Argon Laser Photocoagulation for Senile Macular Degeneration: Results of a Randomized Clinical Trial
Abstract
The Senile Macular Degeneration Study (SMDS) is a multicenter controlled clinical trial designed to answer the question, "Is argon laser photocoagulation useful in preventing severe visual loss in eyes with evidence of senile macular degeneration and a choroidal neovascular membrane outside the fovea?" Eligible patients were assigned randomly to a "treatment" group or a "no treatment" group. Recruitment in the SMDS has been terminated because, after 18 months of follow-up, 60% of untreated eyes v 25% of treated eyes had experienced severe visual loss. Follow-up of all patients continues to assess long-term results of treatment. Patients with senile macular degeneration who are at risk for the development of choroidal neovascularization should be examined periodically so that if symptomatic neovascularization develops, treatment can be considered before irreversible visual loss occurs.
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The Macular Photocoagulation Study showed a reduction in vision loss associated with thermal laser photocoagulation, provided the neovascular lesion had well-demarcated (classic) boundaries.
“In the 1980s, the Macular Photo-coagulation Study159,160 showed a reduction in vision loss associated with thermal laser photocoagulation, provided the neovascular lesion had well-demarcated (classic) boundaries.”
From Age-related macular degeneration (2008) · cites this paper as [160]
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- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1982-06-01
- Volume
- 100
- Issue
- 6
- Pages
- 912
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W4243472760
- Cited by
- 405
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 13 · 2013: 5 · 2012: 13
- FWCI
- 25.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- argon laser photocoagulation, senile macular degeneration, choroidal neovascularization, blindness prevention
- MeSH terms
- Aged, Clinical Trials as Topic, Fluorescein Angiography, Follow-Up Studies, Humans, Lasers, Macular Degeneration, Middle Aged, Random Allocation, Vision Disorders, Laser Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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