Neuroprotection by histone deacetylase-related protein

Histone deacetylases (HDACs): characterization of the classical HDAC family

RUIJTER, A. J. M. D., GENNIP, A. H. V., CARON, H. N., KEMP, S., & KUILENBURG, A. B. P. V. (2003) · Biochemical Journal · doi:10.1042/bj20021321 · Cited by 3,114 · see citing works

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

Yang, D. D., Kuan, C.-Y., Whitmarsh, A. J., Rinócn, M., Zheng, T. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1997) · Nature · doi:10.1038/39899 · Cited by 1,230 · see citing works

Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway

Brunet, A., Datta, S. R., & Greenberg, M. E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00211-7 · Cited by 1,193 · see citing works

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

McKinsey, T. A., Zhang, C., Lu, J., & Olson, E. N. (2000) · Nature · doi:10.1038/35040593 · Cited by 1,051 · see citing works

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

D'Mello, S. R., Galli, C., Ciotti, T., & Calissano, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.10989 · Cited by 892 · see citing works

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

Hockly, E., Richon, V. M., Woodman, B., Smith, D. L., Zhou, X., Rosa, E., Sathasivam, K., Ghazi‐Noori, S., Mahal, A., Lowden, P. A. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437870100 · Cited by 847 · see citing works

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

Ham, J., Babij, C., Whitfield, J. R., Pfarr, C. M., Lallemand, D., Yaniv, M., & Rubin, L. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90331-3 · Cited by 796 · see citing works

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

Ferrante, R. J., Kubilus, J. K., Lee, J.-H., Ryu, H., Beesen, A. A., Zucker, B., Smith, K., Kowall, N. W., Ratan, R. R., Luthi‐Carter, R., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09418.2003 · Cited by 694 · see citing works

Class II histone deacetylases: versatile regulators

Verdin, E., Dequiedt, F., & Kasler, H. G. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00073-8 · Cited by 664 · see citing works

Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5

McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.260501497 · Cited by 520 · see citing works

Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

Lu, J., McKinsey, T. A., Nicol, R. L., & Olson, E. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080064097 · Cited by 518 · see citing works

Histone Deacetylase Inhibitors

Marks, P. A., Richon, V. M., Miller, T., & Kelly, W. K. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)91004-4 · Cited by 424 · see citing works

Phosphorylation of c-Jun Is Necessary for Apoptosis Induced by Survival Signal Withdrawal in Cerebellar Granule Neurons

Watson, A., Eilers, A., Lallemand, D., Kyriakis, J. M., Rubin, L. L., & Ham, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00751.1998 · Cited by 360 · see citing works

Critical loss of CBP/p300 histone acetylase activity by caspase‐6 during neurodegeneration

Rouaux, C., Jokic, N., Mbebi, C., Boutillier, S., Loeffler, J., & Boutillier, A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg615 · Cited by 302 · see citing works

Role of extracellular signal regulated kinases 1 and 2 in neuronal survival

Hetman, M., & Góźdź, A. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04133.x · Cited by 274 · see citing works

Regulating histone acetyltransferases and deacetylases

Legube, G., & Trouche, D. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor941 · Cited by 261 · see citing works

Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway

Ryu, H., Lee, J.-H., Olofsson, B. A., Mwidau, A., Deodoglu, A., Escudero, M., Flemington, E. K., Azizkhan‐Clifford, J., Ferrante, R. J., & Ratan, R. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737363100 · Cited by 261 · see citing works

c-Jun and the transcriptional control of neuronal apoptosis

Ham, J., Eilers, A., Whitfield, J. R., Neame, S. J., & Shah, B. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00372-5 · Cited by 242 · see citing works

A Comprehensive Screen for TWIST Mutations in Patients with Craniosynostosis Identifies a New Microdeletion Syndrome of Chromosome Band 7p21.1

Johnson, D., Horsley, S. W., Moloney, D. M., Oldridge, M., Twigg, S. R. F., Walsh, S., Barrow, M., Njølstad, P. R., Kunz, J., Ashworth, G. J., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/302122 · Cited by 230 · see citing works

MEF‐2 function is modified by a novel co‐repressor, MITR

Sparrow, D. B., Miska, E. A., Langley, E., Reynaud‐Deonauth, S., Kotecha, S., Towers, N., Spohr, G., Kouzarides, T., & Mohun, T. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5085 · Cited by 196 · see citing works

Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death

Bolger, T. A., & Yao, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1826-05.2005 · Cited by 190 · see citing works

c-Jun N-Terminal Protein Kinase (JNK) 2/3 Is Specifically Activated by Stress, Mediating c-Jun Activation, in the Presence of Constitutive JNK1 Activity in Cerebellar Neurons

Coffey, E. T., Smiciene, G., Hongisto, V., Cao, J., Brecht, S., Herdegen, T., & Courtney, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04335.2002 · Cited by 184 · see citing works

Strong nuclear factor-?B-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic alzheimer's disease superior temporal lobe neocortex

Lukiw, W. J., & Bazan, N. G. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980901)53:5 · Cited by 183 · see citing works

Remodeling Chromatin and Stress Resistance in the Central Nervous System: Histone Deacetylase Inhibitors as Novel and Broadly Effective Neuroprotective Agents

Langley, B. C., Gensert, J. M., Beal, M. F., & Ratan, R. R. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053005091 · Cited by 169 · see citing works

The Histone Deacetylase 9 Gene Encodes Multiple Protein Isoforms

Petrie, K. R., Guidez, F., Howell, L., Healy, L. E., Waxman, S., Greaves, M. F., & Zelent, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212935200 · Cited by 146 · see citing works

Mixed-Lineage Kinases: A Target for the Prevention of Neurodegeneration

Wang, L. H., Besirli, C. G., & Johnson, E. M. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121840 · Cited by 145 · see citing works

Calcium/calmodulin‐dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons

Sée, V., Boutillier, A., Bito, H., & Loeffler, J. (2001) · The FASEB Journal · doi:10.1096/fj.00-0106com · Cited by 138 · see citing works

Targeting JNK3 for the treatment of neurodegenerative disorders

Resnick, L., & Fennell, M. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03251-9 · Cited by 128 · see citing works

Inactivation of the Myocyte Enhancer Factor-2 Repressor Histone Deacetylase-5 by Endogenous Ca2//Calmodulin-dependent Kinase II Promotes Depolarization-mediated Cerebellar Granule Neuron Survival

Linseman, D. A., Bartley, C. M., Le, S. S., Laessig, T. A., Bouchard, R. J., Meintzer, M. K., Li, M., & Heidenreich, K. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307245200 · Cited by 124 · see citing works

Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5

Zhou, X., Richon, V. M., Rifkind, R. A., & Marks, P. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1056 · Cited by 120 · see citing works

The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis

Zhang, C. L., McKinsey, T. A., & Olson, E. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131198498 · Cited by 118 · see citing works

Neuronal apoptosis induced by histone deacetylase inhibitors

Salminen, A., Tapiola, T., Korhonen, P., & Suuronen, T. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00210-1 · Cited by 109 · see citing works

Promotion of granule cell survival by high K+ or excitatory amino acid treatment and Ca2+/calmodulin-dependent protein kinase activity

Hack, N., Hidaka, H., Wakefield, M. J., & Balázs, R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90108-r · Cited by 103 · see citing works

Targeting the JNK Signaling Pathway for Stroke and Parkinsons Diseases Therapy

Kuan, C.-Y., & Burke, R. E. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053005145 · Cited by 100 · see citing works

Phenotypic findings due to trisomy 7p15.3-pter including theTWIST locus

Stankiewicz, P., Thiele, H., Baldermann, C., Kr�ger, A., Giannakudis, I., D�rr, S., Werner, N., Kunz, J., Rappold, G. A., & Hansmann, I. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1512 · Cited by 97 · see citing works

NF‐κB is involved in the survival of cerebellar granule neurons: association of Iκβ phosphorylation with cell survival

Koulich, E., Nguyen, T. N., Johnson, K., Giardina, C. A., & D’Mello, S. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00134.x · Cited by 97 · see citing works

Selective E2F‐dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis

Boutillier, A., Trinh, E., & Loeffler, J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01581.x · Cited by 94 · see citing works

Diversity in the Sir2 family of protein deacetylases

Buck, S. W., Gallo, C. M., & Smith, J. S. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0903424 · Cited by 94 · see citing works

The c‐Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK‐ERK and Akt‐independent mechanism

Chin, P. C., Liu, L., Morrison, B. E., Siddiq, A., Ratan, R. R., Bottiglieri, T., & D’Mello, S. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02530.x · Cited by 93 · see citing works

NF‐κB is involved in the survival of cerebellar granule neurons: association of IκBβ phosphorylation with cell survival

Koulich, E., Nguyen, T. N., Johnson, K., Giardina, C. A., & D’Mello, S. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00303.x · Cited by 77 · see citing works

Targeting the JNK Pathway for Therapeutic Benefit in CNS Disease

Bozyczko‐Coyne, D., Saporito, M. S., & Hudkins, R. L. (2002) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007023339472 · Cited by 68 · see citing works

The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold

Graczyk, P. P., Khan, A., Bhatia, G. S., Palmer, V. H., Medland, D., Numata, H., Oinuma, H., Catchick, J., Dunne, A., Ellis, M. V., et al. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.07.076 · Cited by 56 · see citing works

c-Jun N-terminal Kinase 3 Deficiency Protects Neurons from Axotomy-induced Death in Vivo through Mechanisms Independent of c-Jun Phosphorylation

Keramaris, E., Vanderluit, J. L., Bahadori, M. H., Mousavi, K., Davis, R. J., Flavell, R. A., Slack, R. S., & Park, D. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410127200 · Cited by 42 · see citing works

Apoptosis in cerebellar granule neurons is associated with reduced interaction between CREB‐binding protein and NF‐κB

Yalcin, A., Koulich, E., Mohamed, S. A., Liu, L., & D’Mello, S. R. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01540.x · Cited by 39 · see citing works

Loss of heterozygosity at 7p in Wilms’ tumour development

Powlesland, R. M., CHARLES, A. K., Malik, K. T. A., Reynolds, P. A., Pires, S., Boavida, M. G., & Brown, K. W. (2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.0922 · Cited by 38 · see citing works

Gains of 12q are the most frequent genomic imbalances in adult fibrosarcoma and are correlated with a poor outcome

Schmidt, H., Taubert, H. W., Würl, P., Kappler, M., Lange, H., Bartel, F., Bache, M., Holzhausen, H. ‐., & Hinze, R. (2002) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10036 · Cited by 32 · see citing works

Constitutive Repression of E2F1 Transcriptional Activity through HDAC Proteins Is Essential for Neuronal Survival

Boutillier, A., Trinh, E., & Loeffler, J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04679.x · Cited by 28 · see citing works

Evidence that the Saethre-Chotzen syndrome locus lies between D7S664 and D7S507, by genetic analysis and detection of a microdeletion in a patient.

Lewanda, A. F., Green, E. D., Weissenbach, J., Jerald, H., Taylor, E. W., Summar, M. L., Phillips, J. A., COHEN, M. P., Feingold, M., & Mouradian, W. E. (1994) · PubMed Central · Cited by 22 · see citing works

In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis

Borrás, E., Zaragozá, R., Morante, M., Garcı́a, C., Gimeno, A., López‐Rodas, G., Barber, T., Miralles, V. J., Vinã, J. R., & Torres, L. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03511.x · Cited by 19 · see citing works

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

Kazantsev, A. G., & Thompson, L. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2681 · Cited by 715 · see citing works

The Role of PI3K/Akt and ERK in Neurodegenerative Disorders

Nand, S., Dilnashin, H., Birla, H., Singh, S. S., Zahra, W., Singh, B. K., Singh, S. P., & Singh, S. P. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-0003-y · Cited by 480 · see citing works

Epigenetic regulation of gene expression in physiological and pathological brain processes

Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works

Targeting the correct HDAC(s) to treat cognitive disorders

Fischer, A., Sananbenesi, F., Mungenast, A. E., & Tsai, L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.09.003 · Cited by 355 · see citing works

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

Kim, D., Frank, C. L., Dobbin, M. M., Tsunemoto, R. K., Tu, W., Peng, P. L., Guan, J.-S., Lee, B.-H., Moy, L. Y., Giusti, P., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.015 · Cited by 286 · see citing works

AFMK, a melatonin metabolite, attenuates X‐ray‐induced oxidative damage to DNA, proteins and lipids in mice

Manda, K., Ueno, M., & Anzai, K. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00432.x · Cited by 222 · see citing works

HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage

Kim, J. Y., Shen, S., Dietz, K., He, Y., Howell, O. W., Reynolds, R., & Casaccia, P. (2009) · Nature Neuroscience · doi:10.1038/nn.2471 · Cited by 215 · see citing works

Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

Kumar, V., Kundu, S., Singh, A., & Singh, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x19666210609160017 · Cited by 210 · see citing works

Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation

Brunmeir, R., Lagger, S., & Seiser, C. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082649rb · Cited by 196 · see citing works

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6

Kozikowski, A. P., Tapadar, S., Luchini, D. N., Kim, K. H., & Billadeau, D. D. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8002894 · Cited by 190 · see citing works

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

Lee, S. J., Krauthauser, C. M., Maduskuie, V., Fawcett, P. T., Olson, J. M., & Langhans, S. A. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-144 · Cited by 168 · see citing works

Histone deacetylases 1 and 2 are expressed at distinct stages of neuro‐glial development

MacDonald, J. L., & Roskams, A. J. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21626 · Cited by 166 · see citing works

Necdin Regulates p53 Acetylation via Sirtuin1 to Modulate DNA Damage Response in Cortical Neurons

Hasegawa, K., & Yoshikawa, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3052-08.2008 · Cited by 162 · see citing works

Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3β

Bardai, F. H., & D’Mello, S. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5704-10.2011 · Cited by 158 · see citing works

Histone deacetylases (HDACs) and brain function

Volmar, C.-H., & Wahlestedt, C. (2015) · Neuroepigenetics · doi:10.1016/j.nepig.2014.10.002 · Cited by 151 · see citing works

Confirmed rare copy number variants implicate novel genes in schizophrenia

Tam, G. W. C., van de Lagemaat, L. N., Redon, R., Strathdee, K. E., Croning, M. D. R., Malloy, M. P., Muir, W. J., Pickard, B. S., Deary, I. J., Blackwood, D. H. R., et al. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380445 · Cited by 139 · see citing works

Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death

Bardai, F. H., Price, V. J., Zaayman, M., Wang, L., & D’Mello, S. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.394544 · Cited by 134 · see citing works

Epigenetic regulation of nervous system development by DNA methylation and histone deacetylation

MacDonald, J. L., & Roskams, A. J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.002 · Cited by 136 · see citing works

HDAC4 inhibits cell‐cycle progression and protects neurons from cell death

Majdzadeh, N., Wang, L., Morrison, B. E., Bassel‐Duby, R., Olson, E. N., & D’Mello, S. R. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20637 · Cited by 135 · see citing works

A Series of Potent and Selective, Triazolylphenyl-Based Histone Deacetylases Inhibitors with Activity against Pancreatic Cancer Cells and Plasmodium falciparum

Chen, Y., Lopez-Sanchez, M., Savoy, D. N., Billadeau, D. D., Dow, G. S., & Kozikowski, A. P. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701606b · Cited by 133 · see citing works

HDAC inhibitors and neurodegeneration: At the edge between protection and damage

Dietz, K. C., & Casaccia, P. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.01.011 · Cited by 126 · see citing works

Functional Differences in Epigenetic ModulatorsSuperiority of Mercaptoacetamide-Based Histone Deacetylase Inhibitors Relative to Hydroxamates in Cortical Neuron Neuroprotection Studies

Kozikowski, A. P., Chen, Y., Gaysin, A. M., Chen, B., D’Annibale, M. A., Suto, C. M., & Langley, B. C. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070178x · Cited by 122 · see citing works

HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells

Caslini, C., Hong, S., Ban, Y. J., Chen, X. S., & Ince, T. A. (2019) · Oncogene · doi:10.1038/s41388-019-0897-0 · Cited by 121 · see citing works

The promise and perils of HDAC inhibitors in neurodegeneration

Didonna, A., & Opal, P. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.147 · Cited by 120 · see citing works

Space radiation‐induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: ameliorative potential of the melatonin metabolite, AFMK

Manda, K., Ueno, M., & Anzai, K. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00611.x · Cited by 101 · see citing works

FoxG1 Promotes the Survival of Postmitotic Neurons

Dastidar, S. G., Landrieu, P. M. Z., & D’Mello, S. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2897-10.2011 · Cited by 99 · see citing works

Effect of different exercise protocols on histone acetyltransferases and histone deacetylases activities in rat hippocampus

Elsner, V. R., Lovatel, G. A., Bertoldi, K., Vanzella, C., Santos, F., Spindler, C. D. F., de Almeida, E. F., Nardin, P., & Siqueira, I. R. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.066 · Cited by 98 · see citing works

Cranial irradiation‐induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: attenuation by melatonin pretreatment

Manda, K., Ueno, M., & Anzai, K. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00632.x · Cited by 97 · see citing works

Shaping brain connections through spontaneous neural activity

Yamamoto, N., & López‐Bendito, G. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08101.x · Cited by 86 · see citing works

Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons

Sugo, N., Oshiro, H., Takemura, M., Kobayashi, T., Kohno, Y., Uesaka, N., Song, W., & Yamamoto, N. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07218.x · Cited by 85 · see citing works

Histone deacetylases: Focus on the nervous system

Morrison, B. E., Majdzadeh, N., & D’Mello, S. R. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7035-9 · Cited by 81 · see citing works

Neuroprotection by Histone Deacetylase-7 (HDAC7) Occurs by Inhibition of c-jun Expression through a Deacetylase-independent Mechanism

Ma, C., & D’Mello, S. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.146860 · Cited by 80 · see citing works

Egr-1 TransactivatesBimGene Expression to Promote Neuronal Apoptosis

Xie, B., Wang, C., Zheng, Z., Song, B., Ma, C., Thiel, G., & Li, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5504-10.2011 · Cited by 77 · see citing works

Pharmacological intervention of histone deacetylase enzymes in the neurodegenerative disorders

Gupta, R. V., Ambasta, R. K., & Kumar, P. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117278 · Cited by 79 · see citing works

Complex neuroprotective and neurotoxic effects of histone deacetylases

Thomas, E. A., & D’Mello, S. R. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14309 · Cited by 75 · see citing works

Aminoglycoside‐induced histone deacetylation and hair cell death in the mouse cochlea

Chen, F., Schacht, J., & Sha, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05871.x · Cited by 75 · see citing works

Unique functional roles for class I and class II histone deacetylases in central nervous system development and function

Morris, M. J., & Monteggia, L. M. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.02.005 · Cited by 75 · see citing works

Regional and subcellular distribution of HDAC4 in mouse brain

Darcy, M. J., Calvin, K., Cavnar, K., & Ouimet, C. C. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22241 · Cited by 69 · see citing works

Role of Nitric Oxide and Hydrogen Sulfide in Ischemic Stroke and the Emergent Epigenetic Underpinnings

Narne, P., Pandey, V., & Phanithi, P. B. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1141-6 · Cited by 70 · see citing works

Histone Hyperacetylation Up-regulates Protein Kinase Cδ in Dopaminergic Neurons to Induce Cell Death

Jin, H., Kanthasamy, A., Harischandra, D. S., Kondru, N. C., Ghosh, A., Panicker, N., Anantharam, V., Rana, A., & Kanthasamy, A. G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.576702 · Cited by 67 · see citing works

Histone deacetylase (HDAC) 9: versatile biological functions and emerging roles in human cancer

Yang, C., Croteau, S., & Hardy, P. (2021) · Cellular Oncology · doi:10.1007/s13402-021-00626-9 · Cited by 63 · see citing works

Modulating epigenetic HAT activity for reinstating acetylation homeostasis: A promising therapeutic strategy for neurological disorders

Ganai, S. A., Banday, S., Farooq, Z., & Altaf, M. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.001 · Cited by 60 · see citing works

Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors

Thomas, E. A. (2014) · Pharmaceuticals · doi:10.3390/ph7060634 · Cited by 51 · see citing works

A novel method to identify high order gene-gene interactions in genome-wide association studies: Gene-based MDR

Oh, S., Lee, J., Kwon, M., Weir, B. S., Ha, K., & Park, T. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-s9-s5 · Cited by 50 · see citing works

Multisite phosphorylation of c-Jun at threonine 91/93/95 triggers the onset of c-Jun pro-apoptotic activity in cerebellar granule neurons

Edamakanti, C. R., Albanito, L., Marco, P. D., Aiello, D., Maggiolini, M., Napoli, A., & Musti, A. M. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.381 · Cited by 50 · see citing works

Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities

Pirooznia, S. K., & Elefant, F. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00030 · Cited by 51 · see citing works

HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells.

Lang, B., Alrahbeni, T. M. A., Clair, D. S., Blackwood, D., McCaig, C., & Shen, S. (2012) · Europe PMC (PubMed Central) · Cited by 48 · see citing works

Protein kinase C‐related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases

Harrison, B. C., Huynh, K. Q., Lundgaard, G. L., Helmke, S. M., Perryman, M. B., & McKinsey, T. A. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.057 · Cited by 49 · see citing works

KSRP: A checkpoint for inflammatory cytokine production in astrocytes

Li, X., Lin, W., Chen, C., Si, Y., Zhang, X., Lu, L., Suswam, E. A., Zheng, L., & King, P. H. (2012) · Glia · doi:10.1002/glia.22396 · Cited by 47 · see citing works

Histone deacetylase‐related protein inhibits AES‐mediated neuronal cell death by direct interaction

Zhang, X., Chen, H., Jaramillo, E., Wang, L., & D’Mello, S. R. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21680 · Cited by 44 · see citing works

Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling

Balmik, A. A., & Chinnathambi, S. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151202 · Cited by 44 · see citing works

Class IIA HDACs in the regulation of neurodegeneration

Majdzadeh, N. (2007) · Frontiers in bioscience · doi:10.2741/2745 · Cited by 44 · see citing works

Suppression of HDAC2 in Spinal Cord Alleviates Mechanical Hyperalgesia and Restores KCC2 Expression in a Rat Model of Bone Cancer Pain

Hou, X., Weng, Y., Wang, T., Ouyang, B., Li, Y., Song, Z., Pan, Y., Zhang, Z., Zou, W., Huang, C., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.026 · Cited by 44 · see citing works

Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: Effects on HDAC biology and antiproliferative activity

Tapadar, S., He, R. L., Luchini, D. N., Billadeau, D. D., & Kozikowski, A. P. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.04.058 · Cited by 42 · see citing works

Targeting histone deacetylases for heart failure

Bush, E. W., & McKinsey, T. A. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902939161 · Cited by 42 · see citing works

Histone deacetylases 1 and 2 are required for brain development

Jaworska, J., Ziemka‐Nałęcz, M., & Zalewska, T. (2015) · The International Journal of Developmental Biology · doi:10.1387/ijdb.150071tz · Cited by 41 · see citing works

Identification of novel 1,4‐benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration

Wang, L., Ankati, H., Akubathini, S. K., Balderamos, M., Storey, C. A., Patel, A. V., Price, V. J., Kretzschmar, D., Biehl, E. R., & D’Mello, S. R. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22352 · Cited by 40 · see citing works

Class II and IV HDACs function as inhibitors of osteoclast differentiation

Blixt, N. C., Faulkner, B., Astleford, K., Lelich, R., Schering, J., Spencer, E., Gopalakrishnan, R., Jensen, E. D., & Mansky, K. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185441 · Cited by 39 · see citing works

Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17

Mojsa, B., Mora, S., Bossowski, J. P., Lassot, I., & Desagher, S. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.141 · Cited by 38 · see citing works

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease

Chung, J., Zhang, X., Allen, M., Wang, X., Ma, Y., Beecham, G. W., Montine, T. J., Younkin, S. G., Dickson, D. W., Golde, T. E., et al. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0349-z · Cited by 37 · see citing works

Opportunities for histone deacetylase inhibition in amyotrophic lateral sclerosis

Klingl, Y. E., Pakravan, D., & Bosch, L. V. D. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15217 · Cited by 32 · see citing works

Transducin-like Enhancer of Split-1 (TLE1) Combines with Forkhead Box Protein G1 (FoxG1) to Promote Neuronal Survival

Dastidar, S. G., Narayanan, S., Stifani, S., & D’Mello, S. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.328336 · Cited by 33 · see citing works

Expression of Class I Histone Deacetylases in Ipsilateral and Contralateral Hemispheres after the Focal Photothrombotic Infarction in the Mouse Brain

Demyanenko, S. V., Neginskaya, M. A., & Berezhnaya, E. V. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0595-6 · Cited by 33 · see citing works

Microarray Analysis on Human Neuroblastoma Cells Exposed to Aluminum, β1–42-Amyloid or the β1–42-Amyloid Aluminum Complex

Gatta, V., Drago, D., Fincati, K., Valenti, M. T., Carbonare, L. D., Sensi, S. L., & Zatta, P. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015965 · Cited by 30 · see citing works

HDAC1 deregulation promotes neuronal loss and deficit of motor function in stroke pathogenesis

Chen, J., Wang, H., Hsu, C.-Y., Su, Y.-T., Chen, J., Liang, C., Hsieh, P. C. H., Wu, C., & Kwan, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-95837-3 · Cited by 29 · see citing works

Synthesis and Structure-Activity Relationship Studies of 3-Substituted Indolin-2-ones as Effective Neuroprotective Agents

Balderamos, M., Ankati, H., Akubathini, S. K., Patel, A. V., Kamila, S., Mukherjee, C., Wang, L., Biehl, E. R., & D’Mello, S. R. (2008) · Experimental Biology and Medicine · doi:10.3181/0805-rm-153 · Cited by 29 · see citing works

Histone deacetylase in neuropathology

Gupta, R. V., Ambasta, R. K., & Kumar, P. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.09.004 · Cited by 28 · see citing works

Histone Deacetylase 9 Activates γ-Globin Gene Expression in Primary Erythroid Cells

Muralidhar, S. A., Ramakrishnan, V., Kalra, I. S., Li, W., & Pace, B. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.115725 · Cited by 28 · see citing works

Conditional deletion of histone deacetylase‐4 in the central nervous system has no major effect on brain architecture or neuronal viability

Price, V. J., Wang, L., & D’Mello, S. R. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23170 · Cited by 28 · see citing works

Regulation of Central Nervous System Development by Class I Histone Deacetylases

D’Mello, S. R. (2019) · Developmental Neuroscience · doi:10.1159/000505535 · Cited by 28 · see citing works

Histone deacetylase inhibition reduces cardiac connexin43 expression and gap junction communication

Xu, Q., Lin, X., Andrews, L. E., Patel, D., Lampe, P. D., & Veenstra, R. D. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00044 · Cited by 27 · see citing works

Validity of the MPTP-Treated Mouse as a Model for Parkinson’s Disease

Klemann, C. J. H. M., Martens, G. J. M., Poelmans, G., & Visser, J. E. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9103-8 · Cited by 26 · see citing works

The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression

Titus, A. S. C. L. S., Sharma, D., Kim, M. S., & D’Mello, S. R. (2019) · BMC Neuroscience · doi:10.1186/s12868-019-0546-0 · Cited by 26 · see citing works

Histone deacetylase-3: Friend and foe of the brain

D’Mello, S. R. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220928278 · Cited by 26 · see citing works

Polydactyly in Mice Lacking HDAC9/HDRP

Morrison, B. E., & D’Mello, S. R. (2008) · Experimental Biology and Medicine · doi:10.3181/0802-rm-48 · Cited by 24 · see citing works

Association between histone deacetylases and the loss of cochlear hair cells: Role of the former in noise-induced hearing loss

Wen, L., Wang, J., WANG, Y., & Chen, F. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2236 · Cited by 22 · see citing works

Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement

Salian‐Mehta, S., Xu, M., McKinsey, T. A., Tobet, S. A., & Wierman, M. E. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.640482 · Cited by 19 · see citing works

Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases

Boutillier, A., Rouaux, C., Panteleeva, I., & Loeffler, J. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5466-1_12 · Cited by 19 · see citing works

Effect of exercise and grape juice on epigenetic modulation and functional outcomes in PD: A randomized clinical trial

Oliveira, G. S. D., Iraci, L., Pinheiro, G. S., Casal, M. Z., Haas, A. N., Pochmann, D., Martinez, F. G., Elsner, V. R., & Dani, C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113135 · Cited by 18 · see citing works

A post-translational modification cascade employing HDAC9-PIASy-RNF4 axis regulates chondrocyte hypertrophy by modulating Nkx3.2 protein stability

Choi, H.-J., Kwon, S., & Kim, D. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.06.006 · Cited by 18 · see citing works

Restoration of HDAC1 Enzymatic Activity after Stroke Protects Neurons from Ischemia/Reperfusion Damage and Attenuates Behavioral Deficits in Rats

Chen, J., Wang, H., Su, Y.-T., Hsu, C.-Y., Chen, J., Liang, C., Wu, C., & Kwan, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910654 · Cited by 17 · see citing works

Implications of epigenetic modulation for novel treatment approaches in patients with schizophrenia.

Cha, D., Kudlow, P., Baskaran, A., Mansur, R., & McIntyre, R. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.08.038 · Cited by 20 · see citing works

Temporal, spatial and molecular pattern of dopaminergic neurodegeneration in the AAV-A53T α-synuclein rat model of Parkinson’s disease

Musacchio, T., Yin, J., Kremer, F., Koprich, J. B., Brotchie, J. M., Volkmann, J., & Ip, C. W. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113968 · Cited by 14 · see citing works

Proteomic analysis identifies NPTX1 and HIP1R as potential targets of histone deacetylase-3-mediated neurodegeneration

Qu, Z., & D’Mello, S. R. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218761149 · Cited by 14 · see citing works

Intracellular translocation of histone deacetylase 5 regulates neuronal cell apoptosis

Wei, J., Lu, Q., Li, W., & He, W. (2015) · Brain Research · doi:10.1016/j.brainres.2015.01.043 · Cited by 13 · see citing works

HDACi: The Columbus’ Egg in Improving Cancer Treatment and Reducing Neurotoxicity?

Squarzoni, A., Scuteri, A., & Cavaletti, G. (2022) · Cancers · doi:10.3390/cancers14215251 · Cited by 11 · see citing works

Human neuronal cells: epigenetic aspects

Kukucka, J., Wyllie, T., Read, J. L., Mahoney, L., & Suphioglu, C. (2013) · BioMolecular Concepts · doi:10.1515/bmc-2012-0053 · Cited by 10 · see citing works

With Gottlieb beyond Gottlieb: The Role of Epigenetics in Psychobiological Development

Lux, V. (2013) · International Journal of Developmental Science · doi:10.3233/dev-1300073 · Cited by 10 · see citing works

Epigenetic Study of Parkinson's Disease in Experimental Animal Model

Salama, A. F., Ibrahim, W., Tousson, E., Sakr, S. A., Masoud, A., Akela, M. A., & El-Rahman, M. A. A. (2015) · Clinical and experimental neurology · doi:10.12691/ijcen-3-1-3 · Cited by 9 · see citing works

Histone-Mediated Transgenerational Epigenetics

Li, J., Ding, Y., & Zheng, L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405944-3.00009-x · Cited by 9 · see citing works

Neuroprotective Strategies and Cell-Based Biomarkers for Manganese-Induced Toxicity in Human Neuroblastoma (SH-SY5Y) Cells

Cahill, C. M., Sarang, S. S., Bakshi, R., Xia, N., Lahiri, D. K., & Rogers, J. T. (2024) · Biomolecules · doi:10.3390/biom14060647 · Cited by 8 · see citing works

Histone modifications and depression: epigenetic mechanisms, therapeutic targets, and translational outlook

Lv, L.-Z., Wang, Z.-D., Ren, J.-J., Li, L.-H., Liu, X.-B., Li, J.-L., Zhu, H., Jiang, B., Han, Y.-P., Zhou, X.-M., et al. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2025.1722453 · Cited by 7 · see citing works

Mapping the Interactions Among Class IIa Histone Deacetylases and Myocyte Enhancer Factor 2s

Gautam, N., WANG, S. S., Üren, A., Chapagain, P. P., Adhikari, N. P., & Tiwari, P. B. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c00858 · Cited by 4 · see citing works

Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1

Pfister, J. A., Ma, C., & D’Mello, S. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215208 · Cited by 4 · see citing works

HDAC6

Yan, Y., & Jiao, R. (2015) · Wiley eBooks · doi:10.1002/9781119017127.ch6 · Cited by 1 · see citing works

Characterization of HDAC4's role in brain

Darcy, M. (2010)

Characterization of HDAC9 isoforms in brain microvessel bEnd.3 cells upon oxygen and glucose deprivation–reperfusion injury

Lee, Y. A., Na, W., Lee, K., Lee, H. S., & Ju, B. (2015) · Genes & Genomics · doi:10.1007/s13258-015-0282-5

Chemical hypoxia in human pluripotent NT2 stem cell-derived neurons: Effect of hydroxamic acid and benzamide-based epigenetic drugs

Bagchi, R. A., Bagchi, A. K., Salunke, A., Hens, D. K., & Parikh, P. (2019) · Neuroscience Research Notes · doi:10.31117/neuroscirn.v2i3.30

Differential Expression of Necroptosis-Related Genes with regulating lncRNA in Triple Negative Breast Cancer to Predict Prognosis and Immunotherapy Response

Zhao, Z., Diao, X., Cao, Q., & Lu, X. (2023) · Annals of Medical and Clinical Oncology · doi:10.29011/2833-3497.000144

Epigenetic changes associated with the progression of prion disease in Syrian hamsters ( Mesocricetus auratus )

Frank, L. E., Flack, N., Faulk, C. D., Block, A. J., Bartz, J. C., & Larsen, P. A. (2026) · Prion · doi:10.1080/19336896.2026.2710965

Neuroprotection by Histone Deacetylase-7 (HDAC7) Occurs by Inhibition of c-jun Expression through a Deacetylase-independent Mechanism

Ma, C., & D’Mello, S. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.146860 · Cited by 80 · see citing works

Histone deacetylase‐related protein inhibits AES‐mediated neuronal cell death by direct interaction

Zhang, X., Chen, H., Jaramillo, E., Wang, L., & D’Mello, S. R. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21680 · Cited by 44 · see citing works

Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death

Bardai, F. H., Price, V. J., Zaayman, M., Wang, L., & D’Mello, S. R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.394544 · Cited by 134 · see citing works

Histone deacetylases: Focus on the nervous system

Morrison, B. E., Majdzadeh, N., & D’Mello, S. R. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7035-9 · Cited by 81 · see citing works

Toll-Like Signaling and the Cytokine IL-6 Regulate Histone Deacetylase Dependent Neuronal Survival

Forgione, N., & Tropepe, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041033 · Cited by 20 · see citing works