A Test in Context
Open accessAbstract
The inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) adds prognostic information on cardiovascular risk comparable to blood pressure or cholesterol. Values <1, 1 to 3, and >3 mg/l indicate lower, average, or higher relative cardiovascular risk, respectively. Global risk algorithms that include hsCRP outperform those solely using Framingham covariates. Although diet, exercise, and smoking cessation are first steps for patients with a proinflammatory response, JUPITER (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) trial data demonstrate that statins reduce by 47% the rate of first myocardial infarction, stroke, or confirmed cardiovascular death when given to patients with low-density lipoprotein-C levels of <130 mg/dl and hsCRP of >2 mg/l (hazard ratio: 0.53; 95% confidence interval: 0.40 to 0.69; p < 0.00001). In current U.S. guidelines, hsCRP carries a class IIb assessment and is most appropriate in primary prevention when clinical decisions to initiate statin therapy are uncertain. Ongoing multinational trials are pursuing whether reducing inflammation will decrease vascular event rates.
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These hsCRP categories are also used to predict CV outcomes.
“These hsCRP categories are also used to predict CV outcomes [8].”
From Impact of semaglutide on high-sensitivity C-reactive protein: exploratory patient-level analyses of SUSTAIN and PIONEER randomized clinical trials (2022) · cites this paper as [8]
High-sensitivity C-reactive protein predicts cardiovascular events in men and women.
“the inflammatory biomarker high-sensitivity C-reactive protein (CRP) is a predictor of cardiovascular events in men and women40.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [40]
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- Authors
- Ridker, P. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Ridker, Paul M
- ORCID
- Ridker, Paul M
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 67
- Issue
- 6
- Pages
- 712-723
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2264523161
- Cited by
- 414
- References
- 64
- Citations by year
- 2026: 54 · 2025: 51 · 2024: 45 · 2023: 47 · 2022: 35 · 2021: 35 · 2020: 48 · 2019: 34 · 2018: 30 · 2017: 19 · 2016: 16
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- AstraZeneca
- American College of Cardiology Foundation
- National Heart, Lung, and Blood Institute (U01HL101422)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Keywords
- high-sensitivity C-reactive protein, inflammation, cardiovascular risk, cardiovascular risk prediction, statins, rosuvastatin, JUPITER trial, primary prevention, Framingham risk factors, LDL cholesterol, myocardial infarction, stroke, cardiovascular mortality
- MeSH terms
- C-Reactive Protein, Cardiovascular Diseases, Humans, Predictive Value of Tests, Global Health, Reproducibility of Results, Biomarkers, Incidence, Survival Rate, Risk Assessment
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