Diabetes in heart failure: prevalence and impact on outcome in the population

From, Aaron M.; Leibson, Cynthia L.; Bursi, Francesca; Redfield, Margaret M.; Weston, Susan A.; Jacobsen, Steven J.; Rodeheffer, Richard J.; Roger, Véronique L.

doi:10.1016/j.amjmed.2006.05.024

Cited by 295Heart Failure Treatment and ManagementCardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins

Diabetes in heart failure: prevalence and impact on outcome in the population

From, Aaron M., Leibson, Cynthia L., Bursi, Francesca, Redfield, Margaret M., Weston, Susan A., Jacobsen, Steven J., Rodeheffer, Richard J., Roger, Véronique L.·2006·The American Journal of Medicine

DOI 10.1016/j.amjmed.2006.05.024

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Abstract

Purpose Little is known on the prevalence and prognostic importance of diabetes mellitus (DM) among individuals with heart failure (HF) in community-based cohorts.Methods Within Olmsted County, Minnesota, a random sample of all subjects with a first diagnosis of HF between 1979 and 1999 was validated using Framingham criteria. DM was validated using glycemic criteria.Results Among 665 subjects with HF (mean age 77+/-12 years, 46% male), 20% had prior DM. Subjects with DM were younger, had greater body mass index (BMI), and lower left ventricular ejection fraction than subjects without diabetes. The prevalence of DM increased markedly over time (3.8% per year; 95% confidence interval [CI], 0.8 to 6.9; P=.024), independently of BMI, particularly in older subjects (odds ratio of having DM in 1999 compared with 1979 was 3.93 [95% CI, 1.57 to 9.83] in subjects > or = 75 years vs. 1.11 [95% CI, .40 to 3.05] in subjects <75 years). Five-year survival was 37% among subjects with DM versus 46% among subjects without (P=.017). The risk of death associated with DM differed markedly according to clinical coronary artery disease (CAD) (P=.025). Subjects with DM and no CAD had a higher risk of death (relative risk [RR]=1.79 [95% CI, 1.33 to 2.41]) than those with CAD (RR=1.11 [95% CI, .81 to 1.51]), independently of age, sex, BMI, renal function, calendar year of HF, comorbidity and EF.Conclusions Among community-dwelling patients with HF, the prevalence of DM increased markedly over time. DM is associated with a large increase in mortality, particularly among subjects without clinical CAD, underscoring the importance of aggressive management of DM in HF.

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The majority of the available data suggests that T2DM is associated with higher risk of mortality in both patients of ischaemic and non-ischaemic aetiology.
“The majority of the available data suggests that T2DM is associated with higher risk of mortality in both patients of ischaemic and non-ischaemic aetiology (Table 6).29,88,94,96 -99”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [29]
Two smaller population-based studies in the United States and France and one Spanish single-centre study suggested that diabetes was only associated with higher mortality in those with non-ischaemic aetiology.
“These consistent findings conflict with two smaller population-based studies in the United States 29 and France 97 and one Spanish single-centre study 101 of patients hospitalized with HF, which suggested that diabetes was only associated with higher mortality in those with non-ischaemic aetiology.”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [29]

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BackgroundResult
Sleep disordered breathing and post-discharge mortality in patients with acute heart failure
Khayat, R., Jarjoura, D., Porter, K., Sow, A., Wannemacher, J., Dohar, R., Pleister, A., & Abraham, W. T. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu522 · Cited by 278 · see citing works
“Heart failure (HF), a leading cause of morbidity and mortality in the developed world, continues to increase in incidence.(1,2) The mortality rates of HF remain largely unchanged despite several advances in the management of cardiovascular disease.”
Background
Congestive heart failure is a rare event in patients receiving imatinib therapy
Atallah, E. L., Durand, J., Kantarjian, H. M., & Cortes, J. E. (2007) · Blood · doi:10.1182/blood-2007-01-070144 · Cited by 252 · see citing works
“600 mg 8 (36) 800 mg 5 (23) Albumin, g/L 33 (17-49)”
Background
Transforming growth factor beta (TGF-β) mediates cardiac fibrosis and induces diabetic cardiomyopathy
Yue, Y., Meng, K., Pu, Y., & Zhang, X. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.08.018 · Cited by 242 · see citing works
“diabetes when compared to non-diabetic individuals [8].”
Diabetes, left ventricular systolic dysfunction, and chronic heart failure
MacDonald, M. R., Petrie, M. C., Hawkins, N. M., Petrie, J. R., Fisher, M., McKelvie, R., Aguilar, D., Krum, H., & McMurray, J. J. V. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn156 · Cited by 227 · see citing works
“population study found the increased mortality risk of DM was confined to patients with HF of non-ischaemic aetiology.(27) This”
Background
Relationship of Hemoglobin A1C and Mortality in Heart Failure Patients With Diabetes
Aguilar, D. A., Bozkurt, B., Ramasubbu, K., & Deswal, A. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.049 · Cited by 217 · see citing works
Comorbidity and Ventricular and Vascular Structure and Function in Heart Failure With Preserved Ejection Fraction
Mohammed, S. F., Borlaug, B. A., Roger, V. L., Mirzoyev, S. A., Rodeheffer, R. J., Chirinos, J. A., & Redfield, M. M. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.968594 · Cited by 213 · see citing works
Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: A large multinational cohort study
Birkeland, K. I., Bodegard, J., Eriksson, J. W., Norhammar, A., Haller, H., Linssen, G. C. M., Banerjee, A., Thuresson, M., Okami, S., Garal‐Pantaler, E., et al. (2020) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14074 · Cited by 223 · see citing works
Metformin Use and Mortality in Ambulatory Patients With Diabetes and Heart Failure
Aguilar, D. A., Chan, W., Bozkurt, B., Ramasubbu, K., & Deswal, A. M. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.952556 · Cited by 204 · see citing works
“In a recent community based survey in Olmstead County, investigators determined that 20% of individuals presenting with a first episode of HF had a prior diagnosis of diabetes.(1) In addition, the investigators demonstrated that prevalence of diabetes in patients with HF had increased markedly over a 20-year period (3.”
Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial
Sarma, S., Mentz, R. J., Kwasny, M. J., Fought, A. J., Huffman, M., Subacius, H., Nodari, S., Konstam, M., Swedberg, K., Maggioni, A. P., et al. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs153 · Cited by 202 · see citing works
The presentation and outcome of heart failure in patients with rheumatoid arthritis differs from that in the general population
Davis, J. M., Roger, V. L., Crowson, C. S., Kremers, H. M., Therneau, T. M., & Gabriel, S. E. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23798 · Cited by 176 · see citing works
“50) Hepatojugular reflux 11 (11) 153 (20) 0.”
Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes
Park, J. J. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0282 · Cited by 179 · see citing works
“Diabetes increases the risk for HF [9-11] and complicates its course, such that HF patients with DM had worse outcomes than those without DM [12,13].”
Background
Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology
Cubbon, R. M., Adams, B., Rajwani, A., Mercer, B. N., Patel, P. A., Gherardi, G., Gale, C. P., Batin, P. D., Ajjan, R., Kearney, L., et al. (2013) · Diabetes and Vascular Disease Research · doi:10.1177/1479164112471064 · Cited by 167 · see citing works
“The principal findings of this study are as follows: (1) DM remains an adverse prognostic factor in patients with CHF receiving contemporary evidence-based therapy and (2) DM impacts similarly upon total and cardiovascular mortality in ischaemic and non-ischaemic cardiomyopathies.”
Result
The burden of diabetes and its complications: Trends and implications for intervention
Chaturvedi, N. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.01.019 · Cited by 169 · see citing works
Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure: Findings from Get With The Guidelines-Heart Failure registry
Echouffo-Tcheugui, J. B., Xu, H., DeVore, A. D., Schulte, P. J., Butler, J., Yancy, C. W., Bhatt, D. L., Hernandez, A. F., Heidenreich, P. A., & Fonarow, G. C. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.07.025 · Cited by 160 · see citing works
The Prevalence of Diabetic Cardiomyopathy: A Population-Based Study in Olmsted County, Minnesota
Dandamudi, S., Slusser, J. P., Mahoney, D. W., Redfield, M. M., Rodeheffer, R. J., & Chen, H. H. (2014) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.02.007 · Cited by 160 · see citing works
Central Sleep Apnea is a Predictor of Cardiac Readmission in Hospitalized Patients With Systolic Heart Failure
Khayat, R., Abraham, W. T., Patt, B. T., Brinkman, V. E., Wannemacher, J., Porter, K. M., & Jarjoura, D. G. (2012) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2012.05.003 · Cited by 145 · see citing works
Type 2 diabetes mellitus and heart failure, a scientific statement from the American Heart Association and Heart Failure Society of America
Dunlay, S. M., Givertz, M. M., Aguilar, D., Allen, L. A., Chan, M., Desai, A. S., Deswal, A., Dickson, V. V., Kosiborod, M. N., Lekavich, C. L., et al. (2019) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2019.05.007 · Cited by 145 · see citing works
“In HF cohorts, including both HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), the prevalence of DM ranges from 10% to 47%.(11) 15 The prevalence of DM is higher in patients hospitalized with HF, with some reports of >40%.”
Glucagon-Like Peptide 1 Receptor Agonists and Heart Failure: The Need for Further Evidence Generation and Practice Guidelines Optimization
Khan, M. S., Fonarow, G. C., McGuire, D. K., Hernandez, A. F., Vaduganathan, M., Rosenstock, J., Handelsman, Y., Verma, S., Anker, S. D., McMurray, J. J. V., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.045888 · Cited by 139 · see citing works
LncRNA H19 inhibits autophagy by epigenetically silencing of DIRAS3 in diabetic cardiomyopathy
Zhuo, C., Jiang, R., Lin, X., & Shao, M. (2016) · Oncotarget · doi:10.18632/oncotarget.13637 · Cited by 139 · see citing works
“Prospective population-based studies have shown that the risk of heart failure is increased significantly by diabetes [1, 2].”
Background
Management of chronic heart failure in the older population.
Azad, N., & Lemay, G. (2014) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2014.04.008 · Cited by 161 · see citing works
Diabetes leading to heart failure and heart failure leading to diabetes: epidemiological and clinical evidence
Palazzuoli, A., & Iacoviello, M. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10238-6 · Cited by 122 · see citing works
Diabetic Cardiomyopathy
Schilling, J. D., & Mann, D. L. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.06.007 · Cited by 117 · see citing works
Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin
Lekli, I., Szabó, G. V., Juhász, B., Das, S., Das, M., Varga, E., Szendrei, L., Gesztelyi, R., Váradi, J., Bak, I., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01048.2007 · Cited by 113 · see citing works
“Diabetes is a major risk factor for the development of cardiovascular diseases, which accounts largely for the high morbidity and mortality in diabetic populations (3, 17, 33).”
Association of Diabetes Mellitus on Cardiac Remodeling, Quality of Life, and Clinical Outcomes in Heart Failure With Reduced and Preserved Ejection Fraction
Yap, J. J. L., Tay, W. T., Teng, T. K., Anand, I. S., Richards, M., Ling, L. H., MacDonald, M. R., Chandramouli, C., Tromp, J., Siswanto, B. B., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013114 · Cited by 111 · see citing works
“Most previous studies of diabetesmellitus and HF have focused on Western populations, and data on the relationship between diabetes mellitus and HF phenotypes in Asia are lacking.(2) Knowledge gleaned from Western cohorts may not be readily extrapolated toAsians, particularly in light of recent studiesshowing distinct…”
Background
The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma
Rothhammer-Hampl, T., Hahne, J. C., Florin, A., Poser, I., Soncin, F., Wernert, N., & Bosserhoff, A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3337-8 · Cited by 108 · see citing works
Electrocardiographic and cardiac magnetic resonance imaging parameters as predictors of a worse outcome in patients with idiopathic dilated cardiomyopathy
Hombach, V., Merkle, N., Torzewski, J., Kraus, J. M., Kunze, M., Zimmermann, O., Kestler, H. A., & Wöhrle, J. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp293 · Cited by 100 · see citing works
Comparison of patients with heart failure and preserved left ventricular ejection fraction among those with versus without diabetes mellitus
Aguilar, D., Deswal, A., Ramasubbu, K., Mann, D. L., & Bozkurt, B. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.09.041 · Cited by 96 · see citing works
p53 Promotes Cardiac Dysfunction in Diabetic Mellitus Caused by Excessive Mitochondrial Respiration-Mediated Reactive Oxygen Species Generation and Lipid Accumulation
Nakamura, H., Matoba, S., Iwai‐Kanai, E., Kimata, M., Hoshino, A., Nakaoka, M., Katamura, M., Okawa, Y., Ariyoshi, M., Mita, Y., et al. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.111.961565 · Cited by 94 · see citing works
“Genetic type 2 diabetes mice db/db mice [2], defect in the leptin receptor, have obesity, insulin resistance, and diabetes.”
Background
Heart Failure and Diabetes Mellitus: Epidemiology and Management of an Alarming Association
Solal, A. C., Beauvais, F., & Logeart, D. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.04.001 · Cited by 93 · see citing works
Concomitant Diabetes Mellitus and Heart Failure
Dei, A., Fonarow, G. C., Gheorghiade, M., & Butler, J. (2014) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2014.09.002 · Cited by 92 · see citing works
Diabetes Mellitus and Heart Failure: Epidemiology, Mechanisms, and Pharmacotherapy
Masoudi, F. A., & Inzucchi, S. E. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.11.013 · Cited by 89 · see citing works
Change in Comorbidity Prevalence with Advancing Age Among Persons with Heart Failure
Ahluwalia, S. C., Gross, C. P., Chaudhry, S. I., Leo-Summers, L. S., Ness, P. H. V., & Fried, T. R. (2011) · Journal of General Internal Medicine · doi:10.1007/s11606-011-1725-6 · Cited by 90 · see citing works
Long-term excess risk of heart failure in people with type 1 diabetes: a prospective case-control study
Rosengren, A., Vestberg, D., Svensson, A., Kosiborod, M., Clements, M. A., Rawshani, A., Pivodic, A., Guðbjörnsdóttir, S., & Lind, M. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00292-2 · Cited by 87 · see citing works
The Mitochondria in Diabetic Heart Failure: From Pathogenesis to Therapeutic Promise
Schilling, J. D. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6294 · Cited by 90 · see citing works
“Diabetes is also extremely common in patients who have HF with reduced EF (HFrEF), with a prevalence approaching 40% in many HF registries and clinical trials.”
Prevalence and clinical significance of diabetes in asian versus white patients with heart failure
Bank, I. E. M., Gijsberts, C. M., Teng, T.-H. K., Benson, L., Sim, D., Yeo, P. S. D., Ong, H. Y., Jaufeerally, F., Leong, G. K. T., Ling, L. H., et al. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2016.09.015 · Cited by 87 · see citing works
Diabetes mellitus, cachexia and obesity in heart failure: rationale and design of the Studies Investigating Co‐morbidities Aggravating Heart Failure (SICA‐HF)
von Haehling, S., Lainščak, M., Doehner, W., Ponikowski, P. P., Rosano, G. M. C., Jordan, J., Rozentryt, P., Rauchhaus, M., Karpov, R. S., Va, T., et al. (2010) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-010-0013-3 · Cited by 87 · see citing works
“The prevalence of this co-morbidity ranges between 20% and 30% in prospective large-scale studies of ambulatory heart failure [21, 22], and elevated levels of glycated haemoglobin have been shown to be strong predictors of mortality among patients with heart failure [23].”
Background
From Bedside to Bench: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Comorbidity and Multiple Morbidity in Older Adults
Boyd, C. M., Ritchie, C. S., Tipton, E. F., Studenski, S. A., & Wieland, D. (2008) · Aging Clinical and Experimental Research · doi:10.1007/bf03324775 · Cited by 85 · see citing works
Diabetic Cardiomyopathy: Current Approach and Potential Diagnostic and Therapeutic Targets
Gîlcă-Blanariu, G.-E., Ștefănescu, G., Bădulescu, O. V., Tănase, D. M., Bararu, I., & Ciocoiu, M. (2017) · Journal of Diabetes Research · doi:10.1155/2017/1310265 · Cited by 86 · see citing works
“As a consequence, early detection and progression prevention of diabetic cardiomyopathy are essential for this patient category, especially considering the worse prognosis of heart failure among diabetic patients [3].”
Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice
Sun, Y., Lu, F., Yu, X., Wang, B., Chen, J., Lu, F., Peng, S., Sun, X., Yu, M., Chen, H., et al. (2020) · Aging and Disease · doi:10.14336/ad.2019.0524 · Cited by 83 · see citing works
“Large epidemiological studies have confirmed that type 2 diabetes is associated with increased mortality caused by augmented risk of cardiovascular death [1].”
Background
Disturbed angiogenic activity of adipose-derived stromal cells obtained from patients with coronary artery disease and diabetes mellitus type 2
Dzhoyashvili, N. A., Efimenko, A. Y., Kochegura, T. N., Kalinina, N., Koptelova, N. V., Sukhareva, O. Y., Shestakova, M. V., Akchurin, R. S., Va, T., & Parfyonova, Y. V. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0337-4 · Cited by 82 · see citing works
“Most of cardiac pathologies as well as T2DM result in permanent cardiac tissue damage followed by heart failure [1-4].”
Background
Impact of Comorbidity on Mortality Among Older Persons with Advanced Heart Failure
Ahluwalia, S. C., Gross, C. P., Chaudhry, S. I., Ning, Y. M., Leo-Summers, L. S., Ness, P. H. V., & Fried, T. R. (2011) · Journal of General Internal Medicine · doi:10.1007/s11606-011-1930-3 · Cited by 81 · see citing works
Aggravated Postinfarct Heart Failure in Type 2 Diabetes Is Associated with Impaired Mitophagy and Exaggerated Inflammasome Activation
Devi, T. D., Babu, M., Mäkinen, P. I., Kaikkonen, M. U., Heinäniemi, M., Laakso, H., Ylä‐Herttuala, E., Rieppo, L., Liimatainen, T., Naumenko, N. V., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.08.023 · Cited by 76 · see citing works
“[1-3] Diabetic patients are susceptible to myocardial infarction (MI) due to extensive coronar y therosclerosis.”
Background
The microvascular effects of insulin resistance and diabetes on cardiac structure, function, and perfusion: a cardiovascular magnetic resonance study
Larghat, A., Swoboda, P., Biglands, J. D., Kearney, M. T., Greenwood, J. P., & Plein, S. (2014) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeu142 · Cited by 74 · see citing works
“Observational studies have demonstrated that patients with systolic heart failure and diabetes have a mortality that is almost doubled compared with their normoglycaemic counterparts.(7,8)”
Background
Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides
Ghosh, N., & Katare, R. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0684-1 · Cited by 71 · see citing works
“Population-based studies have revealed that the risk of heart failure is augmented 2 to 3-fold by diabetes [9, 10].”
Background
Prognostic impact of diabetes mellitus in patients with heart failure and preserved ejection fraction: a prospective five-year study
Tribouilloy, C. M., Ruşinaru, D., Mahjoub, H., Tartiere, J.-H., Tartière-Kesri, L., Godard, S., & Peltier, M. (2008) · Heart · doi:10.1136/hrt.2007.128769 · Cited by 71 · see citing works
“The prevalence of CAD in diabetic patients in our study is lower compared with other reports.(7) However this issue was poorly studied in patients with HFPEF.”
BackgroundResultInfluential
Diabetic Cardiomyopathy; Summary of 41 years
Yılmaz, S., Canpolat, U., Aydoğdu, S., & Abboud, H. E. (2015) · Korean Circulation Journal · doi:10.4070/kcj.2015.45.4.266 · Cited by 70 · see citing works
Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium
Wallner, M., Kolesnik, E., Ablasser, K., Khafaga, M., Wakula, P., Ljubojević-Holzer, S., Thon-Gutschi, E., Sourij, H., Kapl, M., Edmunds, N. J., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.09.018 · Cited by 70 · see citing works
Non-cardiovascular comorbidity, severity and prognosis in non-selected heart failure populations: A systematic review and meta-analysis
Rushton, C. A., Satchithananda, D. K., Jones, P. W., & Kadam, U. T. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.180 · Cited by 69 · see citing works
Co-morbidities in heart failure
van Deursen, V. M., Damman, K., van der Meer, P., Wijkstra, P. J., Luijckx, G. J., van Beek, A. P., van Veldhuisen, D. J., & Voors, A. A. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9370-7 · Cited by 67 · see citing works
“The risk of development of heart failure is also increased in patients with diabetes and impaired glucose tolerance [42].”
Background
Improved Diabetic Control in Advanced Heart Failure Patients Treated with Left Ventricular Assist Devices
Uriel, N. Y., Naka, Y., Colombo, P. C., FARR, M. A., Pak, S., Cotarlan, V., Albu, J., Gallagher, D., MANCINI, D. M., Ginsberg, H. N., et al. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq204 · Cited by 68 · see citing works
“Congestive heart failure (CHF) will eventually affect one in five Americans and is already responsible for the consumption of an extraordinary proportion of health-care resources.(3,4) A relationship between IR and CHF has long been recognized and is classically attributed to the higher prevalence of coronary artery d…”
Background
Heart Failure in North America
Blair, J. E., Huffman, M. D., & Shah, S. J. (2013) · Current Cardiology Reviews · doi:10.2174/1573403x11309020006 · Cited by 67 · see citing works
Discordant Short- and Long-Term Outcomes Associated With Diabetes in Patients With Heart Failure: Importance of Age and Sex: A Population Study of 5.1 Million People in Scotland
MacDonald, M. R., Jhund, P. S., Petrie, M. C., Lewsey, J. D., Hawkins, N. M., Bhagra, S., Munoz, N., Varyani, F., Redpath, A., Chalmers, J., et al. (2008) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.794008 · Cited by 64 · see citing works
Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial
FESC, F. E. O. A. D.-4. I. O. L. V. D. D. I. P. W. T. 2. D. A. D. C. (. S. I., Oe, H., Nakamura, K., Kihara, H., Shimada, K., Fukuda, S., Takagi, T., Miyoshi, T., Hirata, K., Yoshikawa, J., et al. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0242-z · Cited by 63 · see citing works
“8 % per year) [8].”
Association between type-2 diabetes mellitus and post-discharge outcomes in heart failure patients: Findings from the RICA registry
Carrasco-Sánchez, F. J., Gómez-Huelgas, R., Formiga, F., Martel, A. C., Trullàs, J. C., Bettencourt, P., Arévalo‐Lorido, J. C., & Montero-Pérez-Barquero, M. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.03.015 · Cited by 63 · see citing works
Rosiglitazone treatment improves cardiac efficiency in hearts from diabetic mice
How, O.-J., Larsen, T. S., Hafstad, A. D., Khalid, A. M., Myhre, E. S. P., Murray, A. J., Boardman, N. T., Cole, M. A., Clarke, K., Severson, D. L., et al. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450701783281 · Cited by 59 · see citing works
“Type 2 diabetic patients also have decreased survival after myocardial infarction and increased rates of congestive heart failure (From et al., 2006) and silent ischemia compared with non-diabetic control subjects (Carley et al., 1996).”
Background
Prognostic Significance of Peripheral Microvascular Endothelial Dysfunction in Heart Failure With Reduced Left Ventricular Ejection Fraction
Fujisue, K., Sugiyama, S., Matsuzawa, Y., Akiyama, E., Sugamura, K., Matsubara, J., Kurokawa, H., Maeda, H., Hirata, Y., Kusaka, H., et al. (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0671 · Cited by 59 · see citing works
Gender Differences in Age-Related Changes in Left and Right Ventricular Geometries and Functions
Daimon, M., Watanabe, H., Abe, Y., Hirata, K., Hozumi, T., Ishii, K., Ito, H., Iwakura, K., Izumi, C., Matsuzaki, M., et al. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-0364 · Cited by 59 · see citing works
Heart Failure in Outpatients: Comorbidities and Management by Different Specialists. The EPISERVE Study
González‐Juanatey, J. R., Ezquerra, E. A., Bertoméu, V., Gutiérrez, P. C., Nocito, A. D. S., & Fradera, I. Z. (2008) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(08)60185-1 · Cited by 57 · see citing works
Myocardial Metabolism in Diabetic Cardiomyopathy: Potential Therapeutic Targets
Sung, M. M. Y., Hamza, S. M., & Dyck, J. R. B. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6305 · Cited by 57 · see citing works
“Further to this, diabetic patients also comprise 15%–20% of subjects in HF clinical trials (54), and there is evidence that diabetes itself is an independent predictor of poor outcomes in HF (86, 235).”
Anaemia is an independent predictor of death in patients hospitalized for acute heart failure
von Haehling, S., Schefold, J. C., Hodošček, L. M., Doehner, W., Mannaa, M., Anker, S. D., & Lainščak, M. (2009) · Clinical Research in Cardiology · doi:10.1007/s00392-009-0092-3 · Cited by 56 · see citing works
“Indeed, co-morbidities such as diabetes mellitus [4], kidney failure [5], or cardiac cachexia [6] are important considerations in the patient assessment, because all of them are known to have unfavourable effects on morbidity and mortality.”
Background
Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among Obese Patients With Prediabetes and Known Diabetes Mellitus
Berezin, A. Е., Berezin, A. A., & Lichtenauer, M. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.583175 · Cited by 55 · see citing works
Left ventricular diastolic functional reserve during exercise in patients with impaired myocardial relaxation at rest
Ha, J., Choi, D., Park, S., Choi, E.-Y., Shim, C. Y., Kim, J.-M., Ahn, J.-A., Lee, S.-W., Oh, J. K., & Chung, N. (2008) · Heart · doi:10.1136/hrt.2008.145441 · Cited by 55 · see citing works
CSI position statement on management of heart failure in India
Guha, S., Harikrishnan, S., Ray, S., Sethi, R., Ramakrishnan, S., Banerjee, S., Bahl, V. K., Goswami, K. C., Banerjee, A. K., Shanmugasundaram, S., et al. (2018) · Indian Heart Journal · doi:10.1016/j.ihj.2018.05.003 · Cited by 55 · see citing works
CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis
Chu, P., Walder, K. R., Horlock, D., Williams, D., Nelson, E., BYRNE, M. J., Jandeleit-Dahm, K. A. M., Zimmet, P., & Kaye, D. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133616 · Cited by 53 · see citing works
“In patients with established heart failure, diabetes is an independent risk factor for increased mortality [5, 25, 26].”
Background
Epigenetic regulation in heart failure
Kim, S. Y., Morales, C. R., Gillette, T. G., & Hill, J. A. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000276 · Cited by 49 · see citing works
Insuficiencia cardiaca en consultas ambulatorias: comorbilidades y actuaciones diagnóstico-terapéuticas por diferentes especialistas. Estudio EPISERVE
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Authors: From, A. M., Leibson, C. L., Bursi, F., Redfield, M. M., Weston, S. A., Jacobsen, S. J., Rodeheffer, R. J., & Roger, V. L.
Affiliations: Mayo Clinic (US)
ORCID: Bursi, Francesca
Redfield, Margaret M.
Jacobsen, Steven J.
Rodeheffer, Richard J.
Venue: The American Journal of Medicine
Publisher: Elsevier BV
Published: 2006-07
Volume: 119
Issue: 7
Pages: 591-599
ISSN: 0002-9343 (ISSN-L)
DOI: 10.1016/j.amjmed.2006.05.024
OpenAlex: W1993907769
Cited by: 295
References: 63
Citations by year: 2026: 6 · 2025: 6 · 2024: 11 · 2023: 12 · 2022: 19 · 2021: 9 · 2020: 19 · 2019: 16 · 2018: 15 · 2017: 17 · 2016: 19 · 2015: 19 · 2014: 18 · 2013: 11 · 2012: 20
FWCI: 10.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The American Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: diabetes mellitus, heart failure, prevalence, mortality, coronary artery disease, left ventricular ejection fraction, body mass index, community-dwelling patients, Olmsted County, Minnesota, Framingham criteria
MeSH terms: Aged, Aged, 80 and over, Coronary Disease, Diabetes Mellitus, Female, Heart Failure, Humans, Male, Middle Aged, Minnesota, Prognosis, Retrospective Studies, Cohort Studies, Comorbidity, Prevalence, Diabetes Complications

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Diabetes in heart failure: prevalence and impact on outcome in the population

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