The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities
Abstract
Wound management poses a considerable economic burden on the global healthcare system, considering the impacts of wound infection, delayed healing and scar formation. To this end, multifunctional dressings based on hydrogels have been developed to stimulate skin healing. Herein, we describe the design, fabrication, and characterization of a sprayable hydrogel-based wound dressing loaded with cerium oxide nanoparticles (CeONs) and an antimicrobial peptide (AMP), for combined reactive oxygen species (ROS)-scavenging and antibacterial properties. We adopted a mussel-inspired strategy to chemically conjugate gelatin with dopamine motifs and prepared a hydrogel dressing with improved binding affinity to wet skin surfaces. Additionally, the release of AMP from the hydrogel demonstrated rapid release ablation and contact ablation against four representative bacterial strains, confirming the desired antimicrobial activities. Moreover, the CeONs-loaded hydrogel dressing exhibited favorable ROS-scavenging abilities. The biocompatibility of the multifunctional hydrogel dressing was further proven in vitro by culturing with HaCaT cells. Overall, the benefits of the developed hydrogel wound dressing, including sprayability, adhesiveness, antimicrobial activity, as well as ROS-scavenging and skin-remodeling ability, highlight its promissing translational potentials in wound management.
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Cites
Oxidative Stress and Antioxidant Defense
Birben, E., Sahiner, U. M., Sackesen, C., Erzurum, S., & Kalayci, O. (2012) · World Allergy Organization Journal · doi:10.1097/wox.0b013e3182439613 · Cited by 4,935
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
Sies, H. (2017) · Redox Biology · doi:10.1016/j.redox.2016.12.035 · Cited by 2,148
Staphylococcus epidermidis — the 'accidental' pathogen
Otto, M. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2182 · Cited by 1,808
Inflammation in Chronic Wounds
Zhao, R., Liang, H., Clarke, E., Jackson, C., & Xue, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122085 · Cited by 1,180
Anti-microbial peptides: from invertebrates to vertebrates
Bulet, P., Stöcklin, R., & Menin, L. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0124.x · Cited by 1,107
Griffin, D. R., Weaver, W. M., Scumpia, P. O., Di Carlo, D., & Segura, T. (2015) · Nature Materials · doi:10.1038/nmat4294 · Cited by 981
Liu, H., Wang, C., Li, C., Qin, Y., Wang, Z., Yang, F., Li, Z., & Wang, J. (2018) · RSC Advances · doi:10.1039/c7ra13510f · Cited by 915
Self-citationWang, C., Wang, M., Xu, T., Zhang, X., Lin, C., Gao, W., Xu, H., Lei, B., & Mao, C. (2019) · Theranostics · doi:10.7150/thno.29766 · Cited by 908
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Smart wound dressings for wound healing
Dong, R., & Guo, B. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101290 · Cited by 959
Hydrogels and Wound Healing: Current and Future Prospects
Gounden, V., & Singh, M. (2024) · Gels · doi:10.3390/gels10010043 · Cited by 365
An, H., Gu, Z., Zhou, L., Liu, S., Li, C., Zhang, M., Xu, Y., Zhang, P., & Wen, Y. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.07.016 · Cited by 115
Self-citationHu, S., Yang, Z., Zhai, Q., Li, D., Zhu, X., He, Q., Li, L., Cannon, R. D., Wang, H., Tang, H., et al. (2023) · Small · doi:10.1002/smll.202207437 · Cited by 87
Ge, P., Chang, S., Wang, T., Zhao, Q., Wang, G., & He, B. (2023) · Nanoscale · doi:10.1039/d2nr04908b · Cited by 54
Metadata
- Authors
- Cheng, H., Shi, Z., Yue, K., Huang, X., Xu, Y., Gao, C., Yao, Z., Zhang, Y. S., & Wang, J.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 124
- Pages
- 219-232
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W3127127108
- Cited by
- 371
- References
- 63
- FWCI
- 26.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, H., Shi, Z., Yue, K., Huang, X., Xu, Y., Gao, C., Yao, Z., Zhang, Y. S., & Wang, J. (2021). Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2021.02.002
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