Comparison of patients with heart failure and preserved left ventricular ejection fraction among those with versus without diabetes mellitus
Open accessAbstract
Heart failure (HF) with preserved left ventricular ejection fraction (LVEF) and diabetes commonly coexist, but the impact of diabetes on HF outcomes in patients with HF and preserved LVEF has not been well studied. We assessed the risk of HF death or hospitalization for worsening HF associated with diabetes by studying 987 patients with HF and preserved LVEF enrolled in the Digitalis Investigation Group (DIG) ancillary study. Diabetics (n = 285, 28.9%) were younger, had a larger body mass index, faster heart rate, and higher pulse pressure than nondiabetics. Diabetics were also more likely to be women, have a history of hypertension, ischemic cause for HF, and were more likely to be treated with diuretics. During the mean follow-up of 37 months, 88 (30.9%) diabetics and 133 (19.0%) nondiabetics developed the primary outcome of HF hospitalization or HF death. After adjustments for baseline differences, diabetes was associated with a 68% increased risk of HF hospitalization or HF death (adjusted hazard ratio 1.68, 95% confidence interval 1.26 to 2.25, p <0.001). In conclusion, in patients with HF and preserved LVEF, diabetes is associated with significantly increased risk of developing adverse HF outcomes.
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Both morbidity and long-term mortality of HFpEF are greatly worsened by a coexisting diabetes, and this adverse outcome cannot be offset by effective treatments.
“Both morbidity and long-term mortality of HFpEF are greatly worsened by a coexisting diabetes and this adverse outcome cannot be offset by effective treatments [71,76].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [76]
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- Authors
- Aguilar, D., Deswal, A., Ramasubbu, K., Mann, D. L., & Bozkurt, B.
- Affiliations
- Michael E. DeBakey VA Medical Center (US)
- Washington University in St. Louis (US)
- Corresponding author
- Aguilar, David
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 105
- Issue
- 3
- Pages
- 373-377
- ISSN
- 0002-9149 (ISSN-L)
- PMC
- PMC2813214
- OpenAlex
- W2015863737
- Cited by
- 96
- References
- 23
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (5K01-HL092585-02, K01HL092585)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Keywords
- heart failure with preserved ejection fraction, diabetes mellitus, heart failure hospitalization, heart failure mortality, comorbidities, risk factors
- MeSH terms
- Aged, Female, Follow-Up Studies, Heart Failure, Hospitalization, Humans, Male, Medical Records, Middle Aged, Obesity, Research Design, Risk Factors, Stroke Volume, Texas, Cohort Studies, Body Mass Index, Confidence Intervals, Odds Ratio, Randomized Controlled Trials as Topic, Diabetes Complications
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