Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity

Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies

Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · see citing works

Dietary Intake and Bioavailability of Polyphenols

Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658 · see citing works

Dietary polyphenols and the prevention of diseases

Scalbert, A., Manach, C., Morand, C., Rémésy, C., & Jiménez, L. (2005) · Critical Reviews in Food Science and Nutrition · doi:10.1080/1040869059096 · Cited by 2,999 · see citing works

Oxidative stress in Parkinson's disease

Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053 · see citing works

Dietary phenolics: chemistry, bioavailability and effects on health

Crozier, A., Jaganath, I. B., & Clifford, M. N. (2009) · Natural Product Reports · doi:10.1039/b802662a · Cited by 2,002 · see citing works

Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies

Williamson, G., & Manach, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.243s · Cited by 1,340 · see citing works

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211 · see citing works

Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

Alam, Z. I., Jenner, A., Daniel, S. E., Lees, A. J., Cairns, N., Marsden, C. D., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031196.x · Cited by 845 · see citing works

Polyphenols in foods are more complex than often thought

Cheynier, V. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.223s · Cited by 746 · see citing works

Dopamine covalently modifies and functionally inactivates parkin

LaVoie, M. J., Ostaszewski, B. L., Weihofen, A., Schlossmacher, M. G., & Selkoe, D. J. (2005) · Nature Medicine · doi:10.1038/nm1314 · Cited by 722 · see citing works

Intake of flavonoids and risk of dementia

Commenges, D., Scotet, V., Renaud, S., Jacqmin‐Gadda, H., Barberger‐Gateau, P., & Dartigues, J. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007614613771 · Cited by 647 · see citing works

Flavonoid permeability across an in situ model of the blood–brain barrier

Youdim, K. A., Qaiser, M. Z., Begley, D. J., Rice-Evans, C. A., & Abbott, N. J. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.023 · Cited by 605 · see citing works

Antioxidant activities of flavonoids as bioactive components of food

Rice-Evans, C. A., & Miller, N. J. (1996) · Biochemical Society Transactions · doi:10.1042/bst0240790 · Cited by 584 · see citing works

Interaction between flavonoids and the blood–brain barrier: <i>in vitro</i> studies

Youdim, K. A., Dobbie, M. S., Kuhnle, G., Proteggente, A. R., Abbott, N. J., & Rice‐Evans, C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01652.x · Cited by 578 · see citing works

The neuroprotective potential of flavonoids: a multiplicity of effects

Vauzour, D., Vafeiadou, K., Rodriguez‐Mateos, A., Rendeiro, C., & Spencer, J. P. E. (2008) · Genes & Nutrition · doi:10.1007/s12263-008-0091-4 · Cited by 561 · see citing works

Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition

Agullo, G., Gamet‐Payrastre, L., Manenti, S., Viala, C., Rémésy, C., Chap, H., & Payrastre, B. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)82453-7 · Cited by 535 · see citing works

Resveratrol protects against global cerebral ischemic injury in gerbils

Wang, Q., Xu, J., Rottinghaus, G. E., Simonyi, Á., Lubahn, D. E., Sun, G. Y., & Sun, A. Y. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03543-6 · Cited by 528 · see citing works

Invited Review Free radicals and the pathobiology of brain dopamine systems

Cadet, J. L., & Brannock, C. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(97)00031-4 · Cited by 499 · see citing works

Flavanol monomer-induced changes to the human faecal microflora

Tzounis, X., Vulevic, J., Kuhnle, G., George, T. W., Leonczak, J., Gibson, G. R., Kwik-Uribe, C. L., & Spencer, J. P. E. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507853384 · Cited by 455 · see citing works

Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels

Williams, C. M., Mohsen, M. A. E., Vauzour, D., Rendeiro, C., Butler, L. T., Ellis, J. A., Whiteman, M., & Spencer, J. P. E. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.008 · Cited by 426 · see citing works

Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species

Spencer, J. P. E., Jenner, P., Daniel, S. E., Lees, A. J., Marsden, D. C., & Halliwell, B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71052112.x · Cited by 373 · see citing works

Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds

Joseph, J. A., Shukitt‐Hale, B., & Casadesús, G. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.313s · Cited by 368 · see citing works

Kainic Acid-Mediated Excitotoxicity as a Model for Neurodegeneration

Wang, Q., Yu, S. O., Simonyi, Á., Sun, G. Y., & Sun, A. Y. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:003 · Cited by 365 · see citing works

Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model

Joseph, J. A., Arendash, G. W., Gordon, M. N., Diamond, D. M., Shukitt‐Hale, B., Morgan, D., & Denisova, N. A. (2003) · Nutritional Neuroscience · doi:10.1080/1028415031000111282 · Cited by 361 · see citing works

Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability

Spencer, J. P. E., Rice-Evans, C. A., & Williams, R. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305063200 · Cited by 350 · see citing works

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter, H., BOYD, C., SPENCER, J., WILLIAMS, R., Cadenas, E., & Rice-Evans, C. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00075-1 · Cited by 338 · see citing works

A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes

Esposito, E., Rotilio, D., DIMATTEO, V., Giulio, C. D., Cacchio, M., & Algeri, S. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00078-7 · Cited by 327 · see citing works

Bioavailability of phenolic acids

Lafay, S., & Gil‐Izquierdo, Á. (2007) · Phytochemistry Reviews · doi:10.1007/s11101-007-9077-x · Cited by 309 · see citing works

Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide‐related toxicity in cultured hippocampal neurons

Bastianetto, S., Zheng, W., & Quirion, R. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703626 · Cited by 302 · see citing works

Esterase Activity Able To Hydrolyze Dietary Antioxidant Hydroxycinnamates Is Distributed along the Intestine of Mammals

Andreasen, M. F., Kroon, P. A., Williamson, G., & García‐Conesa, M. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010668c · Cited by 298 · see citing works

Fruit and vegetable phytochemicals: chemistry, nutritional value and stability

la Rosa, L. A. D., ́Álvarez-Parrilla, E., & González-Aguilar, G. A. (2009) · Andalas University Repository (Andalas University) · Cited by 294 · see citing works

Human fecal water content of phenolics: The extent of colonic exposure to aromatic compounds

Jenner, A. M., Rafter, J. J., & Halliwell, B. B. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.020 · Cited by 268 · see citing works

Biochemical and toxicological properties of the oxidation products of catecholamines

Bindoli, A., Rigobello, M. P., & Deeble, D. J. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90182-g · Cited by 264 · see citing works

Activation of pro‐survival Akt and ERK1/2 signalling pathways underlie the anti‐apoptotic effects of flavanones in cortical neurons

Vauzour, D., Vafeiadou, K., Rice-Evans, C. A., Williams, R. J., & Spencer, J. P. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04841.x · Cited by 254 · see citing works

Microbial metabolism of caffeic acid and its esters chlorogenic and caftaric acids by human faecal microbiota in vitro

Gonthier, M., Rémésy, C., Scalbert, A., Cheynier, V., Souquet, J., Poutanen, K., & Aura, A. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.084 · Cited by 247 · see citing works

Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death

Sawada, H., Ibi, M., Kihara, T., Urushitani, M., Akaike, A., & Shimohama, S. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19981201)54:5 · Cited by 246 · see citing works

Dietary Flavonoids as Potential Neuroprotectants

Youdim, K. A., Spencer, J. P. E., Schroeter, H., & Rice-Evans, C. A. (2002) · Biological Chemistry · doi:10.1515/bc.2002.052 · Cited by 210 · see citing works

Ca2+-Permeable AMPA Receptors Induce Phosphorylation of cAMP Response Element-Binding Protein through a Phosphatidylinositol 3-Kinase-Dependent Stimulation of the Mitogen-Activated Protein Kinase Signaling Cascade in Neurons

Perkinton, M. S., Sihra, T. S., & Williams, R. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05861.1999 · Cited by 198 · see citing works

Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter

Whitehead, R. E., Ferrer, J. V., Javitch, J. A., & Justice, J. B. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00125.x · Cited by 194 · see citing works

Tyrosine Hydroxylase Is Inactivated by Catechol‐Quinones and Converted to a Redox‐Cycling Quinoprotein

Kuhn, D. M., Arthur, R. E., Thomas, D. M., & Elferink, L. A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731309.x · Cited by 183 · see citing works

Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation

Sul, D., Kim, H.-S., Lee, D., Joo, S. S., Hwang, K. W., & Park, S. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.12.001 · Cited by 158 · see citing works

Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine, dopa and dopac in the brains of eight mammalian species

Fornstedt, B., Rosengren, E., & Carlsson, A. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90242-x · Cited by 155 · see citing works

Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects

Corona, G., Deiana, M., Incani, A., Vauzour, D., Dessì, M., & Spencer, J. P. E. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.049 · Cited by 153 · see citing works

Iron-Mediated Generation of the Neurotoxin 6-Hydroxydopamine Quinone by Reaction of Fatty Acid Hydroperoxides with Dopamine: A Possible Contributory Mechanism for Neuronal Degeneration in Parkinson's Disease

Pezzella, A., d’Ischia, M., Napolitano, A., Misuraca, G., & Prota, G. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970099t · Cited by 133 · see citing works

Effects of L-Cysteine on the Oxidation Chemistry of Dopamine: New Reaction Pathways of Potential Relevance to Idiopathic Parkinson's Disease

Zhang, F., & Dryhurst, G. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00034a006 · Cited by 129 · see citing works

Phenolic Composition of Champagnes from Chardonnay and Pinot Noir Vintages

Chamkha, M., Cathala, B., Cheynier, V., et al. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf021105j · Cited by 128 · see citing works

Resveratrol Protects Against Neurotoxicity Induced by Kainic Acid

Wang, Q., Yu, S. O., Simonyi, Á., Rottinghaus, G. E., Sun, G. Y., & Sun, A. Y. (2004) · Neurochemical Research · doi:10.1007/s11064-004-6883-z · Cited by 123 · see citing works

Inhibition of Peroxynitrite‐Mediated Oxidation of Dopamine by Flavonoid and Phenolic Antioxidants and Their Structural Relationships

Kerry, N. L., & Rice-Evans, C. A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730247.x · Cited by 114 · see citing works

5‐S‐Cysteinyl‐conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase‐3 activity in neurons

Spencer, J. P. E., Whiteman, M., Jenner, P. G., & Halliwell, B. B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00808.x · Cited by 113 · see citing works

Alcohol, ischemic heart disease, and the french paradox

Constant, J. (1997) · Clinical Cardiology · doi:10.1002/clc.4960200504 · Cited by 110 · see citing works

Irreversible Inhibition of Mitochondrial Complex I by 7‐(2‐Aminoethyl)‐3,4‐Dihydro‐5‐Hydroxy‐2H‐1,4‐Benzothiazine‐3‐Carboxylic Acid (DHBT‐1): A Putative Nigral Endotoxin of Relevance to Parkinson's Disease

Li, H., & Dryhurst, G. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041530.x · Cited by 110 · see citing works

Neuroprotective effect of tyrosol on transient focal cerebral ischemia in rats

Bu, Y., Rho, S., Kim, J., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.094 · Cited by 109 · see citing works

Evidence of postprandial absorption of olive oil phenols in humans.

Bonanome, A., Pagnan, A., Caruso, D., Toia, A., Xamin, A., Fedeli, E., Berra, B., Zamburlini, A., Ursini, F., & Galli, G. (2000) · PubMed · Cited by 100 · see citing works

Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson’s disease and protection by polyphenols

Vauzour, D., Ravaioli, G. M., Vafeiadou, K., Rodriguez‐Mateos, A., Angeloni, C., & Spencer, J. P. E. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.011 · Cited by 96 · see citing works

Neuroinflammation and its Modulation by Flavonoids

Vafeiadou, K., Vauzour, D., & Spencer, J. P. E. (2007) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153007781662521 · Cited by 83 · see citing works

Further Insights into the Influence of l -Cysteine on the Oxidation Chemistry of Dopamine: Reaction Pathways of Potential Relevance to Parkinson's Disease

Shen, X.-M., & Dryhurst, G. (1996) · Chemical Research in Toxicology · doi:10.1021/tx960008f · Cited by 76 · see citing works

Striatal Transporter for Dopamine: Catechol Structure‐Activity Studies and Susceptibility to Chemical Modification

Meiergerd, S. M., & Schenk, J. O. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62030998.x · Cited by 74 · see citing works

In vitro inhibition of the activity of phosphorylase kinase, protein kinase C and protein kinase A by caffeic acid and a procyanidin-rich pine bark (Pinus marittima) extract

Nardini, M., Scaccini, C., Packer, L., et al. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00009-x · Cited by 69 · see citing works

ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis

Stefanelli, C., Bonavita, F., Stanić, I., et al. (1997) · Biochemical Journal · doi:10.1042/bj3220909 · Cited by 59 · see citing works

Dietary antioxidants, peroxidation and cardiovascular risks.

Barbaste, M., Berke, B., Dumas, M., et al. (2002) · PubMed · Cited by 43 · see citing works

Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols

Vauzour, D., Vafeiadou, K., & Spencer, J. P. E. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.153 · Cited by 42 · see citing works

Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers

Vauzour, D., Houseman, E. J., George, T. W., Corona, G., Garnotel, R., Jackson, K. G., Sellier, C., Gillery, P., Kennedy, O. B., Lovegrove, J. A., et al. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992959 · Cited by 39 · see citing works

Champagne Wine Polyphenols Protect Primary Cortical Neurons against Peroxynitrite-Induced Injury

Vauzour, D., Vafeiadou, K., Corona, G., Pollard, S. E., Tzounis, X., & Spencer, J. P. E. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf063304z · Cited by 38 · see citing works

Caffeic acid as biomarker of red wine intake

Simonetti, P., Gardana, C., & Pietta, P. (2001) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(01)35237-0 · Cited by 28 · see citing works

5-S-Cysteinyl-dopamine effect on the human dopaminergic neuroblastoma cell line SH-SY5Y

Mosca, L., Lendaro, E., D’Erme, M., et al. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.01.023 · Cited by 27 · see citing works

Red wine consumption and brain aging

Bastianetto, S. (2002) · Nutrition · doi:10.1016/s0899-9007(01)00745-6 · Cited by 21 · see citing works

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

Williams, R. J., & Spencer, J. P. E. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.010 · Cited by 448 · see citing works

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works

Effects of Oleuropein, Tyrosol, and Caffeic Acid on the Growth of Mold Isolated from Olives

Gourama, H., Letutour, B., Tantaoui‐Elaraki, A., et al. (1989) · Journal of Food Protection · doi:10.4315/0362-028x-52.4.264 · Cited by 15 · see citing works

Effect of Added Caffeic Acid and Tyrosol on the Fatty Acid and Volatile Profiles of Camellia Oil following Heating

Hai-yan, Z., Bedgood, D. R., Bishop, A., et al. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061974z · Cited by 46 · see citing works

Peroxyl and hydroxyl radical scavenging activity of some natural phenolic antioxidants

Chimi, H., Cillard, J., Cillard, P., & Rahmani, M. (1991) · Journal of the American Oil Chemists Society · doi:10.1007/bf02657682 · Cited by 302 · see citing works

Spectrophotometric Characterization of the Action of Tyrosinase on p-Coumaric and Caffeic Acids: Characteristics of o-Caffeoquinone

Garcia-Jimenez, A., Muñoz-Muñoz, J., Garcı́a-Molina, F., et al. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b00446 · Cited by 22 · see citing works

Co-production of caffeic acid and p-hydroxybenzoic acid from p-coumaric acid by Streptomyces caeruleus MTCC 6638

Sachan, A., Sachan, S. G., Sen, S. K., et al. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0197-1 · Cited by 47 · see citing works