The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The reeler gene-associated antigen on cajal-retzius neurons is a crucial molecule for laminar organization of cortical neurons
Open accessAbstract
In the neurological mutant mouse reeler, the histological organization of the neocortex develops abnormally and essentially results in an inversion of the relative positions of the cortical layers. The reeler mutation, therefore, provides an insight into the molecular mechanisms underlying the formation of the cortical layers. We have generated a monoclonal antibody (CR-50) that probes a distinct allelic antigen present in wild-type but not in reeler mutant mice. CR-50 reacted specifically with Cajal-Retzius neurons, one of the first cortical neurons to differentiate in the neocortex, but whose functional role is not known. When dissociated cerebral cortical cells were incubated with CR-50 in reaggregation culture, the genotype-dependent histogenetic assembly of wild-type cortical cells resembled that of reeler mutants. These findings revealed that the selective expression of a distinct molecule on Cajal-Retzius neurons is critical for the normal lamination of cortical neurons in the mammalian neocortex.
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In the citing paper
“These data suggest that Reelin proteins are assembled and anchored to the surface of a cell membrane of the Reelin-secreting cells.”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“The CR-50 antibody has neutralizing activity of Reelin both in vitro and in vivo (13, 19–21).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“CR-50 antibody shows a function-blocking effect on Reelin from around this concentration (13)”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“some of the secreted Reelin is anchored to the surface of the Reelin-producing cells by an unknown mechanism.”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“This epitope region is essential for the Reelin functions, because CR-50 antibody inhibits laminar pattern formation in cortical reaggregation cultures (13), Purkinje cell alignment in cerebellar explant cultures (20), and an axonal branching pattern in the entorhinohippocampal pathway in vitro (19) and disrupts hippocampal development in vivo (21).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
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“…ependymal layer to the first lamina (using radial glia as guides), their transformation into pyramidal neurons, the order of migration, the neuron size and the eventual stratification of the gray matter (Marín-Padilla, 1992, 2014; Ogawa et al., 1995; Meyer et al., 1999; Soriano and Del Río, 2005).”
BackgroundDab2ip Regulates Neuronal Migration and Neurite Outgrowth in the Developing Neocortex
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“In early stages of cortical development, Reelin protein is secreted from Cajal-Retzius cells, which are located at the most superficial layer of the cortex (Ogawa et al. 1995; Schiffmann et al. 1997).”
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“C-R cells are known for their specific expression of reelin (Alcantara et al., 1998; Ogawa et al., 1995).”
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Mühlfriedel, S., Kirsch, F., Gruß, P., Chowdhury, K., & Stoykova, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05639.x · Cited by 25
“These cells secrete the extracellular matrix protein Reelin that has an important role for the proper layering of the cortex (Marin-Padilla, 1978; Ogawa et al., 1995).”
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“The N-terminal fragment contains an epitope for the functionblocking antibody CR-50 and is also important for homodimer formation (Ogawa et al., 1995; Miyata et al., 1997; Nakajima et al., 1997; Utsunomiya-Tate et al., 2000; Kubo et al., 2002).”
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“While the secretion of RLN by Cajal Retzius cells (D’Arcangelo et al., 1995; Ogawa et al., 1995; Soriano et al., 2005) is required for the proper lamination of the neocortex (Caviness, 1982), homo-topic and isochronic transplants of MGE cells lacking the intracellular adaptor Dab1 required for RLN signaling revealed n…”
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“The antibodies used were anti-Rab11 (Invitrogen), anti-GFP (Nakalai Tesque, Kyoto, Japan), and anti-Reelin (CR-50 [13]).”
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“A third model suggests that Reelin repels subplate neurons, thus allowing the cortical plate to form between the marginal zone and the subplate (Ogawa et al., 1995; Schiffmann et al., 1997).”
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Development of Thalamocortical Projections in Normal and Mutant Mice
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“…archicortical and neocortical Cajal-Retzius cells are immunoreactive for reelin, an extracellular matrix protein that plays a critical role in neuronal migration and positioning (Ogawa et al., 1995; D’Arcangelo et al., 1995, 1997; Frotscher, 1997; Meyer and Goffinet, 1998; Forster et al., 2002).”
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“Reelin is a huge extracellular matrix protein secreted by Cajal–Retzius cells, which are located in the PP and MZ (D'Arcangelo et al., 1995; Ogawa et al., 1995), and it regulates the proper migration and positioning of projection neurons.”
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“This antibody recognizes Cajal-Retzius cells in developing brain (D’Arcangelo et al., 1995; Hirotsune et al., 1995; Ogawa et al., 1995; Garcı́a-Moreno et al., 2007).”
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“Hem derived CR cells express reelin, p73 and Calretinin (Alcantara et al., 1998; del Rio et al., 1995; Hevner et al., 2003b; Meyer et al., 2004, 1999, 2002; Ogawa et al., 1995; Soda et al., 2003).”
BackgroundInfluentialThe cerebellar deficient folia (cdf) gene acts intrinsically in Purkinje cell migrations
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“Cryostat sections (10 m) were incubated with anti-mDab1 B3 (1:200; Howell et al., 1997a) or anti-reelin (1:10; Ogawa et al., 1995) antibodies.”
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“Reelin is produced near the pial surface of the developing brain by Cajal Retzius cells (Ogawa et al., 1995).”
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“Cajal-Retzius cells secrete a molecule, Reelin, that is essential for orderly lamination of cortical neurons (D'Arcangelo et al., 1995, 1997; Ogawa et al., 1995; Schiffmann et al., 1997).”
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“Double-immunostaining for reelin (expressed in the Cajal-Retzius neurons) (D’Arcangelo et al., 1995; Ogawa et al., 1995) and Tbr1 revealed strongly Tbr1-positive, but reelin-negative, neurons (deep layer neurons) (Hevner et al.”
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Genescu, I., & Garel, S. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.003 · Cited by 21
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“At both culture time points the anti-Reelin antibody CR50, which identifies Cajal-Retzius cells in layer 1 [13], labeled few apposed cells.”
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“…in the germinative ventricular and subventricular zones, orchestrating the correct lamination of the cerebral cortex and favoring an inside--out gradient of generation (Caviness 1982; Ogawa et al. 1995; Schiffmann et al. 1997; Marı́n-Padilla 1998; Beffert et al. 2004; Soriano and Del Rı́o 2005).”
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“(1999, 2000), in addition to the layer-specific location of the recorded cells, evaluated the presence of reelin by single cell (RT)-PCR or immunocytochemistry, as Cajal-Retzius cells are a critical cellular source of this important glycoprotein (Ogawa et al., 1995; Del Río et al., 1997).”
BackgroundInfluentialSaito, K., Okamoto, M., Watanabe, Y., Noguchi, N., Nagasaka, A., Nishina, Y., Shinoda, T., Sakakibara, A., & Miyata, T. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.075 · Cited by 20
Self-citationMarchionni, I., Beaumont, M. A., & Maccaferri, G. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.224873 · Cited by 20
“These functions are mediated by the glycoprotein reelin, of which Cajal–Retzius cells are a critical cellular source (Ogawa et al. 1995).”
BackgroundHerrick, T. M., & Cooper, J. A. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.03.022 · Cited by 19
Glutamate released by Cajal-Retzius cells impacts specific hippocampal circuits and behaviors
Anstötz, M., Lee, S. K., & Maccaferri, G. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110822 · Cited by 21
“In particular, the synthesis and secretion of the glycoprotein reelin by CRs (D’Arcangelo et al., 1995; Ogawa et al., 1995) suggested a key link to the formation of cortical layers (Frotscher, 1998) because this latter process is impaired in reelin mutants (Caviness and Sidman, 1973a, 1973b; Goffinet, 1984; Rice and C…”
BackgroundScaling Proprioceptor Gene Transcription by Retrograde NT3 Signaling
Lee, J. H., Friese, A., Mielich, M., Sigrist, M., & Arber, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045551 · Cited by 18
Development and evolution of cortical fields
Arai, Y., & Pierani, A. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.06.005 · Cited by 24
Meseke, M., Neumüller, F. H., Brunne, B., Li, X., Anstötz, M., Pohlkamp, T., Rogalla, M. M., Herz, J., Rune, G. M., & Bender, R. A. (2018) · eNeuro · doi:10.1523/eneuro.0258-18.2018 · Cited by 19
Cajal‐Retzius neurons are required for the development of the human hippocampal fissure
Meyer, G., González‐Arnay, E., Moll, U. M., Nemajerová, A., Tissir, F., & González‐Gómez, M. (2019) · Journal of Anatomy · doi:10.1111/joa.12947 · Cited by 19
“…(dorsal, intermediate and ventral) were described in the mouse HC based on gene expression, connectivity and function (Fanselow & Dong, 2010; O’Reilly et al. 2015), even though there are differences in gene regulation between mouse and human HC (Hawrylycz et al. 2012; Alzu’bi et al. 2017).”
BackgroundPahle, J., Muhia, M., Wagener, R. J., Tippmann, A., Bock, H. H., Graw, J., Herz, J., Staiger, J. F., Drakew, A., Kneussel, M., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz196 · Cited by 21
Distinct NMDA and AMPA Receptor–Mediated Responses in Mouse and Human Cajal-Retzius Cells
Lu, S., Zečević, N., & Yeh, H. H. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.5.2642 · Cited by 19
Anstötz, M., & Maccaferri, G. (2020) · eNeuro · doi:10.1523/eneuro.0516-19.2019 · Cited by 23
“…although Cajal–Retzius cells do express reelin and are the major source of this molecule at early developmental stages (D’Arcangelo et al., 1995; Ogawa et al., 1995; Derer et al., 2001), reelin-expressing interneurons are also abundant in the hippocampal molecular layers at postnatal stages…”
BackgroundResultFukaya, M., Yamada, K., Nagashima, M., Tanaka, K., & Watanabe, M. (1999) · Neuroscience Research · doi:10.1016/s0168-0102(99)00052-8 · Cited by 19
A ‘Marginal’ tale: the development of the neocortical layer 1
Gesuita, L., & Karayannis, T. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.09.002 · Cited by 20
New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction
Tsuneura, Y., NAKAI, T., Mizoguchi, H., & Yamada, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031829 · Cited by 19
de Guglielmo, G., Iemolo, A., Nur, A., Turner, A. V., Montilla‐Perez, P., Martinez, A. R., Crook, C., Roberts, A. J., & Telese, F. (2022) · Genes Brain & Behavior · doi:10.1111/gbb.12828 · Cited by 15
Increased Blood-Reelin-Levels in First Episode Schizophrenia
Hornig, T., Sturm, L., Fiebich, B. L., & van Elst, L. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134671 · Cited by 18
CXCR7 Receptor Controls the Maintenance of Subpial Positioning of Cajal–Retzius Cells
Trousse, F., Poluch, S., Pierani, A., Dutriaux, A., Bock, H. H., Nagasawa, T., Verdier, J., & Rossel, M. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu164 · Cited by 18
“CR cells are located in the marginal zone (MZ) and participate in the control of the radial migration of pyramidal neurons by secreting the extracellular protein Reelin (D’Arcangelo et al. 1995; Ogawa et al. 1995; Rice and Curran 2001; Tissir and Goffinet 2003).”
BackgroundÁbrahám, H., Tóth, Z., Bari, F., Domoki, F., & Seress, L. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.039 · Cited by 18
Cortical Migration Defects in Mice Expressing A-RAF from the B-RAF Locus
Camarero, G., Tyrsin, O. Y., Xiang, C., Pfeiffer, V., Pleiser, S., Wiese, S., Götz, R., & Rapp, U. R. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00424-06 · Cited by 19
“that play a key role in neuronal lamination (28, 37).”
Background(2009) · Neuromethods · doi:10.1007/978-1-60327-263-6 · Cited by 18
Gu, X., Yan, Y., Li, H., He, D., Pleasure, S. J., & Zhao, C. (2009) · genesis · doi:10.1002/dvg.20472 · Cited by 18
Wang, Y., Bagheri‐Fam, S., & Harley, V. R. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.12.010 · Cited by 18
Reelin expression during embryonic development of the pig brain
Nielsen, K. B., Søndergaard, A., Johansen, M., Schauser, K., Vejlsted, M., Nielsen, A. L., Jørgensen, A. L., & Holm, I. E. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-75 · Cited by 18
“In mammals, Reelin has the highest expression in Cajal-Retzius (CR) cells during neocortical development [5,6,10,30,33,34].”
BackgroundReelin-expressing neurons in the anterior commissure and corpus callosum of the rat
Misaki, K., Kikkawa, S., & Terashima, T. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.10.009 · Cited by 18
Kerjan, G., & Gleeson, J. G. (2007) · Genes & Development · doi:10.1101/gad.1622907 · Cited by 17
Honda, T., & Nakajima, K. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv162 · Cited by 19
“The secreted glycoprotein Reelin has critically important roles in these processes, because the disruption of this gene causes a roughly inverted positioning of the neurons (Falconer 1951; Caviness 1982; Goffinet 1983; Bar et al. 1995; D’Arcangelo et al. 1995; Ogawa et al. 1995; Nakajima et al. 1997; D’Arcangelo 2005;…”
BackgroundChan, C., & Yeh, H. H. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.042556 · Cited by 17
“Their absence results in disruption of normal neuronal migration and laminar formation (Ogawa et al. 1995; Mallamaci et al. 2000; Super et al. 2000).”
BackgroundInfluentialIdentification of Stk25 as a Genetic Modifier of Tau Phosphorylation in Dab1-Mutant Mice
Matsuki, T., Zaka, M., Guerreiro, R. J., van der Brug, M. P., Cooper, J. A., Cookson, M., Hardy, J., & Howell, B. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031152 · Cited by 17
“cord [5,6].”
Metadata
- Authors
- Ogawa, M., Miyata, T., Nakajimat, K., Yagyu, K., Seike, M., Ikenaka, K., Yamamoto, H., & Mikoshibat, K.
- Affiliations
- Kochi Medical School Hospital (JP)
- National Institute for Physiological Sciences (JP)
- National Institute of Neuroscience (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 14
- Issue
- 5
- Pages
- 899-912
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2036838270
- Cited by
- 889
- References
- 61
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 5 · 2023: 20 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 25 · 2018: 20 · 2017: 23 · 2016: 22 · 2015: 25 · 2014: 18 · 2013: 32 · 2012: 25
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Cajal-Retzius neurons, cortical lamination, neocortex development, histogenesis
- MeSH terms
- Reelin Protein, Animals, Antibodies, Monoclonal, Cell Adhesion, Cell Communication, Cerebral Cortex, Extracellular Space, Hybridomas, Immunohistochemistry, Mice, Neurologic Mutants, Mutation, Nerve Tissue Proteins, Neurons, Serine Endopeptidases, Tissue Distribution, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Mice
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