The DOI matches its Crossref record; 187 of the 189 references it cites were found in a registry or an index.
Potential and challenges of tannins as an alternative to in-feed antibiotics for farm animal production
Open accessAbstract
Naturally occurring plant compounds including tannins, saponins and essential oils are extensively assessed as natural alternatives to in-feed antibiotics. Tannins are a group of polyphenolic compounds that are widely present in plant region and possess various biological activities including antimicrobial, anti-parasitic, anti-viral, antioxidant, anti-inflammatory, immunomodulation, etc. Therefore, tannins are the major research subject in developing natural alternative to in-feed antibiotics. Strong protein affinity is the well-recognized property of plant tannins, which has successfully been applied to ruminant nutrition to decrease protein degradation in the rumen, and thereby improve protein utilization and animal production efficiency. Incorporations of tannin-containing forage in ruminant diets to control animal pasture bloat, intestinal parasite and pathogenic bacteria load are another 3 important applications of tannins in ruminant animals. Tannins have traditionally been regarded as "anti-nutritional factor" for monogastric animals and poultry, but recent researches have revealed some of them, when applied in appropriate manner, improved intestinal microbial ecosystem, enhanced gut health and hence increased productive performance. The applicability of plant tannins as an alternative to in-feed antibiotics depends on many factors that contribute to the great variability in their observed efficacies.
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“Prolonged use of the purified form of secondary compounds can lead to antimicrobial resistance; however, tannin supplementation as a crude extract of mixtures (having different molecular sizes) offers a major advantage to control antimicrobial resistance (226).”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [226]
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Cited by
Sorted by citations
Tian, M., He, X., Feng, Y., Wang, W., Chen, H., Gong, M., Liu, D., Clarke, J. L., & van Eerde, A. (2021) · Antibiotics · doi:10.3390/antibiotics10050539 · Cited by 298
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Metadata
- Authors
- Huang, Q., Liu, X., Zhao, G., Hu, T., & Wang, Y.
- Affiliations
- Yangzhou University (CN)
- Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences (CN)
- Northwest A&F University (CN)
- Agriculture and Agri-Food Canada (CA)
- Corresponding author
- Wang, Yuxi
- Venue
- Animal nutrition
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 4
- Issue
- 2
- Pages
- 137-150
- ISSN
- 2405-6383 (ISSN-L)
- 2405-6545
- PMC
- PMC6104569
- OpenAlex
- W2761389834
- Cited by
- 555
- References
- 189
- Citations by year
- 2026: 58 · 2025: 68 · 2024: 94 · 2023: 70 · 2022: 83 · 2021: 86 · 2020: 61 · 2019: 25 · 2018: 9
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Animal nutrition (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Jiangsu Province (BK20170494)
- Agriculture Research System of China (CARS-36)
- Agriculture and Agri-Food Canada
- China Postdoctoral Science Foundation (2017M611930)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Keywords
- tannins, in-feed antibiotics, natural antibiotic alternatives, polyphenols, ruminant nutrition, protein degradation, intestinal parasites, poultry gut health, antinutritional factors, antimicrobial activity, saponins, essential oils, livestock productivity
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