Effect of Anodal Transcranial Direct Current Stimulation at the Right Dorsolateral Prefrontal Cortex on the Cognitive Function in Patients With Mild Cognitive Impairment: A Randomized Double-Blind Controlled Trial
Abstract
OBJECTIVES Study the effect of anodal transcranial direct stimulation (atDCS) of the right dorsolateral prefrontal cortex (DLPFC) on cognitive function and side effects in patients with mild cognitive impairment (MCI). STUDY DESIGN Experimental double-blind randomized, sham-controlled trial SETTING: Department of Rehabilitation Medicine, Tertiary Hospital SUBJECTS: Volunteers with MCI METHODS: Participants (45) who met the inclusion criteria were randomly allocated by block randomization into two groups. The atDCS group (23 participants) were stimulated at 2 mA for 20 min with the anode on the right DLPFC and cathode on the left supraorbital area. The control group (22 participants) received placebo stimulation. Baseline cognitive function was assessed by the Cambridge Neuropsychological Test Automated Battery (CANTAB) test. Participants were treated three times per week for four weeks (12 sessions). Cognitive function and side effects were assessed immediately after the first stimulation, the last session and 4 weeks post-treatment. RESULTS CANTAB results revealed a significant improvement in the accuracy of the visual sustained attention (VSA) in the atDCS group at all three time points, the spatial working memory (SWM) and visual memory (VM) immediately after the first stimulation and a decreased VM reaction time after 12 sessions. Long lasting effect on VSA and VM were found 4 weeks post-treatment. CONCLUSION Anodal tDCS over the right DLPFC enhanced the VSA, SWM and VM a…
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- Authors
- Stonsaovapak, C., Hemrungroj, S., Terachinda, P., & Piravej, K.
- Affiliations
- King Chulalongkorn Memorial Hospital (TH)
- Chulalongkorn University (TH)
- Corresponding author
- Piravej, Krisna
- Venue
- Archives of Physical Medicine and Rehabilitation
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 101
- Issue
- 8
- Pages
- 1279-1287
- ISSN
- 0003-9993 (ISSN-L)
- OpenAlex
- W3023396093
- Semantic Scholar
- ce97f3039a0989c32565e398792edfead8ded692
- Cited by
- 33
- References
- 32
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 1
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Physical Medicine and Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chulalongkorn University (RA 58/095)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- anodal tDCS, dorsolateral prefrontal cortex, mild cognitive impairment, cognitive function, spatial working memory, visual memory, reaction time, non-invasive brain stimulation
- MeSH terms
- Aged, Cognition, Double-Blind Method, Electrodes, Female, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Reaction Time, Prefrontal Cortex, Cognitive Dysfunction, Spatial Memory, Transcranial Direct Current Stimulation
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