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Cited by 796

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

Open access
Ham, Jonathan, Babij, Carol, Whitfield, Jonathan, Pfarr, Curt M, Lallemand, Dominique, Yaniv, Moshe, Rubin, Lee L·1995·Neuron
DOI 10.1016/0896-6273(95)90331-3
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Abstract

Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member. When sympathetic neurons are deprived of NGF, the level of c-Jun protein significantly increases, whereas the levels of the other members of the Jun and Fos family remain relatively constant. c-Jun also becomes more phosphorylated, probably on its amino terminal transactivation domain. When microinjected into sympathetic neurons, an expression vector for a c-Jun dominant negative mutant protects them against NGF withdrawal-induced death, indicating that AP-1 activity is essential for neuronal cell death. Furthermore, overexpression of the full-length c-Jun protein is, in itself, sufficient to induce apoptosis in sympathetic neurons.

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Metadata

Authors
Ham, J., Babij, C., Whitfield, J., Pfarr, C. M., Lallemand, D., Yaniv, M., & Rubin, L. L.
Venue
Neuron
Publisher
Elsevier BV
Published
1995-05
Volume
14
Issue
5
Pages
927-939
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/0896-6273(95)90331-3
OpenAlex
W1968015127
Cited by
796
References
6
FWCI
26.05
Type
journal article
Language
en
Open access
hybrid

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.