The P-loop — a common motif in ATP- and GTP-binding proteins

Modeling of loops in protein structures

Fiser, A., Do, R. K. G., & Šali, A. (2000) · Protein Science · doi:10.1110/ps.9.9.1753 · Cited by 2,116

The Guanine Nucleotide-Binding Switch in Three Dimensions

Vetter, I. R., & Wittinghofer, A. (2001) · Science · doi:10.1126/science.1062023 · Cited by 1,875

Inositol Trisphosphate Receptor Ca2+Release Channels

Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188

Classification and evolution of P-loop GTPases and related ATPases

Leipe, D. D., Wolf, Y. I., Koonin, E. V., & Aravind, L. (2002) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5378 · Cited by 1,148

DMC1: A meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression

Bishop, D. K., Park, D., Xu, L., & Kleckner, N. (1992) · Cell · doi:10.1016/0092-8674(92)90446-j · Cited by 1,144

A minimal gene set for cellular life derived by comparison of complete bacterial genomes

Mushegian, A. R., & Koonin, E. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10268 · Cited by 916

ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes

Troelstra, C., van Gool, A., de Wit, J., Vermeulen, W., Bootsma, D., & Hoeijmakers, J. H. J. (1992) · Cell · doi:10.1016/0092-8674(92)90390-x · Cited by 729

MDMX: a novel p53‐binding protein with some functional properties of MDM2.

Shvarts, A., Steegenga, W. T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R. C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00919.x · Cited by 648

Sulfonation and molecular action

Strott, C. A. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0040 · Cited by 487

PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.

Balzi, E., Wang, M., Leterme, S., Van Dyck, L., & Goffeau, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42155-7 · Cited by 447

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

Lioubin, M. N., Algate, P. A., Tsai, S., Carlberg, K., Aebersold, A., & Rohrschneider, L. R. (1996) · Genes & Development · doi:10.1101/gad.10.9.1084 · Cited by 418

The essential role of the Walker A motifs of SUR1 in K‐ATP channel activation by Mg‐ADP and diazoxide

Gribble, F. M., Tucker, S. J., & Ashcroft, F. M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.6.1145 · Cited by 341

ADP-Glucose pyrophosphorylase, a regulatory enzyme for bacterial glycogen synthesis

Ballicora, M. A., Iglesias, A. A., & Preiss, J. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.2.213-225.2003 · Cited by 259

Steroid sulfotransferases

STROTT, C. A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-6-670 · Cited by 200

The Interaction of nucleotides with the tolbutamide block of cloned atp‐sensitive k+ channel currents expressed in xenopus oocytes: a reinterpretation

Gribble, F. M., Tucker, S. J., & Ashcroft, F. M. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.00035.x · Cited by 161

Molecular characterization of hpuAB, the haemoglobin–haptoglobin‐utilization operon of Neisseria meningitidis

Lewis, L. A., Gray, E., Wang, Y., Roe, B. A., & Dyer, D. W. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.2501619.x · Cited by 145

Carnitine transport: Pathophysiology and metabolism of known molecular defects

Tein, I. (2003) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1024481016187 · Cited by 140

Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum

Dorner, C., Ciossek, T., Müller, S., Møller, N. P. H., Ullrich, A., & Lammers, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20267 · Cited by 136

Mechanisms of EHD/RME‐1 Protein Function in Endocytic Transport

Grant, B. D., & Caplan, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00834.x · Cited by 137

Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE

Buchwald, G., Friebel, A., Galán, J. E., Hardt, W., Wittinghofer, A., & Scheffzek, K. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf329 · Cited by 135

Corynebacterium diphtheriae genes required for acquisition of iron from haemin and haemoglobin are homologous to ABC haemin transporters

Drazek, E. S., Hammack, C. A., Sr, & Schmitt, M. P. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01818.x · Cited by 128

Human Adeno-Associated Virus Type 5 Is Only Distantly Related to Other Known Primate Helper-Dependent Parvoviruses

Bantel-Schaal, U., Delius, H., Schmidt, R., & zur Hausen, H. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.939-947.1999 · Cited by 128

EHD1 Interacts with Retromer to Stabilize SNX1 Tubules and Facilitate Endosome‐to‐Golgi Retrieval

Gokool, S., Tattersall, D., & Seaman, M. N. J. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00652.x · Cited by 128

Propulsive nanomachines: the convergent evolution of archaella, flagella and cilia

Beeby, M., Ferreira, J. L., Tripp, P., Albers, S.-V., & Mitchell, D. R. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa006 · Cited by 110

Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): A novel link between G-protein and tyrosine kinase signaling and drug resistance

Awasthi, S., Singhal, S. S., Sharma, R., Zimniak, P., & Awasthi, Y. C. (2003) · International Journal of Cancer · doi:10.1002/ijc.11260 · Cited by 120

C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?

Naslavsky, N., & Caplan, S. (2005) · Journal of Cell Science · doi:10.1242/jcs.02595 · Cited by 98

ATP synthase evolution on a cross-braced dated tree of life

Mahendrarajah, T. A., Moody, E. R. R., Schrempf, D., Szánthó, L. L., Dombrowski, N., Davín, A. A., Pisani, D., Donoghue, P. C. J., Szöllősi, G. J., Williams, T. A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42924-w · Cited by 86

RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics

Awasthi, S., Sharma, R., Singhal, S. S., Zimniak, P., & Awasthi, Y. C. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.12.1300 · Cited by 86

Plastid Movement Impaired 2, a New Gene Involved in Normal Blue-Light-Induced Chloroplast Movements in Arabidopsis

Luesse, D. R., DeBlasio, S. L., & Hangarter, R. P. (2006) · Plant Physiology · doi:10.1104/pp.106.080333 · Cited by 74

γ-Syntrophin scaffolding is spatially and functionally distinct from that of the α/β syntrophins

Alessi, A., Bragg, A. D., Percival, J. M., Yoo, J., Albrecht, D. E., Froehner, S. C., & Adams, M. E. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.06.019 · Cited by 60

Mutations in LIS1 (ERG6) gene confer increased sodium and lithium uptake in Saccharomyces cerevisiae

Welihinda, A. A., Beavis, A. D., & Trumbly, R. J. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90339-5 · Cited by 68

Evolution of the Genetic Code by Incorporation of Amino Acids that Improved or Changed Protein Function

Francis, B. R. (2013) · Journal of Molecular Evolution · doi:10.1007/s00239-013-9567-y · Cited by 34

Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

Porter, J. R., Meller, A., Zimmerman, M. I., Greenberg, M. J., & Bowman, G. R. (2020) · eLife · doi:10.7554/elife.55132 · Cited by 31

Modelling of Bet v 1 Binding to Lipids

Mattila, K., & Renkonen, R. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2009.02277.x · Cited by 29

RLIP76: A Structural and Functional Triumvirate

Cornish, J., Owen, D., & Mott, H. R. (2021) · Cancers · doi:10.3390/cancers13092206 · Cited by 8

Skin-associated Corynebacterium amycolatum shares cobamides

Swaney, M. H., Henriquez, N., Campbell, T., Handelsman, J., & Kalan, L. R. (2025) · mSphere · doi:10.1128/msphere.00606-24 · Cited by 3

Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

Porter, J. R., Meller, A., Zimmerman, M. I., Greenberg, M. J., & Bowman, G. R. (2019) · doi:10.1101/2019.12.16.878264

De novo design of ATPase based on a blueprint optimized for harboring the P‐loop motif

Kosugi, T., Tanabe, M., & Koga, N. (2025) · Protein Science · doi:10.1002/pro.70132