Pregnancy outcome after oocyte donation in patients with Turner's syndrome and partial X monosomy
Abstract
BACKGROUND: Fertility expectations for patients with Turner's syndrome (TS) have clearly changed in the last three decades. However, medical risks during pregnancy are supposed to be highly increased. The aim of the study was to assess clinical outcome and obstetrical complications in a series of patients with TS in an oocyte donor programme. METHODS: A retrospective study was carried out on 24 women with TS seeking a pregnancy in the Fertility Clinic of the Erasme Hospital from 1992 up until March 2011. RESULTS: Twenty-three patients with TS were included in an oocyte donation cycle. Forty-nine oocyte donation cycles were performed, which led to 45 fresh and 10 frozen-thawed embryo transfers. Altogether, 18 pregnancies were obtained, 10 deliveries (9 singletons and 1 pair of twins), 3 miscarriages and 5 biochemical pregnancies. The clinical pregnancy rate per transfer was 24.4% in fresh cycles and 20% in frozen replacement cycles. Complications of pregnancy occurred in 5 of 10 pregnancies (50%), which led to three premature deliveries because of pregnancy-induced hypertensive disorders. The mean birthweight (g) (±SD) for singletons and twins was 2728 ± 577 and 2335 ± 318, respectively. Four babies were below the 10th percentile. No cardiac complications were observed in any of the pregnant women. CONCLUSIONS: Pregnancy rates after oocyte donation in patients with TS are comparable with those previously published but a high risk of pregnancy hypertensive disorders and a high risk of low birthweight can be highlighted from our study. Strict inclusion criteria and single embryo transfer are necessary to minimize complications during pregnancy in this high-risk group.
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Women with TS are at increased risk for hypertensive disorders of pregnancy, including pre-eclampsia.
“Women with TS are at increased risk for hypertensive disorders of pregnancy, including pre-eclampsia.522-524”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [522]
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- Authors
- Mercadal, B. A., Imbert, R., Demeestere, I., Englert, Y., & Delbaere, A.
- Affiliations
- Université Libre de Bruxelles (BE)
- Corresponding author
- Mercadal, B. A.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-06
- Volume
- 26
- Issue
- 8
- Pages
- 2061-2068
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2166920036
- Cited by
- 60
- References
- 62
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 1 · 2022: 9 · 2021: 2 · 2020: 8 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- Fonds Erasme
- Fondation pour la Recherche Médicale
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- Turner syndrome, oocyte donation, pregnancy outcomes, pregnancy complications, hypertensive disorders of pregnancy, low birth weight, miscarriage, clinical pregnancy rate, frozen embryo transfer, single embryo transfer, twins
- MeSH terms
- Adult, Embryo Transfer, Female, Humans, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Retrospective Studies, Turner Syndrome, Oocyte Donation, Pregnancy Rate
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