Cited by 154Phytochemicals and Antioxidant ActivitiesDrug Solubulity and Delivery SystemsAgricultural and Biological Research

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Methods for determining bioavailability and bioaccessibility of bioactive compounds and nutrients

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Santos, Diana I., Saraiva, Jorge Manuel Alexandre, Vicente, António A., Moldão-Martins, Margarida·2019·Innovative Thermal and Non-Thermal Processing, Bioaccessibility and Bioavailability of Nutrients and Bioactive Compounds

DOI 10.1016/b978-0-12-814174-8.00002-0

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Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 3,942
Apple phytochemicals and their health benefits
Boyer, J., & Liu, R. H. (2004) · Nutrition Journal · doi:10.1186/1475-2891-3-5 · Cited by 1,645
Food Microstructure Affects the Bioavailability of Several Nutrients
Parada, J., & Aguilera, J. M. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2007.00274.x · Cited by 1,082
In vitro human digestion models for food applications
Hur, S. J., Lim, B. O., Decker, E. A., & McClements, D. J. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.08.036 · Cited by 951
Comparison of Five In Vitro Digestion Models To Study the Bioaccessibility of Soil Contaminants
Oomen, A. G., Hack, A., Minekus, M., Zeijdner, E. E., Cornelis, C., Schoeters, G. E. R., Verstraete, W., de Wiele, T. V., Wragg, J., Rompelberg, C. J. M., et al. (2002) · Environmental Science & Technology · doi:10.1021/es010204v · Cited by 812
Applicability of an in vitro digestion model in assessing the bioaccessibility of mycotoxins from food
Versantvoort, C. H. M., Oomen, A. G., de Kamp, E. V., Rompelberg, C. J. M., & Sips, A. J. A. M. (2004) · Food and Chemical Toxicology · doi:10.1016/j.fct.2004.08.007 · Cited by 767
Bioavailability of bioactive food compounds: a challenging journey to bioefficacy.
Rein, M. J., Renouf, M., Cruz-Hernandez, C., Actis-Goretta, L., Thakkar, S. K., & Pinto, M. I. D. S. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04425.x · Cited by 763
Intake and bioaccessibility of total polyphenols in a whole diet
Saura-Calixto, F. D., Serrano, J. C. E., & Goñi, I. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.02.006 · Cited by 740
An in vitro method for estimation of iron availability from meals
Miller, D. D., Schricker, B. R., Rasmussen, R. R., & Campen, D. R. V. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.10.2248 · Cited by 708
The Role of Dietary Fiber in the Bioaccessibility and Bioavailability of Fruit and Vegetable Antioxidants
Palafox-Carlos, H., Ayala-Zavala, J. F., & González-Aguilar, G. A. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01957.x · Cited by 686
A Multicompartmental Dynamic Computer-controlled Model Simulating the Stomach and Small Intestine
Minekus, M., Marteau, P., Havenaar, R., & Veld, J. H. J. H. I. (1995) · Alternatives to Laboratory Animals · doi:10.1177/026119299502300205 · Cited by 686
In vitro bio-accessibility and antioxidant activity of grape polyphenols
Tagliazucchi, D., Verzelloni, E., Bertolini, D., & Conte, A. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.10.030 · Cited by 683
Fruits and vegetables, as a source of nutritional compounds and phytochemicals: Changes in bioactive compounds during lactic fermentation
Septembre‐Malaterre, A., Remize, F., & Poucheret, P. (2017) · Food Research International · doi:10.1016/j.foodres.2017.09.031 · Cited by 657
Total phenolics, flavonoids, anthocyanins and antioxidant activity following simulated gastro-intestinal digestion and dialysis of apple varieties: Bioaccessibility and potential uptake
Bouayed, J., Hoffmann, L., & Bohn, T. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.02.052 · Cited by 656
Disintegration of Solid Foods in Human Stomach
Kong, F., & Singh, R. P. (2008) · Journal of Food Science · doi:10.1111/j.1750-3841.2008.00766.x · Cited by 629
Relevance and challenges in modeling human gastric and small intestinal digestion
Guerra, A., Etienne‐Mesmin, L., Livrelli, V., Denis, S., Blanquet‐Diot, S., & Alric, M. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.08.001 · Cited by 612
In vitro bioaccessibility assessment as a prediction tool of nutritional efficiency
Fernández‐García, E., Carvajal-Lérida, I., & Pérez‐Gálvez, A. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.09.016 · Cited by 597
Analytical Methods for Determining Bioavailability and Bioaccessibility of Bioactive Compounds from Fruits and Vegetables: A Review.
Carbonell-Capella, J. M., Buniowska, M., Barba, F., Esteve, M., & Frígola, A. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12049 · Cited by 580
Bioavailability of dietary flavonoids and phenolic compounds
Crozier, A., Rio, D. D., & Clifford, M. N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.007 · Cited by 568
Stability of polyphenols in chokeberry (Aronia melanocarpa) subjected to in vitro gastric and pancreatic digestion
BERMUDEZSOTO, M., Tomás-Barberán, F. A., & García‐Conesa, M. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.06.025 · Cited by 564
Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants
Holst, B., & Williamson, G. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.03.003 · Cited by 536
C AROTENOID B IOAVAILABILITY AND B IOCONVERSION
Yeum, K., & Russell, R. M. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102834 · Cited by 535
Development of an in Vitro Digestion Method To Assess Carotenoid Bioavailability from Meals
Garrett, D., Failla, M. L., & Sarama, R. J. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9903298 · Cited by 505
A computer-controlled system to simulate conditions of the large intestine with peristaltic mixing, water absorption and absorption of fermentation products
Minekus, M., Smeets-Peeters, M. J. E., Bernalier, A., Marol-Bonnin, S., Havenaar, R., Marteau, P. R., Alric, M., Fonty, G., & Veld, J. H. J. H. I. (1999) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051622 · Cited by 459
A Human Gastric Simulator (HGS) to Study Food Digestion in Human Stomach
Kong, F., & Singh, R. P. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01856.x · Cited by 428
Application of in vitro bioaccessibility and bioavailability methods for calcium, carotenoids, folate, iron, magnesium, polyphenols, zinc, and vitamins B6, B12, D, and E
Etcheverry, P., Grusak, M. A., & Fleige, L. E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00317 · Cited by 395
Food processing strategies to enhance phenolic compounds bioaccessibility and bioavailability in plant-based foods
Ribas, A. I., Martín‐Belloso, O., Soliva‐Fortuny, R., & Elez‐Martínez, P. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1331200 · Cited by 374
Organotypic liver culture models: meeting current challenges in toxicity testing
LeCluyse, E. L., Witek, R. P., Andersen, M. E., & Powers, M. J. (2012) · Critical Reviews in Toxicology · doi:10.3109/10408444.2012.682115 · Cited by 363
Modulation of adipose tissue inflammation by bioactive food compounds
Siriwardhana, N., Kalupahana, N. S., Cekanova, M., LeMieux, M. J., Greer, B. P., & Moustaïd‐Moussa, N. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.12.013 · Cited by 360
Advances and perspectives in in vitro human gut fermentation modeling
Payne, A. N., Zihler, A., Chassard, C., & Lacroix, C. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.06.011 · Cited by 359
Bioaccessibility and antioxidant potential of millet grain phenolics as affected by simulated in vitro digestion and microbial fermentation
Chandrasekara, A., & Shahidi, F. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2011.11.001 · Cited by 334
Micro- and nano bio-based delivery systems for food applications: In vitro behavior
Simões, L. S., Madalena, D. A., Pinheiro, A. C., Teixeira, J. A., Vicente, A. A., & Ramos, Ó. L. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.02.010 · Cited by 312
Self-citation
Bioaccessibility of bioactive compounds from fruits and vegetables after thermal and nonthermal processing
Barba, F. J., Mariutti, L. R. B., Bragagnolo, N., Mercadante, A. Z., Barbosa‐Cánovas, G. V., & Orlien, V. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.07.006 · Cited by 296
Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability
Mahler, G. J., Shuler, M. L., & Glahn, R. P. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.05.006 · Cited by 289
Chlorogenic Acid Is Absorbed in Its Intact Form in the Stomach of Rats
Lafay, S., Gil‐Izquierdo, Á., Manach, C., Morand, C., Besson, C., & Scalbert, A. (2006) · Journal of Nutrition · doi:10.1093/jn/136.5.1192 · Cited by 256
A dynamic model that simulates the human upper gastrointestinal tract for the study of probiotics
Mainville, I., Arcand, Y., & Farnworth, E. R. (2004) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2004.08.020 · Cited by 245
Challenges to understanding and measuring carotenoid bioavailability
Faulks, R. M., & Southon, S. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.11.012 · Cited by 230
Ferulic Acid Is Quickly Absorbed from Rat Stomach as the Free Form and Then Conjugated Mainly in Liver
Zhao, Z., Egashira, Y., & Sanada, H. (2004) · Journal of Nutrition · doi:10.1093/jn/134.11.3083 · Cited by 216
In Vitro Bioaccessibility of Carotenoids, Flavonoids, and Vitamin C from Differently Processed Oranges and Orange Juices [Citrus sinensis (L.) Osbeck]
Aschoff, J. K., Kaufmann, S., Kalkan, O., Neidhart, S., Carle, R., & Schweiggert, R. M. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf505297t · Cited by 210
An in vitro method to simulate phenolic compound release from the food matrix in the gastrointestinal tract
Gil‐Izquierdo, Á., Zafrilla, P., & Tomás-Barberán, F. A. (2002) · European Food Research and Technology · doi:10.1007/s00217-001-0428-3 · Cited by 209
Bioaccessibility assessment methodologies and their consequences for the risk–benefit evaluation of food
Cardoso, C. L., Afonso, C. M., Lourenço, H. M., Costa, S., & Nunes, M. L. (2014) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2014.08.008 · Cited by 200
In vitro bioaccessibility and antioxidant activity of anthocyanins from mulberry (Morus atropurpurea Roxb.) following simulated gastro-intestinal digestion
Liang, L., Wu, X., Zhao, T., Zhao, J., Li, F., Zou, Y., Mao, G., & Yang, L. (2011) · Food Research International · doi:10.1016/j.foodres.2011.11.024 · Cited by 198
Assessment of Lutein Bioavailability from Meals and a Supplement Using Simulated Digestion and Caco-2 Human Intestinal Cells
Chitchumroonchokchai, C., Schwartz, S. J., & Failla, M. L. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2280 · Cited by 198
Assessment of Degradation and Intestinal Cell Uptake of Carotenoids and Chlorophyll Derivatives from Spinach Puree Using an In Vitro Digestion and Caco-2 Human Cell Model
Ferruzzi, M. G., Failla, M. L., & Schwartz, S. J. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000775r · Cited by 189
Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)
Ribnicky, D., Roopchand, D. E., Oren, A., Grace, M. H., Poulev, A., Lila, M. A., Havenaar, R., & Raskin, I. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.07.073 · Cited by 188
Changes in Vitamin C, Phenolic, and Carotenoid Profiles Throughout in Vitro Gastrointestinal Digestion of a Blended Fruit Juice
Roque, M. J. R., Rojas‐Graü, M. A., Elez‐Martínez, P., & Martín‐Belloso, O. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3044204 · Cited by 188
A method for the determination of cellular permeability coefficients and aqueous boundary layer thickness in monolayers of intestinal epithelial ( Caco-2) cells grown in permeable filter chambers
Karlsson, J. E., & Artursson, P. (1991) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(91)90067-x · Cited by 187
In-vivo and in-vitro testing to assess the bioaccessibility and the bioavailability of arsenic, selenium and mercury species in food samples
Moreda-Piñeiro, J., Moreda-Piñeiro, A., Romarís-Hortas, V., Moscoso-Pérez, C., López-Mahía, P., Muniategui-Lorenzo, S., Bermejo-Barrera, P., & Prada-Rodríguez, D. (2011) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2010.09.008 · Cited by 182
Bound Ferulic Acid from Bran Is More Bioavailable than the Free Compound in Rat
Rondini, L., Maillard, M., Marsset‐Baglieri, A., Fromentin, G., Durand, P., Tomé, D., Prost, M., & Berset, C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0348323 · Cited by 178
In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer
Boyer, J., Brown, D. L., & Liu, R. H. (2005) · Nutrition Journal · doi:10.1186/1475-2891-4-1 · Cited by 176
Bioaccessibility of carotenes from carrots: Effect of cooking and addition of oil
Hornero‐Méndez, D., & Mínguez‐Mosquera, M. I. (2007) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2007.03.014 · Cited by 172
Application of in vitro gastrointestinal digestion and colonic fermentation models to pomegranate products (juice, pulp and peel extract) to study the stability and catabolism of phenolic compounds
Mosele, J. I., Macià, A., Romero, M.-P., Motilva, M., & Rubió, L. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.02.026 · Cited by 168
Stability and metabolism of Arbutus unedo bioactive compounds (phenolics and antioxidants) under in vitro digestion and colonic fermentation
Mosele, J. I., Macià, A., Romero, M.-P., & Motilva, M.-J. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.01.076 · Cited by 168
In vitro digestion and fermentation methods, including gas production techniques, as applied to nutritive evaluation of foods in the hindgut of humans and other simple-stomached animals
Coles, L., Moughan, P., & Darragh, A. (2005) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2005.04.021 · Cited by 162
Achieving Antral Grinding Forces in Biorelevant In Vitro Models: Comparing the USP Dissolution Apparatus II and the Dynamic Gastric Model with Human In Vivo Data
Vardakou, M., Mercuri, A., Barker, S. A., Craig, D. Q. M., Faulks, R. M., & Wickham, M. S. J. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9616-z · Cited by 162
Bioaccessibility of minerals in school meals: Comparison between dialysis and solubility methods
Cámara‐Martos, F., Amaro, M., Barberá, R., & Clemente, G. (2004) · Food Chemistry · doi:10.1016/j.foodchem.2004.08.009 · Cited by 160
Bioavailability of Phenolic Antioxidants Associated with Dietary Fiber: Plasma Antioxidant Capacity After Acute and Long-Term Intake in Humans
Pérez‐Jiménez, J., Serrano, J. C. E., Tabernero, M., Arranz, S., Diaz-Rubio, M. E., García‐Diz, L., Goñi, I., & Saura-Calixto, F. D. (2009) · Plant Foods for Human Nutrition · doi:10.1007/s11130-009-0110-7 · Cited by 159
Changes in β-carotene bioaccessibility and concentration during processing of carrot puree
Knockaert, G., Lemmens, L., Buggenhout, S. V., Hendrickx, M., & Loey, A. M. V. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2011.12.066 · Cited by 154
High pressure homogenization processing, thermal treatment and milk matrix affect in vitro bioaccessibility of phenolics in apple, grape and orange juice to different extents
He, Z., Tao, Y., Zeng, M., Zhang, S., Tao, G., Qin, F., & Chen, J. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.01.045 · Cited by 151
Novel and established intestinal cell line models – An indispensable tool in food science and nutrition
Langerholc, T., Maragkoudakis, P. A., Wollgast, J., Gradišnik, L., & Čenčič, A. (2011) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2011.03.010 · Cited by 150
Phenolic Acids Are Absorbed from the Rat Stomach with Different Absorption Rates
Konishi, Y., Zhao, Z., & Shimizu, M. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061554+ · Cited by 143
Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment
Brandon, E. F. A., Oomen, A. G., Rompelberg, C. J. M., Versantvoort, C. H. M., van Engelen, J. G. M., & Sips, A. J. A. M. (2005) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2005.10.002 · Cited by 136
Effect of Orange Juice’s Processing on the Color, Particle Size, and Bioaccessibility of Carotenoids
Stinco, C. M., Fernández‐Vázquez, R., Escudero-Gilete, M. L., Heredia, F. J., Meléndez‐Martínez, A. J., & Vicario, I. M. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2043949 · Cited by 134
Bioaccessibility of Tocopherols, Carotenoids, and Ascorbic Acid from Milk- and Soy-Based Fruit Beverages: Influence of Food Matrix and Processing
Cilla, A., Alegrı́a, A., de Ancos, B., Sánchez‐Moreno, C., Cano, M. P., Plaza, L., Clemente, G., Lagarda, M. J., & Barberá, R. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301165r · Cited by 133
Effect of in vitro gastrointestinal digestion on the bioavailability of phenolic components and the antioxidant potentials of some Turkish fruit wines
Celep, E., Charehsaz, M., Akyüz, S., Acar, E. T., & Yeşilada, E. (2015) · Food Research International · doi:10.1016/j.foodres.2015.10.009 · Cited by 132
A level A in vitro/in vivo correlation in fasted and fed states using different methods: Applied to solid immediate release oral dosage form
Souliman, S., Blanquet, S., Beyssac, E., & Cardot, J. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.08.006 · Cited by 132
Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment
Vermeiren, J., den Abbeele, P. V., Laukens, D., Vigsnæs, L. K., Vos, M. D., Boon, N., & de Wiele, T. V. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01252.x · Cited by 126
The influences of drying method and metabisulfite pre-treatment on the color, functional properties and phenolic acids contents and bioaccessibility of pumpkin flour
Aydın, E., & Göçmen, D. (2014) · LWT · doi:10.1016/j.lwt.2014.08.025 · Cited by 125
Bioaccessibility of essential elements from white cheese, bread, fruit and vegetables
Khouzam, R. B., Pohl, P., & Łobiński, R. (2011) · Talanta · doi:10.1016/j.talanta.2011.08.049 · Cited by 123
Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation
Feng, Y., Sun, C., Yuan, Y., Zhu, Y., Wan, J., Firempong, C. K., Omari‐Siaw, E., Xu, Y., Pu, Z., Yu, J., et al. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.01.081 · Cited by 119
Flavanols: digestion, absorption and bioactivity
Hackman, R. M., Polagruto, J. A., Zhu, Q. Y., Sun, B., Fujii, H., & Keen, C. L. (2007) · Phytochemistry Reviews · doi:10.1007/s11101-007-9070-4 · Cited by 118
Changes in the antioxidant activities of vegetables as a consequence of interactions between active compounds
Gawlik‐Dziki, U. (2012) · Journal of Functional Foods · doi:10.1016/j.jff.2012.06.004 · Cited by 117
In vitro fermentation of juçara pulp ( Euterpe edulis ) by human colonic microbiota
Guergoletto, K. B., Costabile, A., Flores, G., García, S., & Gibson, G. R. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.09.048 · Cited by 116
Estimation of carotenoid bioavailability from fresh stir-fried vegetables using an in vitro digestion/Caco-2 cell culture model
Garrett, D., Failla, M. L., & Sarama, R. J. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00122-4 · Cited by 114
Bioaccessibility of polyphenols and cinnamaldehyde in cinnamon beverages subjected to in vitro gastro-pancreatic digestion
Helal, A., Tagliazucchi, D., Verzelloni, E., & Conte, A. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.01.005 · Cited by 113
An Investigation into the Utility of a Multi-compartmental, Dynamic, System of the Upper Gastrointestinal Tract to Support Formulation Development and Establish Bioequivalence of Poorly Soluble Drugs
Dickinson, P. A., Abu-Rmaileh, R., Ashworth, L., Barker, R. A., Burke, W., Patterson, C. M., Stainforth, N. M., & Yasin, M. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9333-x · Cited by 111
Chlorogenic acid is poorly absorbed, independently of the food matrix: A Caco‐2 cells and rat chronic absorption study
Dupas, C., Marsset‐Baglieri, A., Ordonaud, C. S., Tomé, D., & Maillard, M. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600034 · Cited by 105
Bioaccessibility of bioactive compounds and antioxidant potential of juçara fruits (Euterpe edulis Martius) subjected to in vitro gastrointestinal digestion
Schulz, M., Biluca, F. C., Gonzaga, L. V., Borges, G. D. S. C., Vitali, L., Micke, G. A., de Gois, J. S., Almeida, T. S., Borges, D. L. G., Miller, P. R., et al. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.02.038 · Cited by 105
Carotenoid and polyphenol bioaccessibility and cellular uptake from plum and cabbage varieties
Kaulmann, A., André, C. M., Schneider, Y., Hoffmann, L., & Bohn, T. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.10.049 · Cited by 103
Effect of Stevia rebaudiana addition on bioaccessibility of bioactive compounds and antioxidant activity of beverages based on exotic fruits mixed with oat following simulated human digestion
Carbonell‐Capella, J. M., Buniowska, M., Esteve, M. J., & Frígola, A. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.03.095 · Cited by 102
Nutritional composition and bioactive properties of commonly consumed wild greens: Potential sources for new trends in modern diets
Pereira, C., Barros, L., Carvalho, A. M., & Ferreira, I. C. F. R. (2011) · Food Research International · doi:10.1016/j.foodres.2011.05.012 · Cited by 100
Ultrasound processing to enhance drying of cashew apple bagasse puree: Influence on antioxidant properties and in vitro bioaccessibility of bioactive compounds
Fonteles, T. V., Leite, A. K. F., Silva, A. R. A., Carneiro, A. P. D. G., Miguel, E. D. C., Cavada, B. S., Fernandes, F. A. N., & Rodrigues, S. (2016) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2016.01.003 · Cited by 99
Effects of freezing, freeze drying and convective drying on in vitro gastric digestion of apples
Dalmau, E., Bornhorst, G. M., Eim, V. S., Rosselló, C., & Simal, S. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.07.134 · Cited by 98
Nutraceutical potential and antioxidant benefits of selected fruit seeds subjected to an in vitro digestion
Chen, G., Chen, S.-G., Chen, F., Xie, Y.-Q., Han, M.-D., Luo, C., Zhao, Y., & Gao, Y. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.11.003 · Cited by 97
Bioaccessibility of (poly)phenolic compounds of raw and cooked cardoon (Cynara cardunculus L.) after simulated gastrointestinal digestion and fermentation by human colonic microbiota
Juániz, I., Ludwig, I. A., Bresciani, L., Dall’Asta, M., Mena, P. R., Rio, D. D., Cid, C., & Peña, M.-P. D. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.02.033 · Cited by 96
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Gökmen, V. (2015) · Cited by 96
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See all 154

Authors: Santos, D. I., Saraiva, J. M. A., Vicente, A. A., & Moldão-Martins, M.
Affiliations: University of Lisbon (PT)
University of Minho (PT)
ORCID: Santos, Diana I.
Vicente, António A.
Venue: Innovative Thermal and Non-Thermal Processing, Bioaccessibility and Bioavailability of Nutrients and Bioactive Compounds
Publisher: Elsevier
Published: 2019
Pages: 23-54
DOI: 10.1016/b978-0-12-814174-8.00002-0
OpenAlex: W2957447663
Cited by: 153
References: 123
Citations by year: 2026: 13 · 2025: 19 · 2024: 12 · 2023: 24 · 2022: 38 · 2021: 33 · 2020: 13 · 2019: 1
FWCI: 21.77
Type: book chapter
Language: en
Open access: green
repositorium.uminho.pt
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Elsevier eBooks (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
Funders: Fundação para a Ciência e a Tecnologia
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
Keywords: bioavailability, bioaccessibility, bioactive compounds, nutrients, in vitro digestion, gastrointestinal digestion, intestinal absorption, food matrix

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