The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Development of tannin-inspired antimicrobial bioadhesives
Open accessAbstract
Tissue adhesives play an important role in surgery to close wounds, seal tissues, and stop bleeding, but existing adhesives are costly, cytotoxic, or bond weakly to tissue. Inspired by the water-resistant adhesion of plant-derived tannins, we herein report a new family of bioadhesives derived from a facile, one-step Michael addition of tannic acid and gelatin under oxidizing conditions and crosslinked by silver nitrate. The oxidized polyphenol groups of tannic acid enable wet tissue adhesion through catecholamine-like chemistry, while both tannic acid and silver nanoparticles reduced from silver nitrate provide antimicrobial sources inherent within the polymeric network. These tannin-inspired gelatin bioadhesives are low-cost and readily scalable and eliminate the concerns of potential neurological effect brought by mussel-inspired strategy due to the inclusion of dopamine; variations in gelatin source (fish, bovine, or porcine) and monomer feeding ratios resulted in tunable gelation times (36 s to 8 min), controllable degradation (up to 100% degradation within a month), considerable wet tissue adhesion strengths (up to 3.7 times to that of fibrin glue), excellent cytocompatibility, as well as antibacterial and antifungal properties. The innate properties of tannic acid as a natural phenolic crosslinker, molecular glue, and antimicrobial agent warrant a unique and significant approach to bioadhesive design.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Plant Products as Antimicrobial Agents
Cowan, M. M. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.4.564 · Cited by 9,043
Antimicrobial properties of tannins
Scalbert, A. (1991) · Phytochemistry · doi:10.1016/0031-9422(91)83426-l · Cited by 2,321
Multiple dopamine functions at different time courses
Schultz, W. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135722 · Cited by 1,415
Colorless Multifunctional Coatings Inspired by Polyphenols Found in Tea, Chocolate, and Wine
Sileika, T. S., Barrett, D. G., Zhang, R., Lau, K. H. A., & Messersmith, P. B. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201304922 · Cited by 875
Chen, Q.-Z., Bismarck, A., Hansen, U., Junaid, S., Tran, M. Q., Harding, S. E., Ali, N. N., & Boccaccini, A. R. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.09.010 · Cited by 530
Supramolecular Hydrogel Formation Based on Tannic Acid
Fan, H., Wang, L., Feng, X., Bu, Y., Wu, D., & Jin, Z. (2017) · Macromolecules · doi:10.1021/acs.macromol.6b02106 · Cited by 474
Design Strategies and Applications of Tissue Bioadhesives
Mehdizadeh, M., & Yang, J. (2013) · Macromolecular Bioscience · doi:10.1002/mabi.201200332 · Cited by 448
Self-citationMehdizadeh, M., Weng, H., Gyawali, D., Tang, L., & Yang, J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.07.055 · Cited by 422
Self-citationStrauss, G., & Gibson, S. M. (2004) · Food Hydrocolloids · doi:10.1016/s0268-005x(03)00045-6 · Cited by 393
Hydrophobic interaction in tannin-protein complexes
Oh, H. I., Hoff, J. E., Armstrong, G. S., & Haff, L. A. (1980) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60228a020 · Cited by 365
Cited by
Tannic acid: a crosslinker leading to versatile functional polymeric networks: a review
Chen, C., Yang, H., Yang, X., & Ma, Q. (2022) · RSC Advances · doi:10.1039/d1ra07657d · Cited by 561
Álvarez-Martínez, F. J., Barrajón-Catalán, E., Herranz-López, M., & Micol, V. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153626 · Cited by 560
Chouhan, D., Dey, N., Bhardwaj, N., & Mandal, B. B. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119267 · Cited by 522
Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing
Pourshahrestani, S., Zeimaran, E., Kadri, N. A., Mutlu, N., & Boccaccini, A. R. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000905 · Cited by 448
Polyphenol scaffolds in tissue engineering
Zhang, X., Li, Z., Yang, P., Duan, G., Liu, X., Gu, Z., & Li, Y. (2021) · Materials Horizons · doi:10.1039/d0mh01317j · Cited by 417
Metadata
- Authors
- Guo, J., Sun, W., Kim, J. P., Lu, X., Li, Q., Lin, M., Mrowczynski, O., Rizk, E. B., Cheng, J., Qian, G., & Yang, J.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 72
- Pages
- 35-44
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2793513753
- Cited by
- 323
- References
- 37
- FWCI
- 26.39
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Development of tannin-inspired antimicrobial bioadhesives. https://app.cochat.ai/papers/10.1016/j.actbio.2018.03.008
- The paper
- Guo, J., Sun, W., Kim, J. P., Lu, X., Li, Q., Lin, M., Mrowczynski, O., Rizk, E. B., Cheng, J., Qian, G., & Yang, J. (2018). Development of tannin-inspired antimicrobial bioadhesives. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2018.03.008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
