The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The reeler gene-associated antigen on cajal-retzius neurons is a crucial molecule for laminar organization of cortical neurons
Open accessAbstract
In the neurological mutant mouse reeler, the histological organization of the neocortex develops abnormally and essentially results in an inversion of the relative positions of the cortical layers. The reeler mutation, therefore, provides an insight into the molecular mechanisms underlying the formation of the cortical layers. We have generated a monoclonal antibody (CR-50) that probes a distinct allelic antigen present in wild-type but not in reeler mutant mice. CR-50 reacted specifically with Cajal-Retzius neurons, one of the first cortical neurons to differentiate in the neocortex, but whose functional role is not known. When dissociated cerebral cortical cells were incubated with CR-50 in reaggregation culture, the genotype-dependent histogenetic assembly of wild-type cortical cells resembled that of reeler mutants. These findings revealed that the selective expression of a distinct molecule on Cajal-Retzius neurons is critical for the normal lamination of cortical neurons in the mammalian neocortex.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These data suggest that Reelin proteins are assembled and anchored to the surface of a cell membrane of the Reelin-secreting cells.”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“The CR-50 antibody has neutralizing activity of Reelin both in vitro and in vivo (13, 19–21).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“CR-50 antibody shows a function-blocking effect on Reelin from around this concentration (13)”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“some of the secreted Reelin is anchored to the surface of the Reelin-producing cells by an unknown mechanism.”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
In the citing paper
“This epitope region is essential for the Reelin functions, because CR-50 antibody inhibits laminar pattern formation in cortical reaggregation cultures (13), Purkinje cell alignment in cerebellar explant cultures (20), and an axonal branching pattern in the entorhinohippocampal pathway in vitro (19) and disrupts hippocampal development in vivo (21).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [13]
Citations
Cites
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic, P. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450105 · Cited by 2,170
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
ANGEVINE, J. B., & SIDMAN, R. L. (1961) · Nature · doi:10.1038/192766b0 · Cited by 1,530
Rakic, P. (1974) · Science · doi:10.1126/science.183.4123.425 · Cited by 1,161
Altman, J. (1972) · The Journal of Comparative Neurology · doi:10.1002/cne.901450305 · Cited by 912
Kostović, I., & RAKIC, P. T. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902970309 · Cited by 912
The migration of neuroblasts in the developing cerebral cortex.
Berry, M., & Rogers, A. W. (1965) · PubMed · Cited by 674
Allendoerfer, K. L., & Shatz, C. J. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.001153 · Cited by 653
Mechanisms of Cortical Development: A View From Mutations in Mice
Caviness, V. S., & RAKIC, P. T. (1978) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.01.030178.001501 · Cited by 653
Caviness, V. S. (1982) · Developmental Brain Research · doi:10.1016/0165-3806(82)90141-9 · Cited by 639
Falconer, D. S. (1951) · Journal of Genetics · doi:10.1007/bf02996215 · Cited by 539
Research works printed but not linked: 1
- Berry, 1965, The migration of neuroblastin the developing cerebral cortex, J. Anat., 99, 691
Cited by
Sorted by citations
Items 601–700 of 890
Normal formation of the postsynaptic elements of GABAergic synapses in the reeler cerebellum
Takayama, C., & Inoue, Y. (2003) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.08.003 · Cited by 16
“The reeler mouse is a consequence of the reelin gene mutation [10, 21, 43], and suffers from reeling ataxic gait, tremor action, and dystonic posture [12, 18].”
Missense mutations resulting in type 1 lissencephaly
Reiner, O., & Coquelle, F. M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4344-0 · Cited by 17
Chapter 22 The surface of the developing cerebral cortex; still special cells one century later
Fairén, A., Morante, J., & Frassoni, C. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36024-2 · Cited by 16
Cadherin-related Neuronal Receptors in Incisor Development
Fukumoto, E., Sakai, H., Fukumoto, S., Yagi, T., Takagi, O., & Kato, Y. (2003) · Journal of Dental Research · doi:10.1177/154405910308200105 · Cited by 16
“Recently, it was reported that the N-terminal conserved region of CNRs bound reelin, a secreted glycoprotein in the matrix, which regulates layering and positioning of neurons (Ogawa et al., 1995; Frotscher, 1997; Senzaki et al., 1999).”
BackgroundRostro-Caudal and Caudo-Rostral Migrations in the Telencephalon: Going Forward or Backward?
Ruiz-Reig, N., & Studer, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00692 · Cited by 21
“Frontiers in Neuroscience | www.frontiersin.org 7 December 2017 | Volume 11 | Article 692 for the correct organization of OB layers (Ogawa et al., 1995), and on the other hand, RLN secretion by the mitral and tufted cells is crucial for the radial migration of neuroblasts within the OB (Hack et…”
BackgroundYoshiura, K.-I., Noda, Y., Kinoshita, A., & Niikawa, N. (2000) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(200005)43:2 · Cited by 16
Histological study in the brain of the reelin/Dab1-compound mutant mouse
Yamamoto, T., Setsu, T., Okuyama‐Yamamoto, A., & Terashima, T. (2009) · Anatomical Science International · doi:10.1007/s12565-008-0009-7 · Cited by 16
“brain development ( Ogawa et al. 1995 ), and it also regulates positioning of cortical neurons migrating toward the pial surface from the ventricular zone.”
BackgroundWoodhams, P. L., & Terashima, T. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00150.x · Cited by 16
Dawson, G., & Toth, K. (2015) · Wiley eBooks · doi:10.1002/9780470939406.ch8 · Cited by 17
Peptidergic modulation of fear responses by the Edinger-Westphal nucleusPreprint
Priest, M. F., Freda, S. N., Badong, D., Dumrongprechachan, V., & Kozorovitskiy, Y. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.05.455317 · Cited by 16
“Cajal-Retzius cells are crucial for proper cortical development in early life (Ogawa et al., 1995) and may have a predominantly developmental role, rather than one dependent on”
BackgroundGlutamatergic cerebellar granule neurons synthesize and secrete reelin in vitro
Sinagra, M., Gonzalez Campo, C., Verrier, D., Moustié, O., Manzoni, O. J., & Chavis, P. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x09990214 · Cited by 15
“The role of reelin during brain development has been extensively studied showing that reelin is crucial for the proper cytoarchitecture of laminated structures (D’Arcangelo et al., 1995; Ogawa et al., 1995; Tissir and Goffinet, 2003).”
BackgroundThe α6 integrin subunit in the developing mouse olfactory bulb
Whitley, M. J., Treloar, H. B., Arcangelis, A. D., Georges‐Labouesse, E., & Greer, C. A. (2005) · Journal of Neurocytology · doi:10.1007/s11068-005-5049-5 · Cited by 15
Disabled-1 Alternative Splicing in Human Fetal Retina and Neural Tumors
Katyal, S., Glubrecht, D. D., Li, L., Gao, Z., & Godbout, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028579 · Cited by 15
Spinal Motor Neuron Migration and the Significance of Topographic Organization in the Nervous System
Kania, A. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-7687-6_8 · Cited by 18
Neuronal Migration and Neurodegeneration: 2 Sides of the Same Coin
Reiner, O., Shmueli, A., & Sapir, T. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp039 · Cited by 16
Tkachenko, L. A., Александрович, З. П., Nasyrov, R. A., & Ивановна, К. Е. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00026 · Cited by 16
Darmanto, W., Inouye, M., Takagishi, Y., Ogawa, M., Mikoshiba, K., & Murata, Y. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.3.251 · Cited by 15
Self-citationDevelopmental Biology: Frontiers for Clinical Genetics
McInnes, R. R. (1998) · Clinical Genetics · doi:10.1111/j.1399-0004.1998.tb02667.x · Cited by 15
Cajal–Retzius and Subplate Cells
Luhmann, H. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397266-8.00009-0 · Cited by 15
Liao, J., Dong, G., Wulaer, B., Sawahata, M., Mizoguchi, H., Mori, D., Ozaki, N., Nabeshima, T., Nagai, T., & Yamada, K. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113569 · Cited by 13
Chuang, S., Wang, Y., Wang, Q., Liu, K.-M., & Shen, Q. (2011) · Developmental Neuroscience · doi:10.1159/000330582 · Cited by 16
Shin, M., Kitazawa, A., Yoshinaga, S., Hayashi, K., Hirata, Y., Dehay, C., Kubo, K., & Nakajima, K. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24634 · Cited by 14
Dlugosz, P., Tresky, R., & Nimpf, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00053 · Cited by 14
“It is expressed in the marginal zone (Hirota et al., 2015) by Cajal-Retzius cells (Ogawa et al., 1995) but also by some cells in the subventricular zone (SVZ) and intermediate zone (Uchida et al., 2009) where it promotes neurogenesis in cooperation with Notch (Lakomá et al., 2011).”
BackgroundSpecification of GABAergic Neocortical Interneurons
Miyoshi, G., Machold, R. P., & Fishell, G. (2013) · Springer eBooks · doi:10.1007/978-4-431-54496-8_5 · Cited by 16
Martín-López, E., Blanchart, A., Carlos, J., & López‐Mascaraque, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026673 · Cited by 13
“The role of this molecule involves different processes during development and maturation of CNS as layering [1,5–7], detachment of neuroblasts [8], differentiation of radial cells [9], neurogenesis and gliogenesis processes [10], signaling [11] and dendritic spines development [12].”
BackgroundPuzzling out the reeler brainteaser: Does reelin signal to unique neural lineages?
Luque, J. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.056 · Cited by 13
Developmental expression of Bis protein in the cerebral cortex and hippocampus of rats
Choi, J., Lee, J. H., Kim, H.-Y., Chun, M., Chung, J.-W., & Lee, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.137 · Cited by 14
Miettinen, R. A., Riedel, A., Kalesnykas, G., Kettunen, H.-P., Puoliväli, J. T., Soininen, H. S., & Arendt, T. (2005) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2005.06.003 · Cited by 14
Ambiguus nucleus neurons innervating the abdominal esophagus are malpositioned in the reeler mouse
Fujimoto, Y., Setsu, T., Ikeda, Y., Miwa, A., Okado, H., & Terashima, T. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00910-x · Cited by 14
Dairaghi, L., Flannery, E., Giacobini, P., Saglam, A., Saadi, H., Constantin, S., Casoni, F., Howell, B. W., & Wray, S. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00228 · Cited by 17
“In humans, several monogenic, as well as digenic, disorders leading to idiopathic hypogonadotropic hypogonadisms (IHH) are caused by disruption of GnRH neuronal ontogeny/migration (Pitteloud et al., 2007).”
BackgroundRegulation of Rap GTPases in mammalian neurons
Shah, B., & Püschel, A. W. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0165 · Cited by 14
“This inside-out migration pattern is organized by the extracellular matrix protein reelin that is secreted by the Cajal-Retzius (CR) cells in the most superficial layer beneath the basement membrane (Ogawa et al., 1995; Meyer, 2010).”
BackgroundOrcinha, C. R., Kilias, A., Paschen, E., Follo, M., & Haas, C. A. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.730811 · Cited by 12
“The neutralizing antibody CR-50 can block Reelin function in vivo and in vitro (Ogawa et al., 1995; del Río et al., 1997; Miyata et al., 1997; Nakajima et al., 1997; Utsunomiya-Tate et al., 2000) and infusion of CR-50 into the hippocampus of normal adult mice induced GCD locally (Heinrich et al.,…”
BackgroundMethodKatyal, S., Gao, Z., Monckton, E. A., Glubrecht, D. D., & Godbout, R. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.01.068 · Cited by 13
Transcriptional Analysis of Estrogen Effects in Human Embryonic Neurons and Glial Cells
Csöregh, L., Andersson, E., & Fried, G. (2008) · Neuroendocrinology · doi:10.1159/000153899 · Cited by 13
Reelin expression in the retina and optic tectum of developing common brown trout
Candal, E., Caruncho, H. J., Sueiro, C., Anadón, R., & Rodríguez‐Moldes, I. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.10.014 · Cited by 13
Postnatal Development of Entorhinodentate Projection of the Reeler Mutant Mouse
Muraoka, D., Katsuyama, Y., Kikkawa, S., & Terashima, T. (2006) · Developmental Neuroscience · doi:10.1159/000096211 · Cited by 13
“In the reeler mouse, laminar organization of the cerebral and cerebellar cortices and hippocampus is disorganized due to the absence of the Reelin protein [Alcantara et al., 1998; D’Arcangelo et al., 1997; Li et al., 2005; Nakajima et al., 1997; Ogawa et al., 1995; Schiffmann et al., 1997].”
BackgroundCerebral gyral dysplasias: molecular genetics and cell biology
Clark, G. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200104000-00004 · Cited by 13
The function of presenilin-1 in amyloid β-peptide generation and brain development
Säftig, P., Hartmann, D., & Strooper, B. D. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050099 · Cited by 13
“Especially chondroitin sulfate pro teoglycans (CSPG) and reelin synthesized and secreted by CR neurons have been discussed to provide the ‘stop signal’ for neuronal migration (Perris and Johansson 1990; Ogawa et al. 1995; Meyer-Puttlitz et al. 1996; Frotscher”
Schaefer, A. W., Poluch, S., & Juliano, S. L. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20601 · Cited by 13
Ghosh, A. (1997) · Nature · doi:10.1038/385023a0 · Cited by 13
Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway
Larios, J. A., Jausoro, I., Benitez, M.-L., Bronfman, F. C., & Marzolo, M.-P. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-108 · Cited by 12
“In this stage, reelin expressed by Cajal-Retzius cells [42,43]”
BackgroundEffects of Ethanol Exposure In Utero on Cajal–Retzius Cells in the Developing Cortex
Skorput, A. G. J., & Yeh, H. H. (2015) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12696 · Cited by 12
“They release the glycoprotein reelin (D'Arcangelo et al., 1995; Hirotsune et al., 1995; Ogawa et al., 1995), implicated in regulating neuronal migration, layering, and neurogenesis in the developing cortex (Franco et al.”
BackgroundInfluentialNavolić, J., Moritz, M., Voß, H., Schlumbohm, S., Schumann, Y., Schlüter, H., Neumann, J. E., & Hahn, J. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02637 · Cited by 11
Neurochemical Phenotype of Reelin Immunoreactive Cells in the Piriform Cortex Layer II
Carceller, H., Rovira-Esteban, L., Nácher, J., Ċastrén, E., & Guirado, R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00065 · Cited by 12
“In the adult rodent brain, Reelin expression is found sparsely across the telencephalon (Alcántara et al., 1998; Pesold et al., 1998; Ramos-Moreno et al., 2006).”
BackgroundResultInfluentialEsmaeilzadeh‐Gharehdaghi, E., Razmara, E., Bitaraf, A., Mahmoudi, M., & Garshasbi, M. (2019) · Cellular and Molecular Biology · doi:10.14715/cmb/2019.65.6.3 · Cited by 12
Modulation of Hippocampal Gamma Oscillations by Dopamine in Heterozygous Reeler Mice in vitro
Wang, L., Zhao, D., Wang, M., Wang, Y., Vreugdenhil, M., Lin, J., & Lu, C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00586 · Cited by 11
Kikkawa, T., Sakayori, N., Yuuki, H., Katsuyama, Y., Matsuzaki, F., Konno, D., Abe, T., Kiyonari, H., & Osumi, N. (2020) · Developmental Dynamics · doi:10.1002/dvdy.156 · Cited by 12
An hypothesis on the early evolution of the development of the isocortex
Aboitiz, F., Montiel, J. F., & López, J. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00681-5 · Cited by 12
Newell, A. J., Lalitsasivimol, D., Willing, J., Gonzales, K. L., Waters, E. M., Milner, T. A., McEwen, B. S., & Wagner, C. K. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24485 · Cited by 15
“Cajal-Retzius neurons express and secrete the extracellular matrix protein reelin (D'Arcangelo et al., 1995; Hirotsune et al., 1995; Ogawa et al., 1995) which is responsible for orchestrating fundamental developmental mechanisms such as neuronal migration, axon target finding, and dendrite maturation in the dentate gy…”
Factors Affecting the Morphology of Radial Glia
Gierdalski, M. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.572 · Cited by 12
Hedin‐Pereira, C., DeMoraes, E. C. P., Santiago, M. F., Méndez‐Otero, R., & Lent, R. (2000) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01332.x · Cited by 12
“…so far available on the role for reelin on the assembly of cortical layers derives from the in situ analysis of cell positioning in reeler mutants (Caviness & Sidman, 1973; Caviness, 1982) and from aggregation cultures (Hoffarth et al., 1995; Ogawa et al., 1995), not from migrating neurons.”
BackgroundMethodInfluentialKrzyzanowska, A., Cabrerizo, M., Clascá, F., & Ramos‐Moreno, T. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00102 · Cited by 11
“…dendritic growth and postsynaptic events during long-term potentiation (Goffinet, 1984; Haas et al., 2002; Frontiers in Neuroanatomy | www.frontiersin.org 1 January 2020 | Volume 13 | Article 102 Hack et al., 2002; Ohshima et al., 2002; Weeber et al., 2002; Niu et al., 2004; Cariboni et al., 2005).”
BackgroundRiva, M., Ferreira, S., Hayashi, K., Saillour, Y., Medvedeva, V. P., Honda, T., Hayashi, K., Altersitz, C., Albadri, S., Rosello, M., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci153097 · Cited by 11
“These “mini-cortex”–like structures closely resemble the characteristic inside-out cell arrangement of the neocortex (54), which is determined by CR cells secreting RELN in the MZ to control radial neuronal migration (3).”
InfluentialDamilou, A., Cai, L., Argunşah, A. Ö., Han, S., Kanatouris, G., Karatsoli, M., Hanley, O., Gesuita, L., Kollmorgen, S., Helmchen, F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50658-6 · Cited by 10
Escudero, B., Moya, M., López-Valencia, L., Árias, F., & Orío, L. (2023) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad034 · Cited by 11
Martinez-Galan, J. R., Moncho-Bogani, J., & Caminos, E. (2013) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155413509381 · Cited by 11
Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly
Vasung, L., Rezayev, A., Yun, H. J., Song, J. W., van der Kouwe, A. J. W., Stewart, N., Palani, A., Shiohama, T., Chouinard-Decorte, F., Levman, J. E. D., et al. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00124 · Cited by 11
Hammond, V. E., So, E., Cate, H. S., Britto, J. M., Gunnersen, J. M., & Tan, S. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp287 · Cited by 11
Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons
Bohannon, A. S., & Hablitz, J. J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00020 · Cited by 11
“Cajal-Retzius cells (CR) in L1 are one of the earliest identifiable cell-types in the neocortex (Bradford et al., 1978; Chun and Shatz, 1989) and are critical for proper cortical development, specifically cortical layering (Peters and Jones, 1984; Ogawa et al., 1995).”
BackgroundΘεοδοσίου, Θ., Papanikolaou, N., Savvaki, M., Bonetto, G., Maxouri, S., Fakoureli, E., Eliopoulos, A. G., Tavernarakis, N., Amoutzias, G. D., Pavlopoulos, G. A., et al. (2020) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqaa005 · Cited by 11
Li, H., Honma, S., Miki, T., Takeuchi, Y., Takeuchi, K., & Kawano, H. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04018.x · Cited by 11
“These aberrant trajectories resemble those seen in reeler mutant mice (Molnar & Blakemore, 1995), which lack the diffusible factor reelin, secreted from Cajal–Retzius cells in the marginal zone (D’Arcangelo et al., 1995; Ogawa et al., 1995).”
BackgroundLi, H., Oohira, A., Ogawa, M., Kawamura, K., & Kawano, H. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04491.x · Cited by 11
“In L1-deficient neonatal mice, thalamocortical axons are hyperfasciculated in the internal capsule and defasciculated in the neocortex (Ohyama et al., 2004; Wiencken-Barger et al., 2004).”
BackgroundSelf-citationReelin: A novel extracellular matrix protein involved in brain lamination
Rugarli, E. I., & Ballabio, A. (1995) · BioEssays · doi:10.1002/bies.950171003 · Cited by 11
Cerebellar histogenesis as seen in identified cells of normal-reeler mouse chimeras
Yoshiki, A., & Kusakabe, M. (1998) · The International Journal of Developmental Biology · doi:10.1387/ijdb.9712524 · Cited by 11
The Subpial Granular Layer in the Developing Cerebral Cortex of Rodents
Meyer, G., Castro, R., Soria, J. M., & Fairén, A. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-48002-0_12 · Cited by 11
Self-Organizing Single-Rosette Brain Organoids From Human Pluripotent Stem CellsPreprint
Tidball, A. M., Niu, W., Ma, Q., Takla, T. N., Walker, J. C., Margolis, J. L., Mojica-Perez, S. P., Sudyk, R., Moore, S. J., Chopra, R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.28.482350 · Cited by 11
“Notably, we only observed neurodevelopmentally normative layering in SOSRS displaying continued expression of Reelin+ cells on their exterior, consistent with the importance of these cells in normal “inside-out” cortical development (Ogawa et al., 1995).”
BackgroundWDFY3 mutation alters laminar position and morphology of cortical neurons
Schaaf, Z. A., Tat, L., Cannizzaro, N., Panoutsopoulos, A. A., Green, R., Rülicke, T., Hippenmeyer, S., & Zarbalis, K. S. (2022) · Molecular Autism · doi:10.1186/s13229-022-00508-3 · Cited by 11
“Migration defects rooted in the loss of extrinsic signals have been extensively studied in reeler mice that carry a mutation in reelin (Reln) [54, 55], a secreted glycoprotein produced by Cajal–Retzius cells occupying the marginal zone during development [56].”
BackgroundRegulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent
Hattori, M. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1546083 · Cited by 10
Nelson, M. M., Hoff, J. D., Zeese, M. L., & Corfas, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.693595 · Cited by 9
Yip, Y. P., Thomas, T., Voss, A. K., & Yip, J. W. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23086 · Cited by 11
“…to that of another anti-reelin monoclonal antibody, CR50 (Yip et al., 2000), which was generated by immunizing reeler with brains from wild-type mice (Ogawa et al., 1995; Nakajima et al., 1997) and whose epitope was mapped between amino acids 251 and 407 of mouse reelin (D’Arcangelo et al. 1997).”
BackgroundIn vivo functions of small GTPases in neocortical development
Shah, B., & Püschel, A. W. (2014) · Biological Chemistry · doi:10.1515/hsz-2013-0277 · Cited by 10
Larios, J. A., & Marzolo, M.-P. (2012) · Frontiers in Biology · doi:10.1007/s11515-011-1186-7 · Cited by 9
“…function of this receptor is to trigger a signal transduction pathway following binding of reelin (Darcangelo et al., 1999), which is an extracellular matrix protein that is secreted in the developing brain and in the adult brain (Ogawa et al., 1995; Del Río et al., 1997; Bar and Goffinet, 1999).”
BackgroundCheng, Q., Yeh, P. W. L., & Yeh, H. H. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05122.x · Cited by 10
“Cajal–Retzius cells synthesize and secrete reelin, an extracellular glycoprotein that binds to the apolipoprotein E receptor 2 and the very low density lipoprotein receptor to regulate cortical development (Ogawa et al., 1995; Curran & D’Arcangelo, 1998; D’Arcangelo et al., 1999).”
BackgroundKatayama, K.-I., Hayashi, K., Inoue, S., Sakaguchi, K., & Nakajima, K. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1497-9 · Cited by 10
Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex
Arai, Y., Cwetsch, A. W., Coppola, E., Cipriani, S., Nishihara, H., Kanki, H., Saillour, Y., Freret-Hodara, B., Dutriaux, A., Okada, N., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.007 · Cited by 12
Ohyama, K., Ikeda, E., Kawamura, K., Maeda, N., & Noda, M. (2003) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.10.012 · Cited by 10
Reelin immunoreactivity in dissociated cultures of the postnatal hippocampus
Scotti, A. L., & Herrmann, G. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03236-x · Cited by 10
The Reelin-Signaling Pathway and Mouse Cortical Development
Bar, I., de Rouvroit, C. L., & Goffinet, A. M. (2000) · Results and problems in cell differentiation · doi:10.1007/978-3-540-48002-0_11 · Cited by 10
Distribution of mesencephalic trigeminal nucleus neurons in the reeler mutant mouse
Terashima, T. (1996) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199604)244:4 · Cited by 10
Setsu, T., Ikeda, Y., Woodhams, P. L., & Terashima, T. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1350 · Cited by 10
“…and controls the positioning of neurons in both laminated and nonlaminated structures in the central nervous system (D’Arcangelo et al., 1995; Hirotsune et al., 1995; Ogawa et al., 1995; Miyata et al., 1996; Nakajima et al., 1997; Lambert de Rouvroit et al., 1999; Utsunomiya-Tate et al., 2000).”
BackgroundDevelopment and Developmental Disorders of the Cerebral Cortex
ten Donkelaar, H. J., Lammens, M. M. Y., Aronica, E., van Bokhoven, H., Ulzen, K. K.-V., & Hori, A. (2014) · Springer eBooks · doi:10.1007/978-3-642-54687-7_10 · Cited by 9
Evidence of Reelin Signaling in GBM and Its Derived Cancer Stem Cells
Biamonte, F., Sica, G., Filippini, A., & D’Alessio, A. (2021) · Brain Sciences · doi:10.3390/brainsci11060745 · Cited by 10
“Reelin is a large secreted extracellular glycoprotein of approximately 400 kDa [13,14] that plays a key role in the regulation of neuronal migration during mammalian brain development [15].”
BackgroundThe structure-function relationship of a signaling-competent, dimeric Reelin fragment
Turk, L. S., Kuang, X., Pozzo, V. D., Patel, K., Chen, M., Huynh, K. W., Currie, M. J., Mitchell, D., Dobson, R. C. J., D’Arcangelo, G., et al. (2021) · Structure · doi:10.1016/j.str.2021.05.012 · Cited by 9
Analysis of the Expression Pattern of Cajal-Retzius Cell Markers in the Xenopus laevis Forebrain
Jiménez, S., & Moreno, N. (2021) · Brain Behavior and Evolution · doi:10.1159/000519025 · Cited by 8
“…genes, which are selectively and highly expressed in both embryos and postnatal stages, have been accurately described [D’Arcangelo et al., 1995; Ogawa et al., 1995; Ikeda and Terashima, 1997; Schiffman et al., 1997; Alcántara et al., 1998; Meyer and Goffinet, 1998; Pesold et al., 1998; Meyer…”
BackgroundGraphical simulation of early development of the cerebral cortex
Ryder, E. F., Bullard, L., Hone, J. R., Olmstead, J., & Ward, M. O. (1999) · Computer Methods and Programs in Biomedicine · doi:10.1016/s0169-2607(98)00096-0 · Cited by 9
Similarities and Differences Between the Wnt and Reelin Pathways in the Forming Brain
Reiner, O., & Sapir, T. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:117 · Cited by 10
Vldlr overexpression causes hyperactivity in rats
Iwata, K., Izumo, N., Matsuzaki, H., Manabe, T., Ishibashi, Y., Ichitani, Y., Yamada, K., Thanseem, I., Anitha, A., Vasu, M. M., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-11 · Cited by 9
“During embryonic development, reelin is secreted by specialized Cajal-Retzius cells to form a highly laminated structure in the neocortex, hippocampus, and cerebellum [2,4-6].”
Dual role of Cajal-Retzius cells and reelin in cortical development
Frotscher, M. (1997) · Springer eBooks · doi:10.1007/978-3-642-60905-3_17 · Cited by 9
Reelin immunoreactivity in the adult sea lamprey brain
Pérez‐Costas, E., Meléndez‐Ferro, M., Pérez‐García, C. G., Caruncho, H. J., & Rodicio, M. C. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.08.005 · Cited by 9
Perspectives in Evo‐Devo of the Vertebrate Brain
Rétaux, S., Bourrat, F., Joly, J., & Hinaux, H. (2013) · Wiley eBooks · doi:10.1002/9781118707449.ch8 · Cited by 10
Intra- and Extracellular Control of Neuronal Migration: Relevance to Cortical Malformations
RAKIC, P. T. (1997) · Research and perspectives in neurosciences · doi:10.1007/978-3-642-60861-2_5 · Cited by 9
Rodent Zic Genes in Neural Network Wiring
Herrera, E. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-7311-3_11 · Cited by 8
Integrity of Cajal–Retzius cells in thereeler‐mouse hippocampus
Anstötz, M., Karsak, M., & Rune, G. M. (2018) · Hippocampus · doi:10.1002/hipo.23049 · Cited by 8
HeterozygousDab1Null Mutation Disrupts Neocortical and Hippocampal Development
Honda, T., Hirota, Y., & Nakajima, K. (2023) · eNeuro · doi:10.1523/eneuro.0433-22.2023 · Cited by 8
“Radially migrating neurons express receptors for Reelin, a large secreted glycoprotein mainly produced by Cajal-Retzius cells in the marginal zone that is critical for the positioning of excitatory neurons (D’Arcangelo et al., 1995; Hirotsune et al., 1995; Ogawa et al., 1995).”
BackgroundMechanisms of Ethanol-Induced Alterations in Neuronal Migration
Siegenthaler, J. A., & Miller, M. W. (2006) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195183139.003.0013 · Cited by 8
Murine modelling of classical lissencephaly
Gambello, M. J., Hirotsune, S., & Wynshaw-Boris, A. J. (1999) · Neurogenetics · doi:10.1007/s100480050056 · Cited by 8
“Reelin is produced by the Cajal-Retzius cells lining the outer layer of the preplate [ 47 ].”
BackgroundTakayama, C., Nakagawa, S., Watanabe, M., Kurihara, H., Mishina, M., & Inoue, Y. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01093-1 · Cited by 8
The Neurochemistry of Schizophrenia
Moghaddam, B., & Krystal, J. H. (2003) · Wiley eBooks · doi:10.1002/9780470987353.ch19 · Cited by 8
The neuronal Golgi in neural circuit formation and reorganization
Nakagawa, N. (2024) · Frontiers in Neural Circuits · doi:10.3389/fncir.2024.1504422 · Cited by 7
Nishibe, M., Katsuyama, Y., & Yamashita, T. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1647-8 · Cited by 8
“1 3 cortical layers during development (Alcantara et al. 1998; Ogawa et al. 1995; D’Arcangelo et al. 1995).”
Background
Metadata
- Authors
- Ogawa, M., Miyata, T., Nakajimat, K., Yagyu, K., Seike, M., Ikenaka, K., Yamamoto, H., & Mikoshibat, K.
- Affiliations
- Kochi Medical School Hospital (JP)
- National Institute for Physiological Sciences (JP)
- National Institute of Neuroscience (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 14
- Issue
- 5
- Pages
- 899-912
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2036838270
- Cited by
- 889
- References
- 61
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 5 · 2023: 20 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 25 · 2018: 20 · 2017: 23 · 2016: 22 · 2015: 25 · 2014: 18 · 2013: 32 · 2012: 25
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Cajal-Retzius neurons, cortical lamination, neocortex development, histogenesis
- MeSH terms
- Reelin Protein, Animals, Antibodies, Monoclonal, Cell Adhesion, Cell Communication, Cerebral Cortex, Extracellular Space, Hybridomas, Immunohistochemistry, Mice, Neurologic Mutants, Mutation, Nerve Tissue Proteins, Neurons, Serine Endopeptidases, Tissue Distribution, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
