., & Grove, E. A. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq142 · Cited by 39
“Given the production of reelin by CR cells (D’Arcangelo et al. 1995; Ogawa et al. 1995; Meyer et al. 1999; Derer et al. 2001), and previous reports of neocortical layering defects in the reeler mutant mouse, which lacks reelin, and other mutants with defects in reelin signaling (Caviness 1982a,…”
BackgroundReelin Signaling Inactivates Cofilin to Stabilize the Cytoskeleton of Migrating Cortical Neurons
Frotscher, M., Zhao, S., Wang, S., & Chai, X. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00148 · Cited by 36
“…such as molecules of the tubulin cytoskeleton (e.g., Meseke et al., 2013; Förster, 2014), proneural transcription factors such as Rnd proteins (Pacary et al., 2011), and CLASP2 (Dillon et al., 2017) are also known to control the cytoskeleton of neuronal cells and extension and orientation of…”
BackgroundChapter 6 The origin and migration of cortical neurons
Parnavelas, J. G., Alifragis, P., & Nadarajah, B. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36008-4 · Cited by 36
The cadherin-related neuronal receptor family: a novel diversified cadherin family at the synapse
Hamada, S., & Yagi, T. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(01)00281-4 · Cited by 35
Siegenthaler, J. A., & Miller, M. W. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.036 · Cited by 36
“All rights reserved. doi:10.1016/j.ydbio.2007.09.036 Cajal–Retzius (CR) neurons (Derer and Derer, 1991; D’Arcangelo et al., 1995; Hirotsune et al., 1995; Ogawa et al., 1995; Meyer and Wahle, 1999; Soda et al., 2003).”
BackgroundInfluentialBrain development: Integrins and the Reelin pathway
Magdaleno, S. M., & Curran, T. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00618-2 · Cited by 34
“suggesting that Reelin inhibits neuronal adhesion [10].”
Topical Review: Neuronal Migration in Cortical Development
Kanatani, S., Tabata, H., & Nakajima, K. (2005) · Journal of Child Neurology · doi:10.1177/08830738050200040201 · Cited by 34
Coulin, C., Drakew, A., Frotscher, M., & Deller, T. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1332 · Cited by 34
Reelin proteolysis affects signaling related to normal synapse function and neurodegeneration
Lussier, A. L., Weeber, E. J., & Rebeck, G. W. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00075 · Cited by 31
“…development Reelin is expressed by Cajal–Retzius cells Frontiers in Cellular Neuroscience | www.frontiersin.org 1 March 2016 | Volume 10 | Article 75 in the hippocampus and cortex and granule cells in the cerebellum (Ogawa et al., 1995; Del Río et al., 1997; Frotscher, 1998; Hirota et al., 2015).”
BackgroundIdentification of RELN variation p.Thr3192Ser in a Chinese family with schizophrenia
Zhou, Z., Hu, Z., Zhang, L., Hu, Z., Liu, H., Liu, Z., Du, J., Zhao, J., Zhou, L., Xia, K., et al. (2016) · Scientific Reports · doi:10.1038/srep24327 · Cited by 33
Role of Reelin in cell positioning in the cerebellum and the cerebellum-like structure in zebrafish
Nimura, T., Itoh, T., Hagio, H., Hayashi, T., Donato, V. D., Takeuchi, M., Itoh, T., Inoguchi, F., Sato, Y., Yamamoto, N., et al. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.07.010 · Cited by 33
Human brain development through the lens of cerebral organoid models
Andrews, M. G., & Nowakowski, T. J. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146470 · Cited by 35
Zic2 Controls the Migration of Specific Neuronal Populations in the Developing Forebrain
Murillo, B. R., Ruiz-Reig, N., Herrera, M., Fairén, A. G., & Herrera, E. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0779-15.2015 · Cited by 33
Three novel repetitive units of reelin
Ichihara, H., Jingami, H., & Toh, H. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00307-2 · Cited by 34
Hippocampal dendritic arbor growth in vitro: Regulation by Reelin–Disabled-1 signaling
MacLaurin, S. A., Krucker, T., & Fish, K. N. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.035 · Cited by 34
“In order to determine the timeline of Reelin's role in facilitating the tempo of dendritic elongation we took advantage of the Reelin antibody CR-50 [24].”
BackgroundNormal and Abnormal Development of the Human Cerebral Cortex
Chan, W. Y., Kostović, I., Takashima, S., Feldhaus, C., Stoltenburg, G., Verney, C., Yew, D. T. W., & Ulfig, N. (2002) · Neuroembryology and Aging · doi:10.1159/000054267 · Cited by 32
Suzuki, I., & Hirata, T. (2012) · Development Growth & Differentiation · doi:10.1111/dgd.12020 · Cited by 33
“The signaling protein reelin is secreted by Cajal-Retzius neurons that are located in the most superficial layer 1 (Ogawa et al. 1995) and generated at the earliest timing of neocortical neurogenesis before production of layer 2–6 neurons as an exception to the “inside-out” rule (Marin-Padilla…”
BackgroundKikkawa, S., Yamamoto, T., Misaki, K., Ikeda, Y., Okado, H., Ogawa, M., Woodhams, P. L., & Terashima, T. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10761 · Cited by 33
“The sections adjoining to the CR-50-immunostained sections were used for calretinin immunohistochemistry.”
MethodInfluentialSelf-citationRegulatory mechanisms of cortical laminar development
Casanova, M. F., & Trippe, J. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.10.002 · Cited by 33
Neuronal subtype specification in establishing mammalian neocortical circuits
Kumamoto, T., & Hanashima, C. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.07.002 · Cited by 33
Balogiannis, S. (2005) · International Journal of Neuroscience · doi:10.1080/00207450590901396 · Cited by 32
“Cajal-Retzius neuron acts mainly by secretion of reelin, the product of the reeler gene (Ogawa et al., 1995), which is a glycoprotein (D’Arcangelo et al.”
How to Construct a Neural Tube
Samat, H. B., & Menkes, J. H. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500210 · Cited by 32
Тарасенко, А. Н., Isaev, D. S., Eremin, A. V., & Kostyuk, P. G. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.385bn.x · Cited by 32
“…simultaneously in the superficial and deep cortical layer neurones; during neocortical development the interaction between neurones of layer I—II (Cajal-Retzius cells) and layer V—VI is extremely important for the correct positioning of migrating neurones and their maturation (Ogawa et al. 1995).”
BackgroundReelin-mediated Signaling during Normal and Pathological Forms of Aging.
Doehner, J., & Knuesel, I. (2010) · Europe PMC (PubMed Central) · Cited by 32
Pasquet, N., Douceau, S., Naveau, M., Lesept, F., Louessard, M., Lebouvier, L., Hommet, Y., Vivien, D., & Bardou, I. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy119 · Cited by 43
Kumar, K., Patro, N., & Patro, I. K. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9942-7 · Cited by 31
“laminar arrangement of neurons in the neocortex, hippocampus, cerebellum and spinal cord (D’Arcangelo et al. 1995; Ogawa et al. 1995; Tissir and Goffinet 2003; Sinagra et al. 2008; Forster et al. 2010).”
BackgroundThe Molecular and Genetic Mechanisms of Neocortex Development
Diaz, A. L., & Gleeson, J. G. (2009) · Clinics in Perinatology · doi:10.1016/j.clp.2009.06.008 · Cited by 33
Martinez-Galan, J. R., López‐Bendito, G., Luján, R., Shigemoto, R., Fairén, A., & Valdeolmillos, M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01494.x · Cited by 31
Britto, J. M., Tait, K. J., Johnston, L. A., Hammond, V. E., Kalloniatis, M., & Tan, S. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq168 · Cited by 31
“Cerebral Cortex May 2011;21:1018--1027 doi:10.1093/cercor/bhq168 Advance Access publication September 16, 2010”
BackgroundInfluentialMorphogenesis timing of genetically programmed brain malformations in relation to epilepsy
Sarnat, H. B., & Flores‐Sarnat, L. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63326-2.00010-7 · Cited by 33
“This gene and its protein transcription product are expressed strongly by Cajal–Retzius neurons of the molecular zone (Frotscher, 1997; Nishikawa et al., 2002; Ogawa et al., 1995; Sarnat and FloresSarnat, 2002).”
BackgroundYamamoto, T., Kato, Y., Karita, M., Takeiri, H., Muramatsu, F., Kobayashi, M., Saito, K., & Ōsawa, M. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0542-8 · Cited by 31
“Several genes involved in neuronal migration have been found, such as reelin [8, 19 ], LIS-1 [5, 6], cdk5 [8], p35 [8], doublecortin [9, 21] and filamin 1 [8].”
BackgroundDevelopment of the Entorhino‐Hippocampal Projection: Guidance by Cajal‐Retzius Cell Axons
Ceranik, K., Zhao, S., & Frotscher, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06718.x · Cited by 34
Role of Cajal-Retzius and subplate neurons in cerebral cortical development
Sarnat, H. B., & Flores‐Sarnat, L. (2002) · Seminars in Pediatric Neurology · doi:10.1053/spen.2002.32506 · Cited by 31
Modulation of Reelin signaling by Cyclin-dependent kinase 5
Ohshima, T., Suzuki, H., Morimura, T., Ogawa, M., & Mikoshiba, K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.121 · Cited by 32
Self-citationMyelin and disorders that affect the formation and maintenance of this sheath
Porter, B. E., & Tennekoon, G. I. (2000) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/(sici)1098-2779(2000)6:1 · Cited by 14
Historical first descriptions of Cajal–Retzius cells: from pioneer studies to current knowledge
Gil, V., Nocentini, S., & del RÃo, J. A. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00032 · Cited by 34
“In 1995, it was described how CR cells are responsible for the correct lamination of the neocortex through the secretion of an extracellular protein called Reelin (D’Arcangelo et al., 1995; Ogawa et al., 1995).”
BackgroundReelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits
Ishii, K., Nagai, T., Hirota, Y., Noda, M., Nabeshima, T., Yamada, K., Kubo, K., & Nakajima, K. (2015) · Neuroscience Research · doi:10.1016/j.neures.2014.12.013 · Cited by 30
“The extracellular protein Reelin has been concluded to be essential to the development of the laminar structure of the cerebral cortex because the layers of the cerebral cortex of Reelin-deficient mice, reeler, are disorganized (Bar et al., 1995; D’Arcangelo et al., 1995; Ogawa et al., 1995).”
BackgroundYoshinaga, S., Shin, M., Kitazawa, A., Ishii, K., Tanuma, M., Kasai, A., Hashimoto, H., Kubo, K., & Nakajima, K. (2021) · iScience · doi:10.1016/j.isci.2021.102277 · Cited by 27
Birth‐date‐dependent segregation of the mouse cerebral cortical neurons in reaggregation cultures
Ajioka, I., & Nakajima, K. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04214.x · Cited by 31
“Electroporation in utero Pregnant Institute of Cancer Research (ICR) mice were purchased from Japan SLC (Japan).”
BackgroundMethodInfluentialMechanisms of Cortical Differentiation
Adnani, L., Han, S., Li, S., Mattar, P. A., & Schuurmans, C. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.07.005 · Cited by 33
Schoof, M., Hellwig, M., Harrison, L., Holdhof, D., Lauffer, M. C., Niesen, J., Virdi, S., Indenbirken, D., & Schüller, U. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14674 · Cited by 32
“The Reeler mouse was first described in 1951 (Falconer, 1951) as a spontaneous mutant with severe neurological deficits and RELN was identified as the causing protein in 1995 (D'Arcangelo et al., 1995; Ogawa et al., 1995).”
BackgroundFernández, A. P., Alonso, D. C., Lizasoaín, I., Serrano, J., Leza, J. C., Bentura, M. L., López, J. C., Encinas, J. M., Fernández‐Vizarra, P., Castro‐Blanco, S., et al. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(03)00068-3 · Cited by 30
Role of p35/Cdk5 in Preplate Splitting in the Developing Cerebral Cortex
Rakić, S., Davis, C., Molnár, Z., Nikolić, M., & Parnavelas, J. G. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj172 · Cited by 31
Disruption of reelin signaling attenuates methamphetamine‐induced hyperlocomotion
Matsuzaki, H., Minabe, Y., Nakamura, K., Suzuki, K., Iwata, Y., Sekine, Y., Tsuchiya, K. J., Sugihara, G., Suda, S., Takei, N., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05564.x · Cited by 30
“To investigate this further, we infused CR-50, a monoclonal antibody against reelin (Ogawa et al., 1995), for 1 week into the lateral ventricles of adult, free-moving, wildtype mice.”
BackgroundMethodInfluentialThe Candidate Schizophrenia Risk Gene DGCR2 Regulates Early Steps of Corticogenesis
Molinard‐Chenu, A., & Dayer, A. G. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.015 · Cited by 29
Metadata
- Authors
- Ogawa, M., Miyata, T., Nakajimat, K., Yagyu, K., Seike, M., Ikenaka, K., Yamamoto, H., & Mikoshibat, K.
- Affiliations
- Kochi Medical School Hospital (JP)
- National Institute for Physiological Sciences (JP)
- National Institute of Neuroscience (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 14
- Issue
- 5
- Pages
- 899-912
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2036838270
- Cited by
- 889
- References
- 61
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 5 · 2023: 20 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 25 · 2018: 20 · 2017: 23 · 2016: 22 · 2015: 25 · 2014: 18 · 2013: 32 · 2012: 25
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Cajal-Retzius neurons, cortical lamination, neocortex development, histogenesis
- MeSH terms
- Reelin Protein, Animals, Antibodies, Monoclonal, Cell Adhesion, Cell Communication, Cerebral Cortex, Extracellular Space, Hybridomas, Immunohistochemistry, Mice, Neurologic Mutants, Mutation, Nerve Tissue Proteins, Neurons, Serine Endopeptidases, Tissue Distribution, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
