The coronavirus disease 2019 vaccine in pregnancy: risks, benefits, and recommendations
Open accessAbstract
The coronavirus disease 2019 has caused over 2 million deaths worldwide, with over 412,000 deaths reported in Unites States. To date, at least 57,786 pregnant women in the United States have been infected, and 71 pregnant women have died. Although pregnant women are at higher risk of severe coronavirus disease 2019-related illness, clinical trials for the available vaccines excluded pregnant and lactating women. The safety and efficacy of the vaccines for pregnant women, the fetus, and the newborn remain unknown. A review of maternal and neonatal coronavirus disease 2019 morbidity and mortality data along with perinatal vaccine safety considerations are presented to assist providers with shared decision-making regarding vaccine administration for this group, including the healthcare worker who is pregnant, lactating, or considering pregnancy. The coronavirus disease 2019 vaccine should be offered to pregnant women after discussing the lack of safety data, with preferential administration for those at highest risk of severe infection, until safety and efficacy of these novel vaccines are validated.
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Both EUA-approved COVID-19 vaccines (Pfizer/BioNTech and Moderna) use mRNA to deliver the SARS-CoV-2 Spike antigen to the immune system.
“both of which utilize mRNA to deliver SARS-CoV-2 Spike to educate the immune system 10,11”
From Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study (2021) · cites this paper as [10]
mRNA COVID-19 vaccines have shown highly effective immune induction in nonpregnant adults.
“While mRNA vaccines have shown highly effective immune induction in non-pregnant adults, the immunogenicity and reactogenicity of this platform in pregnancy remains unclear.”
From Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study (2021) · cites this paper as [10]
The V2 timepoint reflects full antibody complement, achieved one week after Pfizer/BioNTech and two weeks after Moderna/NIH vaccination.
“The V2 timepoint reflects full antibody complement, achieved one week after Pfizer/BioNTech and two weeks after Moderna/NIH 10,11 .”
From Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study (2021) · cites this paper as [10]
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PEMBERIAN VAKSINISASI COVID-19 BAGI IBU HAMIL PADA MASA PANDEMI
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- Authors
- Stafford, I. A., Parchem, J. G., & Sibai, B. M.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Stafford, Irene A.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 224
- Issue
- 5
- Pages
- 484-495
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC7847190
- OpenAlex
- W3129126018
- Cited by
- 89
- References
- 117
- Citations by year
- 2025: 1 · 2024: 10 · 2023: 9 · 2022: 34 · 2021: 34 · 2020: 1
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- COVID-19 vaccines, pregnancy, vaccine safety, neonatal outcomes, maternal morbidity and mortality, lactating women, shared decision-making, vaccine recommendations, SARS-CoV-2
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, Female, Humans, Pregnancy, Pregnancy Complications, Infectious, Vaccination, Infectious Disease Transmission, Vertical
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