Cited by 160Electronic Health Records SystemsClinical Laboratory Practices and Quality ControlPatient Safety and Medication Errors

Notification of Abnormal Lab Test Results in an Electronic Medical Record: Do Any Safety Concerns Remain?

Open access
Singh, Hardeep, Thomas, Eric J., Sittig, Dean F., Wilson, Lindsey, Espadas, Donna, Khan, Myrna M., Petersen, Laura A.·2010·The American Journal of Medicine

Abstract

Background: Follow-up of abnormal outpatient laboratory test results is a major patient safety concern. Electronic medical records can potentially address this concern through automated notification. We examined whether automated notifications of abnormal laboratory results (alerts) in an integrated electronic medical record resulted in timely follow-up actions. Methods: We studied four alerts: hemoglobin A1c (HbA1c) ≥15%, positive hepatitis C antibody (HCV), prostate specific antigen (PSA) ≥15 ng/mL, and thyroid stimulating hormone (TSH) ≥ 15 mIU/L. An alert tracking system determined whether the alert was acknowledged (i.e. provider clicked on and opened the message) within two weeks of transmission; acknowledged alerts were considered read. Within 30 days of result transmission, record review and provider contact determined follow-up actions (e.g. patient contact, treatment etc.). Multivariable logistic regression models analyzed predictors for lack of timely follow-up. Results: Between May 2008 and December 2008, 78,158 tests (HbA1c, HCV, TSH and PSA) were performed, of which 1163 (1.48%) were transmitted as alerts; 10.2% of these (119/1163) were unacknowledged. Timely follow-up was lacking in 79 (6.8%) and was statistically not different for acknowledged and unacknowledged alerts (6.4% vs. 10.1%; p =.13). Two-hundred two alerts (17.4% of 1163) arose from unnecessarily ordered (redundant) tests. Alerts for a new versus known diagnosis were more likely to lack timely follow-up (OR: 7.35; 95% CI: 4.16-12.97) whereas alerts related to redundant tests were less likely to lack timely follow-up (OR: 0.24; 95% CI: 0.07-0.84). Conclusions: Safety concerns related to timely patient follow-up remain despite automated notification of non-life threatening abnormal laboratory results in the outpatient setting.

Integrity signals

Registry

Crossref · 10.1016/j.amjmed.2009.07.027

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 24 cited sources checked · 0 supported · 0 flagged

  • Findingown data

    202 alerts (17.4% of 1,163) were for tests judged redundant or unnecessarily ordered.

    “Two-hundred two alerts (17.4% of 1163) arose from unnecessarily ordered (redundant) tests.”
    • Also stated in: § RESULTS · plain
      “Two-hundred two alerts (17.4% of 1163) were considered redundant”
    Quote in the paperNot a substantial claim
  • Findingown data

    The proportion of alerts lacking timely follow-up was not significantly different between acknowledged and unacknowledged alerts (6.4% vs 10.1%; p=.13).

    “Timely follow-up was lacking in 79 (6.8%) and was statistically not different for acknowledged and unacknowledged alerts (6.4% vs. 10.1%; p =.13).”
    • Also stated in: § Lack of Timely Follow-up · plain
      “Statistically, there was no significant difference in rates of lack of timely follow-up between acknowledged and unacknowledged laboratory alerts (6.4% vs. 10.1%; p=.13).”
    Quote in the paperSubstantial claim
  • Findingown data

    Of 159 alerts deemed redundant because of repetition, only 11 (7%) would have triggered a computerized reminder about potential redundancy.

    “in only 11 (7%) of these 159 cases would the provider have received a computerized reminder prompting them of potential redundancy based on repetition.”
    Quote in the paperSubstantial claim
  • Findingown data

    Timely follow-up was absent for 79 of the 1,163 alerts (6.8%).

    “Timely follow-up was lacking in 79 (6.8%)”
    • Also stated in: § RESULTS · plain
      “Of these, 79 alerts (6.8% of total) were determined to lack timely follow-up.”
    Quote in the paperSubstantial claim
  • Findingown data

    In the study period from May to December 2008, 78,158 HbA1c, PSA, HCV, and TSH tests were performed at the participating VA facility.

    “Between May 2008 and December 2008, 27,092 HbA1c, 22,837 PSA, 6271 HCV and 21,958 TSH tests were performed.”
    • Also stated in: § Results: · plain
      “Between May 2008 and December 2008, 78,158 tests (HbA1c, HCV, TSH and PSA) were performed”
    Quote in the paperNot a substantial claim
  • May combine two claims. 8
  • Classified as probably not a substantial claim. 5
  • May combine two claims.

    Findingown data

    Trainees and specialty services were less likely to acknowledge alerts than attending/staff physicians and primary care providers, respectively (p<.0001 for both).

    “Trainees were less likely to acknowledge alerts compared to attending/staff physicians and allied health providers (physician assistants and nurse practitioners) whereas specialty services (including mental health) were less likely to acknowledge alerts compared to primary care providers (p<.0001 for both).”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Among the 159 repetition-redundant alerts, 28 involved a test ordered too soon after the previous PSA, TSH, or HbA1c, and 131 involved a repeat HCV ELISA despite an earlier positive result.

    “we found 28 cases where the provider ordered the test too soon after the last PSA, TSH or HbA1c and in 131 cases a second HCV ELISA test was ordered despite the presence of a previous positive test.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    No documented follow-up action was found for 307 alerts (26.4%), and 213 of the 1,163 alerts (18.3%) were classified as no-impact.

    “No evidence of documented follow-up action was found in 307 (26.4%) of the alerts, however 213 (18.3% of 1163) cases were categorized as no-impact alerts.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Study design and conductreasoning

    The study's strengths included a large sample size, multiple clinics, more than 500 providers from different specialties, rigorous follow-up determination, explicit redundancy criteria, various abnormal lab alert types, and an advanced integrated EMR used across VA facilities.

    “many factors including a large sample size, multiple clinics, large number of providers (over 500 from different specialties), rigorous methods to determine follow-up, explicit criteria for determination of redundant tests, various types of abnormal lab alerts and an advanced integrated electronic medical record used in VA facilities throughout the US, all add several unique strengths to our study”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Study design and conductown data

    The study lacked comparable data from non-electronic medical record systems and therefore could not assess the effectiveness of automated notification relative to those systems.

    “We also lack comparable data from non-electronic medical record based systems and cannot comment on the effectiveness of automated notification compared to these systems.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationown data

    Alerts for redundant tests appear to distract providers and may contribute to missed alerts for newly diagnosed conditions.

    “notifications of abnormal redundant tests appear to be a distracting influence on providers who are missing essential alerts for newly diagnosed conditions.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Premisecitation

    Outpatient care is often busy and fragmented, making follow-up of abnormal laboratory test results prone to error.

    “Outpatient care is often busy and fragmented, and therefore follow-up of abnormal laboratory test results is prone to error.”
    Quote in the paperSubstantial claim0 of 10 sources checked
    • cites [1] Edelman, 2002, Outpatient diagnostic errors: unrecognized hyperglycemia, Eff Clin Pract

      Not checked in the free run.

    • cites [2] Hickner, 2008, Testing process errors and their harms and consequences reported from family medicine practices: a study of the American Academy of Family Physicians National Research Network, Qual Saf Health Care source

      Not checked in the free run.

    • cites [3] Hickner, 2005, Issues and initiatives in the testing process in primary care physician offices, Jt Comm J Qual Patient Saf

      Not checked in the free run.

    • cites [4] Poon, 2004, “I wish I had seen this test result earlier!”: dissatisfaction with test result management systems in primary care, Arch Intern Med source

      Not checked in the free run.

    • cites [5] Schiff, 2005, Missed hypothyroidism diagnosis uncovered by linking laboratory and pharmacy data, Arch Intern Med source

      Not checked in the free run.

    • cites [6] Wahls, 2007, The continuing problem of missed test results in an integrated health system with an advanced electronic medical record, Jt Comm J Qual Patient Saf

      Not checked in the free run.

    • cites [7] Wahls, 2007, Diagnostic errors and abnormal diagnostic tests lost to follow-up: a source of needless waste and delay to treatment, J Ambul Care Manage source

      Not checked in the free run.

    • cites [8] Bates, 2005, Doing better with critical test results, Jt Comm J Qual Patient Saf

      Not checked in the free run.

    • cites [9] Schiff, 2005, Introduction: communicating critical test results, Jt Comm J Qual Patient Saf

      Not checked in the free run.

    • cites [10] Nepple, 2008, Prevalence of delayed clinician response to elevated prostate-specific antigen values, Mayo Clin Proc source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Study design and conductnone given

    When no follow-up was documented, a second investigator reviewed the record and contacted the provider by telephone to seek additional evidence of undocumented follow-up or a decision not to pursue follow-up.

    “a second study investigator evaluated the medical record to confirm the findings and contacted the provider by telephone to obtain any additional evidence of undocumented follow-up or a decision to not pursue follow-up.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductcitation

    Objective pre-defined explicit criteria were used to determine whether tests were redundant.

    “We used objective pre-defined explicit criteria to determine redundancy of tests (criteria specified in Table 3).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [20] van Walraven, 1998, Do we know what inappropriate laboratory utilization is?, JAMA source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Study design and conductown data

    Hierarchical multivariable logistic regression models accounted for clustering of laboratory tests by providers.

    “Hierarchical multivariable logistic regression models accounting for clustering of laboratory tests by providers were used to identify factors associated with the outcome variables”
    Quote in the paperSubstantial claim
  • Classified as probably not a substantial claim.

    Study design and conductown data

    A reviewer blinded to acknowledgment status used a standardized pre-tested data collection instrument to assess follow-up actions in the medical record.

    “a reviewer blinded to acknowledgement status evaluated the medical record using a standardized pre-tested data collection instrument to determine any follow-up actions”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Premisecitation

    Earlier research found that ordering practitioners may fail to review abnormal diagnostic imaging alerts, and even when they review them, they may not act promptly on the results.

    “In previous work, we found abnormal diagnostic imaging alerts may not always be reviewed by ordering practitioners, and practitioners who review them may not always act upon the transmitted results in a timely manner.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [19] Singh, 2009, Timely follow-up of abnormal diagnostic imaging test results in an outpatient setting: are electronic medical records achieving their potential?, Arch Intern Med source

      Not checked in the free run.

12 of 12
  • The paper relies on this without support.

    Follow-up of an abnormal result depends on providers reviewing and acting on the electronic communication of the result.

    “Abnormal result follow-up, however, will occur only if electronic communication of test results (either through alerts or direct access of test result) is reviewed and acted upon by providers.”
  • The paper relies on this without support.

    A substantial share of outpatient lab results are not urgent enough to require verbal reporting to the ordering clinician.

    “many laboratory test results in the outpatient setting may not be immediately life threatening and hence not verbally reported to the ordering provider.”
2 of 2

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A sample size of 30 participants, each reviewing 35 test results, was required to achieve 80% power to detect a statistically significant difference in cognitive workload and performance.

    “On the basis of the anticipated rate of appropriately identified abnormal test results in the literature12,13,14,15,16,17,18,19,20,21 and the anticipated magnitude of the association of the enhanced EHR, we required a sample size of 30 participants, each reviewing 35 test results, to achieve 80% power to detect a statistically significant difference in cognitive workload and performance.”

    From Association of the Usability of Electronic Health Records With Cognitive Workload and Performance Levels Among Physicians (2019) · cites this paper as [21]

    The citation is attached to the anticipated rate in the literature, not to the citing authors’ sample-size and power calculation. The Results (page unavailable) report rates of acknowledgment and timely follow-up for abnormal-test alerts, but not a rate at which participants appropriately identified abnormal results while reviewing tests. The paper therefore provides related background rates, not the specific rate described. (LLM, conf=0.75)

    Experimental — accuracy not yet measured
  • Even in the EHR environment, with alerts and reminders in place, physicians continue to often inappropriately manage abnormal test results.

    “Even in the EHR environment, with alerts and reminders in place, physicians continue to often inappropriately manage abnormal test results.12,13,14,15,16,17,18,19,20,21”
  • The sociotechnical model accounts for complexities of technology, users, workflow, and larger external or organizational policies and context in assessment of EHR-related safety concerns.

    “The model accounts for the complexities of technology, its users, the involved workflow, and the larger external or organizational policies and context in assessment of EHR-related safety concerns.35 36”
  • Efforts to improve EHR-related patient safety depend on identifying underlying risks and appreciating contributing areas of vulnerability.

    “Efforts to improve EHR-related patient safety rely on identification of underlying risks as well as an appreciation of contributing areas of vulnerability”

Cites

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4 of the 30 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Singh, H., Thomas, E. J., Sittig, D. F., Wilson, L., Espadas, D., Khan, M. M., & Petersen, L. A.
Affiliations
  • Michael E. DeBakey VA Medical Center (US)
  • Memorial Hermann (US)
Corresponding author
Singh, Hardeep
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2010-03
Volume
123
Issue
3
Pages
238-244
ISSN
0002-9343 (ISSN-L)
OpenAlex
W1981106602
Cited by
160
References
30
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 6 · 2020: 10 · 2019: 13 · 2018: 12 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 11 · 2013: 16 · 2012: 10
FWCI
28.08
Type
journal article
Language
en
Open access
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons-TMC (Texas Medical Center) (submittedVersion)
Funders
  • National Institutes of Health (K23CA125585)
  • VA National Center for Patient Safety (R18 HS17244-02)
Topics
  • Health Sciences › Health Professions › Health Information Management › Electronic Health Records Systems
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Health Professions › Emergency Medical Services › Patient Safety and Medication Errors
Keywords
laboratory abnormalities, electronic health records, patient safety, HbA1c, anti-HCV antibodies, prostate-specific antigen, thyroid-stimulating hormone, outpatient care
MeSH terms
Communication, Diagnostic Errors, Female, Follow-Up Studies, Hepatitis C, Humans, Male, Practice Patterns, Physicians', Primary Health Care, Retrospective Studies, United States, Medical Records Systems, Computerized

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