X-ray-activated persistent luminescence nanomaterials for NIR-II imaging
Open accessAbstract
Persistent luminescence is not affected by background autofluorescence, and thus holds the promise of high-contrast bioimaging. However, at present, persistent luminescent materials for in vivo imaging are mainly bulk crystals characterized by a non-uniform size and morphology, inaccessible core-shell structures and short emission wavelengths. Here we report a series of X-ray-activated, lanthanide-doped nanoparticles with an extended emission lifetime in the second near-infrared window (NIR-II, 1,000-1,700 nm). Core-shell engineering enables a tunable NIR-II persistent luminescence, which outperforms NIR-II fluorescence in signal-to-noise ratios and the accuracy of in vivo multiplexed encoding and multilevel encryption, as well as in resolving mouse abdominal vessels, tumours and ureters in deep tissue (~2-4 mm), with up to fourfold higher signal-to-noise ratios and a threefold greater sharpness. These rationally designed nanoparticles also allow the high-contrast multiplexed imaging of viscera and multimodal NIR-II persistent luminescence-magnetic resonance-positron emission tomography imaging of murine tumours.
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- Authors
- Pei, P., Chen, Y., Sun, C., Fan, Y., Yang, Y., Liu, X., Lu, L., Zhao, M., Zhang, H., Zhao, D., Liu, X., & Zhang, F.
- Affiliations
- Fudan University (CN)
- Hebei University (CN)
- Tianjin University (CN)
- Corresponding author
- Fan, Yong
- Yang, Yanmin
- Zhang, Fan
- ORCID
- Venue
- Nature Nanotechnology
- Published
- 2021-06-10
- Volume
- 16
- Issue
- 9
- Pages
- 1011-1018
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W3172984574
- Cited by
- 718
- References
- 53
- Citations by year
- 2026: 72 · 2025: 166 · 2024: 167 · 2023: 151 · 2022: 132 · 2021: 28
- FWCI
- 36.32
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nature Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion, other-oa)
- Funders
- National Natural Science Foundation of China (21904023, 11974097, 22088101, 21725502, 51961145403)
- Science and Technology Commission of Shanghai Municipality (19490713100, 20490710600)
- Chinese Ministry of Science and Technology | Department of S and T for Social Development (2017YFA0207303)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Detection and Scintillator Technologies
- Keywords
- persistent luminescence, NIR-II imaging, X-ray excitation, lanthanide-doped nanoparticles, core-shell nanoparticles, deep tissue imaging, in vivo imaging, multiplexed imaging, multimodal imaging, magnetic resonance imaging, positron emission tomography, tumor imaging
- MeSH terms
- Animals, X-Rays, Lanthanoid Series Elements, Nanostructures, Luminescence, Mice, Nanoparticles, Optical Imaging, Multimodal Imaging
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