Cited by 494Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular Diseases

Atherogenic Lipoprotein Particles in Atherosclerosis

Carmena, Rafael, Duriez, Patrick, Fruchart, Jean-Charles·2004·Circulation

Abstract

The importance of low-density lipoprotein (LDL) cholesterol in the development of atherosclerosis has long been recognized, and LDL cholesterol remains the primary target of therapy for the prevention of coronary heart disease. Nevertheless, increasing research attention over the past decade has been devoted to the heterogeneity of LDL particles and the atherogenicity of lipids and lipoproteins other than LDL. Particularly atherogenic forms of LDL include small, dense LDL particles and oxidized LDL. All lipoproteins that contain apolipoprotein B, such as LDL, very-low-density lipoprotein, and intermediate-density lipoprotein, tend to promote atherosclerosis; however, these particles differ in their apolipoprotein and triglyceride content. High levels of plasma triglycerides increase the risk of acute coronary events. Lipoprotein(a) is now considered an independent risk factor in both men and women. Ultimately, better understanding of the roles of these lipid particles and subfractions in the initiation and progression of atherosclerosis may affect treatment decisions.

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Crossref · 10.1161/01.cir.0000131511.50734.44

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  1. Havel RJ. Role of triglyceride-rich lipoproteins in progression of athero- sclerosis. Circulation. 1990;81:694 -696.

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Authors
Carmena, R., Duriez, P., & Fruchart, J.-C.
Affiliations
Inserm (FR)
Venue
Circulation
Published
2004-06-15
Volume
109
Issue
23_suppl_1
Pages
III2-7
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2022525201
Cited by
494
References
51
Citations by year
2026: 9 · 2025: 14 · 2024: 15 · 2023: 24 · 2022: 15 · 2021: 35 · 2020: 24 · 2019: 20 · 2018: 20 · 2017: 31 · 2016: 26 · 2015: 30 · 2014: 29 · 2013: 21 · 2012: 19
FWCI
24.68
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
atherosclerosis, atherogenic lipoproteins, low-density lipoprotein, small dense LDL, oxidized LDL, apolipoprotein B, VLDL, intermediate density lipoprotein, lipoprotein(a), plasma triglycerides, coronary artery disease, cardiovascular risk factors
MeSH terms
Arteriosclerosis, Centrifugation, Density Gradient, Chromatography, Gel, Coronary Artery Disease, Disease Susceptibility, Female, Humans, Lipoproteins, LDL, Cholesterol, LDL, Male, Particle Size, Risk Factors, Triglycerides, Epidemiologic Research Design, Nuclear Magnetic Resonance, Biomolecular, Metabolic Syndrome

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