Cited by 89COVID-19 Impact on ReproductionSARS-CoV-2 and COVID-19 ResearchVaccine Coverage and Hesitancy

The coronavirus disease 2019 vaccine in pregnancy: risks, benefits, and recommendations

Open access
Stafford, Irene A., Parchem, Jacqueline G., Sibai, Baha M.·2021·American Journal of Obstetrics and Gynecology

Abstract

The coronavirus disease 2019 has caused over 2 million deaths worldwide, with over 412,000 deaths reported in Unites States. To date, at least 57,786 pregnant women in the United States have been infected, and 71 pregnant women have died. Although pregnant women are at higher risk of severe coronavirus disease 2019-related illness, clinical trials for the available vaccines excluded pregnant and lactating women. The safety and efficacy of the vaccines for pregnant women, the fetus, and the newborn remain unknown. A review of maternal and neonatal coronavirus disease 2019 morbidity and mortality data along with perinatal vaccine safety considerations are presented to assist providers with shared decision-making regarding vaccine administration for this group, including the healthcare worker who is pregnant, lactating, or considering pregnancy. The coronavirus disease 2019 vaccine should be offered to pregnant women after discussing the lack of safety data, with preferential administration for those at highest risk of severe infection, until safety and efficacy of these novel vaccines are validated.

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Authors
Stafford, I. A., Parchem, J. G., & Sibai, B. M.
Affiliations
The University of Texas Health Science Center at Houston (US)
Corresponding author
Stafford, Irene A.
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2021-05
Volume
224
Issue
5
Pages
484-495
ISSN
0002-9378 (ISSN-L)
OpenAlex
W3129126018
Cited by
89
References
117
Citations by year
2025: 1 · 2024: 10 · 2023: 9 · 2022: 34 · 2021: 34 · 2020: 1
FWCI
4.00
Type
journal article
Language
en
Open access
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › COVID-19 Impact on Reproduction
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
Keywords
COVID-19 vaccines, pregnancy, vaccine safety, neonatal outcomes, maternal morbidity and mortality, lactating women, shared decision-making, vaccine recommendations, SARS-CoV-2
MeSH terms
COVID-19, SARS-CoV-2, COVID-19 Vaccines, Female, Humans, Pregnancy, Pregnancy Complications, Infectious, Vaccination, Infectious Disease Transmission, Vertical

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