Cited by 117Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases

David, Renaud, Koulibaly, Malick, Benoit, Michel, Garcia, René, Caci, Hervé, Darcourt, Jacques, Robert, Philippe·2008·Clinical Neurology and Neurosurgery

Abstract

Objectives The aim of the present study was to stress the relationship between neuropsychiatric symptoms and most particularly apathy and striatal dopamine uptake in patients with Alzheimer's disease (AD) or dementia with Lewy body (DLB).Patients and methods Twenty-two patients (AD n=14; DLB n=8) were included. All patients had neuropsychological and behavioral examination including Mini Mental Test Examination (MMSE), Neuropsychiatric Inventory (NPI), and UPDRS for the motor activity assessment. Apathy dimensions, emotional blunting, lack of initiative and lack of interest were assessed using the Apathy Inventory (AI). Dopamine transporter (DAT) striatal uptake was assessed using (123)I-FP-CIT (DaTSCAN) SPECT. Quantitative measurements were obtained in 3D using a method which compensates for physical detection biases including partial volume effect.Results We observed a correlation between DAT uptake and NPI's domains only for apathy. More specifically using the AI, lack of initiative significantly correlated with bilateral putamen DAT uptake. Using partial correlation coefficients controlling for the UPDRS score, the correlation remained significant between lack of initiative and right and left putamen DAT uptake.Conclusion These results demonstrate a relationship between apathy and DAT levels independent from motor activity. They suggest that the patients with neurodegenerative diseases presenting with apathy are characterized by some degree of dopaminergic neuronal loss.

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Crossref · 10.1016/j.clineuro.2007.08.007

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  • Apathy in Alzheimer's disease is associated with decreased bilateral putamen dopamine transporter density.

    “Of the two reports involving neurochemical imaging, one reported decreased bilateral putamen dopamine transporter density (David et al., 2008) while the other reported no association with D2/D3 dopamine receptor density (Reeves et al., 2009).”

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Authors
David, R., Koulibaly, M., Benoit, M., Garcia, R., Caci, H., Darcourt, J., & Robert, P.
Affiliations
  • Centre Hospitalier Universitaire de Nice (FR)
  • Centre Antoine Lacassagne (FR)
Corresponding author
David, Renaud
Venue
Clinical Neurology and Neurosurgery
Publisher
Elsevier BV
Published
2008-01
Volume
110
Issue
1
Pages
19-24
ISSN
0303-8467 (ISSN-L)
OpenAlex
W2149316815
Cited by
117
References
52
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 4
FWCI
3.62
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Neurology and Neurosurgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
apathy, dopamine transporter, striatum, putamen, Alzheimer's disease, dementia with Lewy bodies, neuropsychiatric symptoms, lack of initiative, emotional blunting, dopaminergic neuron loss, DaTSCAN, partial volume correction
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Male, Neuropsychological Tests, Tomography, Emission-Computed, Single-Photon, Lewy Body Disease, Dopamine Plasma Membrane Transport Proteins

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