CoChat
Sign Up
Cited by 45Prenatal Substance Exposure EffectsFetal and Pediatric Neurological DisordersAnesthesia and Neurotoxicity Research

The DOI matches its Crossref record; 128 of the 129 references it cites were found in a registry or an index.

Fetal alcohol spectrum disorder

Kathleen K. Sulik·2014·Handbook of Clinical Neurology
DOI 10.1016/b978-0-444-62619-6.00026-4
Open this paper in CoChat — free account

Abstract

This chapter provides an overview of animal model-based studies that have generated information critical to our understanding of the pathogenesis and mechanisms underlying alcohol-induced birth defects, in particular those involving the brain. Focus is placed on the developing organism itself, rather than the mother, placenta, or other extraembryonic tissues. Components of the cascades of alcohol-induced damage that are considered herein are excessive cell death, changes in the cell cycle and proliferation, cell migration, cell morphogenesis, and gene expression as well as free radical damage and interference with cell signaling. The roles played by one or more of these various factors in the genesis of structural and functional birth defects are dependent upon alcohol exposure patterns and dosage, the involved tissue, and the prenatal stage(s) at the time of exposure. Technologic advances and rapidly increasing knowledge in the fields of genetics, cell, developmental, and neurobiology are critical to accurately piecing together experimental evidence in refining our understanding of the genesis of alcohol-induced birth defects, to the planning and execution of future studies, and to applying the knowledge gained to diminish the severity or occurrence of fetal alcohol spectrum disorder.

Overview

Integrity signals

Registry

Crossref · 10.1016/b978-0-444-62619-6.00026-4

Cites

128 of 128 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The type and severity of ethanol-induced birth defects are dependent largely upon the pattern, dose and developmental stage of the embryo at the time of ethanol exposure.

    “While human research has not delineated, and perhaps cannot delineate fully, the pattern, amount and/or critical period of alcohol exposure necessary for structural and/or functional teratogenesis, animal models have shown that all stages of embryonic development are vulnerable to the teratogenic effects of ethanol, and that the type and severity of ethanol‐induced birth defects are dependent larg”

    From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [63]

  • Animal models have shown that all stages of embryonic development are vulnerable to the teratogenic effects of ethanol.

    “While human research has not delineated, and perhaps cannot delineate fully, the pattern, amount and/or critical period of alcohol exposure necessary for structural and/or functional teratogenesis, animal models have shown that all stages of embryonic development are vulnerable to the teratogenic effects of ethanol, and that the type and severity of ethanol‐induced birth defects are dependent larg”

    From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [63]

Citations

Cites

1 retracted

Flagged first, then by citations

1 of the 129 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Metadata

Authors
Sulik, K. K.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
Kathleen K. Sulik
Venue
Handbook of Clinical Neurology
Publisher
Elsevier
Published
2014
Volume
125
Pages
463-475
ISSN
0072-9752 (ISSN-L)
DOI
10.1016/b978-0-444-62619-6.00026-4
OpenAlex
W202227517
Cited by
45
References
129
Citations by year
2026: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 10 · 2016: 6 · 2015: 1
FWCI
43.40
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • Handbook of clinical neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Keywords
fetal alcohol spectrum disorders, prenatal alcohol exposure, animal models, brain development, cell death, cell cycle, cell proliferation, cell migration, morphogenesis, gene expression, oxidative damage, signal transduction, developmental neuroscience, pathogenesis
MeSH terms
Alcohol Drinking, Animals, Brain, Cell Movement, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Cell Death, Epigenesis, Genetic, Fetal Alcohol Spectrum Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review