Plasma Lipid Profile and Incident Ischemic Stroke: The Atherosclerosis Risk in Communities (ARIC) Study
Abstract
Background and Purpose— The role of circulating lipids and lipoproteins in the pathogenesis of ischemic stroke remains uncertain despite 3 decades of research. We examined this issue in a large population-based cohort. Methods— Between 1987 and 1989, 14 175 middle-aged men and women, free of clinical cardiovascular disease, took part in the first examination of the Atherosclerosis Risk in Communities (ARIC) study cohort. Baseline measurements included plasma levels of LDL cholesterol, HDL cholesterol, apolipoprotein B, apolipoprotein A-1, and triglycerides and myriad risk factors for cardiovascular disease. The cohort was followed for cardiovascular disease end points. Results— Over an average follow-up of 10 years (142 704 person-years at risk), we documented clinical ischemic stroke in 305 participants (161 men and 144 women). After multivariable adjustment for stroke risk factors, categorical and spline regression analyses of the entire sample, as well as the sample of men alone, revealed weak and inconsistent associations between ischemic stroke and each of the 5 lipid factors. Among women, the most consistent findings were decreasing risk of ischemic stroke within the top half of the distribution of HDL cholesterol and increasing risk within the lower range of the triglyceride distribution. Conclusions— The relation of circulating cholesterol to ischemic stroke does not resemble its well-known relation to coronary heart disease. Either the pathogenesis of a substantial proportion of ischemic strokes does not involve classic atherosclerotic mechanisms, or the effect of plasma lipids on atherogenesis is substantially different in the intracranial vascular bed.
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In western countries, epidemiological studies such as MRFIT have reported that an increased TC level is associated with an increased risk for cerebral infarction.
“In western countries, epidemiological studies such as MRFIT have reported that an increased TC level is associated with an increased risk for cerebral infarction851–853).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [853]
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Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVES
THE ARIC INVESTIGATORS (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115184 · Cited by 3,491 · see citing works
Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens
Clauss, A. (2009) · Acta Haematologica · doi:10.1159/000205234 · Cited by 3,239 · see citing works
(1989) · PubMed · Cited by 3,139 · see citing works
Lacunar strokes and infarcts: A review
Fisher, C. M. (1982) · Neurology · doi:10.1212/wnl.32.8.871 · Cited by 1,179 · see citing works
Iso, H., Jacobs, D. R., Wentworth, D. N., Neaton, J. D., & Cohen, J. D. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201405 · Cited by 1,130 · see citing works
Dose-Response and Trend Analysis in Epidemiology
Greenland, S. (1995) · Epidemiology · doi:10.1097/00001648-199507000-00005 · Cited by 1,086 · see citing works
Sharrett, A. R., Ballantyne, C. M., Coady, S., HEISS, G. M., Sorlie, P. D., Catellier, D., & Patsch, W. (2001) · Circulation · doi:10.1161/hc3501.095214 · Cited by 942 · see citing works
Self-citationSiedel, J., Hägele, E., Ziegenhorn, J., & Wahlefeld, A. W. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.6.1075 · Cited by 942 · see citing works
The Causes and Risk of Stroke in Patients with Asymptomatic Internal-Carotid-Artery Stenosis
Inzitari, D., Eliasziw, M., Gates, P., Sharpe, B. L., Chan, R., Meldrum, H. E., & Barnett, H. J. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006083422302 · Cited by 874 · see citing works
Prospective Studies Collaboration, & Kromhout, D. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92836-7 · Cited by 851 · see citing works
Stroke Incidence and Survival Among Middle-Aged Adults
Rosamond, W. D., Folsom, A. R., Chambless, L. E., Wang, C.-H., McGovern, P. G., Howard, G., COOPER, L. S., & Shahar, E. (1999) · Stroke · doi:10.1161/01.str.30.4.736 · Cited by 811 · see citing works
Self-citationStroke: Pathophysiology, Diagnosis, and Management.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-506_3 · Cited by 796 · see citing works
Wong, T. Y., Klein, R., Couper, D. J., Cooper, L. S., Shahar, E., Hubbard, L. D., Wofford, M. R., & Sharrett, A. R. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06253-5 · Cited by 783 · see citing works
Self-citationThe arterial lesions underlying lacunes
Fisher, C. M. (1969) · Acta Neuropathologica · doi:10.1007/bf00685305 · Cited by 755 · see citing works
Chambless, L. E., Folsom, A. R., Clegg, L. X., Sharrett, A. R., Shahar, E., Nieto, F. J., Rosamond, W. D., & Evans, G. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010233 · Cited by 750 · see citing works
Self-citationHebert, P. R. (1997) · JAMA · doi:10.1001/jama.1997.03550040069040 · Cited by 740 · see citing works
Statins do more than just lower cholesterol
Vaughan, C. J., Murphy, M. B., & Buckley, B. M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)05190-2 · Cited by 699 · see citing works
Girard, B. (2008) · Cited by 618 · see citing works
Lipoproteins, Cardiovascular Disease, and Death
Gordon, T. (1981) · Archives of Internal Medicine · doi:10.1001/archinte.1981.00340090024008 · Cited by 528 · see citing works
Cholesterol Lowering With Statin Drugs, Risk of Stroke, and Total Mortality
Hebert, P. R., Gaziano, J. M., Chan, K. S., & Hennekens, C. H. (1998) · Survey of Anesthesiology · doi:10.1097/00132586-199806000-00060 · Cited by 506 · see citing works
American Heart Association Prevention Conference IV: Prevention and Rehabilitation of Stroke
Helgason, C. M., & Wolf, P. A. (1997) · Stroke · doi:10.1161/01.str.28.7.1498 · Cited by 440 · see citing works
Capsular Infarcts: The Underlying Vascular Lesions
Fisher, C. M. (1979) · Archives of Neurology · doi:10.1001/archneur.1979.00500380035003 · Cited by 439 · see citing works
Prospective Study of Markers of Hemostatic Function With Risk of Ischemic Stroke
Folsom, A. R., Rosamond, W. D., Shahar, E., Cooper, L. S., Aleksic, N., Nieto, F. J., Rasmussen, M. L., & Wu, K. K. (1999) · Circulation · doi:10.1161/01.cir.100.7.736 · Cited by 407 · see citing works
Self-citationLindenstrom, E., Boysen, G., & Nyboe, J. (1994) · BMJ · doi:10.1136/bmj.309.6946.11 · Cited by 370 · see citing works
Folsom, A. R., Rasmussen, M. L., Chambless, L. E., Howard, G., Cooper, L. S., Schmidt, M. I., & HEISS, G. M. (1999) · Diabetes Care · doi:10.2337/diacare.22.7.1077 · Cited by 356 · see citing works
Self-citationTanizaki, Y., Kiyohara, Y., Kato, I., Iwamoto, H., Nakayama, K., Shinohara, N., Arima, H., Tanaka, K., Ibayashi, S., & Fujishima, M. (2000) · Stroke · doi:10.1161/01.str.31.11.2616 · Cited by 346 · see citing works
Bronner, L., Kanter, D. S., & Manson, J. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511233332106 · Cited by 342 · see citing works
Analysis of Risk Factors for Stroke in a Cohort of Men Born in 1913
Welin, L., Svärdsudd, K., Wilhelmsen, L., Larsson, B., & Tibblin, G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708273170901 · Cited by 338 · see citing works
Jackson, R., Chambless, L. E., Yang, K., Byrne, T., Watson, R. L., Folsom, A. R., Shahar, E., & Kalsbeek, W. D. (1996) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(95)00047-x · Cited by 332 · see citing works
Self-citationStroke, Statins, and Cholesterol
Blauw, G. J., Lagaay, A. M., Smelt, A. H. M., & Westendorp, R. G. J. (1997) · Stroke · doi:10.1161/01.str.28.5.946 · Cited by 313 · see citing works
Nägele, U., Hägele, E., Sauer, G., Wiedemann, E., Lehmann, P., Wahlefeld, A. W., & Gruber, W. (1984) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1984.22.2.165 · Cited by 313 · see citing works
Sacco, R. L., Benson, R. T., Kargman, D. E., Boden-Albala, B., Tuck, C., Lin, I.-F., Cheng, J. F., Paik, M. C., Shea, S., & Berglund, L. (2001) · JAMA · doi:10.1001/jama.285.21.2729 · Cited by 311 · see citing works
Are Retinal Arteriolar Abnormalities Related to Atherosclerosis?
Klein, R., Sharrett, A. R., Klein, B. E. K., Chambless, L. E., Cooper, L. S., Hubbard, L. D., & Evans, G. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1644 · Cited by 303 · see citing works
Self-citationRisk Factors for Ischemic Stroke
Simons, L. A., McCallum, J. C., Friedlander, Y., & Simons, J. (1998) · Stroke · doi:10.1161/01.str.29.7.1341 · Cited by 256 · see citing works
Pedro‐Botet, J., Sentı́, M., Nogués, X., Rubiés-Prat, J., Roquer, J., D'Olhaberriague, L., & Olivé, J. (1992) · Stroke · doi:10.1161/01.str.23.11.1556 · Cited by 245 · see citing works
Risk factors for stroke in middle-aged men in Göteborg, Sweden.
Harmsen, P., Rosengren, A., Tsipogianni, A., & Wilhelmsen, L. (1990) · Stroke · doi:10.1161/01.str.21.2.223 · Cited by 242 · see citing works
Wolf, P. A. (2004) · Elsevier eBooks · doi:10.1016/b0-44-306600-0/50005-5 · Cited by 233 · see citing works
Reductase Inhibitor Monotherapy and Stroke Prevention
Crouse, J. R. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440330039004 · Cited by 221 · see citing works
HDL-Cholesterol, Total Cholesterol, and the Risk of Stroke in Middle-Aged British Men
Wannamethee, S. G., Shaper, A. G., & Ebrahim, S. (2000) · Stroke · doi:10.1161/01.str.31.8.1882 · Cited by 220 · see citing works
Sharrett, A. R., Patsch, W., Sorlie, P. D., HEISS, G. M., Bond, M. G., & DAVIS, C. E. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.7.1098 · Cited by 214 · see citing works
Self-citationInterrater Reliability of an Etiologic Classification of Ischemic Stroke
Johnson, C. J., Kittner, S. J., McCarter, R., Sloan, M. A., Stern, B. J., Buchholz, D. W., & Price, T. R. (1995) · Stroke · doi:10.1161/01.str.26.1.46 · Cited by 197 · see citing works
Ultrasound and Lipoproteins as Predictors of Lipid-Rich, Rupture-Prone Plaques in the Carotid Artery
Grønholdt, M.-L. M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.1.2 · Cited by 190 · see citing works
Assay of Total Plasma Apolipoprotein B Concentration in Human Subjects
Schonfeld, G., Lees, R. S., George, P. K., & Pfleger, B. A. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107694 · Cited by 184 · see citing works
Papp, A. C., Hatzakis, H., Bracey, A., & Wu, K. K. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646519 · Cited by 182 · see citing works
Risk factors of stroke incidence and mortality. A 12-year follow-up of the Oslo Study.
Håheim, L. L., Holme, I., Hjermann, I., & Leren, P. (1993) · Stroke · doi:10.1161/01.str.24.10.1484 · Cited by 180 · see citing works
Hachinski, V. C. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550040031011 · Cited by 153 · see citing works
High-Density Lipoprotein Cholesterol and Risk of Ischemic Stroke Mortality
Tanné, D., Yaari, S., & Goldbourt, U. (1997) · Stroke · doi:10.1161/01.str.28.1.83 · Cited by 148 · see citing works
Risk factors for death from different types of stroke
Neaton, J. D., Wentworth, D. N., Cutler, J. A., Stamler, J., & Kuller, L. H. (1993) · Annals of Epidemiology · doi:10.1016/1047-2797(93)90103-b · Cited by 142 · see citing works
Neck manipulation as a cause of stroke.
Robertson, J. T. (1981) · Stroke · doi:10.1161/01.str.12.1.1 · Cited by 141 · see citing works
Risk Factors and 20-Year Stroke Mortality in Men and Women in the Renfrew/Paisley Study in Scotland
Hart, C., Hole, D. J., & Smith, G. D. (1999) · Stroke · doi:10.1161/01.str.30.10.1999 · Cited by 132 · see citing works
RBenfante, KYano, JHwang, L., DCurb, J., AKagan, & WRoss (1994) · Stroke · Cited by 132 · see citing works
Shahar, E. (1996) · Annals of Epidemiology · doi:10.1016/s1047-2797(96)00104-4 · Cited by 126 · see citing works
Self-citationRelation between blood lipids, lipoproteins, and cerebrovascular atherosclerosis. A review.
Tell, G. S., Crouse, J. R., & Furberg, C. D. (1988) · Stroke · doi:10.1161/01.str.19.4.423 · Cited by 126 · see citing works
SALONEN, J. T., Puska, P., Tuomilehto, J. O., & Homan, K. (1982) · Stroke · doi:10.1161/01.str.13.3.327 · Cited by 120 · see citing works
Crow, R. S., Prineas, R. J., Rautaharju, P. M., Hannan, P. J., & Liebson, P. R. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80769-3 · Cited by 115 · see citing works
Dyken, M. L. (1991) · Springer eBooks · doi:10.1007/978-1-4757-4226-8_6 · Cited by 113 · see citing works
Warnick, G. R., Mayfield, C., Benderson, J., Chen, J.-S., & Albers, J. J. (1982) · American Journal of Clinical Pathology · doi:10.1093/ajcp/78.5.718 · Cited by 95 · see citing works
Kargman, D. E., Tuck, C. H., Berglund, L., Lin, I., Mukherjee, R. S., Thompson, E. V., Jones, J. L., Boden-Albala, B. M., Paik, M. C., & Sacco, R. L. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00085-9 · Cited by 82 · see citing works
Risk Profile and Prediction of Long-Term Ischemic Stroke Mortality
Tanné, D., Yaari, S., & Goldbourt, U. (1998) · Circulation · doi:10.1161/01.cir.98.14.1365 · Cited by 73 · see citing works
Chambless, L. E., McMahon, R. P., Brown, S. A., Patsch, W., HEISS, G. M., & Shen, Y. L. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116572 · Cited by 69 · see citing works
Self-citationRisk Factors for Ischemic Stroke: A Case Control Analysis
Sridharan, R. (1992) · Neuroepidemiology · doi:10.1159/000110903 · Cited by 61 · see citing works
Baker, A. B., & Iannone, A. (1959) · Neurology · doi:10.1212/wnl.9.6.391 · Cited by 53 · see citing works
Cholesterol, atherosclerosis, ischemic heart disease, and stroke.
Dayton, S., Chapman, J. M., Pearce, M., & Popják, G. J. (1970) · Annals of Internal Medicine · doi:10.7326/0003-4819-72-1-97 · Cited by 47 · see citing works
Serum lipoprotein pattern variations in dementia and ischemic stroke
Giubilei, F., D'Antona, R., Antonini, R., et al. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1990.tb00936.x · Cited by 46 · see citing works
Rössner, S., Kjellin, K. G., Mettinger, K. L., Sidén, Å., & Söderström, C. E. (1978) · Atherosclerosis · doi:10.1016/0021-9150(78)90046-1 · Cited by 46 · see citing works
Problems in the Average-Risk Interpretation of Categorical Dose-Response Analyses
Greenland, S. (1995) · Epidemiology · doi:10.1097/00001648-199509000-00020 · Cited by 38 · see citing works
Changes in Serum Lipid Measurements following Acute Ischaemic Stroke
Butterworth, R. J., Marshall, W. J., & Bath, P. M. (1997) · Cerebrovascular Diseases · doi:10.1159/000108156 · Cited by 38 · see citing works
Rhoads, G. G., & Feinleib, M. (1983) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.3.4.316 · Cited by 37 · see citing works
Risk Factors for Death From Stroke in Middle-aged Lithuanian Men
Rastenytė, D., Tuomilehto, J., Domarkienė, S., et al. (1996) · Stroke · doi:10.1161/01.str.27.4.672 · Cited by 37 · see citing works
Brown, S. A., Epps, D. F., Dunn, J. K., Sharrett, A. R., Patsch, J. R., Gotto, A. M., & Patsch, W. (1988) · PubMed · Cited by 32 · see citing works
Self-citationAull, S., Lalouschek, W., Schnider, P., Sinzinger, H. F., Uhl, F., & Zeiler, K. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00199-4 · Cited by 32 · see citing works
KIM, S. G., Roth, J. A., Fisher, J. D., et al. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80768-1 · Cited by 32 · see citing works
Carotid Endarterectomy Revisited
Kistler, J. P., & Furie, K. L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006083422310 · Cited by 32 · see citing works
Gorelick, P. B., & Mazzone, T. (1999) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/204748739900600405 · Cited by 32 · see citing works
Serum Cholesterol and Risk of Ischemic Stroke: Results of a Case-Control Study
Dimascio, R., Marchiolli, R., Vituollo, F., et al. (1995) · Preventive Medicine · doi:10.1006/pmed.1995.1025 · Cited by 26 · see citing works
Very Early Prevention of Stroke Recurrence
Sandercock, P. A., & Tangkanakul, C. (1997) · Cerebrovascular Diseases · doi:10.1159/000108231 · Cited by 23 · see citing works
Effect of blood collection and processing on radioimmunoassay results for apolipoprotein B in plasma
Brown, S. A., Epps, D. F., Dunn, J. K., et al. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.9.1662 · Cited by 18 · see citing works
Brown, S. A., Rhodes, C. E., Dunn, K., et al. (1988) · Clinical Chemistry · doi:10.1093/clinchem/34.5.920 · Cited by 17 · see citing works
Statins for prevention of stroke
Blauw, G. J., Lagaay, A. M., & Westendorp, R. G. J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)85049-6 · Cited by 15 · see citing works
Stroke risk, cholesterol and statins
Futterman, L. G., & Lemberg, L. (1999) · American Journal of Critical Care · doi:10.4037/ajcc1999.8.6.416 · Cited by 13 · see citing works
Serum lipids in acute stroke and a year later.
Kleinman, Y., & Korn‐Lubetzki, I. (1997) · PubMed · Cited by 4 · see citing works
Lipid peroxidation and change of plasma lipids in acute ischemic stroke.
Şerban, M., & Niţă, V. (1994) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Blauw GJ, Lagaay AM, Smelt AH, Westendorp RG. Stroke, statins, and cho- lesterol: a meta-analysis of randomized, placebo-controlled, double-blind trials with HMG-CoA reductase inhibitors. Stroke. 1997;28:946-950.
- Baker AB, Iannone A. Cardiovascular disease, II: the smaller intracere- bral arteries. Neurology. 1959;9:391-396.
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Self-citationHeart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Alonso, A., Beaton, A. Z., Bittencourt, M. S., Boehme, A. K., Buxton, A. E., Carson, A. P., Commodore-Mensah, Y., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001052 · Cited by 5,987 · see citing works
Meschia, J. F., Bushnell, C., Boden-Albala, B., Braun, L. T., Bravata, D. M., Chaturvedi, S., Creager, M. A., Eckel, R. H., Elkind, M. S. V., Fornage, M., et al. (2014) · Stroke · doi:10.1161/str.0000000000000046 · Cited by 2,650 · see citing works
Goldstein, L. B., Bushnell, C. D., Adams, R. J., Appel, L. J., Braun, L. T., Chaturvedi, S., Creager, M. A., Culebras, A., Eckel, R. H., Hart, R. G., et al. (2011) · Stroke · doi:10.1161/str.0b013e3181fcb238 · Cited by 1,306 · see citing works
Lackland, D. T., Roccella, E. J., Deutsch, A. F., Fornage, M., George, M. G., Howard, G., Kissela, B. M., Kittner, S. J., Lichtman, J. H., Lisabeth, L. D., et al. (2014) · Stroke · doi:10.1161/01.str.0000437068.30550.cf · Cited by 815 · see citing works
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
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Davidson, M. H., Ballantyne, C. M., Jacobson, T. A., Bittner, V. A., Braun, L. T., Brown, A. S., Brown, W. V., Cromwell, W. C., Goldberg, R. B., McKenney, J. M., et al. (2011) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2011.07.005 · Cited by 262 · see citing works
Self-citationImamura, T., Doi, Y., Arima, H., Yonemoto, K., Hata, J., Kubo, M., Tanizaki, Y., Ibayashi, S., Iida, M., & Kiyohara, Y. (2009) · Stroke · doi:10.1161/strokeaha.108.529537 · Cited by 235 · see citing works
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Bowman, T. S., Sesso, H. D., Ma, J., Kurth, T., Kase, C. S., Stampfer, M. J., & Gaziano, J. M. (2003) · Stroke · doi:10.1161/01.str.0000102171.91292.dc · Cited by 157 · see citing works
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Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population
Varbo, A., Nordestgaard, B. G., Tybjærg‐Hansen, A., Schnohr, P., Jensen, G. B., & Benn, M. (2011) · Annals of Neurology · doi:10.1002/ana.22384 · Cited by 122 · see citing works
Miller, M., Ginsberg, H. N., & Schaefer, E. J. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.11.046 · Cited by 102 · see citing works
Yokokawa, H., Yasumura, S., Tanno, K., Ohsawa, M., Onoda, T., Itai, K., Sakata, K., Kawamura, K., Tanaka, F., Yoshida, Y., et al. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.5215 · Cited by 83 · see citing works
Autenrieth, C. S., Evenson, K. R., Yatsuya, H., Shahar, E., Baggett, C., & Rosamond, W. D. (2013) · Neuroepidemiology · doi:10.1159/000342151 · Cited by 46 · see citing works
Self-citationUchiyama, S., Nakaya, N., Mizuno, K., Ohashi, Y., Tajima, N., Kushiro, T., Teramoto, T., & Nakamura, H. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.04.002 · Cited by 32 · see citing works
Chernyshev, O. Y., McCarty, D. E., Moul, D. E., Liendo, C., Caldito, G. C., Munjampalli, S. K., Kelley, R., & Chesson Jr, A. L. (2015) · Nature and Science of Sleep · doi:10.2147/nss.s85780 · Cited by 23 · see citing works
- Authors
- Shahar, E., Chambless, L. E., Rosamond, W. D., Boland, L. L., Ballantyne, C. M., McGovern, P. G., & Sharrett, A. R.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Stroke
- Published
- 2003-03
- Volume
- 34
- Issue
- 3
- Pages
- 623-631
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2013909582
- Cited by
- 325
- References
- 83
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 10 · 2023: 14 · 2022: 12 · 2021: 14 · 2020: 13 · 2019: 10 · 2018: 12 · 2017: 15 · 2016: 12 · 2015: 11 · 2014: 15 · 2013: 16 · 2012: 14
- FWCI
- 15.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc55021-47-0-1, n01hc55020-39-0-0, n01hc55016-37-0-0, n01hc055022-024, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc55015-48-0-1)
- National Heart, Lung, and Blood Institute (N01-HC55022, N01-HC-55018, N01 HC 55020, N01 HC 55019, N01-HC55016, N01‐HC‐55015, N01-HC55021)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- ischemic stroke, plasma lipid profile, HDL cholesterol, triglycerides, LDL cholesterol, apolipoprotein B, apolipoprotein A-I, stroke risk factors, sex differences, atherosclerosis, Atherosclerosis Risk in Communities Study
- MeSH terms
- Apolipoproteins B, Brain Ischemia, Female, Follow-Up Studies, Humans, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Prospective Studies, Residence Characteristics, Risk Factors, Triglycerides, United States, Cohort Studies, Comorbidity, Causality, Incidence, Multivariate Analysis, Apolipoprotein A-I, Sex Distribution, Risk Assessment, Stroke
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