Cited by 70Psoriasis: Treatment and PathogenesisDermatology and Skin DiseasesTryptophan and brain disorders

Psoriasis and Depression: The Role of Inflammation

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González-Parra, S., Daudén, E.·2019·Actas Dermo-Sifiliográficas (English Edition)

Abstract

Psoriasis is a chronic, systemic inflammatory disorder with multiple comorbidities. The most common comorbidities are mental disorders, especially depression, which can interact negatively with psoriasis to produce a dangerous vicious circle. Depression in psoriasis has traditionally been explained as a response to psychosocial factors and impaired quality of life. However, a new hypothesis linking depression and psoriasis through chronic inflammation offers insights that should help us to understand and treat these diseases. In this approach, new drugs and lifestyle have an important role.

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Crossref · 10.1016/j.adengl.2018.05.035

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  • Individuals affected with autoimmune disorders are more likely to display comorbid depressive symptomatology.

    “Accordingly, it has been well documented that individual affected with autoimmune disorders (e.g., rheumatoid arthritis, psoriasis, diabetes mellitus, chronic inflammatory bowel disease, and autoimmune thyroiditis) are more likely to display comorbid depressive symptomatology [17,18,19,20,21,22,23].”

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Research works printed but not linked: 3

  1. Cannon TD, Gasperoni TL, van Erp TG, Rosso IM. Quantitative neural indicators of liability to schizophrenia: Implications for molecular genetic studies. Am J Med Genet. 2001;105:16---9.
  2. Nasrallah HA. 10 triggers of inflammation to be avoided, to reduce the risk of depression. Curr Psychiatry. 2015;14:6---715.
  3. Krishnadas R, Cavanagh J. Depression: An inflammatory illness? J Neurol Neurosurg Psychiatry. 2012;83:495---502.

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Authors
González-Parra, S., & Daudén, E.
Affiliations
Hospital Universitario de La Princesa (ES)
Venue
Actas Dermo-Sifiliográficas (English Edition)
Publisher
Elsevier BV
Published
2019-01
Volume
110
Issue
1
Pages
12-19
ISSN
  • 0001-7310 (ISSN-L)
  • 1578-2190
OpenAlex
W2905688756
Cited by
70
References
81
Citations by year
2026: 2 · 2025: 9 · 2024: 7 · 2023: 16 · 2022: 17 · 2021: 12 · 2020: 5 · 2019: 2
FWCI
2.05
Type
journal article
Language
en
Open access
Locations
Actas Dermo-Sifiliográficas (publishedVersion, cc-by-nc-nd)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
psoriasis, depression, chronic inflammation, comorbidities, psychosocial factors, quality of life, inflammatory hypothesis, treatment

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