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Cited by 150Oral microbiology and periodontitis researchGut microbiota and healthInfective Endocarditis Diagnosis and Management

Fusobacterium nucleatum and its associated systemic diseases: epidemiologic studies and possible mechanisms

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Fan, Zixin, Tang, Pengzhou, Li, Cheng, Yang, Qi, Xu, Yan, Su, Chuan, Li, Lu·2023·Journal of Oral Microbiology
DOI 10.1080/20002297.2022.2145729PMC PMC9673791
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Abstract

Background Fusobacterium nucleatum (F. nucleatum) is an anaerobic oral commensal and the major coaggregation bridge organism linking early and late colonisers. In recent years, a large number of studies suggest that F. nucleatum is closely related to the development of various systemic diseases, such as cardiovascular diseases, adverse pregnancy outcomes, inflammatory bowel diseases, cancer, Alzheimer's disease, respiratory infection, rheumatoid arthritis, etc.Objective To review the effect of F. nucleatum on systemic diseases and its possible pathogenesis and to open new avenues for prevention and treatment of F. nucleatum-associated systemic diseases.Design The research included every article published up to July 2022 featuring the keywords 'Systemic diseases' OR 'Atherosclerotic cardiovascular diseases' OR 'Atherosclerosis' OR 'Adverse pregnancy outcomes' OR 'Inflammatory bowel disease' OR 'Ulcerative colitis' OR 'Crohn’s disease' OR 'Cancers' OR 'Oral squamous cell carcinomas' OR 'Gastrointestinal cancers' OR 'Colorectal cancer' OR 'Breast cancer' OR 'Genitourinary cancers' OR 'Alzheimer’s disease ' OR 'Rheumatoid arthritis' OR 'Respiratory diseases' AND 'Fusobacterium nucleatum' OR 'Periodontal pathogen' OR 'Oral microbiota' OR 'Porphyromonas gingivalis' and was conducted in the major medical databases.Results F. nucleatum can induce immune response and inflammation in the body through direct or indirect pathways, and thus affect the occurrence and development of systemic diseases. Only by continuing to investigate the pathogenic lifestyles of F. nucleatum will we discover the divergent pathways that may be leveraged for diagnostic, preventive and therapeutic purposes.

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  • There is a strong epidemiologic association between periodontitis and Alzheimer's disease and related dementia.

    “There is a strong epidemiologic association between periodontitis (PD) and ADRD [5,6,7,8,9,10,11,12,13] but how these two diseases intersect and whether it is at the level of causation is unclear.”

    From Oral Microbially-Induced Small Extracellular Vesicles Cross the Blood–Brain Barrier (2024) · cites this paper as [10]

    The Alzheimer’s disease (AD) section says studies have identified a relationship between periodontitis and AD; the References include a population-based cohort study of that association. The paper does not characterize the epidemiologic association as strong or establish it for related dementias beyond AD. No page number is available in our copy. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Fan, Z., Tang, P., Li, C., Yang, Q., Xu, Y., Su, C., & Li, L.
Affiliations
  • Nanjing Medical University (CN)
  • State Key Laboratory of Reproductive Medicine (CN)
Corresponding author
Li, Lu
ORCID
Venue
Journal of Oral Microbiology
Publisher
Informa UK Limited
Published
2022-11-14
Volume
15
Issue
1
Pages
2145729-2145729
ISSN
2000-2297 (ISSN-L)
DOI
10.1080/20002297.2022.2145729
PMC
PMC9673791
OpenAlex
W4309196183
Cited by
150
References
19
Citations by year
2026: 42 · 2025: 55 · 2024: 39 · 2023: 14
FWCI
5.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Oral Microbiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (82201072)
  • the project of cadre health of Jiangsu Commission of health (BJ19033)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, 2018-87)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
Keywords
Fusobacterium nucleatum, systemic disease, oral microbiota, atherosclerotic cardiovascular disease, adverse pregnancy outcomes, inflammatory bowel disease, colorectal cancer, oral squamous cell carcinoma, Alzheimer's disease, rheumatoid arthritis, respiratory infections, Porphyromonas gingivalis, inflammation, immune response, periodontal pathogens, pathogenesis

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