Atherogenic Lipoprotein Particles in Atherosclerosis
Abstract
The importance of low-density lipoprotein (LDL) cholesterol in the development of atherosclerosis has long been recognized, and LDL cholesterol remains the primary target of therapy for the prevention of coronary heart disease. Nevertheless, increasing research attention over the past decade has been devoted to the heterogeneity of LDL particles and the atherogenicity of lipids and lipoproteins other than LDL. Particularly atherogenic forms of LDL include small, dense LDL particles and oxidized LDL. All lipoproteins that contain apolipoprotein B, such as LDL, very-low-density lipoprotein, and intermediate-density lipoprotein, tend to promote atherosclerosis; however, these particles differ in their apolipoprotein and triglyceride content. High levels of plasma triglycerides increase the risk of acute coronary events. Lipoprotein(a) is now considered an independent risk factor in both men and women. Ultimately, better understanding of the roles of these lipid particles and subfractions in the initiation and progression of atherosclerosis may affect treatment decisions.
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A higher proportion of small, dense LDL particles is strongly linked to coronary heart disease.
“An increased proportion of small, dense LDL particles is strongly associated with the development of CHD (35).”
From Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans (2013) · cites this paper as [35]
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- Authors
- Carmena, R., Duriez, P., & Fruchart, J.-C.
- Affiliations
- Inserm (FR)
- ORCID
- Duriez, Patrick
- Venue
- Circulation
- Published
- 2004-06-15
- Volume
- 109
- Issue
- 23_suppl_1
- Pages
- III2-7
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2022525201
- Cited by
- 494
- References
- 51
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 15 · 2023: 24 · 2022: 15 · 2021: 35 · 2020: 24 · 2019: 20 · 2018: 20 · 2017: 31 · 2016: 26 · 2015: 30 · 2014: 29 · 2013: 21 · 2012: 19
- FWCI
- 24.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- atherosclerosis, atherogenic lipoproteins, low-density lipoprotein, small dense LDL, oxidized LDL, apolipoprotein B, VLDL, intermediate density lipoprotein, lipoprotein(a), plasma triglycerides, coronary artery disease, cardiovascular risk factors
- MeSH terms
- Arteriosclerosis, Centrifugation, Density Gradient, Chromatography, Gel, Coronary Artery Disease, Disease Susceptibility, Female, Humans, Lipoproteins, LDL, Cholesterol, LDL, Male, Particle Size, Risk Factors, Triglycerides, Epidemiologic Research Design, Nuclear Magnetic Resonance, Biomolecular, Metabolic Syndrome
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