Actions of 17β-estradiol and testosterone in the mitochondria and their implications in aging
Open accessAbstract
A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for the investigation of the effects of 17β-estradiol and testosterone on the mitochondrial functions and their relationships with aging. Both steroids trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus, and plasma membrane, and the cytoskeleton plays a key role in these interactions. The result of this signaling is mitochondrial protection. Therefore, the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies. In this review, we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.
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Mitochondria have sex-specific features, and alterations in mitochondrial quality control are associated with changes in sex steroid hormone levels.
“Notably, mitochondria have sex-specific features, and alterations in mitochondrial quality control are associated with changes in sex steroid hormone levels (23, 24).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [23]
Changes in oestrogen levels can modulate the genetic expression of mitochondrial factors and be responsible for mitochondrial dysfunction effect in fat accumulation during ageing.
“Changes in oestrogens levels can also modulate the genetic expression of mitochondrial factors and then, be also responsible of mitochondrial dysfunction effect in fat accumulation during ageing (Vasconsuelo et al., 2013).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Vasconsuelo et al., 2013
Changes in oestrogen levels can modulate genetic expression of mitochondrial factors and be responsible for mitochondrial dysfunction effect in fat accumulation during ageing.
“Changes in oestrogens levels can also modulate the genetic expression of mitochondrial factors and then, be also responsible of mitochondrial dysfunction effect in fat accumulation during ageing (Vasconsuelo et al., 2013).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Vasconsuelo et al., 2013
Oestrogens directly regulate nuclear DNA-encoded proteins and mitochondrial transcription factors, affecting mitochondrial biogenesis.
“These oestrogens would directly regulate nuclear DNA-encoded proteins and mitochondrial transcription factors affecting by this mechanism mitochondrial biogenesis (Vasconsuelo et al., 2013).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Vasconsuelo et al., 2013
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- Authors
- Vasconsuelo, A., Milanesi, L., & Boland, R.
- Affiliations
- Universidad Nacional del Sur (AR)
- Corresponding author
- Vasconsuelo, Andrea
- ORCID
- Vasconsuelo, Andrea
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 12
- Issue
- 4
- Pages
- 907-917
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2004849602
- Cited by
- 55
- References
- 158
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
- Universidad Nacional del Sur of Argentina
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- estradiol, testosterone, mitochondrial function, aging, estrogen receptor, androgen receptor, hormone response elements, nuclear-mitochondrial crosstalk, cytoskeleton, mitochondrial protection, anti-aging therapy, sex steroids
- MeSH terms
- Aging, Animals, Estradiol, Humans, Mitochondria, Testosterone, Signal Transduction, Reactive Oxygen Species
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