Cited by 532Gut microbiota and healthInflammatory Bowel DiseaseTryptophan and brain disorders

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Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

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Alexeev, Erica E., Lanis, Jordi M., Kao, Daniel J., Campbell, Eric L., Kelly, Caleb J., Battista, Kayla D., Gerich, Mark E., Jenkins, Brittany R., Walk, Seth T., Kominsky, Douglas J., Colgan, Sean P.·2018·The American Journal of Pathology

DOI 10.1016/j.ajpath.2018.01.011PMC PMC5906738

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Abstract

Interactions between the gut microbiota and the host are important for health, where dysbiosis has emerged as a likely component of mucosal disease. The specific constituents of the microbiota that contribute to mucosal disease are not well defined. The authors sought to define microbial components that regulate homeostasis within the intestinal mucosa. Using an unbiased, metabolomic profiling approach, a selective depletion of indole and indole-derived metabolites was identified in murine and human colitis. Indole-3-propionic acid (IPA) was selectively diminished in circulating serum from human subjects with active colitis, and IPA served as a biomarker of disease remission. Administration of indole metabolites showed prominent induction of IL-10R1 on cultured intestinal epithelia that was explained by activation of the aryl hydrocarbon receptor. Colonization of germ-free mice with wild-type Escherichia coli, but not E. coli mutants unable to generate indole, induced colonic epithelial IL-10R1. Moreover, oral administration of IPA significantly ameliorated disease in a chemically induced murine colitis model. This work defines a novel role of indole metabolites in anti-inflammatory pathways mediated by epithelial IL-10 signaling and identifies possible avenues for utilizing indoles as novel therapeutics in mucosal disease.

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A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Ulcerative Colitis
Ford Alexander, C., Paul, M., Hanauer Steven, B., 谭蓓, & Dong, W. Z. (2001) · Cited by 3,021
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927

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“Additionally, the gut microbiota mediates the formation of indole derivatives from dietary tryptophan, among which indole- 3-acetic acid (IAA) and indole- 3-propionic acid (IPA) decrease in UC patients [21, 22].”
Intestinal taurine acts as a novel immunometabolic modulator of IBD by degrading redundant mitochondrial RNA
Wu, L.-X., Xie, J.-H., Li, J., Li, W., Mao, X.-T., Huang, L.-J., Chen, H., Zhong, J.-Y., Lin, L., Su, S., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01344-0 · Cited by 7
“Indole-3-propionic acid (IPA) has been shown to enhance gut barrier integrity and exert anti-in ﬂ ammatory effects through AhR activation [15 – 17].”
Citrus-Derived Exosome-like Nanoparticles Attenuate High-Fat Diet-Aggravated Colitis by Gut Microbiota-Metabolites Modulation
Zhan, M., Zhao, C., Han, Y., Chen, B., Chen, Y., Song, M., Cao, Y., & Xiao, H. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c16340 · Cited by 7
Gut microbiota-derived metabolites as systemic messengers: mechanisms of gut-organ communication and translational opportunities
Feng, C., He, Q., Kwok, L., & Sun, Z. (2026) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2026.105818 · Cited by 7
The study of tryptophan metabolite concentrations in blood serum and fecal extracts from obese children
Shestopalov, A. V., Shatova, O. P., Михайлович, Г. А., Moskaleva, N. E., Appolonova, S. A., Tutelyan, A. V., Makarov, V. V., Yudin, S. M., & Roumiantsev, S. A. (2020) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20206606494 · Cited by 7
Small phenolic and indolic gut-dependent molecules in the primate central nervous system: levels vs. bioactivity
Jaskiw, G. E., Xu, D., Obrenovich, M. E., & Donskey, C. J. (2022) · Metabolomics · doi:10.1007/s11306-021-01866-4 · Cited by 7
Modulation of human colon microbiota by naturally debittered olive patè enriched with Lactiplantibacillus plantarum in an in vitro intestinal model.
Nissen, L., Prete, R., Casciano, F., Corsetti, A., Battista, N., Veneziani, G., & Gianotti, A. (2024) · LWT · doi:10.1016/j.lwt.2024.116014 · Cited by 7
Gut Microbial Tryptophan Metabolism Is Involved in Post‐Cardiac Arrest Brain Injury via Pyroptosis Modulation
Wu, C., Diao, M., Yu, S., Xi, S., Zheng, Z., Cao, Y., Wang, S., Zhu, Y. J., Zhang, M., & Hu, W. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70381 · Cited by 7
“The IP is mainly regulated by gut microbiota, and the SP predominantly occurs in gut-resident enterochromaffin cells [13], while the KP is the major route of Trp metabolism in the mammalian brain and degrades 95% of the free Trp [7].”
Potential and Future Therapeutic Applications of Eicosapentaenoic/Docosahexaenoic Acid and Probiotics in Chronic Low-Grade Inflammation
Amedei, A., Lamminpää, I., & Parolini, C. (2025) · Biomedicines · doi:10.3390/biomedicines13102428 · Cited by 6
“Speciﬁcally, in the gastrointestinal tract, dietary tryptophan can be directly transformed into indole and its derivates, which are ligands of the aryl hydrocarbon receptor (AhR) [78].”
Reprogramming offspring liver health: maternal indole supplementation as a preventive strategy against MASLD
Mandala, A., Undi, R. B., Janssen, R. C., Sugino, K. Y., Zhao, W., Nelson, B. N., Teague, A. M., Patil, N. Y., Berry, K. A. Z., Varshney, R., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.106098 · Cited by 7
Microbiota-driven tryptophan metabolism and AhR triggered intestinal stem cell differentiation: mechanisms of huangqin decoction in ulcerative colitis repair
Li, R., Liao, X., Fu, X., Li, X., Liao, X., Cen, S., Zeng, J., Huang, L., Chi, H., & Zou, Y. (2026) · Chinese Medicine · doi:10.1186/s13020-025-01302-y · Cited by 8
“Moreover, indole metabolites are reduced in the mice with colitis induced by DSS [31].”
Current Perspectives on the Inflammatory Bowel Disease Pathogenesis of Microbiota and the Gut-Brain Axis, and Emerging Therapeutics
Lin, Y., Lu, P., Ding, Q., & Liu, M. (2026) · Biomedicines · doi:10.3390/biomedicines14040859 · Cited by 7
“Notably, IPA levels are significantly reduced in UC patients [156], further indicating the compromised state of this pathway in disease.”
Integrating host-microbiota metabolic networks: how aromatic amino acids shape immune homeostasis and affect disease progression
Zhang, Y., Zhao, X., Wang, H., Zhang, Z., Shi, H., Wang, Y., & Zhu, S. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01435-6 · Cited by 8
“…with well ‑ de ﬁ ned immunomodulatory microbial metabolites such as IPA and IAld has been shown to have protective effects in animal models of IBD and infectious diseases [61, 80], but their pharmacokinetics, tissue targeting, and long ‑ term safety in humans require systematic evaluation.”
Host metabolism can produce many indoles and phenols independently of the microbiome
AbuSalim, J. E., Olszewski, K. L., Youssef, S., Mitchell, S. J., Hunter, C. J., Little, J. C., Sidebottom, A. M., Boyer, J. A., Knutson, S. D., Samarah, L. Z., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01550-8 · Cited by 13
“Indole metabolites are ligands for the aryl hydrocarbon receptor, which is a key mediator of gut immune tolerance and epithelial homoeostasis 2–4 .”
Gut–Brain Axis: Role of the Gut Microbiome on Human Health
Poojara, L., Acharya, D., Patel, J. K., & Rawal, R. (2022) · Springer eBooks · doi:10.1007/978-981-16-1626-6_8 · Cited by 7
Molecular Ensembles of Microbiotic Metabolites in Carcinogenesis
Shatova, O. P., Zabolotneva, A. A., & Shestopalov, A. V. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923070027 · Cited by 7
Characterization of physical and chemical properties of dietary fiber from grain bran and its regulation of gut microbiota and metabolite to prevent colitis
Li, A., Gao, S., Li, B., Zheng, Y., Zhang, L., Li, K., Liu, Y., & Qin, X. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140043 · Cited by 6
Microbiota and beneficial metabolites in colorectal cancer
González, A., Fullaondo, A., Odriozola, I., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.08.002 · Cited by 6
Uncovering the mechanisms underlying the efficacy of probiotic strains in mitigating food allergies: an emphasis on gut microbiota and indoleacrylic acid
Pei, Z.-M., Qian, L., Miao, T., Wang, H.-C., Lu, W.-W., Chen, Y., & Zhuang, Q. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1523842 · Cited by 5
Endogenous Metabolites in Metabolic Diseases: Pathophysiologic Roles and Therapeutic Implications
Xiao, M., Zhou, N., Tian, Z., & Sun, C. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.04.017 · Cited by 6
Indole produced during dysbiosis mediates host–microorganism chemical communication
Yang, R.-Q., Chen, Y., Wu, Q.-Y., Tang, J., Niu, S., Zhao, Q., Ma, Y., & Zou, C. (2023) · eLife · doi:10.7554/elife.85362 · Cited by 6
“Interestingly, reduced levels of indole and its derivative indole- 3-propionic acid (IPA) are observed in serum of mice with dextran sulfate sodium-induced colitis and patients with IBD ( Alexeev et al., 2018 ).”
Early E. casseliflavus gut colonization and outcomes of allogeneic hematopoietic cell transplantation
Rashidi, A., Ebadi, M., Shields‐Cutler, R. R., Kruziki, K., Manias, D. A., Barnes, A. M. T., DeFor, T. E., Ferrieri, P., Young, J. H., Knights, D., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220850 · Cited by 6
Hydrazide-based reactive matrices for the sensitive detection of aldehydes and ketones by MALDI mass spectrometry imaging
Lodén, H., Schembri, L. S., Nilsson, A., Kaya, I., Shariatgorji, M., Odell, L. R., & Andrén, P. E. (2024) · Chemical Communications · doi:10.1039/d4cc02475c · Cited by 5
Indole-3-propionic acid supplementation during in vitro maturation improves in vitro production of porcine embryos
Nakayama, Y., Otoi, T., Zhao, N., Nguyen, S. T., Torigoe, N., Lin, Q., Liu, B. W., Widodo, O. S., Tharasanit, T., Chatdarong, K., et al. (2025) · BMC Veterinary Research · doi:10.1186/s12917-025-05049-4 · Cited by 5
“Indole-3-propionic acid (IPA) is an enteric intestinal microbiome-derived deamination product of tryptophan produced by intestinal bacteria [18, 19].”
Microbiota-derived metabolites in cancer: Dual roles in pathogenesis and opportunities for therapy
Rajak, M., Dash, D., & Koiri, R. K. (2025) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2025.100245 · Cited by 9
Dietary patterns influencing the human colonic microbiota from infancy to centenarian age: a narrative review
da Silva, V. G., Roy, N. C., Smith, N. W., Wall, C. R., Mullaney, J. A., & McNabb, W. C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1591341 · Cited by 7
Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines
Zhang, Y., Barupal, D. K., Fan, S., Gao, B., Zhu, C., Flenniken, A. M., McKerlie, C., Nutter, L. M. J., Lloyd, K. C. K., & Fiehn, O. (2023) · Metabolites · doi:10.3390/metabo13080947 · Cited by 7
“Oxylipins, indolyl derivatives, bile acids, amino acids and sphingomyelins were all increased more in female mice than in males, pointing to differences in the use of metabolites with regulatory roles that are well known for sphingomyelins [68], oxylipins [69], or indoles [70] and bile acids [71].”
Wuzi Yanzong Pill alleviates spermatogenesis dysfunction by modulating the gut microbial tryptophan metabolites
Liu, J., Feng, W., Zhang, D., Cheng, H., Zhou, Y., Wu, J., Wang, Z., Wang, Z., Fang, C., Li, G., et al. (2024) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2024.105809 · Cited by 5
Untargeted plasma metabolomic analysis of wild bottlenose dolphins (Tursiops truncatus) indicate protein degradation when in poorer health
Derous, D., Kebke, A. S., Fair, P. A., Styczynski, M. P., Bossart, G. D., Douglas, A., & Lusseau, D. (2022) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2022.100991 · Cited by 5
“In addition, depletion of indole-derived metabolites in serum has been identified in both murine and human colitis (Alexeev et al., 2018), a disease characterized by colon inflammation.”
Background
Role of gut microbiota in the 5-hydroxytryptamine signal transduction mechanism
Hu, G., Zhu, Y., Ding, S., & Zheng, L. (2023) · Metabolism and Translational Medicine · doi:10.54844/mtm.2023.0344 · Cited by 7
Functional foods acting on gut microbiota-related wellness: The multi-unit in vitro colon model to assess gut ecological and functional modulation
Marangelo, C., Marsiglia, R., Nissen, L., Scanu, M., Toto, F., Siroli, L., Gottardi, D., Braschi, G., CHIERICO, F. D., Bordoni, A., et al. (2025) · Food Research International · doi:10.1016/j.foodres.2024.115577 · Cited by 5
Taking intestinal microbes and the immune system as opportunities to maintain the intestinal health of piglets: review
Hou, X., Chen, Y., Chen, F., Yin, Y., & Xu, K. (2025) · Animal Bioscience · doi:10.5713/ab.25.0100 · Cited by 4
“Additionally, IPA also significantly decreased the elevated expression of interferon-γ, tumor necrosis factor-α and IL-1β induced by dextran sulfate sodium in mice and alleviated intestinal inflammation by activating AHR [62].”
Characteristic gene expression profile of intestinal mucosa early in life promotes bacterial colonization leading to healthy development of the intestinal environment
Nishinarita, Y., Miyoshi, J., Kuronuma, S., Wada, H., Oguri, N., Hibi, N., Takeuchi, O., Akimoto, Y., Lee, S. T. M., Matsuura, M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-03661-w · Cited by 4
“The gut microbiome can be affected by the functions of various organs outside the intestinal tract via metabolites 13–17 .”
Synergistic effects of Lactiplantibacillus plantarum strains and tryptophan on intestinal flora and metabolites: anti-inflammatory action via NF-κB and Nrf2 pathways
Gao, X., Liu, Y., Yu, J., Zhu, Y., Wang, A., Mu, G., & Tuo, Y. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106971 · Cited by 5
Potential Impact of Microbial Dysbiosis and Tryptophan Metabolites in Advanced Stages of Colorectal Cancer
Lesne-Hulin, A., Rifflet, A., Castelli, F. A., Gianetto, Q. G., Fenaille, F., Aissat, A., Matondo, M., Fellahi, S., Tournigand, C., Junot, C., et al. (2025) · Biomedicines · doi:10.3390/biomedicines14010026 · Cited by 4
“Additionally, indole derivatives such as indole acetic acid and indole propionic acid, both AhR ligands, may compete for receptor binding, further influencing immune modulation [43].”
Microbiota-Driven Strategies for Managing IBD-Associated Risks: From Infections to Mental Health
Krynicka, P., Valdivia, P. C., Morawski, M., Marlicz, W. M., Skonieczna‐Żydecka, K., & Koulaouzidis, A. (2026) · Pharmaceuticals · doi:10.3390/ph19010118 · Cited by 5
“Animal models have shown that the absence of AHR ligands is associated with increased susceptibility to inflammation and slower mucosal healing [21].”
Exploring the mechanism of dihydromyricetin in alleviating psoriasis based on metabolomics, network pharmacology and experimental validation
Li, W., Chen, H., Xie, Z., Gao, J., Wang, M., Chen, Z., Li, Y., Guo, Z., Huang, S., Jia, J., et al. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121167 · Cited by 4
Neonatal gut Bifidobacterium associates with indole-3-lactic acid levels in blood and risk of ADHD at age 10
Widdowson, M., Shah, S. A., Thorsen, J., Poulsen, C. S., Rosenberg, J. B., Mohammadzadeh, P., Jepsen, J. R. M., Vinding, R., Poulsen, C. E., Rodríguez, C. L., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03480-z · Cited by 4
“Dietary tryptophan in the gut can be converted into kynurenine and indole derivatives, which are important for immune regulation and neurobiological functions [16, 19 – 21].”
Cross-kingdom microbial interactions in the gut during inflammatory bowel disease
Li, L., Cai, F., Liu, Z., Mo, W., Zhang, J., Qin, J., Liang, C., Xu, H., Liu, S., Tang, S., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07692-3 · Cited by 4
“Pleiotropic” Effects of Antibiotics: New Modulators in Human Diseases
Airola, C., Severino, A., Spinelli, I., Gasbarrini, A., Cammarota, G., Ianiro, G., & Ponziani, F. R. (2024) · Antibiotics · doi:10.3390/antibiotics13121176 · Cited by 6
“Notably, microbiota-derived indole metabolites have an anti-inflammatory role with potential benefits in several inflammatory diseases, such as colitis and ankylosing spondylitis [146,147].”
Using metabolomics to investigate the relationship between the metabolomic profile of the intestinal microbiota derivatives and mental disorders in inflammatory bowel diseases: a narrative review
Zarei, P., Adibi, P., Vaez, A., & Keshteli, A. H. (2025) · Research in Pharmaceutical Sciences · doi:10.4103/rps.rps_273_23 · Cited by 4
“…production of serotonin in the enterochromaffin cells; indole, indole-3-propionic acid (IPA), indole-3-acetaldehyde (IAAld), indole-3-acid-acetic (IAA), and indole-3-aldehyde (IAld), in the gut microbiota; and kynurenine pathway in the epithelial cells, lamina propria, and immune cells (123-126).”
Gut Feelings: Linking Dysbiosis to Depression—A Narrative Literature Review
Bibolar, A. C., Nechita, V.-I., Lung, F. C., Crecan-Suciu, B. D., & Paunescu, R. (2025) · Medicina · doi:10.3390/medicina61081360 · Cited by 7
“Indoles play a protective role in the gut by strengthening the epithelial barrier through enhanced tight junction expression and by limiting inflammatory cytokine release [57].”

Authors: Alexeev, E. E., Lanis, J. M., Kao, D. J., Campbell, E. L., Kelly, C. J., Battista, K. D., Gerich, M. E., Jenkins, B. R., Walk, S. T., Kominsky, D. J., & Colgan, S. P.
Affiliations: University of Colorado Anschutz (US)
Queen's University Belfast (GB)
Montana State University (US)
Corresponding author: Kominsky, Douglas J.
Colgan, Sean P.
ORCID: Alexeev, Erica E.
Lanis, Jordi M.
Kao, Daniel J.
Campbell, Eric L.
Kelly, Caleb J.
Gerich, Mark E.
Jenkins, Brittany R.
Walk, Seth T.
Colgan, Sean P.
Venue: The American Journal of Pathology
Publisher: Elsevier BV
Published: 2018-05
Volume: 188
Issue: 5
Pages: 1183-1194
ISSN: 0002-9440 (ISSN-L)
DOI: 10.1016/j.ajpath.2018.01.011
PMC: PMC5906738
OpenAlex: W2788222993
Cited by: 532
References: 55
Citations by year: 2026: 65 · 2025: 84 · 2024: 76 · 2023: 90 · 2022: 68 · 2021: 74 · 2020: 43 · 2019: 22 · 2018: 8
FWCI: 13.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 591 d)
Locations: American Journal Of Pathology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Portal (Queen's University Belfast) (submittedVersion, cc-by-nc-nd)
Funders: NIH (DK1047893, DK50189, DK095491, DK103639, DK103712)
VA Merit (BX002182)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: gut microbiota, indole metabolites, indole-3-propionic acid, interleukin-10 receptor, IL-10 signaling, aryl hydrocarbon receptor, intestinal homeostasis, colitis, germ-free mice, Escherichia coli, intestinal epithelium, mucosal disease, anti-inflammatory therapy
MeSH terms: Animals, Cell Line, Colitis, Disease Models, Animal, Homeostasis, Humans, Indoles, Intestinal Mucosa, Dextran Sulfate, Mice, Receptors, Interleukin-10, Metabolomics, Microbiota

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Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

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