The DOI matches its Crossref record; 378 of the 389 references it cites were found in a registry or an index.
Extracellular matrix structure
Abstract
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation, and are vital for maintaining normal homeostasis. ECM is a highly dynamic structural network that continuously undergoes remodeling mediated by several matrix-degrading enzymes during normal and pathological conditions. Deregulation of ECM composition and structure is associated with the development and progression of several pathologic conditions. This article emphasizes in the complex ECM structure as to provide a better understanding of its dynamic structural and functional multipotency. Where relevant, the implication of the various families of ECM macromolecules in health and disease is also presented.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The ECM's functional characteristics and structural components, such as collagen and proteoglycans, play a critical role in maintaining tissue homeostasis and promoting angiogenesis.”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [4]
In the citing paper
“ECM glycoproteins, like laminin, fibronectin, vitronectin or collagen, mediate stem cell adhesion, pluripotency maintenance, lineage commitment, migration, and neural differentiation through integrin signaling and biomechanical cues (Watt and Huck, 2013; Theocharis et al., 2016; Hagbard et al., 2018).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Theocharis et al., 2016
In the citing paper
“Neuronal cells, particularly those derived from stem cells, require a supportive ECM environment that mimics their natural niche to maintain their viability, morphology, and function, which is why additional ECM components are used as coating during cultivation to enhance cell adhesion, growth, and differentiation (Friedl and Brocker, 2000; Theocharis et al., 2016; Nicolas et al., 2020).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Theocharis et al., 2016
In the citing paper
“Neuronal cells, particularly those derived from stem cells, require a supportive ECM environment that mimics their natural niche to maintain their viability, morphology, and function, which is why additional ECM components are used as coating during cultivation to enhance cell adhesion, growth, and differentiation (Friedl and Brocker, 2000; Theocharis et al., 2016; Nicolas et al., 2020).”
From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Theocharis et al., 2016
Citations
Cites
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Visse, R., & Nagase, H. (2003) · Circulation Research · doi:10.1161/01.res.0000070112.80711.3d · Cited by 4,575
Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538
Remodelling the extracellular matrix in development and disease
Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3904 · Cited by 4,367
The extracellular matrix at a glance
Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101
Collagen Structure and Stability
Shoulders, M. D., & Raines, R. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.032207.120833 · Cited by 3,923
Pierschbacher, M. D., & Ruoslahti, E. I. (1984) · Nature · doi:10.1038/309030a0 · Cited by 3,690
Structure and function of matrix metalloproteinases and TIMPs
Nagase, H., Visse, R., & MURPHY, G. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.12.002 · Cited by 3,507
Tumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413
Flagged first, then by citations
11 of the 389 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 801–900 of 1,004
Ghanemi, A., Yoshioka, M., & St‐Amand, J. (2020) · Applied Sciences · doi:10.3390/app10072388 · Cited by 23
Jo, Y., Hwang, S. H., & Jang, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179367 · Cited by 24
Mueller, A., Brockmueller, A., Kunnumakkara, A. B., & Shakibaei, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031695 · Cited by 23
Frey, N., Ouologuem, L., Blenninger, J., Siow, W. X., Thorn‐Seshold, J., Stöckl, J. B., Abrahamian, C., Fröhlich, T., Vollmar, A. M., Grimm, C. M., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105581 · Cited by 24
Fibrous Remodeling in Eosinophilic Esophagitis: Clinical Facts and Pathophysiological Uncertainties
Arias‐González, L., Rodríguez-Alcolado, L., Mendieta, E. J. L., Navarro, P., Lucendo, A. J., & Grueso-Navarro, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020927 · Cited by 22
Designed modular protein hydrogels for biofabrication
Dranseike, D., Yusuke, O., Edwardson, T. G. W., Guzzi, E. A., Hori, M., Nakic, Z. R., Deshmukh, D., Levasseur, M. D., Mattli, K., Tringides, C. M., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.02.019 · Cited by 22
Anisotropic and Non-Gaussian Diffusion of Thin Nanorods in Polymer Networks
Chen, Y., Xiang, Z., Ren, H., Guo, F., Ganesan, V., & Liu, J. (2024) · Macromolecules · doi:10.1021/acs.macromol.4c00635 · Cited by 22
Molecular mechanisms of ovarian fibrosis
Edepli, B. G., & Yaba, A. (2025) · Molecular Human Reproduction · doi:10.1093/molehr/gaaf058 · Cited by 27
The extracellular matrix in inflammation and cancer
Zhang, W., Xiang, Y., Lu, C., Wang, F., Ren, H., Wu, H., & Yan, M. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00415-6 · Cited by 34
Toward Morphologically Relevant Extracellular Matrix in Vitro Models: 3D Fiber Reinforced Hydrogels
Williams, A., Nowak, J. F., Dass, R., Samuel, J., & Mills, K. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00966 · Cited by 22
Bio Mimicking of Extracellular Matrix
Ghosh, M., Halperin‐Sternfeld, M., & Adler‐Abramovich, L. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9791-2_12 · Cited by 22
Lin, T., Zha, Y., Zhang, X., Chen, J., Li, Y., Wang, Z., Zhang, S., Wang, J., & Li, Z. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.125939 · Cited by 22
Smart Porous Multi-Stimulus Polysaccharide-Based Biomaterials for Tissue Engineering
Alvarado‐Hidalgo, F., Ramírez‐Sánchez, K., & Starbird, R. (2020) · Molecules · doi:10.3390/molecules25225286 · Cited by 22
Hydrogel biomaterials to support and guide vascularization
Chapla, R., & West, J. L. (2020) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/abc947 · Cited by 23
Abalymov, A. A., Santos, C. A. B., der Meeren, L. V., de Walle, D. V., Dewettinck, K., Parakhonskiy, B. V., & Skirtach, A. G. (2021) · Advanced Materials Interfaces · doi:10.1002/admi.202002202 · Cited by 22
Stimuli‐Responsive Natural Proteins and Their Applications
Du, N., Ye, F., Sun, J., & Liu, K. (2021) · ChemBioChem · doi:10.1002/cbic.202100416 · Cited by 24
Targeted activation of androgen receptor signaling in the periosteum improves bone fracture repair
Lan, K., Wei, K.-T., Lin, P., Lin, C., Won, P.-L., Liu, Y., Chen, Y., Cheng, B., Chu, T. G., Chen, J., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04595-1 · Cited by 22
Mastronikolis, S. N., Pagkalou, M., Baroutas, G., Kyriakopoulou, K., Makri, Ο. E., & Georgakopoulos, C. D. (2022) · IUBMB Life · doi:10.1002/iub.2606 · Cited by 22
Francés‐Herrero, E., Rodríguez‐Eguren, A., Gómez‐Álvarez, M., de Miguel–Gómez, L., Ferrero, H., & Cervelló, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073765 · Cited by 23
Dong, Y., Zhu, W., Lei, X., Luo, X., Xiang, Q., Zhu, X., Pan, Q., Jin, P., & Cheng, B. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.908585 · Cited by 23
Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities
Wang, R., Sun, Q., Wu, X., Zhang, Y., Xing, X., Lin, K., Feng, Y., Wang, M., Wang, M., & Wang, Y. (2022) · Cells · doi:10.3390/cells11233735 · Cited by 22
Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration
Huang, J., Zhou, Q., Ren, Q., Luo, L., Ji, G., & Zheng, T. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1094394 · Cited by 23
Islam, T., Rahman, M. R., Khan, A., & Moni, M. A. (2023) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2023.104345 · Cited by 22
Afshar, K., Sanaei, M., Ravari, M. S., Pourbagheri‐Sigaroodi, A., & Bashash, D. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3846 · Cited by 23
Bae, M., Ngo, H., Kang, Y. J., Lee, S., Park, W., Jo, Y., Choi, Y., Kim, J. J., Yi, H., Kim, H., et al. (2023) · Small · doi:10.1002/smll.202308815 · Cited by 21
Perception and response of skeleton to mechanical stress
Ding, S., Chen, Y., Huang, C., Song, L., Liang, Z., & Wei, B. (2024) · Physics of Life Reviews · doi:10.1016/j.plrev.2024.03.011 · Cited by 23
Wu, J., Zhang, Q., Yang, Z., Xu, Y., Liu, X., Wang, X., Peng, J., Xiao, J., Wang, Y., Shang, Z., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70025 · Cited by 22
Integrins functioning in uterine endometrial stromal and epithelial cells in estrus
Park, H. J., Park, J. E., Lee, H., Kim, S.-J., Yun, J. I., Kim, M., Park, K.-H., & Lee, S. T. (2016) · Reproduction · doi:10.1530/rep-16-0516 · Cited by 22
Decellularized ECM-Derived Hydrogels: Modification and Properties
Claudio‐Rizo, J. A., Delgado, J., Quintero‐Ortega, I. A., Mata‐Mata, J. L., & Mendoza‐Novelo, B. (2018) · InTech eBooks · doi:10.5772/intechopen.78331 · Cited by 22
In Situ Drug Delivery to Breast Cancer-Associated Extracellular Matrix
Fleming, J. M., Yeyeodu, S. T., McLaughlin, A., Schuman, D., & Taylor, D. K. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00396 · Cited by 24
Hongjin, W., Chen, H., Baoxiang, J., Shiqi, Y., & Xu, X. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0023 · Cited by 22
Egnell, L., Vidić, I., Jerome, N. P., Bofin, A. M., Bathen, T. F., & Goa, P. E. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27018 · Cited by 24
The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma
Reszegi, A., Horváth, Z., Karászi, K., Regős, E., Postniková, V., Tátrai, P., Kiss, A., Schaff, Z., Kovalszky, I., & Baghy, K. (2020) · Biomolecules · doi:10.3390/biom10081199 · Cited by 22
Filamin A regulates the organization and remodeling of the pericellular collagen matrix
Mezawa, M., Pinto, V. I., Kazembe, M. P., Lee, W. S., & McCulloch, C. A. (2016) · The FASEB Journal · doi:10.1096/fj.201600354rr · Cited by 22
Dynamic Heterogeneities of Rod Rotation in Macromolecular Networks
Zhang, X., Dai, X., Wei, W., Chen, W., Gao, L., & Yan, L. (2023) · Macromolecules · doi:10.1021/acs.macromol.3c01158 · Cited by 21
Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star
Wu, Y., Yang, Y., Lin, Y., Ding, Y., Liu, Z., Xiang, L. F., Picardo, M., & Zhang, C. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.02.007 · Cited by 22
Biomaterials‐Boosted Immunotherapy for Osteosarcoma
Sun, C., Li, S., & Ding, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400864 · Cited by 25
Focus on Pancreatic Cancer Microenvironment
Pratticò, F., & Garajová, I. (2024) · Current Oncology · doi:10.3390/curroncol31080316 · Cited by 21
Mei, X., Yang, Z., Wang, X., Shi, A., Blanchard, J., Elahi, F. M., Kang, H., Orive, G., & Zhang, Y. S. (2025) · Lab on a Chip · doi:10.1039/d4lc00280f · Cited by 24
3D Bioprinting Models for Glioblastoma: From Scaffold Design to Therapeutic Application
Branco, F., Cunha, J., Mendes, M., Sousa, J., & Vitorino, C. (2025) · Advanced Materials · doi:10.1002/adma.202501994 · Cited by 24
Defining the extracellular matrix for targeted immunotherapy in adult and pediatric brain cancer
Day, Z. I., Roberts-Thomson, S. J., Nouri, Y., Dalton, N. S., Wang, S. S., Davenport, A. J., Ludlow, L. E. A., Hulett, M. D., Cross, R. S., & Jenkins, M. R. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00956-z · Cited by 28
Smith, M. M., & Melrose, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189182 · Cited by 21
Manou, D., Bouris, P., Kletsas, D., Götte, M., Greve, B., Moustakas, A., Karamanos, N. K., & Theocharis, A. D. (2020) · Matrix Biology Plus · doi:10.1016/j.mbplus.2020.100033 · Cited by 23
Self-citationEccrine Sweat Gland and Its Regeneration: Current Status and Future Directions
Lin, Y., Chen, L., Zhang, M., Xie, S., Du, L., Zhang, X., & Li, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.667765 · Cited by 23
Qiu, Z., Zhao, J., Huang, F., Bao, L., Chen, Y., Yang, K., Cui, W., & Jin, W. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00154-y · Cited by 21
Hyperelastic material properties of axonal fibers in brain white matter
Chavoshnejad, P., German, G. K., & Razavi, M. J. (2021) · Brain Multiphysics · doi:10.1016/j.brain.2021.100035 · Cited by 21
LncRNA miR205HG hinders HNRNPA0 translation: anti‐oncogenic effects in esophageal carcinoma
Dong, X., Chen, X., Lu, D., Diao, D., Liu, X., Mai, S., Feng, S., & Xiong, G. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13142 · Cited by 21
Snail mucin is a functional food ingredient for skin
Kim, Y., Sim, W., Lee, J.-S., & Lim, T. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105053 · Cited by 23
Liu, R., Dai, M., Gong, G., Chen, M., Cao, C., Wang, T., Hou, Z., Shi, Y., Guo, J., Zhang, Y., et al. (2022) · Journal of Leather Science and Engineering · doi:10.1186/s42825-022-00087-2 · Cited by 22
The Biology of Extracellular Matrix Proteins in Hypertrophic Scarring
Eremenko, E. E., Ding, J., Kwan, P. O., & Tredget, E. E. (2021) · Advances in Wound Care · doi:10.1089/wound.2020.1257 · Cited by 23
Prosthetic heart valves for transcatheter aortic valve replacement
Hu, X., Li, S., Peng, P., Wang, B., Liu, W., Dong, X., Yang, X., Karabaliev, M., Yu, Q., & Gao, C. (2023) · BMEMat · doi:10.1002/bmm2.12026 · Cited by 21
Batsalova, T., & Dzhambazov, B. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129884 · Cited by 22
Fu, Q., le Zhang, K., Fang, Z. W., Yang, M., Liu, M., Yang, R., Wang, Y., Yang, X. R., & Wang, Y. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061700 · Cited by 22
Han, D., Xu, K., Jin, Z., Xu, Y., Li, Y., Wang, L., Cao, Q., Kim, K.-P., Ryu, D. H., Hong, K., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85145 · Cited by 21
A New Player in the Mechanobiology of Deep Fascia: Yes-Associated Protein (YAP)
Pirri, C., Caroccia, B., Angelini, A., Piazza, M., Petrelli, L., Caputo, I., Montemurro, C., Ruggieri, P., De, R., & Stecco, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015389 · Cited by 23
Progress in Biomarkers Related to Biliary Atresia
Kong, F., Dong, R., Chen, G., Sun, S., Yang, Y., Jiang, J., Meng, L., Chen, H., Zhu, J., & Zheng, S. (2024) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2023.00260 · Cited by 23
Single-cell RNA sequencing of mid-to-late stage spider embryos: new insights into spider development
Jiménez, B. I. M., Budd, G. E., & Janßen, R. (2024) · BMC Genomics · doi:10.1186/s12864-023-09898-x · Cited by 21
Injectable extracellular matrix-mimetic hydrogel based on electrospun Janus fibers
Zhang, J.-Z., Zha, X., Liu, G., Zhao, H., Liu, X., & Zha, L. (2024) · Materials Horizons · doi:10.1039/d3mh01789c · Cited by 21
Bai, J., Zhao, Y., Shi, K., Fan, Y., Ha, Y., Chen, Y., Luo, B., Lu, Y., Jie, W., & Shen, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05218-3 · Cited by 21
Enzyme Development for Human Islet Isolation: Five Decades of Progress or Stagnation?
Brandhorst, D., Brandhorst, H., & Johnson, P. (2017) · The Review of Diabetic Studies · doi:10.1900/rds.2017.14.22 · Cited by 23
Zhou, J., Ying, H., Wang, M., Su, D., Lu, G., & Chen, J. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.06.072 · Cited by 21
Jobichen, C., Tan, Y. C., Prabhakar, M. T., Nayak, D., Biswas, D., Pannu, N. S., Hanski, E., & Sivaraman, J. (2018) · Biochemical Journal · doi:10.1042/bcj20180145 · Cited by 20
Tan, F., & Al‐Rubeai, M. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00247 · Cited by 21
Scrimgeour, N. R., Wróbel, A., Pinho, M. J., & Høydal, M. A. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00204.2019 · Cited by 21
Zareei, A., Jiang, H., Chittiboyina, S., Zhou, J., Marin, B. P., Lelièvre, S. A., & Rahimi, R. (2020) · Lab on a Chip · doi:10.1039/c9lc00926d · Cited by 21
Secreted protein acidic and rich in cysteine and cancer: A homeostatic hormone?
Ghanemi, A., Yoshioka, M., & St‐Amand, J. (2020) · Cytokine · doi:10.1016/j.cyto.2020.154996 · Cited by 21
Qi, X., Zhong, X., Xu, S., Zeng, B., Chen, J., Zang, G., Zeng, L., Bai, S., Zhou, C., Wei, H., et al. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00520 · Cited by 21
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice
Yu, Y., Liu, X., Zhao, Z., Xu, Z., Qiao, Y., Zhou, Y., Qiao, H., Zhong, J., Dai, J., & Suo, G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.747223 · Cited by 22
Wu, D., Lei, H., Xie, X. Y., Zhou, L., Zheng, P., Cao, Y., & Zhang, Y. (2022) · Nano Research · doi:10.1007/s12274-022-4089-9 · Cited by 21
Cancer cell resistance to anoikis: MUC1 glycosylation comes to play
Yu, L. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.363 · Cited by 21
Zhang, J., Yun, S., Bi, J., Dai, S., Du, Y., Zannettino, A. C. W., & Zhang, H. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00376a · Cited by 21
Matrix-bound nanovesicles alleviate particulate-induced periprosthetic osteolysis
Liao, R., Dewey, M. J., Rong, J., Johnson, S. A., D’Angelo, W. A., Hussey, G. S., & Badylak, S. F. (2024) · Science Advances · doi:10.1126/sciadv.adn1852 · Cited by 20
Ferchichi, E., Stealey, S. T., Bogert, P., & Zustiak, S. P. (2024) · Frontiers in Biomaterials Science · doi:10.3389/fbiom.2024.1408748 · Cited by 22
Alzahrani, A. R., Mohamed, D. I., Nahas, H. H. A., El-Waseef, D. A. E.-D. A., Altamimi, A. S. A., Youssef, I. H., Ibrahim, I. A. A., Mohamed, S. M. Y., Sabry, Y. G., Falemban, A. H., et al. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s463626 · Cited by 20
Jeon, M. J., Randhawa, A., Kim, H., Dutta, S. D., Ganguly, K., Patil, T. V., Lee, J., Acharya, R., Park, H., Seol, Y., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403983 · Cited by 20
Zhang, A., Li, Q., & Chen, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010225 · Cited by 21
Ai, Y., Hu, C., Wang, Y., Liu, Y., Liu, R., Xu, H., Li, H., Zhao, Y., Wang, Y., Ning, R., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160861 · Cited by 20
Targeting tumor extracellular matrix with nanoparticles to circumvent therapeutic resistance
Ding, X., Liang, Y., Zhou, S., Wu, Y., Sałata, P., Mikolajczk-Martinez, A., Khosrawipour, V., & Zhang, Z. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113786 · Cited by 20
Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment
Aakel, N., Mohammed, R., Fathima, A., Kerzabi, R. I., Abdallah, A. M., & Ibrahim, W. N. (2025) · Cancer Medicine · doi:10.1002/cam4.70941 · Cited by 20
Huang, J., Sun, L., Yin, Y., Yang, H., Zeng, K., Huang, P., Liang, X., Wu, J., Xiang, A. P., & Wang, J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116207 · Cited by 20
Zhao, Z., Dong, P., Wang, H., Su, J., Yu, M., Shi, H., Gao, T., Zhang, Q., Chen, W., Yang, J., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s538490 · Cited by 24
Immune checkpoint blockade in cancer: current insights and future horizons
Saman, H. T., Makni‐Maalej, K., El-Ella, D. M. A., Al-Tamimi, M. Y., AbuHaweeleh, M. N., Abuhayeh, N., Ismail, M. A., Prabhu, K. S., Fernandes, Q., Jabi, T., et al. (2026) · Discover Oncology · doi:10.1007/s12672-025-04361-7 · Cited by 20
Maminskas, J., Pilipavičius, J., Staisiunas, E., Baranovas, G., Alksnė, M., Daugėla, P., & Juodžbalys, G. (2020) · Materials · doi:10.3390/ma13092070 · Cited by 20
Zhang, X., Liu, Y., Clark, K. L., Padget, A.-M., Alexander, P. G., Dai, J., Zhu, W., & Lin, H. (2020) · Biomedical Materials · doi:10.1088/1748-605x/abb6b3 · Cited by 21
THE COSMETIC EFFECTS OF VARIOUS NATURAL BIOFUNCTIONAL INGREDIENTS AGAINST SKIN AGING: A REVIEW
Naser, W. (2021) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2021v13i1.39806 · Cited by 22
Zhang, H., Shi, Q., Yang, Z., Wang, K., Zhang, Z., Huang, Z. Y. X., Cui, X., & Li, F. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.598427 · Cited by 20
Ghasemi, H., Mousavi‐Bahar, S. H., Hashemnia, M., Karimi, J., Khodadadi, I., & Tavilani, H. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06440-8 · Cited by 20
Hyaluronan: A Neuroimmune Modulator in the Microbiota-Gut Axis
Bosi, A., Banfi, D., Bistoletti, M., Moretto, P., Moro, E., Crema, F., Maggi, F., Karousou, E. G., Viola, M., Passi, A. G., et al. (2021) · Cells · doi:10.3390/cells11010126 · Cited by 19
Constitutive modelling of fibre networks with stretch distributions. Part I: Theory and illustration
Britt, B. R., & Ehret, A. E. (2022) · Journal of the Mechanics and Physics of Solids · doi:10.1016/j.jmps.2022.104960 · Cited by 20
Natural/Synthetic Polymer Materials for Bioink Development
Moon, S. H., Choi, H. N., & Yang, Y. J. (2022) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-021-0418-1 · Cited by 20
The PDGF Family Is Associated with Activated Tumor Stroma and Poor Prognosis in Ovarian Cancer
Li, J., Zhi, X., Sun, Y., Chen, M., & Yao, L. (2022) · Disease Markers · doi:10.1155/2022/5940049 · Cited by 20
Okawa, M., Tanabe, A., Ohta, S., Nagatoishi, S., Tsumoto, K., & Ito, T. (2022) · Communications Materials · doi:10.1038/s43246-022-00309-4 · Cited by 22
Molecular mechanism and potential therapeutic targets of liver metastasis from gastric cancer
Li, D., Zhang, X., & Jiang, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1000807 · Cited by 20
Macrophage response mediated by extracellular matrix: recent progress
Xiao, W., Yang, Y., Chu, C., Rung, S., Wang, Z., Man, Y., Lin, J., & Qu, Y. (2022) · Biomedical Materials · doi:10.1088/1748-605x/aca946 · Cited by 21
Elastin-like Recombinamer Hydrogels as Platforms for Breast Cancer Modeling
Blanco‐Fernandez, B., Ibáñez‐Fonseca, A., Orbanić, D., Ximenes-Carballo, C., Pérez‐Amodio, S., Rodríguez‐Cabello, J. C., & Engel, E. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.2c01080 · Cited by 22
Aa, I., Kuznetsova, A. V., Попова, О. П., Danilova, T. I., Latyshev, A. V., & Yanushevich, O. O. (2023) · Cells · doi:10.3390/cells12192335 · Cited by 21
Ge, Y., Wang, Z., Chen, X., Wang, W., Liu, Z., Sun, H., & Zhang, L. (2023) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5774 · Cited by 20
MicroRNA in Fibrotic Disorders: A Potential Target for Future Therapeutics
Mehjabin, A., Kabir, M., Micolucci, L., Akhtar, M. M., Mollah, A. K. M. M., & Islam, M. S. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2811317 · Cited by 20
Physical cues of scaffolds promote peripheral nerve regeneration
Cao, W., Zhang, Y., Li, L., Liu, B., Ding, J., & Chen, X. (2024) · Applied Physics Reviews · doi:10.1063/5.0189181 · Cited by 20
Yang, Q., Yan, C., Sun, Y., Xie, Z., Yang, L., Jiang, M., Ni, J., Chen, B., Xu, S., Yuan, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202400480 · Cited by 22
Metadata
- Authors
- Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K.
- Affiliations
- University of Patras (GR)
- Corresponding author
- Karamanos, Nikos K.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 97
- Pages
- 4-27
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2187985754
- Cited by
- 2,598
- References
- 389
- Citations by year
- 2026: 270 · 2025: 343 · 2024: 332 · 2023: 332 · 2022: 319 · 2021: 315 · 2020: 269 · 2019: 167 · 2018: 120 · 2017: 88 · 2016: 39
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- European Union
- Greek National Funds through the Operational Program “Education and Lifelong Learning” of the National Strategic Reference Framework (NSRF) Research Funding Program: Thales
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- extracellular matrix, collagen, proteoglycans, glycosaminoglycans, elastin, fibronectin, laminin, cell adhesion receptors, extracellular matrix remodeling, matrix-degrading enzymes
- MeSH terms
- Animals, Extracellular Matrix, Humans, Receptors, Cell Surface, Extracellular Matrix Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review