A magnetic resonance imaging study of putamen nuclei in major depression
Abstract
The basal ganglia are recognized as putative mediators of certain cognitive and behavioral symptoms of major depression. Moreover, patients with basal ganglia lesions have repeatedly exhibited significant affective symptomatology, including apathy, depressive mood, and psychosis. Using high resolution, axial T2 intermediate magnetic resonance images, and a systematic sampling stereologic method, we assessed putamen nuclei volumes in 41 patients with major depression (DSM-III) and 44 healthy volunteer controls of similar age. Depressed patients had significantly smaller putamen nuclei compared with controls. Age was negatively correlated with putamen size in both groups. These results are the first demonstration of diminished putamen volumes in depression and further support a role for basal ganglia structures in the etiopathogenesis of depression.
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The putamen was smaller in depressives than controls.
“In the striatum Husain et al. (1991) reported that the putamen was smaller in depressives than controls, and Krishnan et al. (1992) found a smaller caudate nucleus volume in depressives than controls.”
From Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008) · cites this paper as Husain et al. (1991)
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- Authors
- Husain, M. M., McDonald, W. M., Doraiswamy, P. M., Figiel, G. S., Na, C., Escalona, P. R., Boyko, O. B., Nemeroff, C. B., & Krishnan, K. R. R.
- Affiliations
- Duke Medical Center (US)
- Duke University (US)
- Washington University in St. Louis (US)
- Corresponding author
- Krishnan, K.Ranga R.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 1991-10
- Volume
- 40
- Issue
- 2
- Pages
- 95-99
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2075104388
- Cited by
- 256
- References
- 1
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 6
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t01mh017632-06, 5r01mh044716-06)
- National Institute of Mental Health (MH-17632, MH-44716)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- major depressive disorder, putamen, basal ganglia, brain volume, neuroanatomy, age effects, T2-weighted MRI
- MeSH terms
- Adult, Aged, Basal Ganglia Diseases, Brain Damage, Chronic, Depressive Disorder, Female, Humans, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Putamen, Neurocognitive Disorders
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