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Evidence of a role for T-☐ genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity
Open accessAbstract
Tetrapod fore-and hindlimbs have evolved from the pectoral and pelvic fins of an ancient vertebrate ancestor. In this ancestor, the pectoral fin appears to have arisen following the rostral homeotic recapitulation of an existing pelvic appendage (Tabin and Laufer (1993), Nature 361, 692-693). Thus the basic appendage outgrowth program is reiterated in both tetrapod fore- and hindlimbs and the pectoral and pelvic fins of extant teleost fishes (Sordino et al. (1995) Nature 375, 678-681). Recently a novel family of putative transcription factors, which includes the T (Brachyury) locus, has been identified and dubbed the "T-box' family. In mice, all of these genes have expression patterns indicative of involvement in embryonic induction (Chapman et al. (1996) Dev. Dyn., in press), and four (Tbx2-Tbx5) are represented as two cognate, linked gene pairs (Agulnik et al., (1996), Genetics, in press). We now report that, whereas Tbx2 and Tbx3 are expressed in similar spatiotemporal patterns in both limbs, Tbx5 and Tbx4 expression is primarily restricted to the developing fore- and hindlimb buds, respectively. These observations suggest that T-box genes have played a role in the evolution of fin and limb morphogenesis, and that Tbx5 and Tbx4 may have been divergently selected to play a role in the differential specification of fore- (pectoral) versus hind- (pelvic) limb (fin) identity.
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Cites
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Self-citationSzeto, D. P., Rodriguez-Esteban, C., Ryan, A. K., O'Connell, S. M., Liu, F., Kioussi, C., Gleiberman, A. S., Izpisua-Belmonte, J. C., & Rosenfeld, M. G. (1999) · Genes & Development · doi:10.1101/gad.13.4.484 · Cited by 426
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Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity
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Self-citationThe Spectrum of Mutations in TBX3: Genotype/Phenotype Relationship in Ulnar-Mammary Syndrome
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Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
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The roles and regulation of TBX3 in development and disease
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“5, expression of Tbx3 in the AER is restricted to the tips of the digits (Chapman et al., 1996; Gibson-Brown et al., 1996).”
BackgroundThe Role of Tbx2 and Tbx3 in Mammary Development and Tumorigenesis
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The little skate genome and the evolutionary emergence of wing-like fins
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Diverse functional networks of Tbx3 in development and disease
Washkowitz, A. J., Gavrilov, S., Begum, S., & Papaioannou, V. E. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1162 · Cited by 58
Self-citationBickley, S. R. B., & Logan, M. P. O. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409913111 · Cited by 46
Metadata
- Authors
- Gibson-Brown, J. J., Agulnik, S. I., Chapman, D. L., Alexiou, M., Garvey, N., Lee, S. M., & Papaioannou, V. E.
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 56
- Issue
- 1-2
- Pages
- 93-101
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W1988796697
- Cited by
- 279
- References
- 1
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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