The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Oral delivery of proteins and peptides: Challenges, status quo and future perspectives
Open accessAbstract
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeutic PPs are usually administered by parenteral route. Given the big demand for oral administration in clinical use, a variety of researches focused on developing new technologies to overcome GI barriers of PPs, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, as well as intestinal microdevices. Some new technologies have been developed under clinical trials and even on the market. This review summarizes the history, the physiological barriers and the overcoming approaches, current clinical and preclinical technologies, and future prospects of oral delivery of PPs.
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Cites
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Cited by
Aroda, V. R., Blonde, L., & Pratley, R. E. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09735-8 · Cited by 135
Metadata
- Authors
- Zhu, Q., Chen, Z., Paul, P. K., Lu, Y., Wu, W., & Qi, J.
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 11
- Issue
- 8
- Pages
- 2416-2448
- ISSN
- 2211-3835 (ISSN-L)
- OpenAlex
- W3157245446
- Cited by
- 353
- References
- 16
- FWCI
- 15.95
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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