The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The role of mucus on drug transport and its potential to affect therapeutic outcomes
Open accessAbstract
Abstract A layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell debris. This complex composition yields a tenacious viscoelastic hydrogel that lubricates and protects the exposed epithelia from external threats and enzymatic degradation. The natural protective role of mucus is nowadays acknowledged as a major barrier to be overcome in non‐invasive drug delivery. The heterogeneity of mucus components offers a wide range of potential chemical interaction sites for macromolecules, while the mesh‐like architecture given to mucus by the intermolecular cross‐linking of mucin molecules results in a dense network that physically, and in a size‐dependent manner, hinders the diffusion of nanoparticles through mucus. Consequently, drug diffusion, epithelial absorption, drug bioavailability, and ultimately therapeutic outcomes of mucosal drug delivery can be attenuated. Graphical abstract Figure. No Caption available.
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Cites
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Mucus clearance as a primary innate defense mechanism for mammalian airways
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Cited by
Recent progress of micro/nanomotors to overcome physiological barriers in the gastrointestinal tract
Zhang, S., Zhu, C., Huang, W., Liu, H., Yang, M., Zeng, X., Zhang, Z., Liu, J., Shi, J., Hu, Y., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.07.005 · Cited by 59
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Metadata
- Authors
- Murgia, X., Loretz, B., Hartwig, O., Hittinger, M., & Lehr, C.-M.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 124
- Pages
- 82-97
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2765425655
- Cited by
- 324
- References
- 11
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
