RISING STARS: Bumps and bacteria: influence of the maternal microbiota on pregnancy outcomes
Abstract
During pregnancy, all major physiological systems undergo remarkable changes, driven largely by alterations in the maternal hormonal milieu. In healthy pregnancies, maternal cardiovascular and metabolic adaptation to pregnancy occurs to support fetal growth and maternal well-being. Impaired maternal adaptation to pregnancy is associated with a range of pregnancy complications, including gestational diabetes and preeclampsia. There is growing recognition of the importance of different maternal microbiota, including in the gut, vagina and oral cavity, in supporting normal maternal adaptations to pregnancy as well as evidence for microbial disturbances associating with pregnancy pathologies. Here, we aim to summarise emerging evidence demonstrating that differences in maternal microbiota associate with pregnancy outcomes and discuss potential therapeutic approaches under development that might restore an ‘optimal’ microbiome. In particular, we highlight recent work by ourselves and others exploring the role of the oral microbiome in pregnancy, given established links between poor oral health (e.g. periodontitis) and adverse pregnancy outcomes. Our research has focussed on specific nitrate-reducing oral bacteria which play a role in the generation of nitric oxide (NO) and other bioactive nitrogen oxides associated with cardiovascular health and maternal cardiovascular adaption to pregnancy. Ongoing research aims to define whether altered microbial profiles have clinical utility in the prediction of pregnancy pathologies, and whether interventions designed to optimise specific maternal microbiota could help prevent future complications.
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- Willmott, T., & Cottrell, E. C.
- Affiliations
- University of Manchester (GB)
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- Journal of Endocrinology
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- Bioscientifica
- Published
- 2024-02-09
- Volume
- 261
- Issue
- 2
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W4391683714
- Semantic Scholar
- 69df40863d1ef5b9816038ee7a44075d1ef2bc2c
- Cited by
- 0
- References
- 101
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- maternal microbiota, pregnancy outcomes, oral microbiota, nitrate-reducing bacteria, nitric oxide, periodontitis, maternal cardiovascular adaptation, gestational diabetes mellitus, preeclampsia, gut microbiota, vaginal microbiota, pregnancy complications, microbiota-targeted interventions
- MeSH terms
- Bacteria, Female, Humans, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Fetal Development, Microbiota
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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