CoChat
Sign Up
Cited by 93Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesConnective tissue disorders researchVascular anomalies and interventions

Abnormalities of the major intrathoracic arteries in Turner syndrome as revealed by magnetic resonance imaging

Mortensen, Kristian Havmand, Hjerrild, Britta Eilersen, Andersen, Niels Holmark, Sørensen, Keld Ejvind, Hørlyck, Arne, Pedersen, Erik Morre, Lundorf, Erik, Christiansen, Jens Sandahl +1 more·2010·Cardiology in the Young
DOI 10.1017/s1047951110000041
Open this paper in CoChat — free account

Abstract

BACKGROUND: Ectatic aortopathy and arterial abnormalities cause excess morbidity and mortality in Turner syndrome, where a state of vasculopathy seemingly extends into the major head and neck branch arteries. OBJECTIVE: We investigated the prevalence of abnormalities of the major intrathoracic arteries, their interaction with arterial dimensions, and their association with karyotype. DESIGN: Magnetic resonance imaging scans determined the arterial abnormalities as well as head and neck branch artery and aortic dimensions in 99 adult women with Turner syndrome compared with 33 healthy female controls. Echocardiography determined aortic valve morphology. RESULTS: In Turner syndrome, the relative risk of any congenital abnormality was 7.7 (p = 0.003) and 6.7 of ascending aortic dilation (p = 0.02). A bovine aortic arch was seen in both Turner syndrome and controls. Other abnormalities were only encountered in Turner syndrome: elongated transverse aortic arch (47%), bicuspid aortic valve (27%), aortic coarctation (13%), aberrant right subclavian artery (8%), and aortic arch hypoplasia (2%). The innominate and left common carotid arteries were enlarged in Turner syndrome (p < 0.001). Significant associations were first, bicuspid aortic valve with aortic coarctation, elongated transverse aortic arch, and ascending aortic dilation; second, aortic coarctation with elongated aortic arch and descending aortic dilation; third, 45,X with aortic coarctation, elongated transverse aortic arch and ascending aortic dilation; and fourth, branch artery dilation with bicuspid aortic valve, aortic coarctation, elongated transverse aortic arch and 45,X. CONCLUSION: An increased risk of arterial abnormalities, aortic dilation, and enlargement of the branch arteries was found in Turner syndrome without distinct patterns of co-segregation.

Integrity signals

Registry

Crossref · 10.1017/s1047951110000041

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Non-invasive imaging is an essential part of cardiovascular screening and surveillance across the life span of individuals with TS.

    “Non-invasive imaging is an essential part of cardiovascular screening and surveillance across the life span of individuals with TS,233,388,396,418-423 but imaging remains underutilized and not systematically applied.420,424”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [419]

  • Dilation of the aorta, brachiocephalic and carotid arteries may be present even in the absence of structural heart disease, consistent with an underlying generalized arteriopathy.

    “Dilation of the aorta, brachiocephalic and carotid arteries may be present even in the absence of structural heart disease, consistent with an underlying generalized arteriopathy.419,436,437”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [419]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Mortensen, K. H., Hjerrild, B. E., Andersen, N. H., Sørensen, K. E., Hørlyck, A., Pedersen, E. M., Lundorf, E., Christiansen, J. S., & Gravholt, C. H.
Affiliations
Aarhus University Hospital (DK)
Corresponding author
Mortensen, Kristian Havmand
ORCID
Venue
Cardiology in the Young
Publisher
Cambridge University Press (CUP)
Published
2010-03-22
Volume
20
Issue
2
Pages
191-200
ISSN
  • 1047-9511 (ISSN-L)
  • 1467-1107
DOI
10.1017/s1047951110000041
OpenAlex
W2123664848
Cited by
93
References
24
Citations by year
2025: 2 · 2024: 26 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 2 · 2014: 1 · 2013: 8 · 2012: 8
FWCI
3.42
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Cardiology in the Young (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Cambridge
  • Snedkermester Sophus Jacobsen og Hustru Astrid Jacobsens Fond
  • Mokslo, Inovaciju ir Technologiju Agentura
  • Danish Agency for Science and Higher Education
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Health Sciences › Medicine › Surgery › Vascular anomalies and interventions
Keywords
Turner syndrome, aortic dilatation, coarctation of the aorta, bicuspid aortic valve, aberrant right subclavian artery, aortic arch hypoplasia, bovine aortic arch, karyotype, 45,X, aortic valve morphology, congenital arterial anomalies
MeSH terms
Adolescent, Adult, Aorta, Thoracic, Dilatation, Pathologic, Female, Head, Humans, Magnetic Resonance Imaging, Middle Aged, Neck, Subclavian Artery, Turner Syndrome, Ultrasonography, Brachiocephalic Trunk, Carotid Artery, Common, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review