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Cited by 349

The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.

Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications

Open access
Liang, Yingkai, Kiick, Kristi L.·2014·Acta Biomaterialia

Abstract

Heparin plays an important role in many biological processes, via its interaction with various proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties such as anticoagulant activity, growth factor binding, as well as antiangiogenic and apoptotic effects, making them great candidates for emerging applications. Accordingly, this review summarizes recent efforts in the preparation of heparin-based hydrogels and formation of nanoparticles, as well as the characterization of their properties and applications. The challenges and future perspectives for heparin-based materials are also discussed. Prospects are promising for heparin-containing polymeric biomaterials in diverse applications ranging from cell carriers for promoting cell differentiation to nanoparticle therapeutics for cancer treatment.

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Crossref · 10.1016/j.actbio.2013.07.031

Cites

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Metadata

Authors
Liang, Y., & Kiick, K. L.
Venue
Acta Biomaterialia
Publisher
Elsevier BV
Published
2014-04
Volume
10
Issue
4
Pages
1588-1600
ISSN
1742-7061 (ISSN-L)
OpenAlex
W1997209259
Cited by
349
References
115
FWCI
8.72
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications. https://app.cochat.ai/papers/10.1016/j.actbio.2013.07.031
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Liang, Y., & Kiick, K. L. (2014). Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2013.07.031

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.