CoChat
Sign Up
Cited by 127Antifungal resistance and susceptibilityReproductive tract infections researchUrinary Tract Infections Management

The DOI matches its Crossref record; 13 of the 14 references it cites were found in a registry or an index.

Individualized decreasing-dose maintenance fluconazole regimen for recurrent vulvovaginal candidiasis (ReCiDiF trial)

Donders, Gilbert, Bellen, Gert, Byttebier, Geert, Verguts, Luc, Hinoul, Piet, Walckiers, Ronald, Stalpaert, Michel, Vereecken, Annie, Van Eldere, Johan·2008·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2008.06.029
Open this paper in CoChat — free account

Abstract

Objective Although many women with recurrent vulvovaginal candidiasis initially benefit from prophylactic intermittent treatment with antimycotics, most of them experience relapse after cessation of therapy, and often they return to the pretreatment recurrence rate. The purpose of this study was to demonstrate the efficacy and safety of an individualized, degressive, prophylactic regimen in 136 women with recurrent vulvovaginal candidiasis.Study design After an induction dose of 600 mg fluconazole during the first week, 117 women started maintenance therapy: 200 mg fluconazole weekly for 2 months, followed by 200 mg biweekly for 4 months, and 200 mg monthly for 6 months, according to their individual response to therapy. All women were tested for recurrences monthly with wet mount microscopy and vaginal culture during the first 6 months and bimonthly during the next 6 months. Patients were allowed to move on to the next level of maintenance therapy only if they were symptom free and microscopy and culture negative.Results Of the women who were cured successfully after the induction phase, 101 women (90%) were disease-free after 6 months of maintenance therapy with this degressive regimen, and 80 women (77%) were disease-free after 1 year. The weekly incidence of the first clinical relapse was 0.5% during any period of the maintenance phase, and the rate of all new relapses, which included evidence of mycologic or microscopic colonization, was 1% per week. Women who experienced several relapses (poor responders) had experienced more relapses before entering the study compared with the optimal responders (odds ratio, 4.9; 95% CI,1.8-13.7; P = .002), experienced the disease for a longer period of time (6.5 vs 3.7 years; P = .06), and harbored significantly more Candida non-albicans during maintenance therapy (P = .001). No serious side-effects were noted.Conclusion Individualized, degressive, prophylactic maintenance therapy with oral fluconazole is an efficient treatment regimen to prevent clinical relapses in women with recurrent vulvovaginal candidiasis.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.ajog.2008.06.029

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 14 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Donders, G., Bellen, G., Byttebier, G., Verguts, L., Hinoul, P., Walckiers, R., Stalpaert, M., Vereecken, A., & Van Eldere, J.
Affiliations
  • Universitair Ziekenhuis Leuven (BE)
  • Ziekenhuis Oost-Limburg (BE)
Corresponding author
Donders, Gilbert
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2008-12
Volume
199
Issue
6
Pages
613.e1-613.e9
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2008.06.029
OpenAlex
W2099216984
Cited by
127
References
14
Citations by year
2026: 2 · 2025: 7 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 12 · 2016: 7 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 5
FWCI
3.20
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Urology › Urinary Tract Infections Management
Keywords
recurrent vulvovaginal candidiasis, fluconazole, maintenance therapy, prophylaxis, individualized dosing, relapse prevention, non-albicans Candida, treatment response
MeSH terms
Administration, Oral, Adolescent, Adult, Antifungal Agents, Candidiasis, Vulvovaginal, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Middle Aged, Probability, Prospective Studies, Severity of Illness Index, Time Factors, Fluconazole, Treatment Outcome, Patient Satisfaction, Risk Assessment, Kaplan-Meier Estimate, Secondary Prevention, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review