Cited by 2,598Cellular Mechanics and InteractionsProteoglycans and glycosaminoglycans researchCell Adhesion Molecules Research

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Extracellular matrix structure

Theocharis, Achilleas D., Skandalis, Spyros S., Gialeli, Chrysostomi, Karamanos, Nikos K.·2016·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2015.11.001

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Abstract

Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and several other glycoproteins. Matrix components bind each other as well as cell adhesion receptors forming a complex network into which cells reside in all tissues and organs. Cell surface receptors transduce signals into cells from ECM, which regulate diverse cellular functions, such as survival, growth, migration, and differentiation, and are vital for maintaining normal homeostasis. ECM is a highly dynamic structural network that continuously undergoes remodeling mediated by several matrix-degrading enzymes during normal and pathological conditions. Deregulation of ECM composition and structure is associated with the development and progression of several pathologic conditions. This article emphasizes in the complex ECM structure as to provide a better understanding of its dynamic structural and functional multipotency. Where relevant, the implication of the various families of ECM macromolecules in health and disease is also presented.

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Authors: Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K.
Affiliations: University of Patras (GR)
Corresponding author: Karamanos, Nikos K.
ORCID: Theocharis, Achilleas D.
Skandalis, Spyros S.
Gialeli, Chrysostomi
Karamanos, Nikos K.
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2016-02
Volume: 97
Pages: 4-27
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2015.11.001
OpenAlex: W2187985754
Cited by: 2,598
References: 389
Citations by year: 2026: 270 · 2025: 343 · 2024: 332 · 2023: 332 · 2022: 319 · 2021: 315 · 2020: 269 · 2019: 167 · 2018: 120 · 2017: 88 · 2016: 39
FWCI: 8.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: European Union
Greek National Funds through the Operational Program “Education and Lifelong Learning” of the National Strategic Reference Framework (NSRF) Research Funding Program: Thales
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: extracellular matrix, collagen, proteoglycans, glycosaminoglycans, elastin, fibronectin, laminin, cell adhesion receptors, extracellular matrix remodeling, matrix-degrading enzymes
MeSH terms: Animals, Extracellular Matrix, Humans, Receptors, Cell Surface, Extracellular Matrix Proteins

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