Influence of pregnancy on aortic diameter in women with the Turner syndrome
Open accessAbstract
Women with Turner syndrome (TS) have high prevalence of cardiovascular anomalies. Literature suggests pregnancy is associated with a higher dissection risk, presumably preceded by aortic dilatation. Whether the aortic diameter truly changes during pregnancy in TS is not well investigated. This study aims to evaluate ascending aortic diameter change during pregnancy and reports on cardiac events during and directly after pregnancy. This tertiary hospital retrospective study investigated all TS women pregnancies (2009 to 2018). Outcome parameters included aortic diameter growth and aortic complications, specifically dissection. Thirty-five pregnancies in 30 TS women, 57% assisted by oocyte donation. Mean age at delivery 32 ± 5 years. In 27 pregnancies of 22 women imaging was available. From over 350 childless TS women a comparison group of 27 was individually matched. The median ascending aortic diameter growth between pre- and postpregnancy imaging was 1.0 mm (IQR -1.0; 2.0), no significant change (p = 0.077). Whether the patient had a bicuspid aortic valve (p = 0.571), monosomy X or mosaic karyotype (p = 0.071) or spontaneous pregnancy or resulting from oocyte donation (p = 0.686) had no significant influence on diameter change. Aortic growth between pregnancy and matched childless group (0.23 vs 0.32 mm/year, p = 0.788) was not significant over 3.3 ± 2 versus 4.4 ± 1 years. During pregnancy or the first 6 months after delivery no aortic complications were observed. In conclusion, this study suggests pregnancy in TS women does not induce faster ascending aortic diameter increase. Also not in presence of a bicuspid aortic valve, monosomy X karyotype, and oocyte donation. No aortic complications occurred. Based on current study pregnancy in TS women seems safe.
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- Authors
- Kooijman, S. S., Duijnhouwer, A. L., van Kimmenade, R. R. J., van Dijk, A. P. J., Hink, E., de Boer, M.-J., Timmermans, J., & Roos-Hesselink, J. W.
- Affiliations
- Radboud University Medical Center (NL)
- Corresponding author
- Kooijman, Silje S
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 140
- Pages
- 122-127
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W3097324084
- Cited by
- 13
- References
- 32
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 2 · 2022: 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- green
- pure.eur.nl
- Licence
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Keywords
- Turner syndrome, pregnancy, ascending aortic diameter, aortic dilatation, aortic dissection, cardiovascular anomalies, bicuspid aortic valve, monosomy X, mosaic karyotype, oocyte donation, pregnancy safety
- MeSH terms
- Adult, Aorta, Thoracic, Echocardiography, Female, Follow-Up Studies, Humans, Pregnancy, Pregnancy Complications, Retrospective Studies, Turner Syndrome, Aortic Aneurysm, Thoracic, Magnetic Resonance Imaging, Cine
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