Cited by 166Oral microbiology and periodontitis researchPreterm Birth and ChorioamnionitisPregnancy and preeclampsia studies

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Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence

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Vander Haar, Emilie L., So, Jeewon, Gyamfi-Bannerman, Cynthia, Han, Yiping W.·2018·Anaerobe

DOI 10.1016/j.anaerobe.2018.01.008PMC PMC6750227

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Abstract

Fusobacterium nucleatum is a Gram-negative anaerobic oral commensal associated with periodontal disease. F. nucleatum has been implicated in a wide spectrum of systemic diseases, including oral, gastro-intestinal, rheumatologic, and vascular pathologies. As pregnancy risk has been linked to periodontal disease, there has also been significant research into the effects of periodontal disease on adverse pregnancy outcomes. This article reviews the epidemiological and mechanistic evidence of the role of F. nucleatum in adverse pregnancy outcomes.

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Fig. 1 Schematic presentation of oral bacteria translocation to the fetal-placental unit. Bacteria enters the circulation through the inflamed gingival tissue (a) and (b). Hematogenously spread bacteria invade the fetal-placental unit through the vasculature in the decidua basalis (c) and (d). Binding of Fusobacterium nucleatum adhesin A (FadA) to vascular endothelial cadherin (VE-cadherin) increases the endothelial permeability, allowing F. nucleatum and other oral bacteria to disseminate into and from the circulation (b) and (c).CC BY-NC-ND · PubMed Central

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Result
Retracted
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Additional file 12 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Dietmar, P., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574691
Additional file 8 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
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Additional file 16 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574712
Additional file 9 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574682
Additional file 5 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574670
Additional file 3 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574664
Additional file 6 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574673
Additional file 4 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574667
Additional file 17 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574715
Additional file 13 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574700
Additional file 1 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574658
Additional file 2 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574661
Additional file 15 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574709
Additional file 11 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574688
Additional file 14 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Dietmar, P., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574706
Additional file 7 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574676
Additional file 10 of Vaginal and neonatal microbiota in pregnant women with preterm premature rupture of membranes and consecutive early onset neonatal sepsis
dos Anjos Borges, L. G., Pastuschek, J., Heimann, Y., Dawczynski, K., Schleußner, E., Pieper, D. H., & Zöllkau, J. (2024) · Figshare · doi:10.6084/m9.figshare.26574685
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172 Periodontitis and Systemic Diseases
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“According to Vander Haar et al., Fusobacterium is capable of traveling via the bloodstream from the oral cavity to the placenta, which can cause intrauterine inflam - mation and may contribute to the advancement of EMs [59].”
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“Persistent colonization may also sustain low ‑ grade inflammation, damaging local tissues and exacerbating systemic conditions such as cardiovascular disease and diabetes [199].”

Authors: Vander Haar, E. L., So, J., Gyamfi-Bannerman, C., & Han, Y. W.
Affiliations: Columbia University Irving Medical Center (US)
Corresponding author: Han, Yiping W.
ORCID: Han, Yiping W.
Venue: Anaerobe
Publisher: Elsevier BV
Published: 2018-04
Volume: 50
Pages: 55-59
ISSN: 1075-9964 (ISSN-L)
DOI: 10.1016/j.anaerobe.2018.01.008
PMC: PMC6750227
OpenAlex: W2791709251
Cited by: 155
References: 60
Citations by year: 2026: 23 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 20 · 2021: 20 · 2020: 13 · 2019: 4 · 2018: 1
FWCI: 1.39
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Anaerobe (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion, cc-by-nc-nd)
Funders: NIH (DE014924, DE023332, CA192111)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords: Fusobacterium nucleatum, adverse pregnancy outcomes, periodontal disease, oral commensals, oral microbiota, systemic inflammation, pregnancy complications, periodontitis
MeSH terms: Animals, Female, Fusobacterium Infections, Humans, Mouth Mucosa, Periodontal Diseases, Pregnancy, Pregnancy Complications, Pregnancy Complications, Infectious, Pregnancy Outcome, Virulence, Fusobacterium nucleatum

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Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence

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