Cited by 55Mitochondrial Function and PathologyEstrogen and related hormone effectsHormonal and reproductive studies

Actions of 17β-estradiol and testosterone in the mitochondria and their implications in aging

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Vasconsuelo, Andrea, Milanesi, Lorena, Boland, Ricardo·2013·Ageing Research Reviews

Abstract

A decline in the mitochondrial functions and aging are two closely related processes. The presence of estrogen and androgen receptors and hormone-responsive elements in the mitochondria represents the starting point for the investigation of the effects of 17β-estradiol and testosterone on the mitochondrial functions and their relationships with aging. Both steroids trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus, and plasma membrane, and the cytoskeleton plays a key role in these interactions. The result of this signaling is mitochondrial protection. Therefore, the molecular components of the pathways activated by the sexual steroids could represent targets for anti-aging therapies. In this review, we discuss previous studies that describe the estrogen- and testosterone-dependent actions on the mitochondrial processes implicated in aging.

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Crossref · 10.1016/j.arr.2013.09.001

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  • Mitochondria have sex-specific features, and alterations in mitochondrial quality control are associated with changes in sex steroid hormone levels.

    “Notably, mitochondria have sex-specific features, and alterations in mitochondrial quality control are associated with changes in sex steroid hormone levels (23, 24).”
  • Changes in oestrogen levels can modulate the genetic expression of mitochondrial factors and be responsible for mitochondrial dysfunction effect in fat accumulation during ageing.

    “Changes in oestrogens levels can also modulate the genetic expression of mitochondrial factors and then, be also responsible of mitochondrial dysfunction effect in fat accumulation during ageing (Vasconsuelo et al., 2013).”

    From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Vasconsuelo et al., 2013

  • Changes in oestrogen levels can modulate genetic expression of mitochondrial factors and be responsible for mitochondrial dysfunction effect in fat accumulation during ageing.

    “Changes in oestrogens levels can also modulate the genetic expression of mitochondrial factors and then, be also responsible of mitochondrial dysfunction effect in fat accumulation during ageing (Vasconsuelo et al., 2013).”

    From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Vasconsuelo et al., 2013

  • Oestrogens directly regulate nuclear DNA-encoded proteins and mitochondrial transcription factors, affecting mitochondrial biogenesis.

    “These oestrogens would directly regulate nuclear DNA-encoded proteins and mitochondrial transcription factors affecting by this mechanism mitochondrial biogenesis (Vasconsuelo et al., 2013).”

    From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Vasconsuelo et al., 2013

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Research works printed but not linked: 5

  1. [The](http://refhub.elsevier.com/S1568-1637(13)00064-0/sbref0615)
  2. [mitochondrial](http://refhub.elsevier.com/S1568-1637(13)00064-0/sbref0615)
  3. [In Vivo](http://refhub.elsevier.com/S1568-1637(13)00064-0/sbref0615)
  4. [4, genome:](http://refhub.elsevier.com/S1568-1637(13)00064-0/sbref0615)
  5. [316-320.](http://refhub.elsevier.com/S1568-1637(13)00064-0/sbref0615)

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Authors
Vasconsuelo, A., Milanesi, L., & Boland, R.
Affiliations
Universidad Nacional del Sur (AR)
Corresponding author
Vasconsuelo, Andrea
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2013-09
Volume
12
Issue
4
Pages
907-917
ISSN
1568-1637 (ISSN-L)
OpenAlex
W2004849602
Cited by
55
References
158
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6
FWCI
0.47
Type
journal article
Language
en
Open access
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
Funders
  • Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)
  • Universidad Nacional del Sur of Argentina
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
estradiol, testosterone, mitochondrial function, aging, estrogen receptor, androgen receptor, hormone response elements, nuclear-mitochondrial crosstalk, cytoskeleton, mitochondrial protection, anti-aging therapy, sex steroids
MeSH terms
Aging, Animals, Estradiol, Humans, Mitochondria, Testosterone, Signal Transduction, Reactive Oxygen Species

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