Psoriasis and Depression: The Role of Inflammation
Open accessAbstract
Psoriasis is a chronic, systemic inflammatory disorder with multiple comorbidities. The most common comorbidities are mental disorders, especially depression, which can interact negatively with psoriasis to produce a dangerous vicious circle. Depression in psoriasis has traditionally been explained as a response to psychosocial factors and impaired quality of life. However, a new hypothesis linking depression and psoriasis through chronic inflammation offers insights that should help us to understand and treat these diseases. In this approach, new drugs and lifestyle have an important role.
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Individuals affected with autoimmune disorders are more likely to display comorbid depressive symptomatology.
“Accordingly, it has been well documented that individual affected with autoimmune disorders (e.g., rheumatoid arthritis, psoriasis, diabetes mellitus, chronic inflammatory bowel disease, and autoimmune thyroiditis) are more likely to display comorbid depressive symptomatology [17,18,19,20,21,22,23].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [18]
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Challenges and Opportunities in Psoriatic Disease: An Integrated View of the Future
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ĐẶC ĐIỂM LÂM SÀNG RỐI LOẠN TRẦM CẢM Ở NGƯỜI BỆNH VẢY NẾN ĐIỀU TRỊ TẠI BỆNH VIỆN DA LIỄU TRUNG ƯƠNG
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Guía Esencial de Medicina Interna en el Primer Nivel de Atención Tomo 3
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Psoriasis and Comorbidities: What and How Much Do We Know?
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López‐Ferrer, A., González‐Cantero, Á., Gutiérrez-Casbas, A., Martorell, A., Olveira, A., Álvarez, M. B. M., Nicolau, J., Carrascosa, J. M., Baniandrés, O., Rivera, R., et al. (2026) · Dermatology and Therapy · doi:10.1007/s13555-026-01759-1
- Authors
- González-Parra, S., & Daudén, E.
- Affiliations
- Hospital Universitario de La Princesa (ES)
- ORCID
- Daudén, E.
- Venue
- Actas Dermo-Sifiliográficas (English Edition)
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 110
- Issue
- 1
- Pages
- 12-19
- ISSN
- 0001-7310 (ISSN-L)
- 1578-2190
- OpenAlex
- W2905688756
- Cited by
- 70
- References
- 81
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 7 · 2023: 16 · 2022: 17 · 2021: 12 · 2020: 5 · 2019: 2
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Actas Dermo-Sifiliográficas (publishedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- psoriasis, depression, chronic inflammation, comorbidities, psychosocial factors, quality of life, inflammatory hypothesis, treatment
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