Medication adherence: a call for action
Open accessAbstract
Poor adherence to efficacious cardiovascular-related medications has led to considerable morbidity, mortality, and avoidable health care costs. This article provides results of a recent think-tank meeting in which various stakeholder groups representing key experts from consumers, community health providers, the academic community, decision-making government officials (Food and Drug Administration, National Institutes of Health, etc), and industry scientists met to evaluate the current status of medication adherence and provide recommendations for improving outcomes. Below, we review the magnitude of the problem of medication adherence, prevalence, impact, and cost. We then summarize proven effective approaches and conclude with a discussion of recommendations to address this growing and significant public health issue of medication nonadherence.
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Adherence is better in patients recruited to clinical trials compared with those treated in the real world.
“Adherence is better in patients recruited to clinical trials compared with those treated in the real world.455,456”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [455]
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- Authors
- Bosworth, H. B., Granger, B. B., Mendys, P., Brindis, R., Burkholder, R., Czajkowski, S. M., Daniel, J. G., Ekman, I., Ho, M., Johnson, M., Kimmel, S. E., Liu, L. Z., Musaus, J., Shrank, W. H., Buono, E. W., Weiss, K., & Granger, C. B.
- Affiliations
- Duke University (US)
- University of North Carolina at Chapel Hill (US)
- American College of Cardiology (US)
- National Consumers League (US)
- National Institutes of Health (US)
- United States Department of Health and Human Services (US)
- University of Gothenburg (SE)
- University of Pennsylvania (US)
- Pfizer (United States) (US)
- Brigham and Women's Hospital (US)
- United States Food and Drug Administration (US)
- Corresponding author
- Bosworth, Hayden B.
- ORCID
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 162
- Issue
- 3
- Pages
- 412-424
- ISSN
- 0002-8703 (ISSN-L)
- PMC
- PMC3947508
- OpenAlex
- W2072773013
- Cited by
- 448
- References
- 83
- Citations by year
- 2026: 20 · 2025: 30 · 2024: 21 · 2023: 18 · 2022: 30 · 2021: 35 · 2020: 25 · 2019: 41 · 2018: 40 · 2017: 46 · 2016: 36 · 2015: 30 · 2014: 29 · 2013: 26 · 2012: 19
- FWCI
- 21.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- VA HSRD (RCS 08-027)
- American Heart Association
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Keywords
- medication adherence, medication non-adherence, cardiovascular drugs, health care costs, morbidity and mortality, stakeholder recommendations, public health policy, community health providers
- MeSH terms
- Cardiovascular Agents, Cardiovascular Diseases, Community Health Services, Community Pharmacy Services, Fees, Pharmaceutical, Humans, Morbidity, United States, Survival Rate, Drug Costs, Drug Monitoring
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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