Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases
Abstract
Objectives The aim of the present study was to stress the relationship between neuropsychiatric symptoms and most particularly apathy and striatal dopamine uptake in patients with Alzheimer's disease (AD) or dementia with Lewy body (DLB).Patients and methods Twenty-two patients (AD n=14; DLB n=8) were included. All patients had neuropsychological and behavioral examination including Mini Mental Test Examination (MMSE), Neuropsychiatric Inventory (NPI), and UPDRS for the motor activity assessment. Apathy dimensions, emotional blunting, lack of initiative and lack of interest were assessed using the Apathy Inventory (AI). Dopamine transporter (DAT) striatal uptake was assessed using (123)I-FP-CIT (DaTSCAN) SPECT. Quantitative measurements were obtained in 3D using a method which compensates for physical detection biases including partial volume effect.Results We observed a correlation between DAT uptake and NPI's domains only for apathy. More specifically using the AI, lack of initiative significantly correlated with bilateral putamen DAT uptake. Using partial correlation coefficients controlling for the UPDRS score, the correlation remained significant between lack of initiative and right and left putamen DAT uptake.Conclusion These results demonstrate a relationship between apathy and DAT levels independent from motor activity. They suggest that the patients with neurodegenerative diseases presenting with apathy are characterized by some degree of dopaminergic neuronal loss.
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Apathy in Alzheimer's disease is associated with decreased bilateral putamen dopamine transporter density.
“Of the two reports involving neurochemical imaging, one reported decreased bilateral putamen dopamine transporter density (David et al., 2008) while the other reported no association with D2/D3 dopamine receptor density (Reeves et al., 2009).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as David et al., 2008
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- Authors
- David, R., Koulibaly, M., Benoit, M., Garcia, R., Caci, H., Darcourt, J., & Robert, P.
- Affiliations
- Centre Hospitalier Universitaire de Nice (FR)
- Centre Antoine Lacassagne (FR)
- Corresponding author
- David, Renaud
- Venue
- Clinical Neurology and Neurosurgery
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 110
- Issue
- 1
- Pages
- 19-24
- ISSN
- 0303-8467 (ISSN-L)
- OpenAlex
- W2149316815
- Cited by
- 117
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 4
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neurology and Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- apathy, dopamine transporter, striatum, putamen, Alzheimer's disease, dementia with Lewy bodies, neuropsychiatric symptoms, lack of initiative, emotional blunting, dopaminergic neuron loss, DaTSCAN, partial volume correction
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Male, Neuropsychological Tests, Tomography, Emission-Computed, Single-Photon, Lewy Body Disease, Dopamine Plasma Membrane Transport Proteins
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