The mitochondrion as a primary site of action of glucocorticoids: the interaction of the glucocorticoid receptor with mitochondrial DNA sequences showing partial similarity to the nuclear glucocorticoid responsive elements
Abstract
Six mitochondrial genome sequences, showing strong similarity to the glucocorticoid responsive element consensus sequence (GRE), four localized within the cytochrome c oxidase (COX) subunit I and II genes (GREs I-IV) and two within the D-loop region (GREs a and b) have been examined as binding sites of glucocorticoid receptor (GR) from rat liver cytosol. Purified GR from rat liver cytosol binds with high specificity to all potential mitochondrial GREs, as shown by filter retention and gel shift assays. Specific binding of protein(s), present in a mitochondrial extract from dexamethasone-induced mice, to all six putative mitochondrial GREs was also documented by the same methodology. Both purified GR and protein(s) from mitochondrial extract give the same band in the gel retardation assay. Using monospecific anti-glucocorticoid receptor polyclonal antibody (EP), a supershift of the gel retarded protein-DNA band was obtained. These results demonstrate that the mitochondrial genome sequences examined have characteristics of GREs, since they show the capacity to specifically bind the respective receptor protein. These findings support the hypothesis that the mitochondrial genome is a primary site of action of steroid and thyroid hormones (Sekeris C.E.: The mitochondrial genome: a possible primary site of action of steroid hormones, In vivo 4 (1990) 317-320).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These elements have been found in mtDNA accompanied by oestrogen and androgen receptors.
“these elements have been found in mtDNA accompanied by oestrogen and androgen receptors (Demonacos et al., 1995; Demonacos et al., 1996).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Demonacos et al., 1995
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318 · see citing works
Sequence and organization of the human mitochondrial genome
Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,640 · see citing works
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,442 · see citing works
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383 · see citing works
Garner, M. M., & Revzin, A. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.13.3047 · Cited by 2,021 · see citing works
STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS
Yamamoto, K. R. (1985) · Annual Review of Genetics · doi:10.1146/annurev.ge.19.120185.001233 · Cited by 1,872 · see citing works
Regulation of Metabolic Processes in Mitochondria
(1967) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(67)83077-3 · Cited by 1,182 · see citing works
Nuclear receptors enhance our understanding of transcription regulation
Green, S., & Chambon, P. (1988) · Trends in Genetics · doi:10.1016/0168-9525(88)90108-4 · Cited by 1,042 · see citing works
Chandler, V. L., Maler, B. A., & Yamamoto, K. R. (1983) · Cell · doi:10.1016/0092-8674(83)90430-0 · Cited by 697 · see citing works
Payvar, F., DeFranco, D. B., Firestone, G. L., Edgar, B. A., Wränge, Ö., Okret, S., Gustafsson, J.-Å., & Yamamoto, K. R. (1983) · Cell · doi:10.1016/0092-8674(83)90171-x · Cited by 678 · see citing works
Scheidereit, C., Geisse, S., Westphal, H. M., & Beato, M. (1983) · Nature · doi:10.1038/304749a0 · Cited by 601 · see citing works
Kadenbach, B., Jarausch, J., Hartmann, R., & Merle, P. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90586-9 · Cited by 431 · see citing works
Inhibition of Electron and Energy Transfer in Mitochondria
Chance, B., & Hollunger, G. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84014-0 · Cited by 366 · see citing works
THE MITOCHONDRIAL PROTEIN IMPORT APPARATUS
Pfanner, N., & Neupert, W. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.001555 · Cited by 308 · see citing works
Purification of the glucocorticoid receptor from rat liver cytosol.
Wränge, Ö., Carlstedt‐Duke, J., & Gustafsson, J. A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86842-4 · Cited by 238 · see citing works
Gustafsson, R. G., Tata, J. R., Lindberg, O. R., & Ernster, L. (1965) · The Journal of Cell Biology · doi:10.1083/jcb.26.2.555 · Cited by 216 · see citing works
Hood, D. A., Zak, R., & Pette, D. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14551.x · Cited by 161 · see citing works
Glucocorticoid receptors recognize DNA sequences in and around murine mammary tumour virus DNA.
Geisse, S., Scheidereit, C., Westphal, H. M., Hynes, N. E., Groner, B., & Beato, M. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01363.x · Cited by 148 · see citing works
Wiesner, R. J., Kurowski, T. T., & Zak, R. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.9.1331777 · Cited by 136 · see citing works
CORTISONE-INDUCED ALTERATIONS IN MITOCHONDRIAL FUNCTION AND STRUCTURE
Kimberg, D. V., Loud, A. V., & Wiener, J. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.37.1.63 · Cited by 98 · see citing works
Suzuki, H., Hosokawa, Y., Nishikimi, M., & Ozawa, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52248-1 · Cited by 97 · see citing works
On the mechanism of hormone action
Congote, L. F., Sekeris, C. E., & Karlson, P. (1969) · Experimental Cell Research · doi:10.1016/0014-4827(69)90023-8 · Cited by 92 · see citing works
Self-citationBeato, M., Biesewig, D., Braendle, W. L., & Sekeris, C. E. (1969) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(69)90399-7 · Cited by 92 · see citing works
Self-citationImport of the glucocorticoid receptor into rat liver mitochondria in vivo and in vitro
Demonacos, C., Tsawdaroglou, N. C., Djordjević-Marković, R., Papalopoulou, M. A., Galanopoulos, V. K., Papadogeorgaki, S., & Sekeris, C. E. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90231-k · Cited by 81 · see citing works
Self-citationItallie, C. M. V., & Dannies, P. S. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-4-332 · Cited by 78 · see citing works
Itallie, C. M. V. (1990) · Endocrinology · doi:10.1210/endo-127-1-55 · Cited by 64 · see citing works
Wiesner, R. J. (1992) · Molecular Endocrinology · doi:10.1210/me.6.9.1458 · Cited by 63 · see citing works
The mitochondrial genome: a possible primary site of action of steroid hormones.
Sekeris, C. E. (1992) · PubMed · Cited by 62 · see citing works
Self-citationCo-ordinate expression of cytochrome c oxidase subunit III and VIc mRNAs in rat tissues
Hood, D. A. (1990) · Biochemical Journal · doi:10.1042/bj2690503 · Cited by 56 · see citing works
Gagnon, J., Kurowski, T. T., Wiesner, R. J., & Zak, R. (1991) · Molecular and Cellular Biochemistry · doi:10.1007/bf02424572 · Cited by 54 · see citing works
Kadowaki, T., & Kitagawa, Y. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81354-1 · Cited by 44 · see citing works
Glucocorticoid-stimulated utilization of substrates in hepatic mitochondria
Wakat, D. K., & Haynes, R. C. (1977) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(77)90466-0 · Cited by 40 · see citing works
Koenig, H., Goldstone, A. D., & Lu, C. (1980) · Biochemical Journal · doi:10.1042/bj1920349 · Cited by 37 · see citing works
In vivo Cortisol Action on RNA Synthesis in Rat Liver Nuclei and Mitochondria
Mansour, A. M., & Nass, S. (1970) · Nature · doi:10.1038/228665a0 · Cited by 37 · see citing works
Dexamethasone treatment increases mitochondrial RNA synthesis in a rat hepatoma cell line.
Itallie, C. M. V. (1992) · Endocrinology · doi:10.1210/endo.130.2.1370790 · Cited by 37 · see citing works
The stimulation of hepatic oxidative phosphorylation following dexamethasone treatment of rats
Allan, E. H., Chisholm, A. B., & Titheradge, M. A. (1983) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(83)90225-6 · Cited by 36 · see citing works
Yu, F. L., & Feigelson, P. (1970) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(70)90014-6 · Cited by 33 · see citing works
Inhibition of mitochondrial respiration by progesterone and an azasteroid
Varricchio, F. E., & Sanadi, D. R. (1967) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(67)90023-9 · Cited by 31 · see citing works
Presence of glucocorticoid responsive elements in the mitochondrial genome.
Im, I., Tsawdaroglou, N. H., & Sekeris, C. E. (1989) · PubMed · Cited by 31 · see citing works
Self-citationPresence of Glucocorticoid Responsive Elements in the Mitochondrial Genome
Ioannou, I. M., Tsawdaroglou, N. H., & Sekeris, C. E. (1988) · National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation) · Cited by 20 · see citing works
Self-citationRNA SYNTHESIS IN RAT LIVER AFTER CORTISOL TREATMENT: A POSSIBLE MITOCHONDRIAL-NUCLEAR RELATIONSHIP
Mansour, A. M., & Nass, S. (1974) · European Journal of Endocrinology · doi:10.1530/acta.0.0770298 · Cited by 16 · see citing works
Dexamethasone treatment increases mitochondrial RNA synthesis in a rat hepatoma cell line
Itallie, C. M. V. (1992) · Endocrinology · doi:10.1210/en.130.2.567 · Cited by 15 · see citing works
LI, G., LIU, Y., & TSANG, S. (1994) · International Journal of Oncology · doi:10.3892/ijo.5.2.301 · Cited by 10 · see citing works
Westphal, H. M., & Beato, M. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80133-0 · Cited by 9 · see citing works
Martin, A. D., & Titheradge, M. A. (1984) · Biochemical Journal · doi:10.1042/bj2220379 · Cited by 9 · see citing works
Tsiriyotis, C., Spandidos, D. A., & Sekeris, C. E. (1993) · International Journal of Oncology · doi:10.3892/ijo.2.6.947 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666 · see citing works
Mitochondrial signal transduction
Picard, M. A., & Shirihai, O. S. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.10.008 · Cited by 666 · see citing works
Mitochondria as key components of the stress response
Manoli, I., Alesci, S., Blackman, M. R., Su, Y. A., Rennert, O. M., & Chrousos, G. P. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.04.004 · Cited by 377 · see citing works
Iuchi, T., Akaike, M., Mitsui, T., Ohshima, Y., Shintani, Y., Azuma, H., & Matsumoto, T. (2003) · Circulation Research · doi:10.1161/01.res.0000050588.35034.3c · Cited by 358 · see citing works
Mitochondrial localization of ERα and ERβ in human MCF7 cells
Chen, J. Q., Delannoy, M., Cooke, C., & Yager, J. D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00508.2003 · Cited by 272 · see citing works
Nuclear Control of Respiratory Chain Expression in Mammalian Cells
Scarpulla, R. C. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022681828846 · Cited by 269 · see citing works
Chen, J., Cammarata, P. R., Baines, C. P., & Yager, J. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.06.001 · Cited by 266 · see citing works
Datson, N. A., van der Perk, J., de Kloet, E. R., & Vreugdenhil, E. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01685.x · Cited by 230 · see citing works
Solakidi, S., Psarra, A. G., Nikolaropoulos, S., & Sekeris, C. E. (2005) · Human Reproduction · doi:10.1093/humrep/dei267 · Cited by 205 · see citing works
Self-citationMitochondrial genes as sites of primary action of steroid hormones
Demonacos, C. V., Karayanni, N., Hatzoglou, E., Tsiriyiotis, C., Spandidos, D. A., & Sekeris, C. E. (1996) · Steroids · doi:10.1016/0039-128x(96)00019-0 · Cited by 177 · see citing works
Self-citationChen, J.-Q., Yager, J., & Russo, J. (2005) · Biochimica et Biophysica Acta · doi:10.1016/j.bbamcr.2005.08.001 · Cited by 173 · see citing works
Glucocorticoids induce mitochondrial gene transcription in HepG2 cells
Psarra, A. G., & Sekeris, C. E. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.05.014 · Cited by 175 · see citing works
Self-citationHunter, R. G., Seligsohn, M., Rubin, T. G., Griffiths, B. B., Ozdemir, Y., Pfaff, D. W., Datson, N. A., & McEwen, B. S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602185113 · Cited by 174 · see citing works
Mitochondrial function, ornamentation, and immunocompetence
Koch, R. E., Josefson, C. C., & Hill, G. E. (2016) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12291 · Cited by 172 · see citing works
Psarra, A. G., Solakidi, S., & Sekeris, C. E. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.025 · Cited by 146 · see citing works
Self-citationChen, J. Q., Eshete, M., Alworth, W. L., & Yager, J. D. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20178 · Cited by 142 · see citing works
Steroid Therapy of a Proliferating Hemangioma: Histochemical and Molecular Changes
Hasan, Q. A., Tan, S. T., Gush, J., Peters, S. G., & Davis, P. F. (2000) · PEDIATRICS · doi:10.1542/peds.105.1.117 · Cited by 130 · see citing works
Wu, T., Yang, L., Jiang, J., Ni, Y., Zhu, J., Zheng, X., Wang, Q., Lu, X., & Fu, Z. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.11.049 · Cited by 126 · see citing works
Nuclear transcription factors in mammalian mitochondria
Leigh-Brown, S., Enrı́quez, J. A., & Odom, D. T. (2010) · Genome biology · doi:10.1186/gb-2010-11-7-215 · Cited by 116 · see citing works
Mitochondrial Glucocorticoid Receptors and Their Actions
Kokkinopoulou, I., & Moutsatsou, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116054 · Cited by 120 · see citing works
Steroid and thyroid hormone receptors in mitochondria
Psarra, A. G., & Sekeris, C. E. (2008) · IUBMB Life · doi:10.1002/iub.37 · Cited by 116 · see citing works
Self-citationSubcellular distribution of native estrogen receptor α and β isoforms in rabbit uterus and ovary
Monje, P. V., & Boland, R. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1182 · Cited by 114 · see citing works
Estrogen, mitochondria, and growth of cancer and non-cancer cells.
Felty, Q. H., & Roy, D. (2005) · Journal of Carcinogenesis · doi:10.1186/1477-3163-4-1 · Cited by 113 · see citing works
Glucocorticoid Hormone Stimulates Mitochondrial Biogenesis Specifically in Skeletal Muscle
Weber, K., Bruck, P. T., Mikes, Z., Küpper, J., Klingenspor, M., & Wiesner, R. J. (2002) · Endocrinology · doi:10.1210/endo.143.1.8600 · Cited by 107 · see citing works
Localization of the Glucocorticoid Receptor in Rat Brain Mitochondria
Moutsatsou, P., Psarra, A. G., Tsiapara, A., Paraskevakou, H., Davaris, P. S., & Sekeris, C. E. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2162 · Cited by 106 · see citing works
Self-citationLocalization of glucocorticoid hormone receptors in mitochondria of human cells
Scheller, K., Sekeris, C. E., Krohne, G., Hock, R., Hansen, I. A., & Scheer, U. (2000) · European Journal of Cell Biology · doi:10.1078/s0171-9335(04)70033-3 · Cited by 105 · see citing works
Self-citationMitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity
López-Lluch, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.005 · Cited by 103 · see citing works
Glucocorticoid receptors modulate mitochondrial function
Du, J., McEwen, B. S., & Manji, H. K. (2009) · Communicative & Integrative Biology · doi:10.4161/cib.2.4.8554 · Cited by 102 · see citing works
Glucocorticoids and their receptors: Insights into specific roles in mitochondria
Lee, S., Kim, H. K., Song, I.-S., Youm, J., Dizon, L. A., Jeong, S.-H., Ko, T.-H., Heo, H.-J., Ko, K. S., Rhee, B. D., et al. (2013) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2013.04.001 · Cited by 99 · see citing works
Leptin Modulates the Glucocorticoid-Induced Ovarian Steroidogenesis1
Barkan, D., Jia, H., Dantes, A., Vardimon, L., Amsterdam, A., & Rubinstein, M. (1999) · Endocrinology · doi:10.1210/endo.140.4.6614 · Cited by 93 · see citing works
CHEN, J., & Yager, J. D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1322.030 · Cited by 92 · see citing works
Psarra, A. G., & Sekeris, C. E. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.11.011 · Cited by 87 · see citing works
Self-citationNovel mutations of mitochondrial complex I in pathologically proven Parkinson disease
Kösel, S., Grasbon-Frodl, E. M., Mautsch, U., Egensperger, R., Eitzen, U. V., Frishman, D., Hofmann, S., Gerbitz, K.-D., Mehraein, P., & Graeber, M. B. (1998) · Neurogenetics · doi:10.1007/s100480050029 · Cited by 86 · see citing works
Solakidi, S., Psarra, A. G., & Sekeris, C. E. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.05.010 · Cited by 80 · see citing works
Self-citationNon-genomic effect of glucocorticoids on cardiovascular system
Lee, S. R., Kim, H. K., Youm, J. B., Dizon, L. A., Song, I. S., Jeong, S. H., Seo, D. Y., Ko, K. S., Rhee, B. D., Kim, N., et al. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1155-2 · Cited by 78 · see citing works
Stress and glucocorticoid receptor regulation of mitochondrial gene expression
Lapp, H. E., Bartlett, A. A., & Hunter, R. G. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0152 · Cited by 78 · see citing works
Sionov, R. V., Spokoini, R., Kfir‐Erenfeld, S., Cohen, O., & Yefenof, E. (2008) · Advances in cancer research · doi:10.1016/s0065-230x(08)00406-5 · Cited by 76 · see citing works
Mitochondrial DNA transcription regulation and nucleoid organization
Rebelo, A. P., Dillon, L. M., & Moraes, C. T. (2011) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-011-9330-8 · Cited by 76 · see citing works
Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection
Arnold, S. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3573-0_13 · Cited by 75 · see citing works
Psarra, A. G., & Sekeris, C. E. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.10.021 · Cited by 74 · see citing works
Self-citationGlucocorticoid and thyroid hormone receptors in mitochondria of animal cells
Scheller, K., Seibel, P., & Sekerist, C. E. (2003) · International review of cytology · doi:10.1016/s0074-7696(02)22011-2 · Cited by 73 · see citing works
Choi, Y.-S., Jeong, J. H., Min, H., Jung, H.-J., Hwang, D., Lee, S., & Pak, Y. K. (2011) · Molecular BioSystems · doi:10.1039/c0mb00277a · Cited by 71 · see citing works
Influence of sex and glucocorticoid exposure on preterm placental pro-oxidant-antioxidant balance
Stark, M. J., Hodyl, N. A., Wright, I. M. R., & Clifton, V. L. (2011) · Placenta · doi:10.1016/j.placenta.2011.08.010 · Cited by 68 · see citing works
Psarra, A. G., Solakidi, S., Trougakos, I. P., Margaritis, L. H., Spyrou, G., & Sekeris, C. E. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.06.015 · Cited by 65 · see citing works
Self-citationThe dynamic localization of the glucocorticoid receptor in rat C6 glioma cell mitochondria
Koufali, M. M., Moutsatsou, P., Sekeris, C. E., & Breen, K. C. (2003) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.07.003 · Cited by 62 · see citing works
Self-citationTsiriyotis, C., Spandidos, D. A., & Sekeris, C. E. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6787 · Cited by 61 · see citing works
Self-citationThyroid hormone and myocardial mitochondrial biogenesis
Marı́n-Garcı́a, J. (2009) · Vascular Pharmacology · doi:10.1016/j.vph.2009.10.008 · Cited by 60 · see citing works
Glucocorticoid Receptor Signaling in Diabetes
Kokkinopoulou, I., Diakoumi, A., & Moutsatsou, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011173 · Cited by 60 · see citing works
Kasahara, E., & Inoue, M. (2014) · Redox Report · doi:10.1179/1351000214y.0000000107 · Cited by 60 · see citing works
Regulation of the epithelial Na+ channel by aldosterone: Open questions and emerging answers
Garty, H. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00961.x · Cited by 58 · see citing works
Estrogen and the regulation of mitochondrial structure and function in the brain
Arnold, S., Victor, M. B., & Beyer, C. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.01.012 · Cited by 57 · see citing works
Mitochondrial-epigenetic crosstalk in environmental toxicology
Weinhouse, C. (2017) · Toxicology · doi:10.1016/j.tox.2017.08.008 · Cited by 57 · see citing works
Kfir‐Erenfeld, S., Sionov, R. V., Spokoini, R., Cohen, O., & Yefenof, E. (2010) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2010.506570 · Cited by 56 · see citing works
Actions of 17β-estradiol and testosterone in the mitochondria and their implications in aging
Vasconsuelo, A., Milanesi, L., & Boland, R. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.001 · Cited by 55 · see citing works
Primary Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes: A 2021 Update
Nicolaides, N. C., & Charmandari, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910839 · Cited by 55 · see citing works
Adžić, M., Djordjevic, A. D., Demonacos, C., Krstic–Demonacos, M., & Radojcic, M. B. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.04.001 · Cited by 55 · see citing works
Self-citationChen, J., Russo, P. A., Cooke, C., Russo, I. H., & Russo, J. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.05.008 · Cited by 55 · see citing works
Myocilin is associated with mitochondria in human trabecular meshwork cells
Wentz‐Hunter, K., Ueda, J., Shimizu, N., & Yue, B. Y. J. T. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.10032 · Cited by 53 · see citing works
Nicolaides, N. C., & Charmandari, E. (2017) · Hormones · doi:10.14310/horm.2002.1728 · Cited by 52 · see citing works
Talabér, G., Boldizsár, F., Bartis, D., Pàlinkàs, L., Szabó, M., Berta, G., Sétáló, G., Németh, P., & Berki, T. (2009) · International Immunology · doi:10.1093/intimm/dxp093 · Cited by 52 · see citing works
Effect of cortisol on bovine oocyte maturation and embryo development in vitro
da Costa, N. N., Brito, K. N. L., Santana, P. D. P. B., Cordeiro, M. S., Silva, T. V. G., Santos, A. X., Ramos, P. D. C. D. A., Santos, S. D. S. D., King, W. A., Miranda, M. D. S., et al. (2015) · Theriogenology · doi:10.1016/j.theriogenology.2015.08.010 · Cited by 51 · see citing works
Mitochondrial Epigenetics and Environmental Exposure
Lambertini, L., & Byun, H. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0103-2 · Cited by 51 · see citing works
Mitochondrial DNA transcription and diseases: Past, present and future
Montoya, J., López-Pérez, M. J., & Ruiz‐Pesini, E. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.023 · Cited by 50 · see citing works
Glucocorticoid and Estrogen Receptors Are Reduced in Mitochondria of Lung Epithelial Cells in Asthma
Simoes, D. C. M., Psarra, A. G., Mauad, T., Pantou, I., Roussos, C., Sekeris, C. E., & Gratziou, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039183 · Cited by 48 · see citing works
Self-citationLambertini, L., Chen, J., & Nomura, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138929 · Cited by 44 · see citing works
Metabolic correlations of glucocorticoids and polyamines in inflammation and apoptosis
Bjelaković, G., Stojanović, I. R., Jevtović−Stoimenov, T., Pavlovic, D. D., Kocic, G. M., Rossi, S., Tabolacci, C., Nikolić, J., Sokolovic, D. T., & Bjelaković, L. (2010) · Amino Acids · doi:10.1007/s00726-010-0489-3 · Cited by 44 · see citing works
Physiological Importance of the T3 Mitochondrial Pathway
Wrutniak‐Cabello, C., Rochard, P., Casas, F., Fraysse, Å. S., CHARRIER, J., & Cabello, G. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10738.x · Cited by 44 · see citing works
Evidence for Site-Specific Occupancy of the Mitochondrial Genome by Nuclear Transcription Factors
Marinov, G. K., Wang, Y. E., Chan, D. C., & Wold, B. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084713 · Cited by 43 · see citing works
Mechanisms of Hormone Carcinogenesis:
Chen, J., Brown, T. R., & Yager, J. D. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-78818-0_1 · Cited by 41 · see citing works
Pronsato, L., Milanesi, L. M., & Vasconsuelo, A. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.110631 · Cited by 40 · see citing works
Hou, Y., Xie, J., Wang, S., Li, D., Wang, L., Wang, H., Ni, X., Leng, S., Li, G., Hou, M., et al. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00859-0 · Cited by 39 · see citing works
Aldo-keto Reductase 1B15 (AKR1B15)
Weber, S., Salabei, J. K., Möller, G., Kremmer, E., Bhatnagar, A., Adamski, J., & Barski, O. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.610121 · Cited by 35 · see citing works
Li, Z., Li, Q., Chen, L., Chen, B.-D., Zhang, C., Wang, X., & Li, W. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.004 · Cited by 34 · see citing works
Lacorn, M., Goerke, M., & Claus, R. (2009) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2009.00955.x · Cited by 31 · see citing works
Generalized and tissue specific glucocorticoid resistance
Martins, C. S., & de Castro, M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111277 · Cited by 30 · see citing works
Solakidi, S., Psarra, A. G., & Sekeris, C. E. (2007) · PubMed · Cited by 31 · see citing works
Self-citationMposhi, A., & Turner, J. D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1215544 · Cited by 29 · see citing works
Psarra, A. G., Bochaton‐Piallat, M., Gabbiani, G., Sekeris, C. E., & Tsacopoulos, M. (2002) · Glia · doi:10.1002/glia.10130 · Cited by 27 · see citing works
Self-citationSepuri, N. B. V., Tammineni, P., Mohammed, F., & Paripati, A. K. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_3 · Cited by 26 · see citing works
Nyberg, C. H., Leonard, W. R., Tanner, S. N., McDade, T. W., Huanca, T., Godoy, R., & Taps Bolivia Study Team (2012) · American Journal of Human Biology · doi:10.1002/ajhb.22304 · Cited by 25 · see citing works
Yu, J., Yu, B., He, J., Zheng, P., Mao, X., Han, G., & Chen, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112628 · Cited by 24 · see citing works
Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells
Bergman, A. M., Pinedo, H. M., & Peters, G. J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00858-5 · Cited by 24 · see citing works
Marquez-Acevedo, A. S., Hood, W. R., Collier, R. J., & Skibiel, A. L. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23340 · Cited by 23 · see citing works
Ogita, K., Fujinami, Y., Kitano, M., & Yoneda, Y. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10720 · Cited by 23 · see citing works
Nicolaides, N. C., & Charmandari, E. (2019) · Experientia supplementum · doi:10.1007/978-3-030-25905-1_6 · Cited by 20 · see citing works
Dynamic regulation of mitochondrial transcription as a mechanism of cellular adaptation
Blomain, E. S., & McMahon, S. B. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.06.004 · Cited by 17 · see citing works
Is the glucocorticoid receptor a key player in prostate cancer?: A literature review
Sakellakis, M., & Flores, L. J. (2022) · Medicine · doi:10.1097/md.0000000000029716 · Cited by 17 · see citing works
Mitochondrial divergence between slow- and fast-aging garter snakes
Schwartz, T. S., Arendsee, Z. W., & Bronikowski, A. M. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.09.004 · Cited by 17 · see citing works
Roy, D. (2006) · Frontiers in bioscience · doi:10.2741/2056 · Cited by 16 · see citing works
Whole blood mitochondrial DNA copy number in depression and response to electroconvulsive therapy
Ryan, K. M., Doody, E., & McLoughlin, D. M. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110656 · Cited by 15 · see citing works
Hoffmann's syndrome in hypothyroid myopathy.Report of a case in an African
Sidibé, E. H., Diop, A. N., Thiam, A. B., Diagne, P. M., Sarr, A., Toure, M. D., & Diop, M. (2001) · Joint Bone Spine · doi:10.1016/s1297-319x(00)00231-1 · Cited by 15 · see citing works
Pandya, J. D., Agarwal, N. A., & Katyare, S. S. (2004) · Drug and Chemical Toxicology · doi:10.1081/dct-200039778 · Cited by 15 · see citing works
Hallmarks of healthy cognitive aging: Inter-individual differences in aging trajectories
Abrous, D. N., Blin, N., Boraxbekk, C., Catheline, G., Fitzsimons, C. P., Hilscher, M. M., Lemoine, M., Lopes, L. V., Maass, A., Nilsson, M., et al. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103102 · Cited by 18 · see citing works
Li, S., Sun, X., Xu, J., Gu, Y., Liu, S., Xu, S., Pan, F., Tao, J., Cai, J., Liu, S., et al. (2018) · Gene · doi:10.1016/j.gene.2018.05.109 · Cited by 14 · see citing works
Karra, A. G., Sioutopoulou, A., Gorgogietas, V. A., Samiotaki, M. K., Panayotou, G., & Psarra, A. G. (2022) · Journal of Proteomics · doi:10.1016/j.jprot.2022.104509 · Cited by 14 · see citing works
Richards, E. M., Rabaglino, M. B., Antolic, A. T., Wood, C. E., & KELLER-WOOD, M. E. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00027.2015 · Cited by 14 · see citing works
Liu, S., Ge, G., Dong, W., Peng, X., Liu, F., Chen, S., & Sun, S. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.07.170 · Cited by 14 · see citing works
Kotula‐Balak, M., Duliban, M., Pawlicki, P., Tuz, R., Bilińska, B., Płachno, B. J., Arent, Z., Krakowska, I., & Tarasiuk, K. (2020) · Acta Histochemica · doi:10.1016/j.acthis.2020.151526 · Cited by 13 · see citing works
Integrating sex and gender in mitochondrial science
Junker, A., Juster, R., & Picard, M. A. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100536 · Cited by 12 · see citing works
Newton, C., Drummond, N., Burgoyne, C. H., Speirs, V., Stalla, G. K., & Atkin, S. L. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1610199 · Cited by 12 · see citing works
- Authors
- Demonacos, C., Djordjevic-Markovic, R., Tsawdaroglou, N., & Sekeris, C. E.
- Affiliations
- National Hellenic Research Foundation (GR)
- Corresponding author
- Sekeris, C.E.
- ORCID
- Demonacos, C.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 55
- Issue
- 1
- Pages
- 43-55
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2047490631
- Cited by
- 131
- References
- 46
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 4 · 2012: 9
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- glucocorticoid receptor, mitochondria, mitochondrial DNA, glucocorticoid response element, cytochrome c oxidase subunit I, cytochrome c oxidase subunit II, D-loop, dexamethasone, steroid hormone action, receptor-DNA binding, rat liver
- MeSH terms
- Animals, Base Sequence, Binding Sites, Binding, Competitive, Electron Transport Complex IV, Cytosol, Dexamethasone, DNA-Binding Proteins, DNA, Mitochondrial, Male, Mice, Inbred BALB C, Mitochondria, Liver, Molecular Sequence Data, Oligodeoxyribonucleotides, Receptors, Glucocorticoid, Regulatory Sequences, Nucleic Acid, Sequence Homology, Nucleic Acid, Consensus Sequence, Rats, Wistar, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review